{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:30:46Z","timestamp":1787236246750,"version":"build-2736575974"},"reference-count":219,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370987"],"award-info":[{"award-number":["32370987"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2025C04047"],"award-info":[{"award-number":["2025C04047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018552","name":"Science and Technology Plan Project of Taizhou","doi-asserted-by":"publisher","award":["202410"],"award-info":[{"award-number":["202410"]}],"id":[{"id":"10.13039\/501100018552","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018552","name":"Science and Technology Plan Project of Taizhou","doi-asserted-by":"publisher","award":["24nyb04"],"award-info":[{"award-number":["24nyb04"]}],"id":[{"id":"10.13039\/501100018552","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018552","name":"Science and Technology Plan Project of Taizhou","doi-asserted-by":"publisher","award":["24nya05"],"award-info":[{"award-number":["24nya05"]}],"id":[{"id":"10.13039\/501100018552","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018552","name":"Science and Technology Plan Project of Taizhou","doi-asserted-by":"publisher","award":["23gya02"],"award-info":[{"award-number":["23gya02"]}],"id":[{"id":"10.13039\/501100018552","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jconrel.2025.113827","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T19:14:07Z","timestamp":1746818047000},"page":"113827","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Animal vaccine revolution: Nanoparticle adjuvants open the future of vaccinology"],"prefix":"10.1016","volume":"383","author":[{"given":"Shangen","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yile","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chibo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.113827_bb0005","doi-asserted-by":"crossref","first-page":"e1345","DOI":"10.1016\/S2214-109X(20)30382-X","article-title":"Africa regional Commission for the Certification of poliomyelitis eradication, certifying the interruption of wild poliovirus transmission in the WHO African region on the turbulent journey to a polio-free world","volume":"8","year":"2020","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.jconrel.2025.113827_bb0010","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1073\/pnas.1704507114","article-title":"Simply put: vaccination saves lives","volume":"114","author":"Orenstein","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jconrel.2025.113827_bb0015","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.1223805","article-title":"Rinderpest eradication: appropriate technology and social innovations","volume":"337","author":"Mariner","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2025.113827_bb0020","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa2035389","article-title":"Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine","volume":"384","author":"Baden","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2025.113827_bb0025","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.scib.2019.08.015","article-title":"China needs long-term solutions for African swine fever","volume":"64","author":"Zhao","year":"2019","journal-title":"Sci. Bull."},{"issue":"2018","key":"10.1016\/j.jconrel.2025.113827_bb0030","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.3201\/eid2411.181274","article-title":"Molecular characterization of african swine fever virus, China","volume":"24","author":"Ge","year":"2018","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.jconrel.2025.113827_bb0035","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1111\/tbed.13515","article-title":"Control of avian influenza in China: strategies and lessons","volume":"67","author":"Liu","year":"2020","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.jconrel.2025.113827_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/jwmg.22171","article-title":"Highly pathogenic avian influenza is an emerging disease threat to wild birds in North America","volume":"86","author":"Ramey","year":"2022","journal-title":"J. Wildl. Manag."},{"key":"10.1016\/j.jconrel.2025.113827_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173692","article-title":"Avian influenza outbreaks: human infection risks for beach users - one health concern and environmental surveillance implications","volume":"943","author":"Tiwari","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jconrel.2025.113827_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodpol.2021.102068","article-title":"When poultry take a sick leave: response costs for the 2014\u20132015 highly pathogenic avian influenza epidemic in the USA","volume":"102","author":"Seeger","year":"2021","journal-title":"Food Policy"},{"key":"10.1016\/j.jconrel.2025.113827_bb0055","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/evj.12600","article-title":"African horse sickness: the potential for an outbreak in disease-free regions and current disease control and elimination techniques","volume":"48","author":"Robin","year":"2016","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.jconrel.2025.113827_bb0060","doi-asserted-by":"crossref","first-page":"618","DOI":"10.3389\/fmicb.2020.00618","article-title":"Genetic diversity of porcine reproductive and respiratory syndrome virus (PRRSV) from 1996 to 2017 in China","volume":"11","author":"Jiang","year":"2020","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/v14020401","article-title":"Yin, mRNA vaccine development for emerging animal and zoonotic diseases","volume":"14","author":"Le","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.jconrel.2025.113827_bb0070","doi-asserted-by":"crossref","first-page":"844","DOI":"10.3390\/v11090844","article-title":"African horse sickness: a review of current understanding and vaccine development","volume":"11","author":"Dennis","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.jconrel.2025.113827_bb0075","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3390\/vaccines11030578","article-title":"Lumpy skin disease-an emerging cattle disease in Europe and Asia","volume":"11","author":"Whittle","year":"2023","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.jconrel.2025.113827_bb0080","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev-publhealth-090419-102240","article-title":"Vaccine hesitancy, acceptance, and anti-vaccination: trends and future prospects for public health","volume":"42","author":"Dub\u00e9","year":"2021","journal-title":"Annu. Rev. Public Health"},{"key":"10.1016\/j.jconrel.2025.113827_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/S2666-5247(21)00177-4","article-title":"Comparative immunogenicity of mRNA and inactivated vaccines against COVID-19","volume":"2","author":"Lim","year":"2021","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.jconrel.2025.113827_bb0090","doi-asserted-by":"crossref","unstructured":"Q. Yin, W. Luo, V. Mallajosyula, Y. Bo, J. Guo, J. Xie, M. Sun, R. Verma, C. Li, C.M. Constantz, L.E. Wagar, J. Li, E. Sola, N. Gupta, C. Wang, O. Kask, X. Chen, X. Yuan, N.C. Wu, J. Rao, Y.-h. Chien, J. Cheng, B. Pulendran, M.M. Davis, A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2, Nat. Mater., 22 (2023) 380\u2013390. doi:https:\/\/doi.org\/10.1038\/s41563-022-01464-2.","DOI":"10.1038\/s41563-022-01464-2"},{"key":"10.1016\/j.jconrel.2025.113827_bb0095","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3390\/vaccines11020453","article-title":"Immunogenicity of different types of adjuvants and nanoadjuvants in veterinary vaccines: a comprehensive review","volume":"11","author":"Nooraei","year":"2023","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.jconrel.2025.113827_bb0100","author":"WOAH"},{"key":"10.1016\/j.jconrel.2025.113827_bb0105","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1136\/bmj.n485","article-title":"Preventing the next pandemic: the power of a global viral surveillance network","volume":"372","author":"Carroll","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.jconrel.2025.113827_bb0110","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41392-023-01557-7","article-title":"Vaccine adjuvants: mechanisms and platforms","volume":"8","author":"Zhao","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2025.113827_bb0115","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.cell.2021.02.030","article-title":"Novel approaches for vaccine development","volume":"184","author":"Gebre","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2025.113827_bb0120","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3390\/vaccines11020199","article-title":"African swine fever virus (ASFV): immunity and vaccine development","volume":"11","author":"Chathuranga","year":"2023","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.jconrel.2025.113827_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.202300293","article-title":"Designing selenium nanoadjuvant as universal agent for live-killed virus-based vaccine","volume":"7","author":"Deng","year":"2023","journal-title":"Small Methods"},{"key":"10.1016\/j.jconrel.2025.113827_bb0130","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41577-018-0103-6","article-title":"Advancing an HIV vaccine; advancing vaccinology","volume":"19","author":"Burton","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0135","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41577-022-00753-w","article-title":"Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies","volume":"23","author":"Haynes","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0140","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1111\/tbed.14110","article-title":"Characterization of four novel H5N6 avian influenza viruses with the internal genes from H5N1 and H9N2 viruses and experimental challenge of chickens vaccinated with current commercially available H5 vaccines","volume":"69","author":"Peng","year":"2022","journal-title":"Transbound. Emerg. Dis."},{"key":"10.1016\/j.jconrel.2025.113827_bb0145","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1007\/s12250-021-00383-x","article-title":"Accelerated evolution of H7N9 subtype influenza virus under vaccination pressure","volume":"36","author":"Wu","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.jconrel.2025.113827_bb0150","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202303531","article-title":"Self-assembled multiepitope nanovaccine provides long-lasting cross-protection against influenza virus","volume":"13","author":"Nie","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2025.113827_bb0155","doi-asserted-by":"crossref","first-page":"5800","DOI":"10.1038\/s41467-024-50087-5","article-title":"Enhancing cross-protection against influenza by heterologous sequential immunization with mRNA LNP and protein nanoparticle vaccines","volume":"15","author":"Dong","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.113827_bb0160","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2174\/2211738507666191024162042","article-title":"Nanoparticles and vaccine development","volume":"8","author":"Kheirollahpour","year":"2020","journal-title":"Pharm. Nanotechnol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0165","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering precision nanoparticles for drug delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2025.113827_bb0170","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adi1625","article-title":"A self-amplifying RNA vaccine prevents enterovirus D68 infection and disease in preclinical models","volume":"16","author":"Warner","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.113827_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113914","article-title":"Vaccine delivery systems toward lymph nodes","volume":"179","author":"Ding","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.113827_bb0180","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s12274-019-2301-3","article-title":"Critical size limit of biodegradable nanoparticles for enhanced lymph node trafficking and paracortex penetration","volume":"12","author":"Howard","year":"2019","journal-title":"Nano Res."},{"key":"10.1016\/j.jconrel.2025.113827_bb0185","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jconrel.2006.01.006","article-title":"In vivo targeting of dendritic cells in lymph nodes with poly (propylene sulfide) nanoparticles","volume":"112","author":"Reddy","year":"2006","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113827_bb0190","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/eji.200737984","article-title":"Nanoparticles target distinct dendritic cell populations according to their size","volume":"38","author":"Manolova","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0195","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1021\/nn3057005","article-title":"Gold nanoparticles as a vaccine platform: influence of size and shape on immunological responses in vitro and in vivo","volume":"7","author":"Niikura","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.113827_bb0200","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/s41565-023-01404-4","article-title":"Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines","volume":"18","author":"Han","year":"2023","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0205","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.3390\/vaccines9101128","article-title":"Evaluation of a virus-like nanoparticle porcine circovirus type-2 (PCV2) capsid protein fused with the pig immunoglobulin fc fragment as a novel vaccine candidate against PCV2 in mice","volume":"9","author":"Luo","year":"2021","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.jconrel.2025.113827_bb0210","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fcimb.2018.00007","article-title":"Targeted delivery of GP5 antigen of PRRSV to M cells enhances the antigen-specific systemic and mucosal immune responses","volume":"8","author":"Du","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0215","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.actbio.2018.09.037","article-title":"Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group a streptococcus","volume":"80","author":"Nevagi","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2025.113827_bb0220","doi-asserted-by":"crossref","first-page":"934","DOI":"10.3389\/fimmu.2018.00934","article-title":"Mucosal immunity and protective efficacy of intranasal inactivated influenza vaccine is improved by chitosan nanoparticle delivery in pigs","volume":"9","author":"Dhakal","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0225","doi-asserted-by":"crossref","first-page":"10939","DOI":"10.1021\/acsnano.9b00326","article-title":"Mucosal immunization with a pH-responsive nanoparticle vaccine induces protective CD8+ lung-resident memory T cells","volume":"13","author":"Knight","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.113827_bb0230","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.apsb.2020.02.011","article-title":"The construction of in vitro nasal cavity-mimic M-cell model, design of M cell-targeting nanoparticles and evaluation of mucosal vaccination by nasal administration","volume":"10","author":"Yang","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2025.113827_bb0235","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ejpb.2023.11.006","article-title":"Activation of the complement system by nanoparticles and strategies for complement inhibition","volume":"193","author":"Haroon","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2025.113827_bb0240","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1021\/acs.biomac.9b00887","article-title":"Amino-modified polymer nanoparticles as adjuvants to activate the complement system and to improve vaccine efficacy in vivo","volume":"20","author":"Pan","year":"2019","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2025.113827_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19030754","article-title":"Gold nanoparticle-induced cell death and potential applications in nanomedicine","volume":"19","author":"Sun","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.113827_bb0250","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1021\/acsnano.4c00654","article-title":"Tumor vaccine exploiting membranes with influenza virus-induced immunogenic cell death to decorate polylactic coglycolic acid nanoparticles","volume":"19","author":"Yang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.113827_bb0255","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nri.2016.107","article-title":"Immunogenic cell death in cancer and infectious disease","volume":"17","author":"Galluzzi","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0260","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1021\/acs.molpharmaceut.8b00126","article-title":"Treatment of canine oral melanoma with nanotechnology-based immunotherapy and radiation","volume":"15","author":"Hoopes","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2025.113827_bb0265","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3390\/jcm9020528","article-title":"Photochemical internalization for intracellular drug delivery. From basic mechanisms to clinical research","volume":"9","author":"Jerjes","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jconrel.2025.113827_bb0270","article-title":"Photochemical internalization enhanced vaccination is safe, and gives promising cellular immune responses to an HPV peptide-based vaccine in a phase I clinical study in healthy volunteers","volume":"11","author":"Otterhaug","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126286","article-title":"An immune-enhanced multivalent DNA nanovaccine to prevent H7 and H9 avian influenza virus in mice","volume":"251","author":"Xu","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.102925","article-title":"Enhance immune response to H9 AIV DNA vaccine based on polygene expression and DGL nanoparticle encapsulation","volume":"102","author":"Xu","year":"2023","journal-title":"Poult. Sci."},{"key":"10.1016\/j.jconrel.2025.113827_bb0285","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02958-23","article-title":"PEDV-spike-protein-expressing mRNA vaccine protects piglets against PEDV challenge","volume":"15","author":"Zhao","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.jconrel.2025.113827_bb0290","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3181\/00379727-37-9625","article-title":"Sensitization and antibody formation after injection of tubercle bacilli and paraffin oil","volume":"37","author":"Freund","year":"1937","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.jconrel.2025.113827_bb0295","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.provac.2013.06.006","article-title":"Reduction of Newcastle disease vaccine dose using a novel adjuvant for cellular immune response in poultry","volume":"7","author":"Arous","year":"2013","journal-title":"Proc. Vaccinol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0300","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.14202\/vetworld.2015.1189-1198","article-title":"Comparative study on the immunopotentiator effect of ISA 201, ISA 61, ISA 50, ISA 206 used in trivalent foot and mouth disease vaccine","volume":"8","author":"Ibrahim","year":"2015","journal-title":"Vet. World"},{"key":"10.1016\/j.jconrel.2025.113827_bb0305","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3390\/vaccines12090963","article-title":"Enhanced effects of ISA 207 adjuvant via intradermal route in foot-and-mouth disease vaccine for pigs","volume":"12","author":"Hwang","year":"2024","journal-title":"Vaccines"},{"key":"10.1016\/j.jconrel.2025.113827_bb0310","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cimid.2014.07.001","article-title":"The Mycoplasma hyopneumoniae recombinant heat shock protein P42 induces an immune response in pigs under field conditions","volume":"37","author":"Jorge","year":"2014","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.jconrel.2025.113827_bb0315","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S0264-410X(00)00337-6","article-title":"Evaluation of three 'ready to formulate' oil adjuvants for foot-and-mouth disease vaccine production","volume":"19","author":"Iyer","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2023.108563","article-title":"Comparative study of the effects of Montanide\u2122 ISA 763A VG and ISA 763B VG adjuvants on the immune response against Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus)","volume":"134","author":"Wangkahart","year":"2023","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0325","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1021\/js990011u","article-title":"Oil-in-water liposomal emulsions: characterization and potential use in vaccine delivery","volume":"88","author":"Muderhwa","year":"1999","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2025.113827_bb0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12917-018-1719-2","article-title":"Development of a novel oil-in-water emulsion and evaluation of its potential adjuvant function in a swine influenza vaccine in mice","volume":"14","author":"Zhang","year":"2018","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.jconrel.2025.113827_bb0335","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/10611860410001688018","article-title":"Preparation and evaluation of multiple emulsions water-in-oil-in-water (w\/o\/w) as delivery system for influenza virus antigens","volume":"12","author":"Bozkir","year":"2004","journal-title":"J. Drug Target."},{"key":"10.1016\/j.jconrel.2025.113827_bb0340","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/10837450.2024.2305107","article-title":"Development and efficacy evaluation of a novel water-in-oil-in-water adjuvant for an inactivated foot-and-mouth disease vaccine","volume":"29","author":"Zhang","year":"2024","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0345","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1080\/03079450120078707","article-title":"Safety and efficacy of water-in-oil-in-water emulsion vaccines containing Newcastle disease virus haemagglutinin-neuraminidase glycoprotein","volume":"30","author":"Fukanoki","year":"2001","journal-title":"Avian Pathol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0350","article-title":"Immunomodulation of water-in-oil-in-water (w\/o\/w) emulsion vaccines of killed Pasteurella multocida (P52) whole cells grown under iron-regulated conditions","volume":"74","author":"Rawat","year":"2004","journal-title":"Indian J. Anim. Sci."},{"key":"10.1016\/j.jconrel.2025.113827_bb0355","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.antiviral.2012.09.019","article-title":"Development of foot-and-mouth disease virus (FMDV) serotype O virus-like-particles (VLPs) vaccine and evaluation of its potency","volume":"96","author":"Subramanian","year":"2012","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jconrel.2025.113827_bb0360","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3390\/vaccines11020271","article-title":"Evaluation of vaccine strains developed for efficient, broad-range protection against foot-and-mouth disease type O","volume":"11","author":"Hwang","year":"2023","journal-title":"Vaccines"},{"key":"10.1016\/j.jconrel.2025.113827_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.cocis.2021.101458","article-title":"Nanoemulsions: the rising star of antiviral therapeutics and nanodelivery system-current status and prospects","volume":"54","author":"Franklyne","year":"2021","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"10.1016\/j.jconrel.2025.113827_bb0370","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jconrel.2022.04.036","article-title":"Oil-in-ionic liquid nanoemulsion-based intranasal delivery system for influenza split-virus vaccine","volume":"346","author":"Lin","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113827_bb0375","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1016\/j.vaccine.2019.06.039","article-title":"An indirect comparison meta-analysis of AS03 and MF59 adjuvants in pandemic influenza a(H1N1) pdm09 vaccines","volume":"37","author":"Hauser","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0380","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1473-3099(10)70296-6","article-title":"Immunogenicity and safety of a two-dose schedule of whole-virion and AS03A-adjuvanted 2009 influenza A (H1N1) vaccines: a randomised, multicentre, age-stratified, head-to-head trial","volume":"11","author":"Nicholson","year":"2011","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.jconrel.2025.113827_bb0385","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003225","article-title":"Reassessment of the risk of narcolepsy in children in England 8 years after receipt of the AS03-adjuvanted H1N1 pandemic vaccine: a case-coverage study","volume":"17","author":"Stowe","year":"2020","journal-title":"PLoS Med."},{"key":"10.1016\/j.jconrel.2025.113827_bb0390","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002954","article-title":"Pre-clinical evaluation of a novel nanoemulsion-based hepatitis B mucosal vaccine","volume":"3","author":"Makidon","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jconrel.2025.113827_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.121180","article-title":"Intranasal vaccine: factors to consider in research and development","volume":"609","author":"Xu","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.113827_bb0400","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nri3251","article-title":"Recent progress in mucosal vaccine development: potential and limitations","volume":"12","author":"Lycke","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0405","doi-asserted-by":"crossref","first-page":"998","DOI":"10.3390\/vaccines9090998","article-title":"Safety and efficacy of spray intranasal live attenuated influenza vaccine: systematic review and meta-analysis","volume":"9","author":"Perego","year":"2021","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.jconrel.2025.113827_bb0410","doi-asserted-by":"crossref","first-page":"6470","DOI":"10.1016\/j.vaccine.2019.08.077","article-title":"Intranasal nanoemulsion-adjuvanted HSV-2 subunit vaccine is effective as a prophylactic and therapeutic vaccine using the guinea pig model of genital herpes","volume":"37","author":"Bernstein","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0415","doi-asserted-by":"crossref","first-page":"6103","DOI":"10.1016\/j.vaccine.2018.08.072","article-title":"The type of adjuvant in whole inactivated influenza a virus vaccines impacts vaccine-associated enhanced respiratory disease","volume":"36","author":"Souza","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0420","doi-asserted-by":"crossref","DOI":"10.3390\/nano12223934","article-title":"Development and efficacy evaluation of a novel Nano-emulsion adjuvant for a foot-and-mouth disease virus-like particles vaccine based on Squalane","volume":"12","author":"Shi","year":"2022","journal-title":"Nanomaterials (Basel)"},{"key":"10.1016\/j.jconrel.2025.113827_bb0425","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2023.1116722","article-title":"Nano-adjuvanted dry powder vaccine for the mucosal immunization against airways pathogens","volume":"10","author":"Canelli","year":"2023","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.jconrel.2025.113827_bb0430","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.ymthe.2018.12.013","article-title":"Self-amplifying RNA vaccines for venezuelan equine encephalitis virus induce robust protective immunogenicity in mice","volume":"27","author":"Samsa","year":"2019","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2025.113827_bb0435","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2217\/nnm-2023-0199","article-title":"Nanoemulsions: summary of a decade of research and recent advances","volume":"19","author":"Chavda","year":"2024","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0440","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20205092","article-title":"Natural polysaccharide nanomaterials: an overview of their immunological properties","volume":"20","author":"Torres","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.113827_bb0445","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ijbiomac.2021.12.129","article-title":"Recent advances on chitosan as an adjuvant for vaccine delivery","volume":"200","author":"Dmour","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.120884","article-title":"Hyaluronic acid modified oral drug delivery system with mucoadhesiveness and macrophage-targeting for colitis treatment","volume":"313","author":"Zhang","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2025.113827_bb0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118999","article-title":"Analysis of clinical trials on biomaterial and therapeutic applications of chitosan: a review","volume":"278","author":"Kantak","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2025.113827_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118050","article-title":"Immunostimulatory effect of chitosan and quaternary chitosan: a review of potential vaccine adjuvants","volume":"264","author":"Li","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2025.113827_bb0465","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.carbpol.2019.05.036","article-title":"Chitosan oligosaccharide-mediated attenuation of LPS-induced inflammation in IPEC-J2 cells is related to the TLR4\/NF-\u03baB signaling pathway","volume":"219","author":"Shi","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2025.113827_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122847","article-title":"Chitosan derivative composite nanoparticles as adjuvants enhance the cellular immune response via activation of the cGAS-STING pathway","volume":"636","author":"Zhao","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.113827_bb0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121346","article-title":"Chitosan-based nano-micelles for potential anti-tumor immunotherapy: synergistic effect of cGAS-STING signaling pathway activation and tumor antigen absorption","volume":"321","author":"Zhang","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2025.113827_bb0480","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1002\/bit.27647","article-title":"High- and low-molecular-weight chitosan act as adjuvants during single-dose influenza a virus protein vaccination through distinct mechanisms","volume":"118","author":"Lampe","year":"2021","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.jconrel.2025.113827_bb0485","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1002\/jmv.24253","article-title":"Conjugating influenza a (H1N1) antigen to n-trimethylaminoethylmethacrylate chitosan nanoparticles improves the immunogenicity of the antigen after nasal administration","volume":"87","author":"Liu","year":"2015","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0490","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13567-020-00762-4","article-title":"Intranasally administered protein coated chitosan nanoparticles encapsulating influenza H9N2 HA2 and M2e mRNA molecules elicit protective immunity against avian influenza viruses in chickens","volume":"51","author":"Hajam","year":"2020","journal-title":"Vet. Res."},{"key":"10.1016\/j.jconrel.2025.113827_bb0495","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ijpharm.2018.09.044","article-title":"Mechanistic study of the adjuvant effect of chitosan-aluminum nanoparticles","volume":"552","author":"Lebre","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.113827_bb0500","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.biologicals.2017.10.004","article-title":"Preparation and immunological evaluation of inactivated avian influenza virus vaccine encapsulated in chitosan nanoparticles","volume":"51","author":"Mohamed","year":"2018","journal-title":"Biologicals"},{"key":"10.1016\/j.jconrel.2025.113827_bb0505","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1016\/j.vaccine.2018.03.065","article-title":"Inactivated infectious bronchitis virus vaccine encapsulated in chitosan nanoparticles induces mucosal immune responses and effective protection against challenge","volume":"36","author":"Lopes","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0510","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jconrel.2015.11.006","article-title":"PEG modified liposomes containing CRX-601 adjuvant in combination with methylglycol chitosan enhance the murine sublingual immune response to influenza vaccination","volume":"223","author":"Oberoi","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113827_bb0515","article-title":"Poly-\u03b3-glutamic acid\/chitosan nanogel greatly enhances the efficacy and heterosubtypic cross-reactivity of H1N1 pandemic influenza vaccine","volume":"7","author":"Yang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113827_bb0520","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001979","article-title":"Oral administration of PEDV-dissolved Alg-CS gel induces high and sustained mucosal immunity in mice","volume":"105","author":"Zhang","year":"2024","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0525","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1111\/jfd.13697","article-title":"The recombinant subunit vaccine encapsulated by alginate-chitosan microsphere enhances the immune effect against Micropterus salmoides rhabdovirus","volume":"45","author":"Xu","year":"2022","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.jconrel.2025.113827_bb0530","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1016\/j.vaccine.2018.02.072","article-title":"Nasal vaccination with r4M2e.HSP70c antigen encapsulated into N-trimethyl chitosan (TMC) nanoparticulate systems: preparation and immunogenicity in a mouse model","volume":"36","author":"Dabaghian","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0535","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/fty070","article-title":"Simultaneous formulation of influenza vaccine and chitosan nanoparticles within CpG oligodesoxi nucleotides leads to dose-sparing and protects against lethal challenge in the mouse model","volume":"76","author":"Sadati","year":"2018","journal-title":"Pathog. Dis."},{"key":"10.1016\/j.jconrel.2025.113827_bb0540","article-title":"Intranasal administration of RBD nanoparticles confers induction of mucosal and systemic immunity against SARS-CoV-2","volume":"9","author":"Jearanaiwitayakul","year":"2021","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.jconrel.2025.113827_bb0545","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1080\/10717544.2017.1388450","article-title":"Quaternized chitosan nanoparticles loaded with the combined attenuated live vaccine against Newcastle disease and infectious bronchitis elicit immune response in chicken after intranasal administration","volume":"24","author":"Zhao","year":"2017","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jconrel.2025.113827_bb0550","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1021\/acs.molpharmaceut.7b00826","article-title":"Enhancing Mucosal immune response of newcastle disease virus DNA vaccine using N-2-hydroxypropyl trimethylammonium chloride chitosan and N,O-Carboxymethyl chitosan nanoparticles as delivery carrier","volume":"15","author":"Zhao","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2025.113827_bb0555","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.carbpol.2016.04.085","article-title":"Biological evaluation of N-2-hydroxypropyl trimethyl ammonium chloride chitosan as a carrier for the delivery of live Newcastle disease vaccine","volume":"149","author":"Zhao","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2025.113827_bb0560","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.vaccine.2023.03.067","article-title":"Adjuvanted quaternized chitosan composite aluminum nanoparticles-based vaccine formulation promotes immune responses in chickens","volume":"41","author":"Liu","year":"2023","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0565","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.imlet.2020.04.014","article-title":"Water-soluble N-2-Hydroxypropyl trimethyl ammonium chloride chitosan enhanced the immunogenicity of inactivated porcine parvovirus vaccine vaccination on sows against porcine parvovirus infection","volume":"223","author":"Zhou","year":"2020","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jconrel.2025.113827_bb0570","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119174","article-title":"Mannose-anchored quaternized chitosan\/thiolated carboxymethyl chitosan composite NPs as mucoadhesive carrier for drug delivery","volume":"283","author":"Jin","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2025.113827_bb0575","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1177\/0885328217704139","article-title":"pH sensitive phosphorylated chitosan hydrogel as vaccine delivery system for intramuscular immunization","volume":"31","author":"Wei","year":"2017","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.jconrel.2025.113827_bb0580","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115423","article-title":"Chitosan, hydroxypropyltrimethyl ammonium chloride chitosan and sulfated chitosan nanoparticles as adjuvants for inactivated Newcastle disease vaccine","volume":"229","author":"Yang","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2025.113827_bb0585","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.ijbiomac.2021.05.050","article-title":"Feasibility of chitosan-based nanoparticles approach for intranasal immunisation of live attenuated Japanese encephalitis vaccine","volume":"183","author":"Dumkliang","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0590","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3390\/ani13050889","article-title":"The oral inactivated porcine epidemic diarrhea virus presenting in the intestine induces mucosal immunity in mice with alginate-chitosan microcapsules","volume":"13","author":"Qin","year":"2023","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.jconrel.2025.113827_bb0595","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.133008","article-title":"Mucoadhesive chitosan-catechol as an efficient vaccine delivery system for intranasal immunization","volume":"273","author":"Deng","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0600","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.2147\/IJN.S370585","article-title":"Chitosan-coated selenium nanoparticles attenuate PRRSV replication and ROS\/JNK-mediated apoptosis in vitro","volume":"17","author":"Shao","year":"2022","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0605","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.vetmic.2017.01.037","article-title":"Evaluation of hydrophobic chitosan-based particulate formulations of porcine reproductive and respiratory syndrome virus vaccine candidate T cell antigens","volume":"209","author":"Mokhtar","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0610","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.rvsc.2017.12.004","article-title":"Enhancement of immune response of piglets to PCV-2 vaccine by porcine IL-2 and fusion IL-4\/6 gene entrapped in chitosan nanoparticles","volume":"117","author":"Chen","year":"2018","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.jconrel.2025.113827_bb0615","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2147\/IJN.S54226","article-title":"Preparation and efficacy of Newcastle disease virus DNA vaccine encapsulated in chitosan nanoparticles","volume":"9","author":"Zhao","year":"2014","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0620","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.584299","article-title":"Immunity and protective efficacy of mannose conjugated chitosan-based influenza nanovaccine in maternal antibody positive pigs","volume":"12","author":"Renu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0625","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.558349","article-title":"Chitosan nanoparticle based mucosal vaccines delivered against infectious diseases of poultry and pigs","volume":"8","author":"Renu","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0630","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1016\/j.vaccine.2012.06.035","article-title":"Hepatitis B surface antigen nanoparticles coated with chitosan and trimethyl chitosan: impact of formulation on physicochemical and immunological characteristics","volume":"30","author":"Tafaghodi","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0635","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jbiotec.2020.01.016","article-title":"Mannosylated chitosan nanoparticles loaded with FliC antigen as a novel vaccine candidate against Brucella melitensis and Brucella abortus infection","volume":"310","author":"Sadeghi","year":"2020","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0640","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00415-21","article-title":"Oral probiotic vaccine expressing koi herpesvirus (KHV) ORF81 protein delivered by chitosan-alginate capsules is a promising strategy for mass oral vaccination of carps against KHV infection","volume":"95","author":"Huang","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0645","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.vetimm.2018.04.006","article-title":"Nasal delivery of chitosan\/alginate nanoparticle encapsulated bee (Apis mellifera) venom promotes antibody production and viral clearance during porcine reproductive and respiratory syndrome virus infection by modulating T cell related responses","volume":"200","author":"Lee","year":"2018","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0650","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001894","article-title":"A new strategy based on SmRho protein loaded chitosan nanoparticles as a candidate oral vaccine against schistosomiasis","volume":"6","author":"Oliveira","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.jconrel.2025.113827_bb0655","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10591","article-title":"Biodegradable scaffolds for enhancing vaccine delivery","volume":"8","author":"Kerr","year":"2023","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.113827_bb0660","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/s41423-021-00667-y","article-title":"Hyaluronan is a natural and effective immunological adjuvant for protein-based vaccines","volume":"18","author":"Dalla Piet\u00e0","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0665","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jconrel.2015.04.010","article-title":"Cationic liposome-hyaluronic acid hybrid nanoparticles for intranasal vaccination with subunit antigens","volume":"208","author":"Fan","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113827_bb0670","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.106092","article-title":"Immunological evaluation of a recombinant vaccine delivered with an analogous hyaluronic acid chitosan nanoparticle-hydrogel against toxoplasma gondii in mice","volume":"179","author":"Li","year":"2023","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.jconrel.2025.113827_bb0675","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241210296","article-title":"Hyaluronic acid: a powerful biomolecule with wide-ranging applications-a comprehensive review","volume":"24","author":"Iaconisi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.113827_bb0680","doi-asserted-by":"crossref","DOI":"10.3390\/polym10010031","article-title":"Polymer-based nanomaterials and applications for vaccines and drugs","volume":"10","author":"Han","year":"2018","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.jconrel.2025.113827_bb0685","doi-asserted-by":"crossref","first-page":"6913","DOI":"10.1021\/acs.macromol.2c00854","article-title":"Immunostimulatory polymers as adjuvants, immunotherapies, and delivery systems","volume":"55","author":"Weiss","year":"2022","journal-title":"Macromolecules"},{"key":"10.1016\/j.jconrel.2025.113827_bb0690","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jconrel.2012.01.043","article-title":"PLGA-based nanoparticles: an overview of biomedical applications","volume":"161","author":"Danhier","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113827_bb0695","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1186\/s12951-022-01730-0","article-title":"Splenic-targeting biomimetic nanovaccine for elevating protective immunity against virus infection","volume":"20","author":"Huo","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0700","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jconrel.2016.12.039","article-title":"Biodegradable nanoparticle delivery of inactivated swine influenza virus vaccine provides heterologous cell-mediated immune response in pigs","volume":"247","author":"Dhakal","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113827_bb0705","doi-asserted-by":"crossref","first-page":"5527","DOI":"10.2147\/IJN.S252515","article-title":"The immunoenhancement effects of polyethylenimine-modified chinese yam polysaccharide-encapsulated PLGA nanoparticles as an adjuvant","volume":"15","author":"Zhang","year":"2020","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0710","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jconrel.2019.06.041","article-title":"Electroporation of a nanoparticle-associated DNA vaccine induces higher inflammation and immunity compared to its delivery with microneedle patches in pigs","volume":"308","author":"Bernelin-Cottet","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113827_bb0715","article-title":"Versatile PLGA-based drug delivery systems for tumor immunotherapy, small","author":"Wang","year":"2025","journal-title":"Methods"},{"key":"10.1016\/j.jconrel.2025.113827_bb0720","doi-asserted-by":"crossref","first-page":"9026","DOI":"10.1016\/j.vaccine.2011.09.033","article-title":"Development and characterization of chitosan coated poly-(\u025b-caprolactone) nanoparticulate system for effective immunization against influenza","volume":"29","author":"Gupta","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0725","first-page":"937","article-title":"Fabrication of nanoadjuvant with poly-\u03b5-caprolactone (PCL) for developing a single-shot vaccine providing prolonged immunity","volume":"9","author":"Prashant","year":"2014","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0730","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ijpharm.2018.05.012","article-title":"pH-sensitive nanoparticles as smart carriers for selective intracellular drug delivery to tumor","volume":"545","author":"Li","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.113827_bb0735","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1080\/09205063.2015.1095023","article-title":"\u0395-Polylysine and next-generation dendrigraft poly-L-lysine: chemistry, activity, and applications in biopharmaceuticals","volume":"26","author":"Shi","year":"2015","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.jconrel.2025.113827_bb0740","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20215458","article-title":"Targeted delivery prodigiosin to choriocarcinoma by peptide-guided dendrigraft poly-l-lysines nanoparticles","volume":"20","author":"Zhao","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.113827_bb0745","article-title":"Dendrigraft poly-L-lysines delivery of DNA vaccine effectively enhances the immunogenic responses against H9N2 avian influenza virus infection in chickens","volume":"27","author":"Zhao","year":"2020","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0750","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202304514","article-title":"Manganese-based nanoparticle vaccine for combating fatal bacterial pneumonia","volume":"35","author":"OuYang","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2025.113827_bb0755","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41573-021-00163-y","article-title":"Emerging concepts in the science of vaccine adjuvants","volume":"20","author":"Pulendran","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2025.113827_bb0760","doi-asserted-by":"crossref","DOI":"10.1016\/j.apsb.2024.09.012","article-title":"Next-generation aluminum adjuvants: immunomodulatory layered double hydroxide nanoalum reengineered from first-line drugs","author":"Su","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2025.113827_bb0765","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/978-1-0716-1892-9_9","article-title":"Adjuvants: engineering protective immune responses in human and veterinary vaccines","volume":"2412","author":"Akache","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0770","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jconrel.2013.10.032","article-title":"Aluminum hydroxide nanoparticles show a stronger vaccine adjuvant activity than traditional aluminum hydroxide microparticles","volume":"173","author":"Li","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113827_bb0775","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1016\/j.vaccine.2018.07.006","article-title":"Comparison of immunogenicity, efficacy and transcriptome changes of inactivated rabies virus vaccine with different adjuvants","volume":"36","author":"Shi","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0780","doi-asserted-by":"crossref","first-page":"10834","DOI":"10.1021\/nn404211j","article-title":"Engineering an effective immune adjuvant by designed control of shape and crystallinity of aluminum oxyhydroxide nanoparticles","volume":"7","author":"Sun","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.113827_bb0785","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.virol.2021.10.010","article-title":"LDH nanoparticle adjuvant subunit vaccine induces an effective immune response for porcine epidemic diarrhea virus","volume":"565","author":"Shi","year":"2022","journal-title":"Virology"},{"key":"10.1016\/j.jconrel.2025.113827_bb0790","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2217\/nnm.13.58","article-title":"Gold nanoparticle-M2e conjugate coformulated with CpG induces protective immunity against influenza a virus","volume":"9","author":"Tao","year":"2014","journal-title":"Nanomedicine (London)"},{"key":"10.1016\/j.jconrel.2025.113827_bb0795","article-title":"Assessment of gold nanoparticles as a size-dependent vaccine carrier for enhancing the antibody response against synthetic foot-and-mouth disease virus peptide","volume":"21","author":"Chen","year":"2010","journal-title":"Nanotechnology"},{"key":"10.1016\/j.jconrel.2025.113827_bb0800","doi-asserted-by":"crossref","first-page":"6752","DOI":"10.1016\/j.vaccine.2018.09.030","article-title":"Golden-star nanoparticles as adjuvant effectively promotes immune response to foot-and-mouth disease virus-like particles vaccine","volume":"36","author":"Teng","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0805","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.2147\/IJN.S140789","article-title":"Nanoparticle orientationally displayed antigen epitopes improve neutralizing antibody level in a model of porcine circovirus type 2","volume":"12","author":"Ding","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0810","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1016\/j.vaccine.2024.03.009","article-title":"Preparation and adjuvanticity against PCV(2) of Viola philippica polysaccharide loaded in chitosan-gold nanoparticle","volume":"42","author":"Xu","year":"2024","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0815","first-page":"1499","article-title":"Toward environmentally favorable nano-sensing by production of reusable gold nanoparticles from gold nano-waste: life cycle and nanocircular economy implications, environmental science","volume":"11","author":"Kang","year":"2024","journal-title":"Nano"},{"key":"10.1016\/j.jconrel.2025.113827_bb0820","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25053032","article-title":"Carbon-based nanomaterials 4.0","volume":"25","author":"D\u00edez-Pascual","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.113827_bb0825","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.3382\/ps\/pez313","article-title":"Novel carbon quantum dots can serve as an excellent adjuvant for the gp85 protein vaccine against avian leukosis virus subgroup J in chickens","volume":"98","author":"Cheng","year":"2019","journal-title":"Poult. Sci."},{"key":"10.1016\/j.jconrel.2025.113827_bb0830","article-title":"Balanced Th1\/Th2 immune response induced by MSP1a functional motif coupled to multiwalled carbon nanotubes as anti-anaplasmosis vaccine in murine model","volume":"24","author":"Pimentel","year":"2020","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0835","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.fsi.2020.08.003","article-title":"Single-walled carbon nanotubes enhance the immune protective effect of a bath subunit vaccine for pearl gentian grouper against Iridovirus of Taiwan","volume":"106","author":"Liu","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0840","doi-asserted-by":"crossref","DOI":"10.3390\/v13112158","article-title":"Evaluation of the effect of inactivated transmissible gastroenteritis virus vaccine with nano silicon on the phenotype and function of porcine dendritic cells","volume":"13","author":"Zheng","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.jconrel.2025.113827_bb0845","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143507","article-title":"Silica vesicle nanovaccine formulations stimulate long-term immune responses to the bovine viral diarrhoea virus E2 protein","volume":"10","author":"Mody","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jconrel.2025.113827_bb0850","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1743-422X-9-108","article-title":"Immunization of mice by hollow mesoporous silica nanoparticles as carriers of porcine circovirus type 2 ORF2 protein","volume":"9","author":"Guo","year":"2012","journal-title":"Virol. J."},{"key":"10.1016\/j.jconrel.2025.113827_bb0855","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2022.105488","article-title":"Current status of silica-based nanoparticles as therapeutics and its potential as therapies against viruses","volume":"210","author":"Tng","year":"2023","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jconrel.2025.113827_bb0860","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202303261","article-title":"Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy","volume":"35","author":"Zong","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2025.113827_bb0865","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41573-023-00859-3","article-title":"Strategies to reduce the risks of mRNA drug and vaccine toxicity","volume":"23","author":"Bitounis","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2025.113827_bb0870","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.addr.2020.06.002","article-title":"Lipid nanoparticles for nucleic acid delivery: current perspectives","volume":"154-155","author":"Samaridou","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.113827_bb0875","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1038\/s41467-018-05482-0","article-title":"Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies","volume":"9","author":"Pardi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.113827_bb0880","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41541-021-00420-6","article-title":"Development of multivalent mRNA vaccine candidates for seasonal or pandemic influenza","volume":"6","author":"Chivukula","year":"2021","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.jconrel.2025.113827_bb0885","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.cell.2017.02.017","article-title":"Modified mRNA vaccines protect against zika virus infection","volume":"168","author":"Richner","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2025.113827_bb0890","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3389\/fmicb.2017.00605","article-title":"Induction of protective immunity against toxoplasma gondii in mice by nucleoside triphosphate hydrolase-ii (ntpase-ii) self-amplifying RNA vaccine encapsulated in lipid nanoparticle (LNP)","volume":"8","author":"Luo","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0895","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.coviro.2018.12.001","article-title":"Emerging and re-emerging coronaviruses in pigs","volume":"34","author":"Wang","year":"2019","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0900","article-title":"A spike-based mRNA vaccine that induces durable and broad protection against porcine deltacoronavirus in piglets","author":"Li","year":"2024","journal-title":"J. Virol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0905","doi-asserted-by":"crossref","DOI":"10.1080\/21645515.2024.2382499","article-title":"Development of mRNA rabies vaccines","volume":"20","author":"Fang","year":"2024","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.jconrel.2025.113827_bb0910","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202301801","article-title":"ISCOMs\/MPLA-adjuvanted SDAD protein nanoparticles induce improved mucosal immune responses and cross-protection in mice","volume":"19","author":"Zhu","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2025.113827_bb0915","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1051\/vetres:2007062","article-title":"Protection, systemic IFNgamma, and antibody responses induced by an ISCOM-based vaccine against a recent equine influenza virus in its natural host","volume":"39","author":"Paillot","year":"2008","journal-title":"Vet. Res."},{"key":"10.1016\/j.jconrel.2025.113827_bb0920","doi-asserted-by":"crossref","DOI":"10.1038\/s41551-024-01208-4","article-title":"Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers","author":"Yin","year":"2024","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2025.113827_bb0925","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12951-021-00806-7","article-title":"Virus-like particles: preparation, immunogenicity and their roles as nanovaccines and drug nanocarriers","volume":"19","author":"Nooraei","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0930","article-title":"Construction of porcine epidemic diarrhea virus-like particles and its immunogenicity in mice","volume":"9","author":"Kim","year":"2021","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.jconrel.2025.113827_bb0935","article-title":"A universal influenza nanovaccine for \u201cmixing vessel\u201d hosts confers potential ability to block cross-species transmission","volume":"8","author":"Ding","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2025.113827_bb0940","doi-asserted-by":"crossref","first-page":"7533","DOI":"10.2147\/IJN.S218057","article-title":"Nanovaccine confers dual protection against influenza a virus and porcine circovirus type 2","volume":"14","author":"Ding","year":"2019","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2025.113827_bb0945","doi-asserted-by":"crossref","DOI":"10.3390\/v16060991","article-title":"Development of a ferritin protein nanoparticle vaccine with PRRSV GP5 protein","volume":"16","author":"Chang","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.jconrel.2025.113827_bb0950","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.virol.2020.10.007","article-title":"Immunization with a recombinant fusion of porcine reproductive and respiratory syndrome virus modified GP5 and ferritin elicits enhanced protective immunity in pigs","volume":"552","author":"Ma","year":"2021","journal-title":"Virology"},{"key":"10.1016\/j.jconrel.2025.113827_bb0955","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/s41423-023-01024-x","article-title":"Hyaluronan as an immunological adjuvant: a novel application for an ancient molecule","volume":"20","author":"Carpanese","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0960","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3390\/pharmaceutics15020615","article-title":"PLGA particles in immunotherapy","volume":"15","author":"Horvath","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.113827_bb0965","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ddtec.2021.02.001","article-title":"Gold nanoparticle-based platforms for vaccine development","volume":"38","author":"Mateu Ferrando","year":"2020","journal-title":"Drug Discov. Today Technol."},{"key":"10.1016\/j.jconrel.2025.113827_bb0970","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.2174\/1386207323999200918112538","article-title":"Carbon Nano tubes: novel drug delivery system in amelioration of Alzheimer\u2019s disease","volume":"24","author":"Mishra","year":"2021","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.jconrel.2025.113827_bb0975","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/17425247.2019.1575806","article-title":"Mesoporous silica nanoparticles: synthesis, classification, drug loading, pharmacokinetics, biocompatibility, and application in drug delivery","volume":"16","author":"Li","year":"2019","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jconrel.2025.113827_bb0980","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1038\/s41598-017-03834-2","article-title":"A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics","volume":"7","author":"Zhao","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113827_bb0985","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jconrel.2021.05.021","article-title":"Impact of lipid nanoparticle size on mRNA vaccine immunogenicity","volume":"335","author":"Hassett","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113827_bb0990","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abq3500","article-title":"Manganese-coordinated mRNA vaccines with enhanced mRNA expression and immunogenicity induce robust immune responses against SARS-CoV-2 variants","volume":"8","author":"Fan","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2025.113827_bb0995","article-title":"Potentials of saponins-based adjuvants for nasal vaccines","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.113827_bb1000","article-title":"Virus-like particle vaccines: a prospective panacea against an avian influenza panzootic","volume":"8","author":"Ninyio","year":"2020","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.jconrel.2025.113827_bb1005","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/bip.22759","article-title":"Different applications of virus-like particles in biology and medicine: vaccination and delivery systems","volume":"105","author":"Shirbaghaee","year":"2016","journal-title":"Biopolymers"},{"key":"10.1016\/j.jconrel.2025.113827_bb1010","article-title":"A single vaccination of chimeric bivalent virus-like particle vaccine confers protection against H9N2 and H3N2 avian influenza in commercial broilers and allows a strategy of differentiating infected from vaccinated animals","volume":"13","author":"Sun","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.113827_bb1015","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1016\/j.biomaterials.2007.08.015","article-title":"Interactions of antigen-loaded polylactide particles with macrophages and their correlation with the immune response","volume":"28","author":"Kanchan","year":"2007","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.113827_bb1020","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.vaccine.2007.12.030","article-title":"Characterization of immune responses elicited in mice by intranasal co-immunization with HIV-1 tat, gp140 DeltaV2Env and\/or SIV gag proteins and the nontoxicogenic heat-labile Escherichia coli enterotoxin","volume":"26","author":"Caputo","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113827_bb1025","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1016\/j.vaccine.2009.03.040","article-title":"Lipid vesicle size of an oral influenza vaccine delivery vehicle influences the Th1\/Th2 bias in the immune response and protection against infection","volume":"27","author":"Mann","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113827_bb1030","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0264-410X(02)00435-8","article-title":"Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres","volume":"21","author":"Gutierro","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113827_bb1035","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.tibtech.2022.03.011","article-title":"Nano toolbox in immune modulation and nanovaccines","volume":"40","author":"Azharuddin","year":"2022","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.jconrel.2025.113827_bb1040","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1021\/acs.molpharmaceut.5b00992","article-title":"Effects of the microparticle shape on cellular uptake","volume":"13","author":"He","year":"2016","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2025.113827_bb1045","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jconrel.2016.07.051","article-title":"Role of nanoparticle size, shape and surface chemistry in oral drug delivery","volume":"238","author":"Banerjee","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113827_bb1050","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ijpharm.2005.03.035","article-title":"Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model","volume":"298","author":"Foged","year":"2005","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.113827_bb1055","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ijpharm.2009.06.006","article-title":"Influence of surface charge of PLGA particles of recombinant hepatitis B surface antigen in enhancing systemic and mucosal immune responses","volume":"379","author":"Thomas","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.113827_bb1060","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1021\/mp100255c","article-title":"Aerosolized PLA and PLGA nanoparticles enhance humoral, mucosal and cytokine responses to hepatitis B vaccine","volume":"8","author":"Thomas","year":"2011","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2025.113827_bb1065","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1021\/ja2108905","article-title":"Nanoparticle hydrophobicity dictates immune response","volume":"134","author":"Moyano","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2025.113827_bb1070","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1039\/c3tb20383b","article-title":"Surface hydrophobicity of microparticles modulates adjuvanticity","volume":"1","author":"Liu","year":"2013","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jconrel.2025.113827_bb1075","first-page":"1","article-title":"Development of a chitosan-modified PLGA nanoparticle vaccine for protection against Escherichia coli K1 caused meningitis in mice","volume":"19","author":"Zhang","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2025.113827_bb1080","series-title":"Drug Delivery Aspects","first-page":"57","article-title":"Chapter 4 - large-scale manufacturing of nanoparticles\u2014An industrial outlook","author":"Shegokar","year":"2020"},{"key":"10.1016\/j.jconrel.2025.113827_bb1085","article-title":"Nanomedicine: techniques, potentials, and ethical implications","volume":"2006","author":"Ebbesen","year":"2006","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.jconrel.2025.113827_bb1090","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1186\/s12951-024-02901-x","article-title":"Nanotechnology in healthcare, and its safety and environmental risks","volume":"22","author":"Ma","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2025.113827_bb1095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2024.04.010","article-title":"Regulatory insights into nanomedicine and gene vaccine innovation: safety assessment, challenges, and regulatory perspectives","volume":"180","author":"Souto","year":"2024","journal-title":"Acta Biomater."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836592500447X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836592500447X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:49:20Z","timestamp":1778629760000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016836592500447X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":219,"alternative-id":["S016836592500447X"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113827","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Animal vaccine revolution: Nanoparticle adjuvants open the future of vaccinology","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113827","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113827"}}