{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:57:48Z","timestamp":1787241468317,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"The national research foundation of Korea","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jconrel.2025.113872","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T19:11:12Z","timestamp":1748286672000},"page":"113872","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["CD44-targeted RIP3 gene delivery strategy for enhanced cancer therapy via necroptosis and immune modulation"],"prefix":"10.1016","volume":"384","author":[{"given":"Sang Eun","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyeon","family":"Bak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Ji","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Seok","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyeon","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Hee","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon-Sun","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jconrel.2025.113872_bb0005","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nri3743","article-title":"Regulated cell death and inflammation: an auto-amplification loop causes organ failure","volume":"14","author":"Linkermann","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113872_bb0010","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrm3737","article-title":"Regulated necrosis: the expanding network of non-apoptotic cell death pathways","volume":"15","author":"Berghe","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.jconrel.2025.113872_bb0015","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","article-title":"The molecular machinery of regulated cell death","volume":"29","author":"Tang","year":"2019","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113872_bb0020","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ncb2883","article-title":"Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis","volume":"16","author":"Cai","year":"2014","journal-title":"Nat. Cell Biol."},{"issue":"6258","key":"10.1016\/j.jconrel.2025.113872_bb0025","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1126\/science.aad0395","article-title":"RIPK1 and NF-\u03baB signaling in dying cells determines cross-priming of CD8+ T cells","volume":"350","author":"Yatim","year":"2015","journal-title":"Science"},{"issue":"36","key":"10.1016\/j.jconrel.2025.113872_bb0030","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aaw2004","article-title":"Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity","volume":"4","author":"Snyder","year":"2019","journal-title":"Sci. Immunol."},{"issue":"3","key":"10.1016\/j.jconrel.2025.113872_bb0035","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/iid3.330","article-title":"Necroptotic-susceptible dendritic cells exhibit enhanced antitumor activities in mice","volume":"8","author":"Zhao","year":"2020","journal-title":"Immun. Inflamm. Dis."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113872_bb0040","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12943-019-1029-8","article-title":"The role of necroptosis in cancer biology and therapy","volume":"18","author":"Gong","year":"2019","journal-title":"Mol. Cancer"},{"issue":"7","key":"10.1016\/j.jconrel.2025.113872_bb0045","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1158\/0008-5472.CAN-08-2281","article-title":"Chemokine expression in melanoma metastases associated with CD8+ T-cell recruitment","volume":"69","author":"Harlin","year":"2009","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.jconrel.2025.113872_bb0050","first-page":"771","article-title":"RIP1\/RIP3-regulated necroptosis as a target for multifaceted disease therapy (review)","volume":"44","author":"Liu","year":"2019","journal-title":"Int. J. Mol. Med."},{"issue":"3","key":"10.1016\/j.jconrel.2025.113872_bb0055","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/mt.2016.10","article-title":"Genome-editing Technologies for Gene and Cell Therapy","volume":"24","author":"Maeder","year":"2016","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113872_bb0060","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/0971-6866.112870","article-title":"Delivery systems for gene therapy","volume":"19","author":"Mali","year":"2013","journal-title":"Indian J. Hum. Genet."},{"key":"10.1016\/j.jconrel.2025.113872_bb0065","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/2277-9175.98152","article-title":"Viral and nonviral delivery systems for gene delivery","volume":"1","author":"Nayerossadat","year":"2012","journal-title":"Adv. Biomed. Res."},{"issue":"7","key":"10.1016\/j.jconrel.2025.113872_bb0070","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1134\/S0006297916070063","article-title":"Viral vectors for gene therapy: current state and clinical perspectives","volume":"81","author":"Lukashev","year":"2016","journal-title":"Biochemistry (Mosc.)"},{"key":"10.1016\/j.jconrel.2025.113872_bb0075","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/sj.gt.3302364","article-title":"Immune responses to gene therapy vectors: influence on vector function and effector mechanisms","volume":"1","author":"Bessis","year":"2004","journal-title":"Gene Ther. Suppl"},{"issue":"8","key":"10.1016\/j.jconrel.2025.113872_bb0080","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nrg3763","article-title":"Non-viral vectors for gene-based therapy","volume":"15","author":"Yin","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jconrel.2025.113872_bb0085","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.addr.2017.07.021","article-title":"Nonviral cancer gene therapy: delivery cascade and vector nanoproperty integration","volume":"115","author":"Zhou","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113872_bb0090","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jconrel.2003.08.004","article-title":"Extracellular and intracellular barriers in non-viral gene delivery","volume":"93","author":"Ruponen","year":"2003","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113872_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2024.213776","article-title":"CD44 targeted-chondroitin sulfate nanoparticles: fine-tuning hydrophobic groups to enhance in vitro pH-responsiveness and in vivo efficacy for advanced breast cancer treatment","volume":"158","author":"Azimijou","year":"2024","journal-title":"Biomater. Adv."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113872_bb0100","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.carbpol.2011.08.075","article-title":"Carbohydrate polymers","volume":"87","author":"Cai","year":"2012","journal-title":"Carbohydr. Polym."},{"issue":"5","key":"10.1016\/j.jconrel.2025.113872_bb0105","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.nano.2014.01.008","article-title":"Targeting of diacerein loaded lipid nanoparticles to intra-articular cartilage using chondroitin sulfate as homing carrier for treatment of osteoarthritis in rats","volume":"10","author":"Jain","year":"2014","journal-title":"Nanomedicine"},{"issue":"10","key":"10.1016\/j.jconrel.2025.113872_bb0110","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1016\/j.bbagen.2013.06.006","article-title":"Biosynthesis and function of chondroitin sulfate","volume":"1830","author":"Mikami","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"45","key":"10.1016\/j.jconrel.2025.113872_bb0115","doi-asserted-by":"crossref","first-page":"35448","DOI":"10.1074\/jbc.M003387200","article-title":"Binding of a large chondroitin sulfate\/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44","volume":"275","author":"Kawashima","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.jconrel.2025.113872_bb0120","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1021\/bm200115v","article-title":"Self-assembled Chlorin e6 conjugated chondroitin sulfate Nanodrug for photodynamic therapy","volume":"12","author":"Li","year":"2011","journal-title":"Biomacromolecules"},{"issue":"21","key":"10.1016\/j.jconrel.2025.113872_bb0125","doi-asserted-by":"crossref","first-page":"10233","DOI":"10.1158\/0008-5472.CAN-06-1464","article-title":"Heparanase, Hyaluronan, and CD44 in cancers: a breast carcinoma perspective","volume":"66","author":"Gotte","year":"2006","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.jconrel.2025.113872_bb0130","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.carbpol.2011.05.011","article-title":"Self-quenchable biofunctional nanoparticles of heparin\u2013folate-photosensitizer conjugates for photodynamic therapy","volume":"86","author":"Li","year":"2011","journal-title":"Carbohydr. Polym."},{"issue":"12","key":"10.1016\/j.jconrel.2025.113872_bb0135","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/mabi.201400361","article-title":"A cancer-recognizing polymeric photosensitizer based on the tumor extracellular pH response of conjugated polymers for targeted cancer photodynamic therapy","volume":"14","author":"Jeong","year":"2014","journal-title":"Macromol. Biosci."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113872_bb0140","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jconrel.2013.08.007","article-title":"pH-responsive and charge shielded cationic micelle of poly(L-histidine)-block-short branched PEI for acidic cancer treatment","volume":"172","author":"Hu","year":"2013","journal-title":"J. Control. Release"},{"issue":"7","key":"10.1016\/j.jconrel.2025.113872_bb0145","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1021\/acs.accounts.9b00177","article-title":"Carriers break barriers in drug delivery: endocytosis and endosomal escape of gene delivery vectors","volume":"52","author":"Degors","year":"2019","journal-title":"Acc. Chem. Res."},{"issue":"6","key":"10.1016\/j.jconrel.2025.113872_bb0150","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s11095-022-03296-w","article-title":"Endosomal escape of bioactives deployed via nanocarriers: insights into the design of polymeric micelles","volume":"39","author":"Butt","year":"2022","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113872_bb0155","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molcel.2014.03.003","article-title":"Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3","volume":"54","author":"Wang","year":"2014","journal-title":"J. Mol. Cell."},{"issue":"6","key":"10.1016\/j.jconrel.2025.113872_bb0160","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1021\/nn900044f","article-title":"Gene expression, biodistribution, and pharmacoscintigraphic evaluation of chondroitin sulfate-PEI nanoconstructs mediated tumor gene therapy","volume":"3","author":"Panthak","year":"2009","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.jconrel.2025.113872_bb0165","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13045-018-0605-5","article-title":"The biology and role of CD44 in cancer progression: therapeutic implications","volume":"11","author":"Chen","year":"2018","journal-title":"J. Hemato. Oncol."},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2025.113872_bb0170","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbagrm.2009.11.014","article-title":"High-mobility group box 1 and cancer","volume":"1799","author":"Tang","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"6","key":"10.1016\/j.jconrel.2025.113872_bb0175","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2016.1149673","article-title":"Contribution of RIP3 and MLKL to immunogenic cell death signaling in cancer chemotherapy","volume":"5","author":"Yang","year":"2016","journal-title":"Oncoimmunology"},{"issue":"2","key":"10.1016\/j.jconrel.2025.113872_bb0180","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s40005-017-0377-x","article-title":"Combination of photodynamic therapy (PDT) and anti-tumor immunity in cancer therapy","volume":"48","author":"Hwang","year":"2018","journal-title":"J. Pharm. Investig."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113872_bb0185","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nri1256","article-title":"Dendritic cells: emerging pharmacological targets of immunosuppressive drugs","volume":"4","author":"Hackstein","year":"2004","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113872_bb0190","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13045-020-00939-6","article-title":"Dendritic cell biology and its role in tumor immunotherapy","volume":"13","author":"Wang","year":"2020","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113872_bb0195","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12943-021-01399-3","article-title":"RIPK3 activation induces TRIM28 derepression in cancer cells and enhances the anti-tumor microenvironment","volume":"20","author":"Park","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jconrel.2025.113872_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2021.101481","article-title":"The role of dendritic cells in cancer and anti-tumor immunity","volume":"52","author":"Marciscano","year":"2021","journal-title":"Semin. Immunol."},{"issue":"4","key":"10.1016\/j.jconrel.2025.113872_bb0205","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nri2274","article-title":"T-cell quality in memory and protection: implications for vaccine design","volume":"8","author":"Seder","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.jconrel.2025.113872_bb0210","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.4049\/jimmunol.164.7.3723","article-title":"Direct visualization of cytokine-producing recall antigen-specific CD4 memory T cells in healthy individuals and HIV patients","volume":"164","author":"Helms","year":"2000","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.113872_bb0215","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41392-022-01046-3","article-title":"Ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy","volume":"7","author":"Gao","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.jconrel.2025.113872_bb0220","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/s41418-020-00658-y","article-title":"The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses","volume":"28","author":"Aaes","year":"2021","journal-title":"Cell Death Differ."},{"issue":"23","key":"10.1016\/j.jconrel.2025.113872_bb0225","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1021\/bi00694a002","article-title":"Poly(8-aminoguanylic acid): formation of ordered self-structures and interaction with poly(cytidylic acid)","volume":"14","author":"Hattori","year":"1975","journal-title":"Biochemistry"},{"issue":"11","key":"10.1016\/j.jconrel.2025.113872_bb0230","doi-asserted-by":"crossref","first-page":"8635","DOI":"10.18632\/oncotarget.3249","article-title":"RIPK3 expression in cervical cancer cells is required for PolyIC-induced necroptosis, IL-1\u03b1 release, and efficient paracrine dendritic cell activation","volume":"6","author":"Schmidt","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.jconrel.2025.113872_bb0235","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3389\/fimmu.2020.00536","article-title":"RIPK3 and caspase-1\/11 are necessary for optimal antigen-specific CD8 T cell response elicited by genetically modified listeria monocytogenes","volume":"11","author":"Rana","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.113872_bb0240","doi-asserted-by":"crossref","first-page":"8566","DOI":"10.1039\/C4TB01274G","article-title":"Imidazolized magnetic nanovectors with endosome disrupting moieties for the intracellular delivery and imaging of siRNA","volume":"2","author":"Kim","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jconrel.2025.113872_bb0245","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.3390\/polym14091659","article-title":"pH- and thermo-responsive water-soluble smart polyion complex (PIC) vesicle with polyampholyte shells","volume":"14","author":"Pham","year":"2022","journal-title":"Polymers"},{"key":"10.1016\/j.jconrel.2025.113872_bb0250","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1021\/am400572b","article-title":"Thermal and pH responsive polymer-tethered multifunctional magnetic nanoparticles for targeted delivery of anticancer drug","volume":"5","author":"Sahoo","year":"2013","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"6","key":"10.1016\/j.jconrel.2025.113872_bb0255","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.bbagen.2005.11.009","article-title":"Effects of molecular size and chemical structure on renal and hepatic removal of exogenously administered chondroitin sulfate in rats","volume":"1760","author":"Pecly","year":"2006","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925004924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925004924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T04:56:13Z","timestamp":1779512173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925004924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":51,"alternative-id":["S0168365925004924"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113872","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD44-targeted RIP3 gene delivery strategy for enhanced cancer therapy via necroptosis and immune modulation","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113872","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113872"}}