{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:12:54Z","timestamp":1790856774090,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20384"],"award-info":[{"award-number":["U22A20384"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204298"],"award-info":[{"award-number":["82204298"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jconrel.2025.113831","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T12:55:23Z","timestamp":1746795323000},"page":"113831","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Integrity of polymeric micelles regulates bioavailability of cyclosporine A: A FRET-based analysis during oral delivery"],"prefix":"10.1016","volume":"383","author":[{"given":"Haihan","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangqun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.113831_bb0005","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jconrel.2021.04.014","article-title":"Harnessing amphiphilic polymeric micelles for diagnostic and therapeutic applications: breakthroughs and bottlenecks","volume":"334","author":"Kaur","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113831_bb0010","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jconrel.2021.02.031","article-title":"Polymeric micelles in drug delivery: an insight of the techniques for their characterization and assessment in biorelevant conditions","volume":"332","author":"Ghezzi","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113831_bb0015","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jconrel.2021.02.016","article-title":"Polymeric micelles in cancer therapy: state of the art","volume":"332","author":"Ghosh","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113831_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114463","article-title":"The in vivo fate of polymeric micelles","volume":"188","author":"Cai","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.113831_bb0025","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jconrel.2020.09.024","article-title":"The biological fate of orally administered mPEG-PDLLA polymeric micelles","volume":"327","author":"He","year":"2020","journal-title":"J. Control. Release"},{"issue":"4","key":"10.1016\/j.jconrel.2025.113831_bb0030","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.apsb.2021.02.018","article-title":"The biological fate of the polymer nanocarrier material monomethoxy poly(ethylene glycol)-block-poly(d,l-lactic acid) in rat","volume":"11","author":"Meng","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"6","key":"10.1016\/j.jconrel.2025.113831_bb0035","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3109\/1061186X.2014.897709","article-title":"Binding and uptake of novel RGD micelles to the alphavbeta3 integrin receptor for targeted drug delivery","volume":"22","author":"Raj","year":"2014","journal-title":"J. Drug Target."},{"issue":"7","key":"10.1016\/j.jconrel.2025.113831_bb0040","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1021\/acs.molpharmaceut.5b00010","article-title":"Multifunctional poly(methyl vinyl ether-co-maleic anhydride)-graft-hydroxypropyl-beta-cyclodextrin amphiphilic copolymer as an Oral high-performance delivery carrier of tacrolimus","volume":"12","author":"Zhang","year":"2015","journal-title":"Mol. Pharm."},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2025.113831_bb0045","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jconrel.2005.11.012","article-title":"Intestinal uptake and biodistribution of novel polymeric micelles after oral administration","volume":"111","author":"Mathot","year":"2006","journal-title":"J. Control. Release"},{"issue":"21","key":"10.1016\/j.jconrel.2025.113831_bb0050","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.1021\/ja413036q","article-title":"Enzyme-responsive amphiphilic PEG-dendron hybrids and their assembly into smart micellar nanocarriers","volume":"136","author":"Harnoy","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2025.113831_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122191","article-title":"Self-assembled block copolymer biomaterials for oral delivery of protein therapeutics","volume":"300","author":"Chapa-Villarreal","year":"2023","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.jconrel.2025.113831_bb0060","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1021\/la0531998","article-title":"Assessment of the integrity of poly(caprolactone)-b-poly(ethylene oxide) micelles under biological conditions: a fluorogenic-based approach","volume":"22","author":"Savic","year":"2006","journal-title":"Langmuir"},{"key":"10.1016\/j.jconrel.2025.113831_bb0065","first-page":"1545","article-title":"The intragastrointestinal fate of paclitaxel-loaded micelles: implications on oral drug delivery","author":"Zoya","year":"2020","journal-title":"Chin. Chem. Lett."},{"issue":"30","key":"10.1016\/j.jconrel.2025.113831_bb0070","doi-asserted-by":"crossref","first-page":"19977","DOI":"10.1039\/C5CP02296G","article-title":"How does bile salt penetration affect the self-assembled architecture of pluronic P123 micelles?--light scattering and spectroscopic investigations","volume":"17","author":"Roy","year":"2015","journal-title":"Phys. Chem. Chem. Phys."},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2025.113831_bb0075","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ijpharm.2006.02.018","article-title":"Polyethylene glycol-phosphatidylethanolamine conjugate (PEG-PE)-based mixed micelles: some properties, loading with paclitaxel, and modulation of P-glycoprotein-mediated efflux","volume":"315","author":"Dabholkar","year":"2006","journal-title":"Int. J. Pharm."},{"issue":"3","key":"10.1016\/j.jconrel.2025.113831_bb0080","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/jbm.a.30490","article-title":"Poly(lactide)-poly(ethylene glycol) micelles as a carrier for griseofulvin","volume":"75","author":"Pierri","year":"2005","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"7","key":"10.1016\/j.jconrel.2025.113831_bb0085","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0142-9612(96)86742-1","article-title":"Degradation of poly(D,L-lactic acid) nanoparticles coated with albumin in model digestive fluids (USP XXII)","volume":"17","author":"Landry","year":"1996","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.jconrel.2025.113831_bb0090","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.drudis.2016.10.002","article-title":"Bioimaging of nanoparticles: the crucial role of discriminating nanoparticles from free probes","volume":"22","author":"Hu","year":"2017","journal-title":"Drug Discov. Today"},{"issue":"9","key":"10.1016\/j.jconrel.2025.113831_bb0095","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1039\/C5CS00699F","article-title":"In vivo degeneration and the fate of inorganic nanoparticles","volume":"45","author":"Feliu","year":"2016","journal-title":"Chem. Soc. Rev."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113831_bb0100","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1021\/acs.jpcb.8b09441","article-title":"Fluorescence resonance energy transfer (FRET): a powerful tool for probing amphiphilic polymer aggregates and supramolecular polymers","volume":"123","author":"Rajdev","year":"2019","journal-title":"J. Phys. Chem. B"},{"issue":"11","key":"10.1016\/j.jconrel.2025.113831_bb0105","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1016\/j.biomaterials.2014.01.027","article-title":"FRET-enabled biological characterization of polymeric micelles","volume":"35","author":"Morton","year":"2014","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.jconrel.2025.113831_bb0110","doi-asserted-by":"crossref","first-page":"6179","DOI":"10.1021\/acsnano.8b02830","article-title":"The blood clearance kinetics and pathway of polymeric micelles in Cancer drug delivery","volume":"12","author":"Sun","year":"2018","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.jconrel.2025.113831_bb0115","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/aps.2014.113","article-title":"Oral delivery of capsaicin using MPEG-PCL nanoparticles","volume":"36","author":"Peng","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113831_bb0120","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jconrel.2007.02.004","article-title":"PLGA nanoparticles for oral delivery of cyclosporine: nephrotoxicity and pharmacokinetic studies in comparison to Sandimmune Neoral","volume":"119","author":"Italia","year":"2007","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.jconrel.2025.113831_bb0125","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jconrel.2005.02.015","article-title":"Micelles of methoxy poly(ethylene oxide)-b-poly(epsilon-caprolactone) as vehicles for the solubilization and controlled delivery of cyclosporine a","volume":"104","author":"Aliabadi","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113831_bb0130","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.jconrel.2022.10.031","article-title":"Core-shell nanosystems designed for effective oral delivery of polypeptide drugs","volume":"352","author":"Li","year":"2022","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.jconrel.2025.113831_bb0135","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.proghi.2009.03.001","article-title":"Recent advances in quantitative colocalization analysis: focus on neuroscience","volume":"44","author":"Zinchuk","year":"2009","journal-title":"Prog. Histochem. Cytochem."},{"issue":"3","key":"10.1016\/j.jconrel.2025.113831_bb0140","article-title":"Validated UPLC-MS method for pharmacokinetic investigations of cyclosporine-A in blood","volume":"11","author":"Raish","year":"2015","journal-title":"Curr. Pharm. Anal."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113831_bb0145","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11095-021-02990-5","article-title":"Pharmacokinetic and tissue distribution of orally administered cyclosporine A-loaded poly(ethylene oxide)-block-poly(epsilon-caprolactone) micelles versus Sandimmune((R)) in rats","volume":"38","author":"Binkhathlan","year":"2021","journal-title":"Pharm. Res."},{"issue":"9","key":"10.1016\/j.jconrel.2025.113831_bb0150","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1021\/acs.biomac.5b00826","article-title":"Decreased Core crystallinity facilitated drug loading in polymeric micelles without affecting their biological performances","volume":"16","author":"Gou","year":"2015","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2025.113831_bb0155","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.addr.2013.12.009","article-title":"Nanoprecipitation and the \u201couzo effect\u201d: application to drug delivery devices","volume":"71","author":"Lepeltier","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.113831_bb0160","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.jconrel.2023.07.026","article-title":"FRET-based analysis on the structural stability of polymeric micelles: another key attribute beyond PEG coverage and particle size affecting the blood clearance","volume":"360","author":"Guo","year":"2023","journal-title":"J. Control. Release"},{"issue":"11","key":"10.1016\/j.jconrel.2025.113831_bb0165","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1021\/acs.molpharmaceut.7b00503","article-title":"Polyester-solid lipid mixed nanoparticles with improved stability in gastro-intestinal tract facilitated Oral delivery of Larotaxel","volume":"14","author":"Gou","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2025.113831_bb0170","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jpba.2017.06.072","article-title":"An overview of in vitro dissolution\/release methods for novel mucosal drug delivery systems","volume":"147","author":"Jug","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"5","key":"10.1016\/j.jconrel.2025.113831_bb0175","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v22.i5.10","article-title":"Polymeric nanoparticles for oral delivery of drugs and vaccines: a critical evaluation of in vivo studies","volume":"22","author":"Galindo-Rodriguez","year":"2005","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.jconrel.2025.113831_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2019.102045","article-title":"Bile salts in digestion and transport of lipids","volume":"274","author":"Macierzanka","year":"2019","journal-title":"Adv. Colloid Interf. Sci."},{"key":"10.1016\/j.jconrel.2025.113831_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114966","article-title":"Native gastrointestinal mucus: critical features and techniques for studying interactions with drugs, drug carriers, and bacteria","volume":"200","author":"Wang","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"9","key":"10.1016\/j.jconrel.2025.113831_bb0190","doi-asserted-by":"crossref","first-page":"9217","DOI":"10.1021\/acsnano.5b03876","article-title":"Impact of surface polyethylene glycol (PEG) density on biodegradable nanoparticle transport in mucus ex vivo and distribution in vivo","volume":"9","author":"Xu","year":"2015","journal-title":"ACS Nano"},{"issue":"7","key":"10.1016\/j.jconrel.2025.113831_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13071075","article-title":"Oral delivery of nucleic acids with passive and active targeting to the intestinal tissue using polymer-based Nanocarriers","volume":"13","author":"Poudel","year":"2021","journal-title":"Pharmaceutics"},{"issue":"6","key":"10.1016\/j.jconrel.2025.113831_bb0200","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1080\/01932699208943341","article-title":"Simultaneous determination of micellar dissociation concentration and critical micellar concentration of bile salts by pH measurements","volume":"13","author":"Chiu","year":"1992","journal-title":"J. Dispers. Sci. Technol."},{"key":"10.1016\/j.jconrel.2025.113831_bb0205","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ijbiomac.2018.01.185","article-title":"Microcalorimetry of the intestinal mucus: hydrogen bonding and self-assembly of mucin","volume":"112","author":"Lousinian","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"issue":"7","key":"10.1016\/j.jconrel.2025.113831_bb0210","doi-asserted-by":"crossref","first-page":"6996","DOI":"10.1021\/acsnano.5b01326","article-title":"Surface functionalization of nanoparticles with polyethylene glycol: effects on protein adsorption and cellular uptake","volume":"9","author":"Pelaz","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.113831_bb0215","doi-asserted-by":"crossref","first-page":"51650","DOI":"10.1021\/acsami.3c07658","article-title":"Betaine-based and Polyguanidine-inserted Zwitterionic micelle as a promising platform to conquer the intestinal mucosal barrier","author":"Liu","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.jconrel.2025.113831_bb0220","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1021\/bm401580k","article-title":"Improved stability and antidiabetic potential of insulin containing folic acid functionalized polymer stabilized multilayered liposomes following oral administration","volume":"15","author":"Agrawal","year":"2014","journal-title":"Biomacromolecules"},{"issue":"26","key":"10.1016\/j.jconrel.2025.113831_bb0225","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.1016\/j.biomaterials.2013.05.006","article-title":"The effect of hydrophilic and hydrophobic structure of amphiphilic polymeric micelles on their transport in epithelial MDCK cells","volume":"34","author":"Yu","year":"2013","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.jconrel.2025.113831_bb0230","doi-asserted-by":"crossref","first-page":"9485","DOI":"10.1021\/nn302317j","article-title":"Probing of the assembly structure and dynamics within nanoparticles during interaction with blood proteins","volume":"6","author":"Li","year":"2012","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.jconrel.2025.113831_bb0235","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/03639040601155665","article-title":"Cyclosporine a: a review of current oral and intravenous delivery systems","volume":"33","author":"Beauchesne","year":"2007","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.jconrel.2025.113831_bb0240","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.fct.2015.04.026","article-title":"Immunomodulatory activity of methanolic extract of Amorphophallus commutatus var. wayanadensis under normal and cyclophosphamide induced immunosuppressive conditions in mice models","volume":"81","author":"Raj","year":"2015","journal-title":"Food Chem. Toxicol."},{"issue":"6","key":"10.1016\/j.jconrel.2025.113831_bb0245","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/mmy\/myx098","article-title":"Experimental sporotrichosis in a cyclophosphamide-induced immunosuppressed mice model","volume":"56","author":"Manente","year":"2018","journal-title":"Med. Mycol."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113831_bb0250","first-page":"136","article-title":"Effects of Electroacupuncture on T-lymphocytes,Spleen Index,Thymus Index and Lymphopoiesis Levels in Strenuous Exercise-induced Stress Rats","volume":"37","author":"Yong-Mei","year":"2012","journal-title":"Acupunct. Res."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113831_bb0255","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1208\/s12248-011-9259-8","article-title":"The immunosuppressive activity of polymeric micellar formulation of cyclosporine a: in vitro and in vivo studies","volume":"13","author":"Hamdy","year":"2011","journal-title":"AAPS J."},{"key":"10.1016\/j.jconrel.2025.113831_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2023.153544","article-title":"Role of cyclosporin a in the treatment of kidney disease and nephrotoxicity","volume":"492","author":"Yu","year":"2023","journal-title":"Toxicology"},{"issue":"32","key":"10.1016\/j.jconrel.2025.113831_bb0265","doi-asserted-by":"crossref","first-page":"21091","DOI":"10.1021\/acsnano.4c02560","article-title":"Milk exosome-liposome hybrid vesicles with self-adapting surface properties overcome the sequential absorption barriers for Oral delivery of peptides","volume":"18","author":"Xiao","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.113831_bb0270","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.actbio.2015.06.017","article-title":"Rational design of block copolymer micelles to control burst drug release at a nanoscale dimension","volume":"24","author":"Soleymani Abyaneh","year":"2015","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113831_bb0275","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijpharm.2005.10.010","article-title":"Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles","volume":"307","author":"Owens","year":"2006","journal-title":"Int. J. Pharm."},{"issue":"16","key":"10.1016\/j.jconrel.2025.113831_bb0280","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202109189","article-title":"Mucus penetrating and cell-binding Polyzwitterionic micelles as potent Oral nanomedicine for Cancer drug delivery","volume":"34","author":"Fan","year":"2022","journal-title":"Adv. Mater."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925004511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925004511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T09:11:42Z","timestamp":1752570702000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925004511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":56,"alternative-id":["S0168365925004511"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113831","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrity of polymeric micelles regulates bioavailability of cyclosporine A: A FRET-based analysis during oral delivery","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113831","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113831"}}