{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:08:48Z","timestamp":1793898528046,"version":"4.8.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EB022018"],"award-info":[{"award-number":["R01EB022018"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL138353"],"award-info":[{"award-number":["R01HL138353"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL164062"],"award-info":[{"award-number":["R01HL164062"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK133949"],"award-info":[{"award-number":["R01DK133949"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL174055"],"award-info":[{"award-number":["R01HL174055"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL138175"],"award-info":[{"award-number":["R01HL138175"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR077616"],"award-info":[{"award-number":["R01AR077616"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG056919"],"award-info":[{"award-number":["R01AG056919"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jconrel.2025.113938","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T11:10:19Z","timestamp":1749208219000},"page":"113938","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Targeted delivery of engineered extracellular vesicles to simultaneously promote vascularization and muscle regeneration in ischemic limbs"],"prefix":"10.1016","volume":"384","author":[{"given":"Ting","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.113938_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpcardiol.2021.101082","article-title":"Peripheral artery disease: a comprehensive updated review","volume":"47","author":"Shamaki","year":"2022","journal-title":"Curr. Probl. Cardiol."},{"key":"10.1016\/j.jconrel.2025.113938_bb0010","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.3390\/ijms22052335","article-title":"Current status of angiogenic cell therapy and related strategies applied in critical limb ischemia","volume":"22","author":"Beltr\u00e1n-Camacho","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.113938_bb0015","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/s13287-022-03043-3","article-title":"Mesenchymal stem cells for critical limb ischemia: their function, mechanism, and therapeutic potential","volume":"13","author":"Lozano Navarro","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jconrel.2025.113938_bb0020","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1186\/s13287-022-03148-9","article-title":"Emerging roles of mesenchymal stem cell therapy in patients with critical limb ischemia","volume":"13","author":"Shirbaghaee","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jconrel.2025.113938_bb0025","first-page":"1","article-title":"Stem cell-based therapy for human diseases","volume":"7","author":"Hoang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2025.113938_bb0030","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s44222-023-00064-2","article-title":"Stem cell-derived exosome versus stem cell therapy","volume":"1","author":"Zhang","year":"2023","journal-title":"Nat. Rev. Bioeng."},{"key":"10.1016\/j.jconrel.2025.113938_bb0035","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201909125","article-title":"Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration","volume":"30","author":"Brennan","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2025.113938_bb0040","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11892-021-01378-4","article-title":"Cell therapy for critical limb ischemia: advantages, limitations, and new perspectives for treatment of patients with critical diabetic vasculopathy","volume":"21","author":"Gu","year":"2021","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.jconrel.2025.113938_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120872","article-title":"Hydrogel-based therapeutic angiogenesis: an alternative treatment strategy for critical limb ischemia","volume":"274","author":"Xing","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.113938_bb0050","doi-asserted-by":"crossref","first-page":"A249","DOI":"10.1161\/res.127.suppl_1.249","article-title":"Plasma exosomes impair angiogenesis in ischemic hind limb of diabetic mice-role of histone methylation","volume":"127","author":"Cheng","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.jconrel.2025.113938_bb0055","doi-asserted-by":"crossref","first-page":"6728","DOI":"10.7150\/thno.42259","article-title":"Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome\/circHIPK3\/FOXO3a pathway","volume":"10","author":"Yan","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2025.113938_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-021-02475-7","article-title":"Exosomes derived from adipose-derived stem cells overexpressing glyoxalase-1 protect endothelial cells and enhance angiogenesis in type 2 diabetic mice with limb ischemia","volume":"12","author":"Zhang","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jconrel.2025.113938_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-020-01669-9","article-title":"Macrophage M2 polarization induced by exosomes from adipose-derived stem cells contributes to the exosomal proangiogenic effect on mouse ischemic hindlimb","volume":"11","author":"Zhu","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jconrel.2025.113938_bb0070","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/s41551-021-00705-0","article-title":"Exosome-eluting stents for vascular healing after ischaemic injury","volume":"5","author":"Hu","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2025.113938_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2021.102235","article-title":"Human mesenchymal stem cells promote ischemic repairment and angiogenesis of diabetic foot through exosome miRNA-21-5p","volume":"52","author":"Huang","year":"2021","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.jconrel.2025.113938_bb0080","doi-asserted-by":"crossref","first-page":"180","DOI":"10.7150\/thno.17133","article-title":"Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model","volume":"7","author":"Tao","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2025.113938_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-021-02282-0","article-title":"Exosomes derived from miR-26a-modified MSCs promote axonal regeneration via the PTEN\/AKT\/mTOR pathway following spinal cord injury","volume":"12","author":"Chen","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jconrel.2025.113938_bb0090","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12669","article-title":"Exosomes derived from miR-375-overexpressing human adipose mesenchymal stem cells promote bone regeneration","volume":"52","author":"Chen","year":"2019","journal-title":"Cell Prolif."},{"key":"10.1016\/j.jconrel.2025.113938_bb0095","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00441-022-03663-4","article-title":"Effectiveness of exosome mediated miR-126 and miR-146a delivery on cardiac tissue regeneration","volume":"390","author":"Shafei","year":"2022","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.jconrel.2025.113938_bb0100","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1002\/jcb.29657","article-title":"Exosome mediated transfer of miRNA-140 promotes enhanced chondrogenic differentiation of bone marrow stem cells for enhanced cartilage repair and regeneration","volume":"121","author":"Won Lee","year":"2020","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jconrel.2025.113938_bb0105","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.actbio.2018.11.024","article-title":"Enhanced extracellular vesicle production and ethanol-mediated vascularization bioactivity via a 3D-printed scaffold-perfusion bioreactor system","volume":"95","author":"Patel","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2025.113938_bb0110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13578-022-00786-7","article-title":"Heterogeneity of mesenchymal stem cell-derived extracellular vesicles is highly impacted by the tissue\/cell source and culture conditions","volume":"12","author":"Almeria","year":"2022","journal-title":"Cell Biosci."},{"key":"10.1016\/j.jconrel.2025.113938_bb0115","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fcvm.2017.00063","article-title":"Toward exosome-based therapeutics: isolation, heterogeneity, and fit-for-purpose potency","volume":"4","author":"Willis","year":"2017","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.jconrel.2025.113938_bb0120","doi-asserted-by":"crossref","first-page":"6163","DOI":"10.7150\/thno.28021","article-title":"Hypoxia-elicited mesenchymal stem cell-derived exosomes facilitates cardiac repair through miR-125b-mediated prevention of cell death in myocardial infarction","volume":"8","author":"Zhu","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2025.113938_bb0125","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.actbio.2022.02.026","article-title":"Exosomes derived from hypoxia preconditioned mesenchymal stem cells laden in a silk hydrogel promote cartilage regeneration via the miR-205\u20135p\/PTEN\/AKT pathway","volume":"143","author":"Shen","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2025.113938_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-020-1726-7","article-title":"Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1\/M2 polarization","volume":"17","author":"Liu","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jconrel.2025.113938_bb0135","doi-asserted-by":"crossref","first-page":"25157","DOI":"10.1021\/acsnano.3c08088","article-title":"Co-delivery of bioengineered exosomes and oxygen for treating critical limb ischemia in diabetic mice","volume":"17","author":"Zhong","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.113938_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119639","article-title":"Niche-mimicking interactions in peptide-functionalized 3D hydrogels amplify mesenchymal stromal cell paracrine effects","volume":"230","author":"Qazi","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.113938_bb0145","first-page":"1","article-title":"Exosomes from IL-1\u03b2-primed mesenchymal stem cells inhibited IL-1\u03b2-and TNF-\u03b1-mediated inflammatory responses in osteoarthritic SW982 cells","author":"Kim","year":"2021","journal-title":"Tissue Eng. Regener. Med."},{"key":"10.1016\/j.jconrel.2025.113938_bb0150","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201902372","article-title":"Fibroblast growth factor 2-mediated regulation of neuronal exosome release depends on VAMP3\/cellubrevin in hippocampal neurons","volume":"7","author":"Kumar","year":"2020","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2025.113938_bb0155","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.7150\/thno.52570","article-title":"Engineering exosomes for targeted drug delivery","volume":"11","author":"Liang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2025.113938_bb0160","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.addr.2020.04.004","article-title":"Extracellular vesicles as drug delivery systems: why and how?","volume":"159","author":"Elsharkasy","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.113938_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120467","article-title":"Extracellular vesicles: a bright star of nanomedicine","volume":"269","author":"Wu","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.113938_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119725","article-title":"Porous bio-click microgel scaffolds control hMSC interactions and promote their secretory properties","volume":"232","author":"Caldwell","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.113938_bb0175","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41467-019-14000-9","article-title":"Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities","volume":"11","author":"Clark","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.113938_bb0180","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nmat3980","article-title":"Harnessing nanotopography and integrin\u2013matrix interactions to influence stem cell fate","volume":"13","author":"Dalby","year":"2014","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jconrel.2025.113938_bb0185","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.actbio.2022.07.050","article-title":"N-cadherin mimetic hydrogel enhances MSC chondrogenesis through cell metabolism","volume":"150","author":"Ke","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2025.113938_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119846","article-title":"Comparative effects of N-cadherin protein and peptide fragments on mesenchymal stem cell mechanotransduction and paracrine function","volume":"239","author":"Qin","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.113938_bb0195","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1021\/acsbiomaterials.0c00318","article-title":"Elastomer-grafted iPSC-derived micro heart muscles to investigate effects of mechanical loading on physiology","volume":"7","author":"Guo","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.jconrel.2025.113938_bb0200","doi-asserted-by":"crossref","first-page":"9777","DOI":"10.1021\/am402903e","article-title":"Surface chemical modification of poly (dimethylsiloxane) for the enhanced adhesion and proliferation of mesenchymal stem cells","volume":"5","author":"Kuddannaya","year":"2013","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2025.113938_bb0205","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41551-017-0182-x","article-title":"Targeted repair of heart injury by stem cells fused with platelet nanovesicles","volume":"2","author":"Tang","year":"2018","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2025.113938_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2021.101210","article-title":"Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury","volume":"39","author":"Hu","year":"2021","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2025.113938_bb0215","first-page":"551","article-title":"Relationship and improvement strategies between drug nanocarrier characteristics and hemocompatibility: what can we learn from the literature","volume":"16","author":"Guo","year":"2021","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2025.113938_bb0220","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.actbio.2019.12.020","article-title":"Hypoxic mesenchymal stem cell-derived exosomes promote bone fracture healing by the transfer of miR-126","volume":"103","author":"Liu","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2025.113938_bb0225","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1186\/s13287-022-03056-y","article-title":"miR-126-3p containing exosomes derived from human umbilical cord mesenchymal stem cells promote angiogenesis and attenuate ovarian granulosa cell apoptosis in a preclinical rat model of premature ovarian failure","volume":"13","author":"Qu","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jconrel.2025.113938_bb0230","article-title":"Extracellular vesicles derived from endothelial progenitor cells modified by Houshiheisan promote angiogenesis and attenuate cerebral ischemic injury via miR-126\/PIK3R2","volume":"14","author":"Zhang","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113938_bb0235","doi-asserted-by":"crossref","first-page":"169","DOI":"10.7150\/thno.21234","article-title":"Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function","volume":"8","author":"Hu","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2025.113938_bb0240","article-title":"DNA tetrahedron delivering miR-21-5p promotes senescent bone defects repair through synergistic regulation of osteogenesis and angiogenesis","volume":"13","author":"Qi","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2025.113938_bb0245","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1289380","article-title":"Microvesicles from human immortalized cell lines of endothelial progenitor cells and mesenchymal stem\/stromal cells of adipose tissue origin as carriers of bioactive factors facilitating angiogenesis","volume":"2020","author":"Krawczenko","year":"2020","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.jconrel.2025.113938_bb0250","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.3390\/ani12202799","article-title":"miR-183\/96\/182 cluster regulates the development of bovine myoblasts through targeting FoxO1","volume":"12","author":"Ru","year":"2022","journal-title":"Animals"},{"key":"10.1016\/j.jconrel.2025.113938_bb0255","article-title":"Elevated PDGF-BB from bone impairs hippocampal vasculature by inducing PDGFR\u03b2 shedding from pericytes","volume":"10","author":"Liu","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2025.113938_bb0260","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","article-title":"VEGF in signaling and disease: beyond discovery and development","volume":"176","author":"Apte","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2025.113938_bb0265","doi-asserted-by":"crossref","first-page":"7237","DOI":"10.7150\/thno.77345","article-title":"MMP 9-instructed assembly of bFGF nanofibers in ischemic myocardium to promote heart repair","volume":"12","author":"Wang","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2025.113938_bb0270","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/08977194.2015.1058260","article-title":"Dose-dependent modulation of myogenesis by HGF: implications for c-met expression and downstream signalling pathways","volume":"33","author":"Walker","year":"2015","journal-title":"Growth Factors"},{"key":"10.1016\/j.jconrel.2025.113938_bb0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12860-017-0131-2","article-title":"Mesenchymal stem cells and myoblast differentiation under HGF and IGF-1 stimulation for 3D skeletal muscle tissue engineering","volume":"18","author":"Witt","year":"2017","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.jconrel.2025.113938_bb0280","doi-asserted-by":"crossref","first-page":"8824","DOI":"10.1038\/s41467-024-53107-6","article-title":"N-cadherin crosstalk with integrin weakens the molecular clutch in response to surface viscosity","volume":"15","author":"Barcelona-Estaje","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.113938_bb0285","doi-asserted-by":"crossref","first-page":"6854","DOI":"10.1038\/s41467-022-34424-0","article-title":"Programmable integrin and N-cadherin adhesive interactions modulate mechanosensing of mesenchymal stem cells by cofilin phosphorylation","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.113938_bb0290","doi-asserted-by":"crossref","first-page":"5565","DOI":"10.1038\/s41467-024-49901-x","article-title":"Single dose of intravenous miR199a-5p delivery targeting ischemic heart for long-term repair of myocardial infarction","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.113938_bb0295","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.yjmcc.2011.02.003","article-title":"Identification of targeting peptides for ischemic myocardium by in vivo phage display","volume":"50","author":"Kanki","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jconrel.2025.113938_bb0300","doi-asserted-by":"crossref","first-page":"5907","DOI":"10.1021\/acsami.0c19271","article-title":"Targeted delivery of a matrix metalloproteinases-2 specific inhibitor using multifunctional nanogels to attenuate ischemic skeletal muscle degeneration and promote revascularization","volume":"13","author":"Dang","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2025.113938_bb0305","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s10529-009-9940-5","article-title":"Validity of DNA analysis to determine cell numbers in tissue engineering scaffolds","volume":"31","author":"Forsey","year":"2009","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.jconrel.2025.113938_bb0310","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nrm3265","article-title":"Satellite cells, the engines of muscle repair","volume":"13","author":"Wang","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jconrel.2025.113938_bb0315","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1038\/s41467-018-06583-6","article-title":"Myogenin promotes myocyte fusion to balance fibre number and size","volume":"9","author":"Ganassi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.113938_bb0320","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.2337\/dc16-0850","article-title":"Diabetes is associated with decreased limb survival in patients with critical limb ischemia: pooled data from two randomized controlled trials","volume":"39","author":"Spreen","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jconrel.2025.113938_bb0325","article-title":"Siglec-5 is a novel marker of critical limb ischemia in patients with diabetes","volume":"7","author":"Li","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.113938_bb0330","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","article-title":"The pathobiology of diabetic complications: a unifying mechanism","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.jconrel.2025.113938_bb0335","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1161\/ATVBAHA.114.303414","article-title":"Impaired fibrous repair: a possible contributor to atherosclerotic plaque vulnerability in patients with type II diabetes","volume":"34","author":"Edsfeldt","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jconrel.2025.113938_bb0340","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s12967-021-02863-w","article-title":"Application of stem cell-derived exosomes in ischemic diseases: opportunity and limitations","volume":"19","author":"Babaei","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.113938_bb0345","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1161\/CIRCRESAHA.119.315806","article-title":"N-cadherin overexpression mobilizes the protective effects of mesenchymal stromal cells against ischemic heart injury through a \u03b2-catenin-dependent manner","volume":"126","author":"Yan","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.jconrel.2025.113938_bb0350","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1007\/s11426-020-9772-0","article-title":"Bioactive polypeptide hydrogels modified with RGD and N-cadherin mimetic peptide promote chondrogenic differentiation of bone marrow mesenchymal stem cells","volume":"63","author":"Rong","year":"2020","journal-title":"SCIENCE CHINA Chem."},{"key":"10.1016\/j.jconrel.2025.113938_bb0355","doi-asserted-by":"crossref","first-page":"19551","DOI":"10.1021\/acsnano.2c10043","article-title":"Rescuing cardiac cells and improving cardiac function by targeted delivery of oxygen-releasing nanoparticles after or even before acute myocardial infarction","volume":"16","author":"Guan","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.113938_bb0360","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1161\/ATVBAHA.119.313800","article-title":"MicroRNA-126-3p inhibits angiogenic function of human lung microvascular endothelial cells via LAT1 (L-type amino acid transporter 1)-mediated mTOR (mammalian target of rapamycin) Signaling","volume":"40","author":"Cao","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jconrel.2025.113938_bb0365","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.2174\/1389201011208062435","article-title":"The role of an experimental model of atherosclerosis: apoE-knockout mice in developing new drugs against atherogenesis","volume":"13","author":"Jawien","year":"2012","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.jconrel.2025.113938_bb0370","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejphar.2017.05.010","article-title":"Animal models of atherosclerosis","volume":"816","author":"Emini Veseli","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jconrel.2025.113938_bb0375","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12944-016-0402-5","article-title":"Mouse models of atherosclerosis: a historical perspective and recent advances","volume":"16","author":"Lee","year":"2017","journal-title":"Lipids Health Dis."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925005589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925005589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T05:00:10Z","timestamp":1779512410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925005589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":75,"alternative-id":["S0168365925005589"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113938","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted delivery of engineered extracellular vesicles to simultaneously promote vascularization and muscle regeneration in ischemic limbs","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.113938","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113938"}}