{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:39:44Z","timestamp":1791895184203,"version":"4.3.4"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160666"],"award-info":[{"award-number":["82160666"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2023YFC2605000"],"award-info":[{"award-number":["2023YFC2605000"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jconrel.2025.113891","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T19:32:24Z","timestamp":1748374344000},"page":"113891","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Chitosan and mannose-modified dual-functional mRNA-LNP vaccines for robust systemic and mucosal immune responses"],"prefix":"10.1016","volume":"384","author":[{"given":"Jing","family":"Yi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haonan","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.113891_bb0005","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.coviro.2021.11.002","article-title":"Host cell-intrinsic innate immune recognition of SARS-CoV-2","volume":"52","author":"Madden","year":"2022","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.jconrel.2025.113891_bb0010","doi-asserted-by":"crossref","first-page":"6582","DOI":"10.3390\/ijms21186582","article-title":"mRNA vaccine era-mechanisms, drug platform and clinical prospection","volume":"21","author":"Xu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.113891_bb0015","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1186\/s12879-022-07418-y","article-title":"SARS-CoV-2 vaccine effectiveness against infection, symptomatic and severe COVID-19: a systematic review and meta-analysis","volume":"22","author":"Ssentongo","year":"2022","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.jconrel.2025.113891_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103788","article-title":"Mucosal immune response in BNT162b2 COVID-19 vaccine recipients","volume":"75","author":"Azzi","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jconrel.2025.113891_bb0025","doi-asserted-by":"crossref","first-page":"eadd4853","DOI":"10.1126\/sciimmunol.add4853","article-title":"Respiratory mucosal immunity against SARS-CoV-2 after mRNA vaccination","volume":"7","author":"Tang","year":"2022","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.jconrel.2025.113891_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104402","article-title":"SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination","volume":"87","author":"Liew","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jconrel.2025.113891_bb0035","doi-asserted-by":"crossref","first-page":"9471","DOI":"10.1038\/s41467-024-53914-x","article-title":"Charge-assisted stabilization of lipid nanoparticles enables inhaled mRNA delivery for mucosal vaccination","volume":"15","author":"Liu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.113891_bb0040","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/s41551-021-00786-x","article-title":"Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs","volume":"5","author":"Lokugamage","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2025.113891_bb0045","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1016\/j.vaccine.2021.03.006","article-title":"Intranasal administration of a recombinant RBD vaccine induced protective immunity against SARS-CoV-2 in mouse","volume":"39","author":"Du","year":"2021","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113891_bb0050","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1080\/14760584.2024.2326094","article-title":"Progress and challenges in the clinical evaluation of immune responses to respiratory mucosal vaccines","volume":"23","author":"Zhang","year":"2024","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.jconrel.2025.113891_bb0055","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S2213-2600(22)00087-X","article-title":"Safety and immunogenicity of heterologous boost immunisation with an orally administered aerosolised Ad5-nCoV after two-dose priming with an inactivated SARS-CoV-2 vaccine in Chinese adults: a randomised, open-label, single-Centre trial","volume":"10","author":"Li","year":"2022","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.jconrel.2025.113891_bb0060","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jtbi.2015.02.023","article-title":"Model of mucociliary clearance in cystic fibrosis lungs","volume":"372","author":"Kurbatova","year":"2015","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.jconrel.2025.113891_bb0065","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1126\/science.1223012","article-title":"A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia","volume":"337","author":"Button","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2025.113891_bb0070","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.chemphyslip.2014.09.002","article-title":"Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films","volume":"185","author":"Parra","year":"2015","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.jconrel.2025.113891_bb0075","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.3390\/ijms23052736","article-title":"Current advances in RNA therapeutics for human diseases","volume":"23","author":"Zogg","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.113891_bb0080","doi-asserted-by":"crossref","first-page":"14792","DOI":"10.1021\/acsnano.2c05647","article-title":"Engineering lipid nanoparticles for enhanced intracellular delivery of mRNA through inhalation","volume":"16","author":"Kim","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.113891_bb0085","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.ijbiomac.2021.05.050","article-title":"Feasibility of chitosan-based nanoparticles approach for intranasal immunisation of live attenuated Japanese encephalitis vaccine","volume":"183","author":"Dumkliang","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jconrel.2025.113891_bb0090","first-page":"216","article-title":"Preparation, characterization and in vivo evaluation of alginate-coated chitosan and trimethylchitosan nanoparticles loaded with PR8 influenza virus for nasal immunization","volume":"14","author":"Mosafer","year":"2019","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2025.113891_bb0095","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1016\/j.vaccine.2018.03.065","article-title":"Inactivated infectious bronchitis virus vaccine encapsulated in chitosan nanoparticles induces mucosal immune responses and effective protection against challenge","volume":"36","author":"Lopes","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113891_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.201700060","article-title":"A polymer chemistry point of view on Mucoadhesion and Mucopenetration","volume":"17","author":"Schattling","year":"2017","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.jconrel.2025.113891_bb0105","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.ijbiomac.2020.03.148","article-title":"Advances and applications of chitosan-based nanomaterials as oral delivery carriers: a review","volume":"154","author":"Lang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jconrel.2025.113891_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.carres.2019.107877","article-title":"Comparative binding and uptake of liposomes decorated with mannose oligosaccharides by cells expressing the mannose receptor or DC-SIGN","volume":"487","author":"Gao","year":"2020","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.jconrel.2025.113891_bb0115","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1007\/s11095-011-0459-9","article-title":"Activation of antigen-specific T cell-responses by mannan-decorated PLGA nanoparticles","volume":"28","author":"Hamdy","year":"2011","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2025.113891_bb0120","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jconrel.2016.05.032","article-title":"Nasal immunization with mannan-decorated mucoadhesive HPMCP microspheres containing ApxIIA toxin induces protective immunity against challenge infection with Actinobacillus pleuropneumoiae in mice","volume":"233","author":"Li","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.113891_bb0125","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.vaccine.2017.12.027","article-title":"Recombinant Lactococcus lactis co-expressing OmpH of an M cell-targeting ligand and IBDV-VP2 protein provide immunological protection in chickens","volume":"36","author":"Liu","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113891_bb0130","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1007\/s00125-018-4593-3","article-title":"Targeted delivery of antigen to intestinal dendritic cells induces oral tolerance and prevents autoimmune diabetes in NOD mice","volume":"61","author":"Chen","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.jconrel.2025.113891_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16111423","article-title":"Modified PEG-lipids enhance the nasal mucosal immune capacity of lipid nanoparticle mRNA vaccines","volume":"16","author":"Li","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.113891_bb0140","article-title":"Formulating and characterizing lipid nanoparticles for gene delivery using a microfluidic mixing platform","volume":"168","author":"Bailey-Hytholt","year":"2021","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jconrel.2025.113891_bb0145","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1021\/bi952000v","article-title":"Poly(ethylene glycol)--lipid conjugates regulate the calcium-induced fusion of liposomes composed of phosphatidylethanolamine and phosphatidylserine","volume":"35","author":"Holland","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.jconrel.2025.113891_bb0150","doi-asserted-by":"crossref","first-page":"6709","DOI":"10.1021\/acsnano.0c10064","article-title":"Apolipoprotein E binding drives structural and compositional rearrangement of mRNA-containing lipid nanoparticles","volume":"15","author":"Sebastiani","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.113891_bb0155","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.colsurfb.2016.09.049","article-title":"Surface modification of nanostructure lipid carrier (NLC) by oleoyl-quaternized-chitosan as a mucoadhesive nanocarrier","volume":"149","author":"Yostawonkul","year":"2017","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"10.1016\/j.jconrel.2025.113891_bb0160","doi-asserted-by":"crossref","first-page":"5323","DOI":"10.1021\/acs.jpcb.0c03444","article-title":"Lipid-raft-mediated direct cytosolic delivery of polymer-coated soft nanoparticles","volume":"124","author":"Panja","year":"2020","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jconrel.2025.113891_bb0165","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41557-021-00854-4","article-title":"Phase-separating peptides for direct cytosolic delivery and redox-activated release of macromolecular therapeutics","volume":"14","author":"Sun","year":"2022","journal-title":"Nat. Chem."},{"key":"10.1016\/j.jconrel.2025.113891_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-immunol-100311-102839","article-title":"Decisions about dendritic cells: past, present, and future","volume":"30","author":"Steinman","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2025.113891_bb0175","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s12026-012-8300-z","article-title":"The specialized roles of immature and mature dendritic cells in antigen cross-presentation","volume":"53","author":"Hopkins","year":"2012","journal-title":"Immunol. Res."},{"key":"10.1016\/j.jconrel.2025.113891_bb0180","article-title":"Clitocybe nuda activates dendritic cells and acts as a DNA vaccine adjuvant, evidence-based complementary","volume":"2013","author":"Chen","year":"2013","journal-title":"Altern. Med."},{"key":"10.1016\/j.jconrel.2025.113891_bb0185","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.vaccine.2005.09.039","article-title":"Hexa-acylation and KDO(2)-glycosylation determine the specific immunostimulatory activity of Neisseria meningitidis lipid a for human monocyte derived dendritic cells","volume":"24","author":"Zughaier","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.jconrel.2025.113891_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.trim.2021.101495","article-title":"T helper type (Th1\/Th2) responses to SARS-CoV-2 and influenza a (H1N1) virus: from cytokines produced to immune responses","volume":"70","author":"Aleebrahim-Dehkordi","year":"2022","journal-title":"Transplant. Immunol."},{"key":"10.1016\/j.jconrel.2025.113891_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105361","article-title":"Influence of Th1 versus Th2 immune bias on viral, pathological, and immunological dynamics in SARS-CoV-2 variant-infected human ACE2 knock-in mice","volume":"108","author":"Verma","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jconrel.2025.113891_bb0200","doi-asserted-by":"crossref","DOI":"10.1126\/science.adk2536","article-title":"A host-adapted auxotrophic gut symbiont induces mucosal immunodeficiency","volume":"385","author":"Lu","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2025.113891_bb0205","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41586-023-06809-8","article-title":"Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization","volume":"624","author":"Ye","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2025.113891_bb0210","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.immuni.2020.11.009","article-title":"SARS-CoV-2 mRNA vaccines Foster potent antigen-specific germinal Center responses associated with neutralizing antibody generation","volume":"53","author":"Lederer","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jconrel.2025.113891_bb0215","doi-asserted-by":"crossref","first-page":"6815","DOI":"10.1038\/s41467-023-42433-w","article-title":"Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination","volume":"14","author":"Mitsi","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.113891_bb0220","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40425-017-0235-4","article-title":"Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy","volume":"5","author":"Sckisel","year":"2017","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jconrel.2025.113891_bb0225","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41590-019-0320-6","article-title":"Human CD8(+) T cell cross-reactivity across influenza a, B and C viruses","volume":"20","author":"Koutsakos","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jconrel.2025.113891_bb0230","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41577-024-01040-6","article-title":"A guide to adaptive immune memory","volume":"24","author":"Lam","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2025.113891_bb0235","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41586-020-2622-0","article-title":"SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness","volume":"586","author":"Corbett","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2025.113891_bb0240","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/bs.ircmb.2018.06.002","article-title":"Metabolism of T lymphocytes in health and disease","volume":"342","author":"Gaber","year":"2019","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.jconrel.2025.113891_bb0245","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/925135","article-title":"CD4+T cells: differentiation and functions","volume":"2012","author":"Luckheeram","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.jconrel.2025.113891_bb0250","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrrheum.2012.58","article-title":"Follicular helper T cells in immunity and systemic autoimmunity","volume":"8","author":"Craft","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jconrel.2025.113891_bb0255","doi-asserted-by":"crossref","first-page":"8509","DOI":"10.1002\/jcp.27782","article-title":"CD8(+) cytotoxic T lymphocytes in cancer immunotherapy: a review","volume":"234","author":"Farhood","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jconrel.2025.113891_bb0260","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.it.2018.11.001","article-title":"Professional and \u2018amateur\u2019 antigen-presenting cells in type 2 immunity","volume":"40","author":"Schuijs","year":"2019","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jconrel.2025.113891_bb0265","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/s41565-023-01548-3","article-title":"Combinatorial development of nebulized mRNA delivery formulations for the lungs","volume":"19","author":"Jiang","year":"2024","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2025.113891_bb0270","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.836274","article-title":"R848 adjuvant laden with self-assembled nanoparticle-based mRNA vaccine elicits protective immunity against H5N1 in mice","volume":"13","author":"Zhuang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.113891_bb0275","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41577-021-00583-2","article-title":"Mucosal vaccines - fortifying the frontiers","volume":"22","author":"Lavelle","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2025.113891_bb0280","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nature21349","article-title":"Elements of cancer immunity and the cancer-immune set point","volume":"541","author":"Chen","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2025.113891_bb0285","doi-asserted-by":"crossref","first-page":"20210146","DOI":"10.1002\/EXP.20210146","article-title":"From structural design to delivery: mRNA therapeutics for cancer immunotherapy","volume":"4","author":"Zhou","year":"2024","journal-title":"Exploration"},{"key":"10.1016\/j.jconrel.2025.113891_bb0290","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jconrel.2023.09.031","article-title":"Spray dried lipid nanoparticle formulations enable intratracheal delivery of mRNA","volume":"363","author":"Friis","year":"2023","journal-title":"J. Control. Release"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925005115?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925005115?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T04:48:20Z","timestamp":1779511700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925005115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":58,"alternative-id":["S0168365925005115"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113891","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chitosan and mannose-modified dual-functional mRNA-LNP vaccines for robust systemic and mucosal immune responses","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113891","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113891"}}