{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:01:31Z","timestamp":1789585291243,"version":"build-2803163510"},"reference-count":232,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek Vlaanderen","doi-asserted-by":"publisher","award":["1226224N"],"award-info":[{"award-number":["1226224N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jconrel.2025.113849","type":"journal-article","created":{"date-parts":[[2025,5,18]],"date-time":"2025-05-18T10:18:02Z","timestamp":1747563482000},"page":"113849","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Toward successful retinal drug delivery after intravitreal injection: Current strategies to overcome the inner limiting membrane"],"prefix":"10.1016","volume":"384","author":[{"given":"Kaat","family":"De Clerck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefaan","family":"De Smedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrien","family":"Remaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Peynshaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.113849_bb0005","doi-asserted-by":"crossref","first-page":"e489","DOI":"10.1016\/S2214-109X(20)30488-5","article-title":"The lancet Global Health Commission on global eye health: vision beyond 2020","volume":"9","author":"Burton","year":"2021","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.jconrel.2025.113849_bb0010","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.drudis.2019.01.023","article-title":"M\u00fcller cells as a target for retinal therapy","volume":"24","author":"Devoldere","year":"2019","journal-title":"Drug Discov. Today"},{"issue":"588","key":"10.1016\/j.jconrel.2025.113849_bb0015","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41586-020-2975-4","article-title":"Reprogramming to recover youthful epigenetic information and restore vision","volume":"7836","author":"Lu","year":"2020","journal-title":"Nature"},{"issue":"27","key":"10.1016\/j.jconrel.2025.113849_bb0020","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/s41591-021-01351-4","article-title":"Partial recovery of visual function in a blind patient after optogenetic therapy","volume":"7","author":"Sahel","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2025.113849_bb0025","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.3390\/cells10061426","article-title":"Retinal ganglion cell transplantation: approaches for overcoming challenges to functional integration","volume":"10","author":"Zhang","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2025.113849_bb0030","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.4103\/1673-5374.306063","article-title":"The future of retinal gene therapy: evolving from subretinal to intravitreal vector delivery","volume":"16","author":"Ross","year":"2021","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0035","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.matbio.2010.04.002","article-title":"Molecular interactions in the retinal basement membrane system: a proteomic approach","volume":"29","author":"Balasubramani","year":"2010","journal-title":"Matrix Biol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0040","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1167\/iovs.05-1480","article-title":"Regulation of eye size by the retinal basement membrane and vitreous body","volume":"47","author":"Halfter","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0045","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/dbio.2001.0396","article-title":"Temporary disruption of the retinal basal lamina and its effect on retinal histogenesis","volume":"238","author":"Halfter","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0050","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1167\/iovs.04-1185","article-title":"Basement membrane\u2013dependent survival of retinal ganglion cells","volume":"46","author":"Halfter","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108545","article-title":"The internal limiting membrane: roles in retinal development and implications for emerging ocular therapies","volume":"206","author":"Zhang","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0060","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/eye.2008.19","article-title":"Origin and turnover of ECM proteins from the inner limiting membrane and vitreous body","volume":"22","author":"Halfter","year":"2008","journal-title":"Eye"},{"key":"10.1016\/j.jconrel.2025.113849_bb0065","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/febs.17007","article-title":"The biophysical and compositional properties of human basement membranes","volume":"291","author":"Schoenenberger","year":"2024","journal-title":"FEBS J."},{"key":"10.1016\/j.jconrel.2025.113849_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067660","article-title":"The bi-functional Organization of Human Basement Membranes","volume":"8","author":"Halfter","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2025.113849_bb0075","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1167\/iovs.11-8502","article-title":"Nanoscale topographic and biomechanical studies of the human internal limiting membrane","volume":"53","author":"Henrich","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0080","first-page":"82","article-title":"Structure of the human vitreoretinal border region","volume":"208","author":"Heegaard","year":"1994","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.jconrel.2025.113849_bb0085","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/02713683.2019.1565890","article-title":"Morphology and composition of the inner limiting membrane: species-specific variations and relevance toward drug delivery research","volume":"44","author":"Peynshaert","year":"2019","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0090","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00415316","article-title":"Vitreoretinal juncture over retinal vessels","volume":"204","author":"Foos","year":"1977","journal-title":"Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0095","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.matbio.2010.03.004","article-title":"Age-dependent changes in the structure, composition and biophysical properties of a human basement membrane","volume":"29","author":"Candiello","year":"2010","journal-title":"Matrix Biol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2019.107843","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the international diabetes federation diabetes atlas","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.jconrel.2025.113849_bb0105","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.exer.2013.09.011","article-title":"Diabetes-induced morphological, biomechanical, and compositional changes in ocular basement membranes","volume":"116","author":"To, M","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0110","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00006982-200504000-00010","article-title":"Histopathologic evaluation of the internal limiting membrane surgically excised from eyes with diabetic maculopathy","volume":"25","author":"Matsunaga","year":"2005","journal-title":"Retina"},{"key":"10.1016\/j.jconrel.2025.113849_bb0115","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1177\/44.12.8985139","article-title":"Basement membrane abnormalities in human eyes with diabetic retinopathy","volume":"44","author":"Ljubimov","year":"1996","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.jconrel.2025.113849_bb0120","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1172\/JCI116979","article-title":"Increased expression of basement membrane collagen in human diabetic retinopathy","volume":"93","author":"Roy","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2025.113849_bb0125","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s10384-012-0130-y","article-title":"Histopathologic analysis of the internal limiting membrane surgically peeled from eyes with diffuse diabetic macular edema","volume":"56","author":"Tamura","year":"2012","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0130","series-title":"Vitreous: In Health and Disease","first-page":"265","article-title":"Pathology of Vitreomaculopathies","author":"Gandorfer","year":"2014"},{"key":"10.1016\/j.jconrel.2025.113849_bb0135","series-title":"Vitreous: In Health and Disease","first-page":"165","article-title":"Vitreoretinal Interface and Inner Limiting Membrane","author":"Halfter","year":"2014"},{"key":"10.1016\/j.jconrel.2025.113849_bb0140","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/ceo.13914","article-title":"Epiretinal membrane: A review","volume":"49","author":"Fung","year":"2021","journal-title":"Clin. Experiment. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0145","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1167\/iovs.65.2.42","article-title":"M\u00fcller glial cells in the macula: their activation and cell-cell interactions in age-related macular degeneration","volume":"65","author":"Navneet","year":"2024","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0150","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/S0161-6420(96)30377-1","article-title":"Characterization of Epiretinal membranes using optical coherence tomography","volume":"103","author":"Wilkins","year":"1996","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jconrel.2025.113849_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220571","article-title":"Nanomechanical mapping helps explain differences in outcomes of eye microsurgery: a comparative study of macular pathologies","volume":"14","author":"Ciasca","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2025.113849_bb0160","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/IAE.0b013e3181f44282","article-title":"Pores of the inner limiting membrane in flat-mounted surgical specimens","volume":"31","author":"Gandorfer","year":"2011","journal-title":"Retina"},{"key":"10.1016\/j.jconrel.2025.113849_bb0165","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1097\/IAE.0000000000003859","article-title":"PORES OF THE INTERNAL LIMITING MEMBRANE: a common finding in Vitreomaculopathies","volume":"43","author":"Schumann","year":"2023","journal-title":"Retina"},{"key":"10.1016\/j.jconrel.2025.113849_bb0170","doi-asserted-by":"crossref","first-page":"5569","DOI":"10.1167\/iovs.18-24676","article-title":"Morphologic, biomechanical, and compositional features of the internal limiting membrane in pathologic myopic Foveoschisis","volume":"59","author":"Chen","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0175","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s10384-017-0542-9","article-title":"Ultrastructural analyses of internal limiting membrane excised from highly myopic eyes with myopic traction maculopathy","volume":"62","author":"Yokota","year":"2018","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0180","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ajo.2004.07.027","article-title":"Ultrastructure of internal limiting membrane in myopic foveoschisis","volume":"139","author":"Bando","year":"2005","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-022-26075-4","article-title":"Inner limiting membrane bridges within Bruch\u2019s membrane defects in pathological myopia","volume":"12","author":"Panda-Jonas","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113849_bb0190","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1167\/iovs.08-3323","article-title":"Retinal basement membrane abnormalities and the retinopathy of Alport syndrome","volume":"51","author":"Savige","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0195","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1080\/13816810.2023.2240881","article-title":"A comparison of the ocular features in Pierson and Alport syndrome: a case report and literature review","volume":"44","author":"Gooley","year":"2023","journal-title":"Ophthalmic Genet."},{"key":"10.1016\/j.jconrel.2025.113849_bb0200","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1167\/iovs.09-4645","article-title":"Defective formation of the inner limiting membrane in laminin \u03b22- and \u03b33-null mice produces retinal dysplasia","volume":"51","author":"Pinz\u00f3n-Duarte","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0205","first-page":"1415","article-title":"Retinal ectopias and mechanically weakened basement membrane in a mouse model of muscle-eye-brain (MEB) disease congenital muscular dystrophy","volume":"16","author":"Hu","year":"2010","journal-title":"Mol. Vis."},{"key":"10.1016\/j.jconrel.2025.113849_bb0210","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0387-7604(01)00189-9","article-title":"Clinicopathological study on eyes from cases of Fukuyama type congenital muscular dystrophy","volume":"23","author":"Hino","year":"2001","journal-title":"Brain and Development"},{"key":"10.1016\/j.jconrel.2025.113849_bb0215","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/hmg\/ddg043","article-title":"Worldwide distribution and broader clinical spectrum of muscle-eye-brain disease","volume":"12","author":"Taniguchi","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jconrel.2025.113849_bb0220","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1167\/iovs.61.2.11","article-title":"Rescue of Defective Electroretinographic Responses in Dp71-null mice with AAV-mediated Reexpression of Dp71","volume":"61","author":"Barboni","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0225","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/glia.22617","article-title":"AAV-mediated gene delivery in Dp71-null mouse model with compromised barriers","volume":"62","author":"Vacca","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.jconrel.2025.113849_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101137","article-title":"Retinal dystrophins and the retinopathy of Duchenne muscular dystrophy","volume":"95","author":"Barboni","year":"2023","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0235","series-title":"Adeno-Associated Virus (AAV)-Based Gene Therapies for Retinal Diseases: Where Are we?","author":"Ail","year":"2023"},{"key":"10.1016\/j.jconrel.2025.113849_bb0240","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/gt.2014.115","article-title":"Antibody neutralization poses a barrier to intravitreal adeno-associated viral vector gene delivery to non-human primates","volume":"22","author":"Kotterman","year":"2015","journal-title":"Gene Ther."},{"key":"10.1016\/j.jconrel.2025.113849_bb0245","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1038\/mt.2009.181","article-title":"Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous","volume":"17","author":"Dalkara","year":"2009","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2025.113849_bb0250","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-3-031-27681-1_18","article-title":"Preexisting neutralizing antibodies against different adeno-associated virus serotypes in humans and large animal models for gene therapy","volume":"1415","author":"Ail","year":"2023","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0255","doi-asserted-by":"crossref","first-page":"9093","DOI":"10.1128\/JVI.00895-06","article-title":"Alpha2,3 and alpha2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6","volume":"80","author":"Wu","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0260","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.02440-20","article-title":"Effects of altering HSPG binding and capsid hydrophilicity on retinal transduction by AAV","volume":"95","author":"Crosson","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0265","doi-asserted-by":"crossref","first-page":"9878","DOI":"10.1128\/JVI.01568-16","article-title":"Heparan sulfate binding promotes accumulation of Intravitreally delivered adeno-associated viral vectors at the retina for enhanced transduction but weakly influences tropism","volume":"90","author":"Woodard","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0270","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1128\/JVI.00200-16","article-title":"Impact of Heparan sulfate binding on transduction of retina by recombinant adeno-associated virus vectors","volume":"90","author":"Boye","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0275","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.135112","article-title":"In vivo\u2013directed evolution of adeno-associated virus in the primate retina","volume":"5","author":"Byrne","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jconrel.2025.113849_bb0280","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005708","article-title":"In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous","volume":"5","author":"Dalkara","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.113849_bb0285","article-title":"Directed Evolution of AAV Targeting Primate Retina by Intravitreal Injection Identifies R100, a Variant Demonstrating Robust Gene Delivery and Therapeutic Efficacy in Non-Human Primates","author":"Kotterman","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.jconrel.2025.113849_bb0290","doi-asserted-by":"crossref","unstructured":"\u00d6zt\u00fcrk, B. E. et al. scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution. doi:https:\/\/doi.org\/10.7554\/eLife.","DOI":"10.7554\/elife"},{"key":"10.1016\/j.jconrel.2025.113849_bb0295","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.15252\/emmm.201404077","article-title":"Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter","volume":"6","author":"Cronin","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jconrel.2025.113849_bb0300","first-page":"1","article-title":"An adeno-associated virus variant enabling efficient ocular-directed gene delivery across species","volume":"15","author":"Luo","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.113849_bb0305","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1016\/j.ymthe.2023.10.001","article-title":"Intravitreal injection of a rationally designed AAV capsid library in non-human primate identifies variants with enhanced retinal transduction and neutralizing antibody evasion","volume":"31","author":"Kellish","year":"2023","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2025.113849_bb0310","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41434-023-00409-x","article-title":"Immunobiology of a rationally-designed AAV2 capsid following intravitreal delivery in mice","volume":"30","author":"Whitehead","year":"2023","journal-title":"Gene Ther."},{"key":"10.1016\/j.jconrel.2025.113849_bb0315","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41434-022-00380-z","article-title":"Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells: comparison of five promoters","volume":"30","author":"Nieuwenhuis","year":"2023","journal-title":"Gene Ther."},{"key":"10.1016\/j.jconrel.2025.113849_bb0320","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jconrel.2013.01.018","article-title":"Nanoparticle diffusion in, and microrheology of, the bovine vitreous ex vivo","volume":"167","author":"Xu","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113849_bb0325","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ejpb.2019.05.023","article-title":"The obstacle course to the inner retina: hyaluronic acid-coated lipoplexes cross the vitreous but fail to overcome the inner limiting membrane","volume":"141","author":"Devoldere","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2025.113849_bb0330","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1021\/acs.molpharmaceut.6b01029","article-title":"Hyaluronic acid coated albumin nanoparticles for targeted peptide delivery to the retina","volume":"14","author":"Huang","year":"2017","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2025.113849_bb0335","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jconrel.2015.01.030","article-title":"Coating nanocarriers with hyaluronic acid facilitates intravitreal drug delivery for retinal gene therapy","volume":"202","author":"Martens","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113849_bb0340","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jconrel.2020.10.028","article-title":"Ocular barriers to retinal delivery of intravitreal liposomes: impact of vitreoretinal interface","volume":"328","author":"Tavakoli","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113849_bb0345","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.preteyeres.2016.12.001","article-title":"Pharmacokinetic aspects of retinal drug delivery","volume":"57","author":"del Amo","year":"2017","journal-title":"Progress in Retinal and Eye Research vol"},{"key":"10.1016\/j.jconrel.2025.113849_bb0350","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.addr.2017.09.007","article-title":"In vitro and ex vivo models to study drug delivery barriers in the posterior segment of the eye","volume":"126","author":"Peynshaert","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.113849_bb0355","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jconrel.2019.06.042","article-title":"Non-viral delivery of chemically modified mRNA to the retina: subretinal versus intravitreal administration","volume":"307","author":"Devoldere","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113849_bb0360","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s11095-008-9745-6","article-title":"Investigating the movement of intravitreal human serum albumin nanoparticles in the vitreous and retina","volume":"26","author":"Kim","year":"2009","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0365","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.2147\/IJN.S157000","article-title":"DNA nanoparticles are safe and nontoxic in non-human primate eyes","volume":"13","author":"Akelley","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2025.113849_bb0370","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.biomaterials.2017.12.004","article-title":"Genomic form of rhodopsin DNA nanoparticles rescued autosomal dominant retinitis pigmentosa in the P23H knock-in mouse model","volume":"157","author":"Mitra","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.113849_bb0375","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1096\/fj.15-270363","article-title":"Genomic DNA nanoparticles rescue rhodopsin-associated retinitis pigmentosa phenotype","volume":"29","author":"Han","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.jconrel.2025.113849_bb0380","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2217\/nnm.11.158","article-title":"Direct gene transfer with compacted DNA nanoparticles in retinal pigment epithelial cells: expression, repeat delivery and lack of toxicity","volume":"7","author":"Han","year":"2012","journal-title":"Nanomedicine (London)"},{"key":"10.1016\/j.jconrel.2025.113849_bb0385","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jconrel.2019.04.015","article-title":"Lipid nanoparticles for delivery of messenger RNA to the back of the eye","volume":"303","author":"Patel","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113849_bb0390","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0241006","article-title":"The effects of PEGylation on LNP based mRNA delivery to the eye","volume":"15","author":"Ryals","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2025.113849_bb0395","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add4623","article-title":"Peptide-guided lipid nanoparticles deliver mRNA to the neural retina of rodents and nonhuman primates","volume":"9","author":"Herrera-Barrera","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2025.113849_bb0400","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2307813120","article-title":"Thiophene-based lipids for mRNA delivery to pulmonary and retinal tissues","volume":"121","author":"Eygeris","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jconrel.2025.113849_bb0405","article-title":"Preformed vesicle approach to LNP manufacturing enhances retinal mRNA delivery","volume":"2400815","author":"Eygeris","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2025.113849_bb0410","doi-asserted-by":"crossref","first-page":"617","DOI":"10.2217\/nnm-2020-0471","article-title":"Intravitreal quantum dots for retinitis Pigmentosa: a first-in-human safety study","volume":"16","author":"Jackson","year":"2021","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2025.113849_bb0415","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3390\/ph17040481","article-title":"Comprehensive ocular and systemic safety evaluation of Polysialic acid-decorated immune modulating therapeutic nanoparticles (PolySia-NPs) to support entry into first-in-human clinical trials","volume":"17","author":"Krishnan","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jconrel.2025.113849_bb0420","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3390\/ph17040517","article-title":"PolySialic acid nanoparticles actuate complement-factor-H-mediated inhibition of the alternative complement pathway: a safer potential therapy for age-related macular degeneration","volume":"17","author":"Peterson","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jconrel.2025.113849_bb0425","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.3390\/ph16121735","article-title":"Sialic Acid Mimetic Microglial Sialic Acid-Binding Immunoglobulin-like Lectin Agonism: Potential to Restore Retinal Homeostasis and Regain Visual Function in Age-Related Macular Degeneration","volume":"16","author":"Tolentino","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jconrel.2025.113849_bb0430","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/17425247.2023.2167979","article-title":"Every nano-step counts: a critical reflection on do\u2019s and don\u2019ts in researching nanomedicines for retinal gene therapy","volume":"20","author":"Peynshaert","year":"2023","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jconrel.2025.113849_bb0435","doi-asserted-by":"crossref","first-page":"5970","DOI":"10.1167\/iovs.09-4504","article-title":"Generation of retinal ganglion\u2013like cells from reprogrammed mouse fibroblasts","volume":"51","author":"Chen","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0440","doi-asserted-by":"crossref","first-page":"188","DOI":"10.5966\/sctm.2011-0005","article-title":"Human M\u00fcller glia with stem cell characteristics differentiate into retinal ganglion cell (RGC) precursors in vitro and partially restore RGC function in vivo following transplantation","volume":"1","author":"Singhal","year":"2012","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.jconrel.2025.113849_bb0445","doi-asserted-by":"crossref","first-page":"192","DOI":"10.5966\/sctm.2015-0125","article-title":"Allogeneic transplantation of M\u00fcller-derived retinal ganglion cells improves retinal function in a feline model of ganglion cell depletion","volume":"5","author":"Becker","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.jconrel.2025.113849_bb0450","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1167\/iovs.09-3884","article-title":"Identification of barriers to retinal engraftment of transplanted stem cells","volume":"51","author":"Johnson","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0455","article-title":"Internal limiting membrane disruption facilitates engraftment of transplanted human stem cell derived retinal ganglion cells","volume":"2022.12.13.519327","author":"Aguzzi","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.jconrel.2025.113849_bb0460","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.stemcr.2020.12.001","article-title":"Role of the internal limiting membrane in structural engraftment and topographic spacing of transplanted human stem cell-derived retinal ganglion cells","volume":"16","author":"Zhang","year":"2021","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.jconrel.2025.113849_bb0465","article-title":"Internal limiting basement membrane inhibits functional engraftment of transplanted human retinal ganglion cells","volume":"2022.12.13.519327","author":"Aguzzi","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.jconrel.2025.113849_bb0470","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.neuron.2011.03.013","article-title":"The oriented emergence of axons from retinal ganglion cells is directed by laminin contact in vivo","volume":"70","author":"Randlett","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.jconrel.2025.113849_bb0475","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.jconrel.2025.113849_bb0480","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"Van Niel","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0485","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1059141","article-title":"Extracellular vesicles: an emerging player in retinal homeostasis","volume":"11","author":"Chatterjee","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0490","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1097456","article-title":"Extracellular vesicles as a new horizon in the diagnosis and treatment of inflammatory eye diseases: a narrative review of the literature","volume":"14","author":"Habibi","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0495","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100849","article-title":"Extracellular vesicle therapy for retinal diseases","volume":"79","author":"Mead","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0500","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jconrel.2014.07.049","article-title":"Extracellular vesicles as drug delivery systems: lessons from the liposome field","volume":"195","author":"Van Der Meel","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113849_bb0505","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/s41565-021-00931-2","article-title":"Extracellular vesicles as a next-generation drug delivery platform","volume":"16","author":"Herrmann","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2021.112792","article-title":"Protective effects of intravitreal administration of mesenchymal stem cell-derived exosomes in an experimental model of optic nerve injury","volume":"407","author":"Cui","year":"2021","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0515","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.celrep.2017.06.009","article-title":"Exosomes mediate mobilization of autocrine Wnt10b to promote axonal regeneration in the injured CNS","volume":"20","author":"Tassew","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.jconrel.2025.113849_bb0520","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1167\/iovs.18-25310","article-title":"Mesenchymal stem cell-derived small extracellular vesicles promote neuroprotection in a genetic DBA\/2J mouse model of Glaucoma","volume":"59","author":"Mead","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0525","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1002\/sctm.16-0428","article-title":"Bone marrow-derived mesenchymal stem cells-derived exosomes promote survival of retinal ganglion cells through miRNA-dependent mechanisms","volume":"6","author":"Mead","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.jconrel.2025.113849_bb0530","first-page":"444","article-title":"Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1\u03b1\/EZH2\/PGC-1\u03b1 pathway","volume":"33","author":"Sun","year":"2023","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jconrel.2025.113849_bb0535","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/stmcls\/sxad078","article-title":"MSC-derived small extracellular vesicles alleviate diabetic retinopathy by delivering miR-22-3p to inhibit NLRP3 Inflammasome activation","volume":"42","author":"Chen","year":"2024","journal-title":"Stem Cells"},{"key":"10.1016\/j.jconrel.2025.113849_bb0540","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-022-02983-0","article-title":"Mesenchymal stem cells-derived small extracellular vesicles alleviate diabetic retinopathy by delivering NEDD4","volume":"13","author":"Sun","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jconrel.2025.113849_bb0545","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1167\/iovs.18-25617","article-title":"Exosomes derived from mesenchymal stem cells modulate miR-126 to ameliorate hyperglycemia-induced retinal inflammation via targeting HMGB1","volume":"60","author":"Zhang","year":"2019","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"10.1016\/j.jconrel.2025.113849_bb0550","first-page":"1","article-title":"Exosomes derived from MSCs ameliorate retinal laser injury partially by inhibition of MCP-1","volume":"2016","author":"Yu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113849_bb0555","doi-asserted-by":"crossref","DOI":"10.3390\/cells11162573","article-title":"Intraocular RGD-engineered exosomes and active targeting of choroidal neovascularization (CNV)","volume":"11","author":"Pollalis","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2025.113849_bb0560","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1080\/02713683.2017.1319491","article-title":"Protective effect of intravitreal Administration of Exosomes Derived from mesenchymal stem cells on retinal ischemia","volume":"42","author":"Moisseiev","year":"2017","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0565","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.155928","article-title":"Bioactive extracellular vesicles from a subset of endothelial progenitor cells rescue retinal ischemia and neurodegeneration","volume":"7","author":"Marra","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.jconrel.2025.113849_bb0570","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.7150\/thno.78426","article-title":"Small extracellular vesicle-loaded bevacizumab reduces the frequency of intravitreal injection required for diabetic retinopathy","volume":"13","author":"Reddy","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2025.113849_bb0575","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-022-03100-x","article-title":"Mesenchymal stem cell-derived extracellular vesicles protect retina in a mouse model of retinitis pigmentosa by anti-inflammation through miR-146a-Nr4a3 axis","volume":"13","author":"Zhang","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jconrel.2025.113849_bb0580","doi-asserted-by":"crossref","DOI":"10.3390\/cells10040730","article-title":"Uptake and distribution of administered bone marrow mesenchymal stem cell extracellular vesicles in retina","volume":"10","author":"Mathew","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2025.113849_bb0585","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1089\/hum.2020.328","article-title":"Intravitreal injection of an exosome-associated adeno-associated viral vector enhances retinoschisin 1 gene transduction in the mouse retina","volume":"32","author":"Wang","year":"2021","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.jconrel.2025.113849_bb0590","first-page":"1","article-title":"Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection","author":"Wassmer","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113849_bb0595","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.addr.2020.04.004","article-title":"Extracellular vesicles as drug delivery systems: why and how?","volume":"159","author":"Elsharkasy","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.113849_bb0600","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/ICB.0b013e3181ae7193","article-title":"The inner limiting membrane does not regrow after indocyanine green-guided peeling: photo-report of two cases","volume":"4","author":"Piven","year":"2010","journal-title":"Retin Cases Brief Rep"},{"key":"10.1016\/j.jconrel.2025.113849_bb0605","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1076\/ceyr.27.6.395.18189","article-title":"Ultrastructure of the vitreoretinal interface following the removal of the internal limiting membrane using indocyanine green","volume":"27","author":"Nakamura","year":"2003","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0610","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/BF00410033","article-title":"Vitreoretinal juncture; healing of experimental wounds","volume":"196","author":"Foos","year":"1975","journal-title":"Albrecht Von Graefes Arch. Klin. Exp. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0615","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.preteyeres.2010.07.001","article-title":"Remodelling of the human vitreous and vitreoretinal interface--a dynamic process","volume":"29","author":"Ponsioen","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0620","first-page":"652","article-title":"Human retinal M\u00fcller cells synthesize collagens of the vitreous and vitreoretinal interface in vitro","volume":"14","author":"Ponsioen","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.jconrel.2025.113849_bb0625","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1076\/ceyr.16.7.663.5061","article-title":"Drug distribution in the vitreous humor of the human eye: the effects of intravitreal injection position and volume","volume":"16","author":"Friedrich","year":"1997","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0630","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.omtm.2020.03.018","article-title":"Peripapillary intravitreal injection improves AAV-mediated retinal transduction","volume":"17","author":"Madrakhimov","year":"2020","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1016\/j.jconrel.2025.113849_bb0635","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.omtm.2020.06.015","article-title":"\u201cPara-retinal\u201d vector administration into the deep vitreous enhances retinal transgene expression","volume":"18","author":"Zeng","year":"2020","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1016\/j.jconrel.2025.113849_bb0640","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.omtm.2021.06.005","article-title":"Pre-retinal delivery of recombinant adeno-associated virus vector significantly improves retinal transduction efficiency","volume":"22","author":"Zhang","year":"2021","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1016\/j.jconrel.2025.113849_bb0645","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/978-1-4939-9139-6_14","article-title":"SubILM injection of AAV for gene delivery to the retina","volume":"1950","author":"Gamlin","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0650","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1089\/hum.2016.085","article-title":"Highly efficient delivery of adeno-associated viral vectors to the primate retina","volume":"27","author":"Boye","year":"2016","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.jconrel.2025.113849_bb0655","doi-asserted-by":"crossref","first-page":"5326","DOI":"10.1167\/iovs.16-19701","article-title":"A novel method combining vitreous aspiration and intravitreal AAV2\/8 injection results in retina-wide transduction in adult mice","volume":"57","author":"Da Costa","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0660","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1089\/hgtb.2016.034","article-title":"Vitrectomy before intravitreal injection of AAV2\/2 vector promotes efficient transduction of retinal ganglion cells in dogs and nonhuman Primates","volume":"27","author":"Tshilenge","year":"2016","journal-title":"Hum Gene Ther Methods"},{"key":"10.1016\/j.jconrel.2025.113849_bb0665","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ymthe.2016.10.008","article-title":"Improved intravitreal AAV-mediated inner retinal gene transduction after surgical internal limiting membrane peeling in Cynomolgus monkeys","volume":"25","author":"Takahashi","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2025.113849_bb0670","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/S1525-0016(16)32838-6","article-title":"29. Novel surgical method for intravitreal AAV administration overcomes transduction barriers in non-human Primates","volume":"24","author":"Comander","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2025.113849_bb0675","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1167\/iovs.18-24333","article-title":"Surgical removal of internal limiting membrane and layering of AAV vector on the retina under air enhances gene transfection in a nonhuman primate","volume":"59","author":"Teo","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0680","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1167\/iovs.64.15.25","article-title":"Mechanical disruption of the inner limiting membrane in vivo enhances targeting to the inner retina","volume":"64","author":"Do","year":"2023","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"27","key":"10.1016\/j.jconrel.2025.113849_bb0685","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/eye.2013.178","article-title":"Vital dyes increase the rigidity of the internal limiting membrane","author":"Haritoglou","year":"2013","journal-title":"Eye"},{"key":"10.1016\/j.jconrel.2025.113849_bb0690","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1159\/000438963","article-title":"The use of vital dyes during vitreoretinal surgery - Chromovitrectomy","volume":"55","author":"Farah","year":"2016","journal-title":"Dev. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0695","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.2147\/OPTH.S284620","article-title":"Spotlight on the internal limiting membrane technique for macular holes: current perspectives","volume":"16","author":"Caporossi","year":"2022","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0700","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/939748","article-title":"Retinal damage induced by internal limiting membrane removal","volume":"2015","author":"Gelman","year":"2015","journal-title":"J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0705","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000138974","article-title":"Toxicity of indocyanine green in vitreoretinal surgery","volume":"42","author":"Gandorfer","year":"2008","journal-title":"Dev. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0710","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000354547","article-title":"Review and perspectives on pharmacological Vitreolysis","volume":"230","author":"Bandello","year":"2013","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.jconrel.2025.113849_bb0715","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4939-1086-1_47","article-title":"Pharmacologic Vitreolysis","volume":"799\u2013815","author":"Sebag","year":"2014","journal-title":"Vitreous: In Health and Disease"},{"key":"10.1016\/j.jconrel.2025.113849_bb0720","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ejps.2018.03.023","article-title":"Effects of enzymatic degradation on dynamic mechanical properties of the vitreous and intravitreal nanoparticle mobility","volume":"118","author":"Huang","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0725","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1167\/iovs.08-1770","article-title":"Human M\u00fcller stem cell (MIO-M1) transplantation in a rat model of Glaucoma: survival, differentiation, and integration","volume":"49","author":"Bull","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0730","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1634\/stemcells.2007-0898","article-title":"Chondroitin sulfate proteoglycans and microglia prevent migration and integration of grafted M\u00fcller stem cells into degenerating retina","volume":"26","author":"Singhal","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.jconrel.2025.113849_bb0735","doi-asserted-by":"crossref","first-page":"188","DOI":"10.5966\/sctm.2011-0005","article-title":"Human M\u00fcller glia with stem cell characteristics differentiate into retinal ganglion cell (RGC) precursors in vitro and partially restore RGC function in vivo following transplantation","volume":"1","author":"Singhal","year":"2012","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.jconrel.2025.113849_bb0740","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF02150029","article-title":"Structure and composition of the inner limiting membrane of the retina. SEM on frozen resin-cracked and enzyme-digested retinas of Macaca mulatta","volume":"224","author":"Heegaard","year":"1986","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0745","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/00006982-199818010-00004","article-title":"Efficacy and safety of enzymatic posterior vitreous detachment by intravitreal injection of hyaluronidase","volume":"18","author":"Harooni","year":"1998","journal-title":"Retina"},{"key":"10.1016\/j.jconrel.2025.113849_bb0750","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/02713680490516747","article-title":"Enzyme-assisted vitrectomy in enucleated pig eyes: a comparison of hyaluronidase, chondroitinase, and plasmin","volume":"29","author":"Staubach","year":"2004","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0755","unstructured":"Effects of hyaluronan lyase, hyaluronidase, and chondroitin ABC lyase on mammalian vitreous gel - PubMed. https:\/\/pubmed.ncbi.nlm.nih.gov\/10476780\/."},{"key":"10.1016\/j.jconrel.2025.113849_bb0760","unstructured":"Effects of Hyaluronan Lyase, Hyaluronidase, and Chondroitin ABC Lyase on Mammalian Vitreous Gel | IOVS | ARVO Journals. https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2162150."},{"key":"10.1016\/j.jconrel.2025.113849_bb0765","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1167\/iovs.11-7909","article-title":"Mapping the differential distribution of Glycosaminoglycans in the adult human retina, choroid, and sclera","volume":"52","author":"Clark","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0770","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/eye.2008.21","article-title":"Adult vitreous structure and postnatal changes","volume":"22","author":"Le Goff","year":"2008","journal-title":"Eye"},{"key":"10.1016\/j.jconrel.2025.113849_bb0775","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S1350-9462(02)00009-5","article-title":"Proteoglycans in retina","volume":"21","author":"Inatani","year":"2002","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0780","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.matbio.2010.03.004","article-title":"Age-dependent changes in the structure, composition and biophysical properties of a human basement membrane","volume":"29","author":"Candiello","year":"2010","journal-title":"Matrix Biol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0785","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1001\/archopht.1980.01020040681018","article-title":"Bacterial collagenase: proposed adjunct to vitrectomy with Membranectomy","volume":"98","author":"Moorhead","year":"1980","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0790","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1167\/iovs.10-6250","article-title":"Intravitreal injection of AAV2 transduces macaque inner retina","volume":"52","author":"Yin","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0795","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000444508","article-title":"Biomechanical properties of the internal limiting membrane after intravitreal Ocriplasmin treatment","volume":"235","author":"Vielmuth","year":"2016","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.jconrel.2025.113849_bb0800","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1167\/iovs.03-0930","article-title":"Posterior vitreous detachment induced by microplasmin","volume":"45","author":"Gandorfer","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0805","unstructured":"Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane - PubMed. https:\/\/pubmed.ncbi.nlm.nih.gov\/6458354\/."},{"key":"10.1016\/j.jconrel.2025.113849_bb0810","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1038\/mt.2009.181","article-title":"Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous","volume":"17","author":"Dalkara","year":"2009","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2025.113849_bb0815","series-title":"Glycosidic Enzymes Enhance Retinal Transduction Following Intravitreal Delivery of AAV2","author":"Cehajic-Kapetanovic","year":"2011"},{"key":"10.1016\/j.jconrel.2025.113849_bb0820","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.omtm.2017.12.002","article-title":"Efficacy and safety of Glycosidic enzymes for improved gene delivery to the retina following intravitreal injection in mice","volume":"9","author":"Cehajic-Kapetanovic","year":"2018","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1016\/j.jconrel.2025.113849_bb0825","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.105308","article-title":"Transplanted human induced pluripotent stem cells- derived retinal ganglion cells embed within mouse retinas and are electrophysiologically functional","volume":"25","author":"Vrathasha","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.jconrel.2025.113849_bb0830","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1442-9071.1989.tb00566.x","article-title":"The history of photocoagulation","volume":"17","author":"Meyer-Schwickerath","year":"1989","journal-title":"Aust. N. Z. J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0835","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-16638-0_11","article-title":"Selective retina therapy","volume":"237\u2013259","author":"Pova\u017eay","year":"2019","journal-title":"High Resolution Imaging in Microscopy and Ophthalmology"},{"key":"10.1016\/j.jconrel.2025.113849_bb0840","series-title":"LASER Manual in Ophthalmology-Fundamentals and Laser Clinical Practice","author":"Henriques","year":"2017"},{"key":"10.1016\/j.jconrel.2025.113849_bb0845","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1089\/hgtb.2013.089","article-title":"Laser photocoagulation enhances adeno-associated viral vector transduction of mouse retina","volume":"25","author":"Lee","year":"2014","journal-title":"Hum Gene Ther Methods"},{"key":"10.1016\/j.jconrel.2025.113849_bb0850","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1089\/hgtb.2015.102","article-title":"Laser photocoagulation induces transduction of retinal pigment epithelial cells by Intravitreally administered adeno-associated viral vectors","volume":"26","author":"Lee","year":"2015","journal-title":"Hum Gene Ther Methods"},{"key":"10.1016\/j.jconrel.2025.113849_bb0855","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s004170100343","article-title":"Internal limiting membrane ablation in pig eyes with the Er:YAG laser under perfluorodecalin","volume":"239","author":"Janknecht","year":"2001","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0860","doi-asserted-by":"crossref","first-page":"6288","DOI":"10.1021\/nn5017742","article-title":"Comparison of gold nanoparticle mediated photoporation: vapor nanobubbles outperform direct heating for delivering macromolecules in live cells","volume":"8","author":"Xiong","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.113849_bb0865","series-title":"Photoporation with Biodegradable Polydopamine Nanosensitizers Enables Safe and Efficient Delivery of mRNA in Human T Cells","author":"Harizaj","year":"2021"},{"key":"10.1016\/j.jconrel.2025.113849_bb0870","doi-asserted-by":"crossref","DOI":"10.1016\/j.cocis.2021.101453","article-title":"Vapor nanobubble-mediated photoporation constitutes a versatile intracellular delivery technology","volume":"54","author":"Ramon","year":"2021","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0875","doi-asserted-by":"crossref","DOI":"10.1002\/jbio.202000234","article-title":"Laser-assisted targeted gene delivery to degenerated retina improves retinal function","volume":"14","author":"Batabyal","year":"2021","journal-title":"J. Biophotonics"},{"key":"10.1016\/j.jconrel.2025.113849_bb0880","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108444","article-title":"Layer-specific nanophotonic delivery of therapeutic opsin-encoding genes into retina","volume":"205","author":"Batabyal","year":"2021","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0885","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.omtm.2020.03.030","article-title":"Near-infrared laser-based spatially targeted Nano-enhanced Optical delivery of therapeutic genes to degenerated retina","volume":"17","author":"Batabyal","year":"2020","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1016\/j.jconrel.2025.113849_bb0890","doi-asserted-by":"crossref","first-page":"6981","DOI":"10.1021\/acs.nanolett.8b02896","article-title":"In vivo laser-mediated retinal ganglion cell Optoporation using KV1.1 conjugated gold nanoparticles","volume":"18","author":"Wilson","year":"2018","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2025.113849_bb0895","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.3390\/pharmaceutics14081716","article-title":"Photodisruption of the Inner Limiting Membrane: Exploring ICG Loaded Nanoparticles as Photosensitizers","volume":"14","author":"De Clerck","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.113849_bb0900","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jconrel.2022.07.002","article-title":"ICG-mediated photodisruption of the inner limiting membrane enhances retinal drug delivery","volume":"349","author":"Peynshaert","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113849_bb0905","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2217\/nnm-2019-0364","article-title":"A focus on the genotoxicity of gold nanoparticles","volume":"15","author":"Wang","year":"2020","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2025.113849_bb0910","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/smll.200700378","article-title":"Size-dependent cytotoxicity of gold nanoparticles","volume":"3","author":"Pan","year":"2007","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2025.113849_bb0915","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.addr.2017.09.008","article-title":"Overcoming ocular drug delivery barriers through the use of physical forces","volume":"126","author":"Huang","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.113849_bb0920","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1080\/17425247.2017.1266334","article-title":"Basic principles and current status of transcorneal and transscleral iontophoresis","volume":"14","author":"Gratieri","year":"2017","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jconrel.2025.113849_bb0925","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jconrel.2007.11.016","article-title":"Charged nanoparticles delivery to the eye using hydrogel iontophoresis","volume":"126","author":"Eljarrat-Binstock","year":"2008","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113849_bb0930","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.exer.2008.04.009","article-title":"Non-invasive gene transfer by iontophoresis for therapy of an inherited retinal degeneration","volume":"87","author":"Souied","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0935","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jconrel.2005.05.020","article-title":"Transcorneal and transscleral iontophoresis of dexamethasone phosphate using drug loaded hydrogel","volume":"106","author":"Eljarrat-Binstock","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113849_bb0940","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.exer.2008.04.009","article-title":"Non-invasive gene transfer by iontophoresis for therapy of an inherited retinal degeneration","volume":"87","author":"Souied","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0945","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1167\/iovs.06-0092","article-title":"Gene transfer to rabbit retina with Electron avalanche transfection","volume":"47","author":"Chalberg","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb0950","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/mt.2011.304","article-title":"Suprachoroidal Electrotransfer: a nonviral gene delivery method to transfect the choroid and the retina without detaching the retina","volume":"20","author":"Touchard","year":"2012","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2025.113849_bb0955","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1039\/D3LC01014G","article-title":"A flexible electrode Array for genetic transfection of different layers of the retina by electroporation","volume":"24","author":"Zhang","year":"2024","journal-title":"Lab Chip"},{"key":"10.1016\/j.jconrel.2025.113849_bb0960","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jconrel.2018.03.001","article-title":"Ocular drug delivery targeted by iontophoresis in the suprachoroidal space using a microneedle","volume":"277","author":"Jung","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113849_bb0965","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.omtm.2018.12.006","article-title":"Trans-ocular electric current in vivo enhances AAV-mediated retinal gene transduction after intravitreal vector administration","volume":"13","author":"Song","year":"2019","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1016\/j.jconrel.2025.113849_bb0970","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1167\/tvst.9.7.28","article-title":"Trans-ocular electric current in vivo enhances AAV-mediated retinal transduction in large animal eye after intravitreal vector administration","volume":"9","author":"Song","year":"2020","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.jconrel.2025.113849_bb0975","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.preteyeres.2018.02.002","article-title":"Neuroprotective strategies for retinal disease","volume":"65","author":"Pardue","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb0980","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1089\/jop.2023.0016","article-title":"In vivo electroporation improves retinal delivery of Intravitreally injected exosomes","volume":"39","author":"Hwang","year":"2023","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2025.113849_bb0985","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0968-4328(01)00002-6","article-title":"Gene transfer into retinal ganglion cells by in vivo electroporation: a new approach","volume":"33","author":"Dezawa","year":"2002","journal-title":"Micron"},{"key":"10.1016\/j.jconrel.2025.113849_bb0990","unstructured":"Rescue of Axotomized Retinal Ganglion Cells by BDNF Gene Electroporation in Adult Rats | IOVS | ARVO Journals. https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2123205."},{"issue":"4","key":"10.1016\/j.jconrel.2025.113849_bb0995","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/sj.gt.3302277","article-title":"Effect of GDNF gene transfer into axotomized retinal ganglion cells using in vivo electroporation with a contact lens-type electrode","volume":"12","author":"Ishikawa","year":"2004","journal-title":"Gene Ther."},{"key":"10.1016\/j.jconrel.2025.113849_bb1000","doi-asserted-by":"crossref","DOI":"10.1002\/adbi.202000057","article-title":"Fluorescence-based quantification of messenger RNA and plasmid DNA decay kinetics in extracellular biological fluids and cell extracts","volume":"4","author":"Zhang","year":"2020","journal-title":"Adv Biosyst"},{"key":"10.1016\/j.jconrel.2025.113849_bb1005","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1039\/D3CS00194F","article-title":"Nucleic acid degradation as barrier to gene delivery: a guide to understand and overcome nuclease activity","volume":"53","author":"Zhang","year":"2023","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jconrel.2025.113849_bb1010","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1177\/153303460700600401","article-title":"Irreversible electroporation in medicine","volume":"6","author":"Rubinsky","year":"2007","journal-title":"Technol. Cancer Res. Treat."},{"key":"10.1016\/j.jconrel.2025.113849_bb1015","article-title":"Immunogenic cell death in electroporation-based therapies depends on pulse waveform characteristics","volume":"11","author":"Polaj\u017eer","year":"2023","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.jconrel.2025.113849_bb1020","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrd1662","article-title":"Healing sound: the use of ultrasound in drug delivery and other therapeutic applications","volume":"4","author":"Mitragotri","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2025.113849_bb1025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.addr.2021.02.015","article-title":"Opening doors with ultrasound and microbubbles: beating biological barriers to promote drug delivery","volume":"172","author":"Deprez","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.113849_bb1030","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jconrel.2012.08.014","article-title":"Crucial factors and emerging concepts in ultrasound-triggered drug delivery","volume":"164","author":"Geers","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113849_bb1035","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.addr.2013.11.008","article-title":"Understanding ultrasound induced sonoporation: definitions and underlying mechanisms","volume":"72","author":"Lentacker","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.113849_bb1040","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1039\/b823051j","article-title":"Drug loaded microbubble design for ultrasound triggered delivery","volume":"5","author":"Lentacker","year":"2009","journal-title":"Soft Matter"},{"key":"10.1016\/j.jconrel.2025.113849_bb1045","article-title":"International Journal of Hyperthermia Treatment of glaucoma with high intensity focused ultrasound","year":"2014","journal-title":"Florent Aptel & Cyril Lafon"},{"key":"10.1016\/j.jconrel.2025.113849_bb1050","doi-asserted-by":"crossref","first-page":"e268","DOI":"10.1111\/aos.12913","article-title":"Multicenter clinical trial of high-intensity focused ultrasound treatment in glaucoma patients without previous filtering surgery","volume":"94","author":"Aptel","year":"2016","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113849_bb1055","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.3892\/mmr.2015.3703","article-title":"Ultrasound-targeted microbubble destruction enhances polyethylenimine-mediated gene transfection in vitro in human retinal pigment epithelial cells and in vivo in rat retina","volume":"12","author":"Wan","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jconrel.2025.113849_bb1060","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/gt.2009.84","article-title":"Ultrasound-targeted microbubble destruction enhances AAV-mediated gene transfection in human RPE cells in vitro and rat retina in vivo","volume":"16","author":"Li","year":"2009","journal-title":"Gene Ther."},{"key":"10.1016\/j.jconrel.2025.113849_bb1065","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15041220","article-title":"Microbubble-assisted ultrasound for drug delivery to the retina in an ex vivo eye model","volume":"15","author":"Rousou","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.113849_bb1070","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1167\/tvst.13.5.5","article-title":"Focused ultrasound as a novel non-invasive method for the delivery of gold nanoparticles to retinal ganglion cells","volume":"13","author":"Park","year":"2024","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.jconrel.2025.113849_bb1075","article-title":"Targeted and reversible blood-retinal barrier disruption via focused ultrasound and microbubbles","volume":"7","author":"Park","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2025.113849_bb1080","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.7150\/thno.42611","article-title":"Focused ultrasound as a novel strategy for noninvasive gene delivery to retinal M\u00fcller glia","volume":"10","author":"Touahri","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2025.113849_bb1085","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ejpb.2014.04.011","article-title":"A novel technology using transscleral ultrasound to deliver protein loaded nanoparticles","volume":"88","author":"Huang","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2025.113849_bb1090","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1167\/iovs.13-11978","article-title":"Ultrasound-mediated Transscleral delivery of macromolecules to the posterior segment of rabbit eye in vivo","volume":"54","author":"Suen","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.113849_bb1095","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.7150\/thno.82884","article-title":"A systematic review of ultrasound-mediated drug delivery to the eye and critical insights to facilitate a timely path to the clinic","volume":"13","author":"Rad","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2025.113849_bb1100","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1007\/s11095-008-9684-2","article-title":"Can ultrasound solve the transport barrier of the neural retina?","volume":"25","author":"Peeters","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2025.113849_bb1105","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/412752","article-title":"Selective gene transfer to the retina using intravitreal ultrasound irradiation","volume":"2012","author":"Sonoda","year":"2012","journal-title":"J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113849_bb1110","series-title":"Ultrasound-mediated nanoparticle delivery across ex vivo bovine retina after intravitreal injection","author":"Huang","year":"2017"},{"key":"10.1016\/j.jconrel.2025.113849_bb1115","series-title":"Stably engineered nanobubbles and ultrasound - An effective platform for enhanced macromolecular delivery to representative cells of the retina","author":"Thakur","year":"2017"},{"key":"10.1016\/j.jconrel.2025.113849_bb1120","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ejpb.2019.01.014","article-title":"Ultrasound-responsive nanobubbles for enhanced intravitreal drug migration: an ex vivo evaluation","volume":"136","author":"Thakur","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2025.113849_bb1125","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4235923","article-title":"Ultrasound microbubbles enhance the neuroprotective effect of mouse nerve growth factor on intraocular hypertension-induced Neuroretina damage in rabbits","volume":"2016","author":"Shen","year":"2016","journal-title":"J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.113849_bb1130","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s12038-017-9677-6","article-title":"Enhanced delivery of biodegradable mPEG-PLGA-PLL nanoparticles loading Cy3-labelled PDGF-BB siRNA by UTMD to rat retina","volume":"42","author":"Du","year":"2017","journal-title":"J. Biosci."},{"key":"10.1016\/j.jconrel.2025.113849_bb1135","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/jgm.2629","article-title":"A novel approach to attenuate proliferative vitreoretinopathy using ultrasound-targeted microbubble destruction and recombinant adeno-associated virus-mediated RNA interference targeting transforming growth factor-\u03b22 and platelet-derived growth factor-B","volume":"14","author":"Zheng","year":"2012","journal-title":"J. Gene Med."},{"key":"10.1016\/j.jconrel.2025.113849_bb1140","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.acra.2010.05.008","article-title":"Ultrasound microbubbles enhance recombinant adeno-associated virus vector delivery to retinal ganglion cells in vivo","volume":"17","author":"Xie","year":"2010","journal-title":"Acad. Radiol."},{"key":"10.1016\/j.jconrel.2025.113849_bb1145","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.3760\/cma.j.issn.0366-6999.2009.22.007","article-title":"Ultrasound-mediated microbubble delivery of pigment epithelium-derived factor gene into retina inhibits choroidal neovascularization","volume":"122","author":"Zhou","year":"2009","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.jconrel.2025.113849_bb1150","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aat4388","article-title":"A swarm of slippery micropropellers penetrates the vitreous body of the eye","volume":"4","author":"Wu","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2025.113849_bb1155","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.3727\/096368911X627435","article-title":"Focused magnetic stem cell targeting to the retina using superparamagnetic Iron oxide nanoparticles","volume":"21","author":"Yanai","year":"2012","journal-title":"Cell Transplant."},{"key":"10.1016\/j.jconrel.2025.113849_bb1160","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1167\/iovs.13-11825","article-title":"Mobility experiments with microrobots for minimally invasive intraocular surgery","volume":"54","author":"Ullrich","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925004699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925004699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T04:59:58Z","timestamp":1779512398000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925004699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":232,"alternative-id":["S0168365925004699"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113849","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toward successful retinal drug delivery after intravitreal injection: Current strategies to overcome the inner limiting membrane","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113849","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113849"}}