{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:23:15Z","timestamp":1793276595915,"version":"4.5.0"},"reference-count":103,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30EY003790"],"award-info":[{"award-number":["P30EY003790"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-21-1-0869"],"award-info":[{"award-number":["W81XWH-21-1-0869"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jconrel.2025.114046","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T15:24:15Z","timestamp":1752679455000},"page":"114046","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Naturally derived mucoadhesive nanosuspension for treatment of multiple staged ocular infections"],"prefix":"10.1016","volume":"386","author":[{"given":"Yuting","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangju","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Vo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitomo","family":"Narimatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghong","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Dana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Annabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.114046_bb0005","first-page":"1","article-title":"Common bacterial causes of external ocular infections, associated risk factors and antibiotic resistance among patients at ophthalmology unit of Felege Hiwot Referral Hospital, Northwest Ethiopia: a cross-sectional study","volume":"11","author":"Ayehubizu","year":"2021","journal-title":"J. Ophthalmic Inflam. Infect."},{"key":"10.1016\/j.jconrel.2025.114046_bb0010","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/s41433-020-01339-3","article-title":"Infectious keratitis: an update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance","volume":"35","author":"Ting","year":"2021","journal-title":"Eye (Lond.)"},{"key":"10.1016\/j.jconrel.2025.114046_bb0015","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1001\/jama.290.15.2057","article-title":"Important causes of visual impairment in the world today","volume":"290","author":"Congdon","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jconrel.2025.114046_bb0020","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12886-017-0612-2","article-title":"Bacterial profile of ocular infections: a systematic review","volume":"17","author":"Teweldemedhin","year":"2017","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.114046_bb0025","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1097\/OPX.0000000000001937","article-title":"Topical review: contact lens eye health and safety considerations in government policy development","volume":"99","author":"Lakkis","year":"2022","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.114046_bb0030","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1097\/OPX.0b013e3181f6fbb3","article-title":"Limitations of current antibiotics for the treatment of bacterial conjunctivitis","volume":"87","author":"Karpecki","year":"2010","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.114046_bb0035","article-title":"Efficiency of nanoparticles for treatment of ocular infections: systematic literature review","volume":"57","author":"Ghafoorianfar","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jconrel.2025.114046_bb0040","doi-asserted-by":"crossref","first-page":"47","DOI":"10.5497\/wjp.v2.i2.47","article-title":"Ocular drug delivery systems: an overview","volume":"2","author":"Patel","year":"2013","journal-title":"World J. Pharmacol."},{"key":"10.1016\/j.jconrel.2025.114046_bb0045","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1136\/bjo.2008.156828","article-title":"Turnover rate of tear-film lipid layer determined by fluorophotometry","volume":"93","author":"Mochizuki","year":"2009","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.114046_bb0050","article-title":"Formulation and optimization of microemulsion based sparfloxacin in-situ gel for ocular delivery: in vitro and ex vivo characterization","volume":"55","author":"Dhaval","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jconrel.2025.114046_bb0055","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0939-6411(01)00246-6","article-title":"Ocular tolerance of preservatives and alternatives","volume":"53","author":"Furrer","year":"2002","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2025.114046_bb0060","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.actbio.2018.11.020","article-title":"Bioinspired hydrogels for drug-eluting contact lenses","volume":"84","author":"Alvarez-Lorenzo","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2025.114046_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.132409","article-title":"Therapeutic hydrogel sheets programmed with multistage drug delivery for effective treatment of corneal abrasion","volume":"429","author":"Luo","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jconrel.2025.114046_bb0070","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.biomaterials.2019.04.013","article-title":"A self-healing hydrogel eye drop for the sustained delivery of decorin to prevent corneal scarring","volume":"210","author":"Chouhan","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.114046_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.126190","article-title":"Multifunctional glutathione-dependent hydrogel eye drops with enhanced drug bioavailability for glaucoma therapy","volume":"402","author":"Lai","year":"2020","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jconrel.2025.114046_bb0080","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10238","article-title":"An ion-paired moxifloxacin nanosuspension eye drop provides improved prevention and treatment of ocular infection","volume":"6","author":"Josyula","year":"2021","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.114046_bb0085","article-title":"Poly(l-histidine)-mediated on-demand therapeutic delivery of roughened ceria nanocages for treatment of chemical eye injury","volume":"10","author":"Yang","year":"2023","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.jconrel.2025.114046_bb0090","doi-asserted-by":"crossref","first-page":"2400484","DOI":"10.1002\/sstr.202400484","article-title":"Design of highly adhesive urchin-like gold nanostructures for effective topical drug administration and symptomatic relief of corneal dryness (vol 6, e240048, 2025)","volume":"6","author":"Ghosh","year":"2025","journal-title":"Small Struct."},{"key":"10.1016\/j.jconrel.2025.114046_bb0095","doi-asserted-by":"crossref","first-page":"6988","DOI":"10.1039\/D0PY00919A","article-title":"Advancing the stimuli response of polymer-based drug delivery systems for ocular disease treatment","volume":"11","author":"Nguyen","year":"2020","journal-title":"Polym. Chem."},{"key":"10.1016\/j.jconrel.2025.114046_bb0100","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2147\/OPTH.S157853","article-title":"Combination of hyaluronic acid, carmellose, and osmoprotectants for the treatment of dry eye disease","author":"Mateo Orobia","year":"2018","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.114046_bb0105","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3389\/fbioe.2020.00228","article-title":"Hydrogel biomaterials for application in ocular drug delivery","volume":"8","author":"Lynch","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jconrel.2025.114046_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2022.111241","article-title":"Advances in adhesive hydrogels for tissue engineering","volume":"172","author":"Yang","year":"2022","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.jconrel.2025.114046_bb0115","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1039\/D0BM00935K","article-title":"Ciprofloxacin-loaded bioadhesive hydrogels for ocular applications","volume":"8","author":"Khalil","year":"2020","journal-title":"Biomater Sci-Uk"},{"key":"10.1016\/j.jconrel.2025.114046_bb0120","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.exer.2018.01.010","article-title":"Topical drug delivery devices: a review","volume":"168","author":"Bertens","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.jconrel.2025.114046_bb0125","doi-asserted-by":"crossref","first-page":"25118","DOI":"10.1021\/acsnano.3c07817","article-title":"Unveiling the power of gabapentin-loaded nanoceria with multiple therapeutic capabilities for the treatment of dry eye disease","volume":"17","author":"Yang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.114046_bb0130","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.3390\/molecules27072326","article-title":"Development and evaluation of chitosan nanoparticles for ocular delivery of Tedizolid phosphate","volume":"27","author":"Kalam","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jconrel.2025.114046_bb0135","doi-asserted-by":"crossref","first-page":"885","DOI":"10.3109\/10717544.2013.858195","article-title":"Chitosan nanoparticles for daptomycin delivery in ocular treatment of bacterial endophthalmitis","volume":"22","author":"Silva","year":"2015","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jconrel.2025.114046_bb0140","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.ijbiomac.2017.11.170","article-title":"Formulation and optimization of levofloxacin loaded chitosan nanoparticle for ocular delivery: in-vitro characterization, ocular tolerance and antibacterial activity","volume":"108","author":"Ameeduzzafar","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jconrel.2025.114046_bb0145","doi-asserted-by":"crossref","DOI":"10.1590\/s2175-97902019000117105","article-title":"Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery","volume":"55","author":"Taghe","year":"2019","journal-title":"Braz. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2025.114046_bb0150","series-title":"AIP Conference Proceedings","doi-asserted-by":"crossref","DOI":"10.1063\/1.4976766","article-title":"Effect of chitosan molecular weight and composition on mucoadhesive properties of mangostin-loaded chitosan-alginate microparticles","author":"Krisanti","year":"2017"},{"key":"10.1016\/j.jconrel.2025.114046_bb0155","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.actbio.2021.10.047","article-title":"Mucoadhesive phenylboronic acid conjugated chitosan oligosaccharide-vitamin E copolymer for topical ocular delivery of voriconazole: synthesis, in vitro\/vivo evaluation, and mechanism","volume":"138","author":"Sun","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2025.114046_bb0160","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.3390\/polym12071519","article-title":"Chitosan and its derivatives for ocular delivery formulations: recent advances and developments","volume":"12","author":"Zamboulis","year":"2020","journal-title":"Polymers"},{"key":"10.1016\/j.jconrel.2025.114046_bb0165","article-title":"An overview on nanoparticles used in biomedicine and their cytotoxicity","volume":"61","author":"Nikzamir","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jconrel.2025.114046_bb0170","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.3390\/vaccines10111906","article-title":"Chitosan-based nanomaterial as immune adjuvant and delivery carrier for vaccines","volume":"10","author":"Gong","year":"2022","journal-title":"Vaccines"},{"key":"10.1016\/j.jconrel.2025.114046_bb0175","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1021\/nn3059295","article-title":"Polymer-coated nanoparticles interacting with proteins and cells: focusing on the sign of the net charge","volume":"7","author":"H\u00fchn","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.114046_bb0180","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s12274-014-0547-3","article-title":"Phenylboronic acid modified mucoadhesive nanoparticle drug carriers facilitate weekly treatment of experimentally induced dry eye syndrome","volume":"8","author":"Liu","year":"2015","journal-title":"Nano Res"},{"key":"10.1016\/j.jconrel.2025.114046_bb0185","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1021\/acs.biomac.6b00054","article-title":"Phenylboronic-acid-based polymeric micelles for mucoadhesive anterior segment ocular drug delivery","volume":"17","author":"Prosperi-Porta","year":"2016","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2025.114046_bb0190","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.actbio.2019.08.035","article-title":"Phenylboronic acid-tethered chondroitin sulfate-based mucoadhesive nanostructured lipid carriers for the treatment of dry eye syndrome","volume":"99","author":"Tan","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2025.114046_bb0195","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1039\/D2TB00856D","article-title":"Recent advances in functionally modified polymers for mucoadhesive drug delivery","volume":"10","author":"Surendranath","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jconrel.2025.114046_bb0200","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1002\/mabi.201200216","article-title":"Development of mucoadhesive drug delivery system using phenylboronic acid functionalized poly (D, L-lactide)-b-dextran nanoparticles","volume":"12","author":"Liu","year":"2012","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.jconrel.2025.114046_bb0205","first-page":"214","article-title":"Molecular design of an ultra-strong tissue adhesive hydrogel with tunable multifunctionality","volume":"29","author":"Zheng","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2025.114046_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.colcom.2022.100654","article-title":"Dynamically crosslinked protien hydrogel composite as multifunctional wound dressing for cutaneous infection","volume":"50","author":"Xie","year":"2022","journal-title":"Colloid Interface Sci Commun"},{"key":"10.1016\/j.jconrel.2025.114046_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043583","article-title":"Gelatin as it is: history and modernity","volume":"24","author":"Mikhailov","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.114046_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.123402","article-title":"Stimuli-responsive hydrogels composed of modified cellulose nanocrystal and gelatin with oriented channels for guiding axonal myelination","volume":"356","author":"Xu","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2025.114046_bb0225","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1002\/mabi.201200216","article-title":"Development of mucoadhesive drug delivery system using phenylboronic acid functionalized poly(D,L-lactide)-b-dextran nanoparticles","volume":"12","author":"Liu","year":"2012","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.jconrel.2025.114046_bb0230","doi-asserted-by":"crossref","first-page":"5354","DOI":"10.1039\/D3MH00717K","article-title":"Dynamic light scattering and transmission electron microscopy in drug delivery: a roadmap for correct characterization of nanoparticles and interpretation of results","volume":"10","author":"Filippov","year":"2023","journal-title":"Mater. Horiz."},{"key":"10.1016\/j.jconrel.2025.114046_bb0235","article-title":"Smart glucose-responsive hydrogel with ROS scavenging and homeostasis regulating properties for diabetic bone regeneration","volume":"497","author":"Liu","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jconrel.2025.114046_bb0240","doi-asserted-by":"crossref","first-page":"42147","DOI":"10.1021\/acsomega.4c02842","article-title":"Synthesis, properties, and biocompatibility of 4-carboxyphenyboronic acid-modified gelatin-methacryloyl: a hydrogel for retinal surgeries","volume":"9","author":"Chou","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.jconrel.2025.114046_bb0245","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/2231-4040.82950","article-title":"Nanosuspension: an approach to enhance solubility of drugs","volume":"2","author":"Patel","year":"2011","journal-title":"J. Adv. Pharm. Technol. Res."},{"key":"10.1016\/j.jconrel.2025.114046_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-bioeng-071811-150124","article-title":"The effect of nanoparticle size, shape, and surface chemistry on biological systems","volume":"14","author":"Albanese","year":"2012","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2025.114046_bb0255","doi-asserted-by":"crossref","first-page":"22544","DOI":"10.1039\/D1RA03333F","article-title":"Porous scaffolds with the structure of an interpenetrating polymer network made by gelatin methacrylated nanoparticle-stabilized high internal phase emulsion polymerization targeted for tissue engineering","volume":"11","author":"Safaei-Yaraziz","year":"2021","journal-title":"RSC Adv."},{"key":"10.1016\/j.jconrel.2025.114046_bb0260","doi-asserted-by":"crossref","first-page":"77","DOI":"10.15171\/apb.2018.010","article-title":"Investigation of effective parameters on size of paclitaxel loaded PLGA nanoparticles","volume":"8","author":"Madani","year":"2018","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.jconrel.2025.114046_bb0265","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.2147\/OPTH.S135550","article-title":"Investigating the potential benefits of a new artificial tear formulation combining two polymers","author":"Simmons","year":"2017","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.114046_bb0270","first-page":"4641","article-title":"Effect of viscosity, surface tension and mucoadhesion on ocular residence time of lubricant eye drops","volume":"50","author":"Doshi","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.114046_bb0275","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/OPX.0b013e3181824de3","article-title":"Precorneal residence time of artificial tears measured in dry eye subjects","volume":"85","author":"Paugh","year":"2008","journal-title":"Optom. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.114046_bb0280","first-page":"3152","article-title":"Clinical performance of a new mid-viscosity artificial tear for dry eye treatment","volume":"43","author":"Prather","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.114046_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/tvst.11.3.1","article-title":"Shear-thinning and temperature-dependent viscosity relationships of contemporary ocular lubricants","volume":"11","author":"Kapadia","year":"2022","journal-title":"Transl. Vision Sci. Technol."},{"key":"10.1016\/j.jconrel.2025.114046_bb0290","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00289-007-0760-2","article-title":"Anomalous viscosity behavior in aqueous solutions of hyaluronic acid","volume":"59","author":"Maleki","year":"2007","journal-title":"Polym. Bull."},{"key":"10.1016\/j.jconrel.2025.114046_bb0295","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.jconrel.2020.05.045","article-title":"Hypromellose\u2013a traditional pharmaceutical excipient with modern applications in oral and oromucosal drug delivery","volume":"324","author":"Ma\u0161kov\u00e1","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114046_bb0300","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/eye.2017.73","article-title":"Osmoprotectants, carboxymethylcellulose and hyaluronic acid multi-ingredient eye drop: a randomised controlled trial in moderate to severe dry eye","volume":"31","author":"Labetoulle","year":"2017","journal-title":"Eye (Lond.)"},{"key":"10.1016\/j.jconrel.2025.114046_bb0305","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1185\/030079907X233197","article-title":"Efficacy, tolerability and comfort of a 0.3% hypromellose gel ophthalmic lubricant in the treatment of patients with moderate to severe dry eye syndrome","volume":"23","author":"Tauber","year":"2007","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.jconrel.2025.114046_bb0310","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/aos.16753","article-title":"Review of hydroxypropyl methylcellulose in artificial tears for the treatment of dry eye disease","volume":"102","author":"Mysen","year":"2024","journal-title":"Acta Opthalmol."},{"key":"10.1016\/j.jconrel.2025.114046_bb0315","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/tvst.8.6.2","article-title":"Physicochemical properties of hyaluronic acid\u2013based lubricant eye drops","volume":"8","author":"Aragona","year":"2019","journal-title":"Transl. Vision Sci. Technol."},{"key":"10.1016\/j.jconrel.2025.114046_bb0320","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1089\/jop.2011.0053","article-title":"Novel formulation of glycerin 1% artificial tears extends tear film break-up time compared with Systane lubricant eye drops","volume":"28","author":"Gensheimer","year":"2012","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2025.114046_bb0325","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.3390\/pharmaceutics14061246","article-title":"Design of topical moxifloxacin mucoadhesive nanoemulsion for the management of ocular bacterial infections","volume":"14","author":"Youssef","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.114046_bb0330","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.fbp.2010.05.003","article-title":"Pre-treatment optimization and properties of gelatin from freshwater fish scales","volume":"89","author":"Zhang","year":"2011","journal-title":"Food Bioprod. Process."},{"key":"10.1016\/j.jconrel.2025.114046_bb0335","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1002\/smll.201600892","article-title":"Redox-triggered release of moxifloxacin from mesoporous silica nanoparticles functionalized with disulfide snap-tops enhances efficacy against pneumonic tularemia in mice","volume":"12","author":"Lee","year":"2016","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2025.114046_bb0340","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1110\/ps.2980102","article-title":"Salt-induced stabilization of apoflavodoxin at neutral pH is mediated through cation-specific effects","volume":"11","author":"Maldonado","year":"2002","journal-title":"Protein Sci."},{"key":"10.1016\/j.jconrel.2025.114046_bb0345","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1021\/acs.jctc.1c01187","article-title":"Approach to study pH-dependent protein association using constant-pH molecular dynamics: application to the dimerization of \u03b2-lactoglobulin","volume":"18","author":"da Rocha","year":"2022","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.jconrel.2025.114046_bb0350","doi-asserted-by":"crossref","DOI":"10.1002\/aic.18067","article-title":"Engineering a drug eluting ocular patch for delivery and sustained release of anti-inflammatory therapeutics","volume":"69","author":"Chen","year":"2023","journal-title":"AICHE J."},{"key":"10.1016\/j.jconrel.2025.114046_bb0355","doi-asserted-by":"crossref","first-page":"6464","DOI":"10.1021\/acsnano.6b00601","article-title":"A hydrogel-based hybrid theranostic contact lens for fungal keratitis","volume":"10","author":"Huang","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.114046_bb0360","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/136590","article-title":"In vitro release kinetics of antituberculosis drugs from nanoparticles assessed using a modified dissolution apparatus","volume":"2013","author":"Gao","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jconrel.2025.114046_bb0365","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12951-024-02448-x","article-title":"Mucoadhesive, antioxidant, and lubricant catechol-functionalized poly(phosphobetaine) as biomaterial nanotherapeutics for treating ocular dryness","volume":"22","author":"Bui","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2025.114046_bb0370","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.actbio.2022.01.044","article-title":"Alleviation of dry eye syndrome with one dose of antioxidant, anti-inflammatory, and mucoadhesive lysine-carbonized nanogels","volume":"141","author":"Lin","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2025.114046_bb0375","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.addr.2005.07.005","article-title":"The use of mucoadhesive polymers in ocular drug delivery","volume":"57","author":"Ludwig","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.114046_bb0380","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jconrel.2021.06.011","article-title":"Ocular drug delivery to the anterior segment using nanocarriers: a mucoadhesive\/mucopenetrative perspective","volume":"336","author":"Dave","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114046_bb0385","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.3390\/nano10071400","article-title":"Mucoadhesive nanoparticles for drug delivery to the anterior eye","volume":"10","author":"Mangiacotte","year":"2020","journal-title":"Nanomaterials"},{"key":"10.1016\/j.jconrel.2025.114046_bb0390","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1021\/acsbiomaterials.6b00051","article-title":"Tannic acid as a degradable mucoadhesive compound","volume":"2","author":"Shin","year":"2016","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.jconrel.2025.114046_bb0395","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1167\/iovs.08-2515","article-title":"Mucoadhesive microdiscs engineered for ophthalmic drug delivery: effect of particle geometry and formulation on preocular residence time","volume":"49","author":"Choy","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.114046_bb0400","doi-asserted-by":"crossref","first-page":"2200211","DOI":"10.1002\/admi.202200211","article-title":"Recent advances in mucoadhesive Interface materials, mucoadhesion characterization, and technologies","volume":"9","author":"Bayer","year":"2022","journal-title":"Adv. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2025.114046_bb0405","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0378-5173(00)00396-3","article-title":"An atomic force microscopy investigation of bioadhesive polymer adsorption onto human buccal cells","volume":"200","author":"Patel","year":"2000","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.114046_bb0410","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1021\/acsbiomaterials.6b00051","article-title":"Tannic acid as a degradable mucoadhesive compound","volume":"2","author":"Shin","year":"2016","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.jconrel.2025.114046_bb0415","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bpj.2011.08.058","article-title":"Distribution of sialic acids on mucins and gels: a defense mechanism","volume":"102","author":"Baos","year":"2012","journal-title":"Biophys. J."},{"key":"10.1016\/j.jconrel.2025.114046_bb0420","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0021-5155(01)00338-0","article-title":"Sialic acid in normal human tear fluid","volume":"45","author":"Nakamura","year":"2001","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.114046_bb0425","doi-asserted-by":"crossref","first-page":"1700261","DOI":"10.1002\/mabi.201700261","article-title":"Hyaluronic acid-based micelles as ocular platform to modulate the loading, release, and corneal permeation of corticosteroids","volume":"17","author":"Bongiov\u00ec","year":"2017","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.jconrel.2025.114046_bb0430","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1039\/D0BM00935K","article-title":"Ciprofloxacin-loaded bioadhesive hydrogels for ocular applications","volume":"8","author":"Khalil","year":"2020","journal-title":"Biomater Sci-Uk"},{"key":"10.1016\/j.jconrel.2025.114046_bb0435","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a025320","article-title":"Topoisomerase inhibitors: fluoroquinolone mechanisms of action and resistance","volume":"6","author":"Hooper","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.jconrel.2025.114046_bb0440","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/420601","article-title":"Viability reagent, prestoblue, in comparison with other available reagents, utilized in cytotoxicity and antimicrobial assays","volume":"2013","author":"Lall","year":"2013","journal-title":"Int. J. Microbiol."},{"issue":"Suppl. 2","key":"10.1016\/j.jconrel.2025.114046_bb0445","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.1086\/428053","article-title":"Clinical implications of pharmacokinetics and pharmacodynamics of fluoroquinolones","volume":"41","author":"Wispelwey","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jconrel.2025.114046_bb0450","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1167\/iovs.04-0041","article-title":"Caspase-1 inhibitor reduces severity of Pseudomonas aeruginosa keratitis in mice","volume":"45","author":"Thakur","year":"2004","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.114046_bb0455","first-page":"2325","article-title":"Human tear fluid protects against Pseudomonas aeruginosa keratitis in a murine experimental model","volume":"75","author":"Kwong","year":"2007","journal-title":"ASM J."},{"key":"10.1016\/j.jconrel.2025.114046_bb0460","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1007\/s13346-020-00856-8","article-title":"Promising bioadhesive ofloxacin-loaded polymeric nanoparticles for the treatment of ocular inflammation: formulation and in vivo evaluation","volume":"11","author":"Salama","year":"2021","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.jconrel.2025.114046_bb0465","doi-asserted-by":"crossref","first-page":"18360","DOI":"10.1021\/acsami.3c18061","article-title":"Glycol chitosan-poly(lactic acid) conjugate nanoparticles encapsulating ciprofloxacin: a mucoadhesive, antiquorum-sensing, and biofilm-disrupting treatment modality for bacterial keratitis","volume":"16","author":"Padaga","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2025.114046_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121558","article-title":"Carboxylated nanofibrillated cellulose empowers moxifloxacin to overcome Staphylococcus aureus biofilm in bacterial keratitis","volume":"324","author":"Malani","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2025.114046_bb0475","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.xphs.2021.12.016","article-title":"Pharmacokinetic and pharmacodynamic evaluation of gemifloxacin chitosan nanoparticles as an antibacterial ocular dosage form","volume":"111","author":"Hassan","year":"2022","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2025.114046_bb0480","doi-asserted-by":"crossref","first-page":"22892","DOI":"10.1021\/acsami.3c01308","article-title":"Effective treatment of Haemophilus influenzae-induced bacterial conjunctivitis by a bioadhesive nanoparticle reticulate structure","volume":"15","author":"Kong","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2025.114046_bb0485","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1021\/acs.biomac.3c00754","article-title":"Multifunctional polymer vesicles for synergistic antibiotic\u2013antioxidant treatment of bacterial keratitis","volume":"24","author":"Chen","year":"2023","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2025.114046_bb0490","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.biomaterials.2015.08.045","article-title":"Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels","volume":"73","author":"Yue","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.114046_bb0495","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1248\/cpb.c17-00838","article-title":"Preparation and in vitro analysis of human serum albumin nanoparticles loaded with anthracycline derivatives","volume":"66","author":"Kimura","year":"2018","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.jconrel.2025.114046_bb0500","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0168-3659(01)00279-6","article-title":"Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system","volume":"73","author":"Srividya","year":"2001","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114046_bb0505","series-title":"Pharmacology","first-page":"201","article-title":"Chapter 10 - pharmacokinetic modeling","author":"Byers","year":"2009"},{"key":"10.1016\/j.jconrel.2025.114046_bb0510","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1167\/iovs.04-0041","article-title":"Caspase-1 inhibitor reduces severity of pseudomonas aeruginosa keratitis in mice","volume":"45","author":"Thakur","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.114046_bb0515","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/ICO.0000000000002186","article-title":"Topical vancomycin 5% is more efficacious than 2.5% and 1.25% for reducing viable methicillin-resistant Staphylococcus aureus in infectious keratitis","volume":"39","author":"Romanowski","year":"2020","journal-title":"Cornea"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925006674?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925006674?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T08:48:26Z","timestamp":1777193306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925006674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":103,"alternative-id":["S0168365925006674"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114046","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Naturally derived mucoadhesive nanosuspension for treatment of multiple staged ocular infections","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114046"}}