{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:17:28Z","timestamp":1793229448791,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["MZGC20240069"],"award-info":[{"award-number":["MZGC20240069"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024NSFSC0623"],"award-info":[{"award-number":["2024NSFSC0623"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019014","name":"Chengdu Science and Technology Program","doi-asserted-by":"publisher","award":["2024-YF05-00244-SN"],"award-info":[{"award-number":["2024-YF05-00244-SN"]}],"id":[{"id":"10.13039\/501100019014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003784"],"award-info":[{"award-number":["82003784"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2682024ZTPY007"],"award-info":[{"award-number":["2682024ZTPY007"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jconrel.2025.114022","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T11:57:42Z","timestamp":1752580662000},"page":"114022","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Manganese oxide nanoparticle acts as a promising immune adjuvant via tuning ferroptosis signaling"],"prefix":"10.1016","volume":"385","author":[{"given":"Xiaoyu","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canquan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jconrel.2025.114022_bb0005","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMp2029466","article-title":"Vaccine innovations-past and future","volume":"384","author":"Gerberding","year":"2021","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.jconrel.2025.114022_bb0010","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/s41423-021-00669-w","article-title":"Manganese salts function as potent adjuvants","volume":"18","author":"Zhang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"6","key":"10.1016\/j.jconrel.2025.114022_bb0015","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41573-021-00163-y","article-title":"Emerging concepts in the science of vaccine adjuvants","volume":"20","author":"Pulendran","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114022_bb0020","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41392-023-01557-7","article-title":"Vaccine adjuvants: mechanisms and platforms","volume":"8","author":"Zhao","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"9","key":"10.1016\/j.jconrel.2025.114022_bb0025","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/s41551-024-01221-7","article-title":"Strategies for the development of metalloimmunotherapies","volume":"8","author":"Sun","year":"2024","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2025.114022_bb0030","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.jconrel.2022.07.032","article-title":"Smart combination of aluminum hydroxide and MF59 to induce strong cellular immune responses","volume":"349","author":"Chen","year":"2022","journal-title":"J. Control. Release"},{"issue":"11","key":"10.1016\/j.jconrel.2025.114022_bb0035","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S1474-4422(21)00238-6","article-title":"The role of manganese dysregulation in neurological disease: emerging evidence","volume":"20","author":"Budinger","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jconrel.2025.114022_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.anireprosci.2022.106924","article-title":"Functions of manganese in reproduction","volume":"238","author":"Studer","year":"2022","journal-title":"Anim. Reprod. Sci."},{"issue":"19","key":"10.1016\/j.jconrel.2025.114022_bb0045","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202205409","article-title":"Manganese-based tumor immunotherapy","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv. Mater."},{"issue":"11","key":"10.1016\/j.jconrel.2025.114022_bb0050","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/s41565-021-00962-9","article-title":"Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy","volume":"16","author":"Sun","year":"2021","journal-title":"Nat. Nanotechnol."},{"issue":"51","key":"10.1016\/j.jconrel.2025.114022_bb0055","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1126\/sciadv.abq3500","article-title":"Manganese-coordinated mRNA vaccines with enhanced mRNA expression and immunogenicity induce robust immune responses against SARS-CoV-2 variants","volume":"8","author":"Fan","year":"2022","journal-title":"Sci. Adv."},{"issue":"7","key":"10.1016\/j.jconrel.2025.114022_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108053","article-title":"Mn(2+) directly activates cGAS and structural analysis suggests Mn(2+) induces a noncanonical catalytic synthesis of 2\u20323\u2019-cGAMP","volume":"32","author":"Zhao","year":"2020","journal-title":"Cell Rep."},{"issue":"8","key":"10.1016\/j.jconrel.2025.114022_bb0065","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1093\/nar\/gkaa084","article-title":"Allosteric coupling between Mn2+ and dsDNA controls the catalytic efficiency and fidelity of cGAS","volume":"48","author":"Hooy","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.jconrel.2025.114022_bb0070","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41580-020-0270-8","article-title":"Emerging connectivity of programmed cell death pathways and its physiological implications","volume":"21","author":"Bedoui","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jconrel.2025.114022_bb0075","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jconrel.2024.04.039","article-title":"Emerging advances in delivery systems for mRNA cancer vaccines","volume":"370","author":"Jiang","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114022_bb0080","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jconrel.2023.04.036","article-title":"A MnAl double adjuvant nanovaccine to induce strong humoral and cellular immune responses","volume":"358","author":"Qiao","year":"2023","journal-title":"J. Control. Release"},{"issue":"8","key":"10.1016\/j.jconrel.2025.114022_bb0085","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1016\/j.apsb.2022.03.017","article-title":"An antigen self-assembled and dendritic cell-targeted nanovaccine for enhanced immunity against cancer","volume":"13","author":"Zhang","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2025.114022_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2021.101139","article-title":"Engineering a self-navigated MnARK nanovaccine for inducing potent protective immunity against novel coronavirus","volume":"38","author":"Wang","year":"2021","journal-title":"Nano Today"},{"issue":"1","key":"10.1016\/j.jconrel.2025.114022_bb0095","doi-asserted-by":"crossref","first-page":"5685","DOI":"10.1038\/s41467-022-33301-0","article-title":"A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.114022_bb0100","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jconrel.2025.01.009","article-title":"Antigens and adjuvants co-stabilized Pickering emulsions amplify immune responses of subunit vaccines","volume":"379","author":"Guo","year":"2025","journal-title":"J. Control. Release"},{"issue":"21","key":"10.1016\/j.jconrel.2025.114022_bb0105","doi-asserted-by":"crossref","first-page":"21782","DOI":"10.1021\/acsnano.3c07632","article-title":"The distinct properties of polysaccharide nanoparticles tune immune responses against mRNA antigen via stimulator of interferon genes-mediated autophagy and inflammasome","volume":"17","author":"Wu","year":"2023","journal-title":"ACS Nano"},{"issue":"16","key":"10.1016\/j.jconrel.2025.114022_bb0110","doi-asserted-by":"crossref","first-page":"1900037","DOI":"10.1002\/advs.201900037","article-title":"Multifunctional nanoregulator reshapes immune microenvironment and enhances immune memory for tumor immunotherapy","volume":"6","author":"Yu","year":"2019","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2025.114022_bb0115","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-immunol-030409-101256","article-title":"The role of antibodies in HIV vaccines","volume":"28","author":"Mascola","year":"2010","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114022_bb0120","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12989-024-00571-z","article-title":"Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury","volume":"21","author":"Wang","year":"2024","journal-title":"Part. Fibre Toxicol."},{"issue":"Pt 7","key":"10.1016\/j.jconrel.2025.114022_bb0125","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1099\/jmm.0.038943-0","article-title":"Alum adjuvant: some of the tricks of the oldest adjuvant","volume":"61","author":"Kool","year":"2012","journal-title":"J. Med. Microbiol."},{"issue":"7","key":"10.1016\/j.jconrel.2025.114022_bb0130","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.4049\/jimmunol.0900164","article-title":"Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity","volume":"183","author":"McKee","year":"2009","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.jconrel.2025.114022_bb0135","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1021\/acsnano.0c00962","article-title":"Cell-penetrating nanoparticles activate the inflammasome to enhance antibody production by targeting microtubule-associated protein 1-light chain 3 for degradation","volume":"14","author":"Zhu","year":"2020","journal-title":"ACS Nano"},{"issue":"7","key":"10.1016\/j.jconrel.2025.114022_bb0140","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.cell.2014.11.036","article-title":"Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production","volume":"159","author":"White","year":"2014","journal-title":"Cell"},{"issue":"7747","key":"10.1016\/j.jconrel.2025.114022_bb0145","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41586-019-1006-9","article-title":"Autophagy induction via STING trafficking is a primordial function of the cGAS pathway","volume":"567","author":"Gui","year":"2019","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jconrel.2025.114022_bb0150","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.immuni.2021.01.018","article-title":"Autophagy in inflammation, infection, and immunometabolism","volume":"54","author":"Deretic","year":"2021","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.jconrel.2025.114022_bb0155","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/s41590-021-00996-0","article-title":"Selenium-GPX4 axis protects follicular helper T cells from ferroptosis","volume":"22","author":"Yao","year":"2021","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.jconrel.2025.114022_bb0160","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41556-020-0461-8","article-title":"Energy-stress-mediated AMPK activation inhibits ferroptosis","volume":"22","author":"Lee","year":"2020","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.jconrel.2025.114022_bb0165","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.jconrel.2025.114022_bb0170","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/j.apsb.2025.03.006","article-title":"Polysaccharide nanoparticles as potential immune adjuvants: mechanism and function","volume":"15","author":"Jiang","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"issue":"3","key":"10.1016\/j.jconrel.2025.114022_bb0175","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.celrep.2017.12.077","article-title":"p53 suppresses metabolic stress-induced ferroptosis in cancer cells","volume":"22","author":"Tarangelo","year":"2018","journal-title":"Cell Rep."},{"issue":"33","key":"10.1016\/j.jconrel.2025.114022_bb0180","doi-asserted-by":"crossref","first-page":"9906","DOI":"10.1021\/bi027434m","article-title":"Sulfenic acid formation in human serum albumin by hydrogen peroxide and peroxynitrite","volume":"42","author":"Carballal","year":"2003","journal-title":"Biochemistry"},{"issue":"11","key":"10.1016\/j.jconrel.2025.114022_bb0185","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.chembiol.2022.10.006","article-title":"Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein","volume":"29","author":"Armenta","year":"2022","journal-title":"Cell Chem. Biol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114022_bb0190","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1142\/S0192415X23500064","article-title":"Ginsenoside Rd inhibited ferroptosis to alleviate CCl(4)-induced acute liver injury in mice via cGAS\/STING pathway","volume":"51","author":"Li","year":"2023","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jconrel.2025.114022_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116102","article-title":"STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease","volume":"222","author":"Zhao","year":"2024","journal-title":"Biochem. Pharmacol."},{"issue":"4","key":"10.1016\/j.jconrel.2025.114022_bb0200","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41422-023-00788-1","article-title":"Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression","volume":"33","author":"Qiu","year":"2023","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114022_bb0205","doi-asserted-by":"crossref","first-page":"6339","DOI":"10.1038\/s41467-020-20154-8","article-title":"Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173\/STING-dependent DNA sensor pathway","volume":"11","author":"Dai","year":"2020","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.jconrel.2025.114022_bb0210","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41590-020-0699-0","article-title":"Redox homeostasis maintained by GPX4 facilitates STING activation","volume":"21","author":"Jia","year":"2020","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.jconrel.2025.114022_bb0215","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41419-023-05716-0","article-title":"The interaction between ferroptosis and inflammatory signaling pathways","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.jconrel.2025.114022_bb0220","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1126\/sciadv.adk2444","article-title":"Lymph-targeted high-density lipoprotein-mimetic nanovaccine for multi-antigenic personalized cancer immunotherapy","volume":"10","author":"Liu","year":"2024","journal-title":"Sci. Adv."},{"issue":"11","key":"10.1016\/j.jconrel.2025.114022_bb0225","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nrd4608","article-title":"From sewer to saviour-targeting the lymphatic system to promote drug exposure and activity","volume":"14","author":"Trevaskis","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"issue":"35","key":"10.1016\/j.jconrel.2025.114022_bb0230","doi-asserted-by":"crossref","first-page":"7117","DOI":"10.1039\/D1TB01001H","article-title":"Manganese oxide nanomaterials boost cancer immunotherapy","volume":"9","author":"Ding","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jconrel.2025.114022_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101583","article-title":"Advances in the biological mechanism and application of manganese-based nanoformulations for enhanced immunotherapy","volume":"46","author":"Chen","year":"2022","journal-title":"Nano Today"},{"issue":"11","key":"10.1016\/j.jconrel.2025.114022_bb0240","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/s41422-020-00395-4","article-title":"Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy","volume":"30","author":"Lv","year":"2020","journal-title":"Cell Res."},{"issue":"9","key":"10.1016\/j.jconrel.2025.114022_bb0245","doi-asserted-by":"crossref","first-page":"15471","DOI":"10.1021\/acsnano.2c08013","article-title":"Immunogenic cell death augmented by manganese zinc sulfide nanoparticles for metastatic melanoma immunotherapy","volume":"16","author":"Li","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.114022_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122745","article-title":"Manganese-coordinated nanoparticle with high drug-loading capacity and synergistic photo\u2212\/immuno-therapy for cancer treatments","volume":"312","author":"Chen","year":"2025","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.jconrel.2025.114022_bb0255","doi-asserted-by":"crossref","first-page":"27009","DOI":"10.1002\/EXP.70009","article-title":"Cancer immunotherapy based on the bidirectional reprogramming of the tumor microenvironment by a \u201cbrakes off\/step on the accelerator\u201d core-shell manganese phosphate\/siPD-L1 modulator","volume":"5","author":"Xia","year":"2025","journal-title":"Exploration"},{"issue":"38","key":"10.1016\/j.jconrel.2025.114022_bb0260","doi-asserted-by":"crossref","first-page":"16381","DOI":"10.1002\/anie.202005111","article-title":"MnO(x) nanospikes as nanoadjuvants and immunogenic cell death drugs with enhanced antitumor immunity and antimetastatic effect","volume":"59","author":"Ding","year":"2020","journal-title":"Angew. Chem. Int. Ed. Eng."},{"issue":"3","key":"10.1016\/j.jconrel.2025.114022_bb0265","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.apsb.2023.12.003","article-title":"Targeting the Warburg effect: a revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer","volume":"14","author":"Liao","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2025.114022_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216837","article-title":"The emerging role of lactate in tumor microenvironment and its clinical relevance","volume":"590","author":"Chen","year":"2024","journal-title":"Cancer Lett."},{"issue":"10","key":"10.1016\/j.jconrel.2025.114022_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108487","article-title":"HCAR1\/MCT1 regulates tumor ferroptosis through the lactate-mediated AMPK-SCD1 activity and its therapeutic implications","volume":"33","author":"Zhao","year":"2020","journal-title":"Cell Rep."},{"issue":"21","key":"10.1016\/j.jconrel.2025.114022_bb0280","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.3390\/ijms21218363","article-title":"Lactic acid and an acidic tumor microenvironment suppress anticancer immunity","volume":"21","author":"Wang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114022_bb0285","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41392-024-02082-x","article-title":"Lactate and lactylation in cancer","volume":"10","author":"Chen","year":"2025","journal-title":"Signal Transduct. Target. Ther."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925006431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925006431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:26:08Z","timestamp":1778945168000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925006431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":57,"alternative-id":["S0168365925006431"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114022","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Manganese oxide nanoparticle acts as a promising immune adjuvant via tuning ferroptosis signaling","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114022"}}