{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T03:10:24Z","timestamp":1793934624235,"version":"4.8.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003769","name":"Eisai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jconrel.2025.114055","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T16:45:46Z","timestamp":1753116346000},"page":"114055","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Ionizable lipid chemistry in lipid nanoparticles determines delivery efficiency to hepatic stellate cells"],"prefix":"10.1016","volume":"385","author":[{"given":"Hiroki","family":"Muto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kubara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Hitaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihide","family":"Osada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.114055_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.dmpk.2021.100424","article-title":"Difference in the lipid nanoparticle technology employed in three approved siRNA (Patisiran) and mRNA (COVID-19 vaccine) drugs","volume":"41","author":"Suzuki","year":"2021","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.jconrel.2025.114055_bb0010","doi-asserted-by":"crossref","first-page":"7233","DOI":"10.1038\/s41467-021-27493-0","article-title":"An ionizable lipid toolbox for RNA delivery","volume":"12","author":"Han","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.114055_bb0015","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/s41565-019-0591-y","article-title":"The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs","volume":"14","author":"Akinc","year":"2019","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2025.114055_bb0020","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1056\/NEJMoa2107454","article-title":"CRISPR-Cas9 in vivo gene editing for transthyretin amyloidosis","volume":"385","author":"Gillmore","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2025.114055_bb0025","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1056\/NEJMoa2309149","article-title":"CRISPR-Cas9 in vivo gene editing of KLKB1 for hereditary angioedema","volume":"390","author":"Longhurst","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2025.114055_bb0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.abm0594","article-title":"CAR T cells produced in vivo to treat cardiac injury","volume":"375","author":"Rurik","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2025.114055_bb0035","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1021\/acsnano.3c10109","article-title":"mRNA-laden lipid-nanoparticle-enabled in situ CAR-macrophage engineering for the eradication of multidrug-resistant Bacteria in a Sepsis mouse model","volume":"18","author":"Tang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.114055_bb0040","first-page":"3106","article-title":"Critical considerations of mRNA\u2013LNP technology for CAR-T therapy: components, payloads and emerging horizons, materials chemistry","volume":"8","author":"Qu","year":"2024","journal-title":"Frontiers"},{"key":"10.1016\/j.jconrel.2025.114055_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114708","article-title":"Nanoparticle biodistribution coefficients: a quantitative approach for understanding the tissue distribution of nanoparticles","volume":"194","author":"Kumar","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.114055_bb0050","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1053\/j.gastro.2008.03.003","article-title":"Mechanisms of hepatic fibrogenesis","volume":"134","author":"Friedman","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jconrel.2025.114055_bb0055","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jconrel.2025.114055_bb0060","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.114055_bb0065","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nbt1396","article-title":"Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone","volume":"26","author":"Sato","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jconrel.2025.114055_bb0070","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41467-022-35637-z","article-title":"Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis","volume":"14","author":"Han","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.114055_bb0075","doi-asserted-by":"crossref","first-page":"6305","DOI":"10.1021\/acsnano.0c02633","article-title":"Liver-targeted siRNA lipid nanoparticles treat hepatic cirrhosis by dual Antifibrotic and anti-inflammatory activities","volume":"14","author":"Zhang","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.114055_bb0080","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jconrel.2020.02.049","article-title":"Hyperbranched lipoid-based lipid nanoparticles for bidirectional regulation of collagen accumulation in liver fibrosis","volume":"321","author":"Qiao","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114055_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11050640","article-title":"Active targeting strategies using biological ligands for nanoparticle drug delivery systems","volume":"11","author":"Yoo","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jconrel.2025.114055_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2018.02.040","article-title":"Towards clinical translation of ligand-functionalized liposomes in targeted cancer therapy: challenges and opportunities","volume":"277","author":"Belfiore","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114055_bb0095","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jconrel.2015.10.024","article-title":"siRNA-lipid nanoparticles with long-term storage stability facilitate potent gene-silencing in vivo","volume":"220","author":"Suzuki","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114055_bb0100","doi-asserted-by":"crossref","first-page":"8529","DOI":"10.1002\/anie.201203263","article-title":"Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo","volume":"51","author":"Jayaraman","year":"2012","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.jconrel.2025.114055_bb0105","doi-asserted-by":"crossref","first-page":"12992","DOI":"10.1021\/acs.jmedchem.0c01407","article-title":"Property-driven design and development of lipids for efficient delivery of siRNA","volume":"63","author":"Rajappan","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jconrel.2025.114055_bb0110","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jconrel.2019.01.001","article-title":"Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo","volume":"295","author":"Sato","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114055_bb0115","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1002\/hep.27936","article-title":"Specific hepatic delivery of procollagen alpha1(I) small interfering RNA in lipid-like nanoparticles resolves liver fibrosis","volume":"62","author":"Jimenez Calvente","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jconrel.2025.114055_bb0120","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.jconrel.2023.08.021","article-title":"Reprogramming activated hepatic stellate cells by siRNA-loaded nanocarriers reverses liver fibrosis in mice","volume":"361","author":"Younis","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114055_bb0125","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/14728222.2021.1861249","article-title":"HSP47: a potential target for fibrotic diseases and implications for therapy","volume":"25","author":"Bellaye","year":"2021","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.jconrel.2025.114055_bb0130","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0168-8278(02)00050-8","article-title":"Expression of reelin in hepatic stellate cells and during hepatic tissue repair: a novel marker for the differentiation of HSC from other liver myofibroblasts","volume":"36","author":"Kobold","year":"2002","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jconrel.2025.114055_bb0135","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/j.1460-2075.1990.tb08184.x","article-title":"Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice","volume":"9","author":"Yan","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/j.jconrel.2025.114055_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2025.102467","article-title":"In vivo production of engineered ACE2 decoy protects lungs from SARS-CoV-2 infection","volume":"36","author":"Suzuki","year":"2025","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.jconrel.2025.114055_bb0145","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.ymthe.2024.01.020","article-title":"Lymph node macrophages drive innate immune responses to enhance the anti-tumor efficacy of mRNA vaccines","volume":"32","author":"Kubara","year":"2024","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2025.114055_bb0150","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1038\/mt.2013.124","article-title":"Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics","volume":"21","author":"Maier","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2025.114055_bb0155","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1016\/j.celrep.2018.02.014","article-title":"A single administration of CRISPR\/Cas9 lipid nanoparticles achieves robust and persistent in vivo genome editing","volume":"22","author":"Finn","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jconrel.2025.114055_bb0160","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.ymthe.2018.03.010","article-title":"A novel amino lipid series for mRNA delivery: improved endosomal escape and sustained pharmacology and safety in non-human Primates","volume":"26","author":"Sabnis","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2025.114055_bb0165","article-title":"Nanomaterial delivery systems for mRNA vaccines","volume":"9","author":"Buschmann","year":"2021","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.jconrel.2025.114055_bb0170","article-title":"Unsaturated, Trialkyl Ionizable lipids are versatile lipid-nanoparticle components for therapeutic and vaccine applications","volume":"35","author":"Lam","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2025.114055_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.omtn.2019.01.013","article-title":"Optimization of lipid nanoparticles for intramuscular administration of mRNA vaccines","volume":"15","author":"Hassett","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.jconrel.2025.114055_bb0180","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.ymthe.2019.03.003","article-title":"Non-viral delivery of zinc finger nuclease mRNA enables highly efficient in vivo genome editing of multiple therapeutic gene targets","volume":"27","author":"Conway","year":"2019","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2025.114055_bb0185","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1021\/acs.oprd.1c00076","article-title":"Development of a safe and scalable process for the production of a high-purity Thiocarbamate-based Ionizable lipid as an excipient in mRNA-encapsulating lipid nanoparticles","volume":"25","author":"Rajappan","year":"2021","journal-title":"Org. Process. Res. Dev."},{"key":"10.1016\/j.jconrel.2025.114055_bb0190","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.ijpharm.2016.06.124","article-title":"Structure, activity and uptake mechanism of siRNA-lipid nanoparticles with an asymmetric ionizable lipid","volume":"510","author":"Suzuki","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.114055_bb0195","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/mt.2010.85","article-title":"Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms","volume":"18","author":"Akinc","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2025.114055_bb0200","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2353\/ajpath.2010.090136","article-title":"The role of liver sinusoidal cells in hepatocyte-directed gene transfer","volume":"176","author":"Jacobs","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jconrel.2025.114055_bb0205","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1679\/aohc.46.401","article-title":"Electron microscopic studies on the sinusoidal cells in the monkey liver","volume":"46","author":"Tanuma","year":"1983","journal-title":"Arch. Histol. Jpn."},{"key":"10.1016\/j.jconrel.2025.114055_bb0210","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.addr.2020.06.017","article-title":"Lipid-based nanoparticle technologies for liver targeting","volume":"154\u2013155","author":"Bottger","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.114055_bb0215","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1124\/jpet.118.256156","article-title":"Targeted drug delivery to hepatic stellate cells for the treatment of liver fibrosis","volume":"370","author":"Chen","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jconrel.2025.114055_bb0220","unstructured":"Cationic lipids for therapeutic agent delivery formulations, US10669229B2."},{"key":"10.1016\/j.jconrel.2025.114055_bb0225","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/hep.32181","article-title":"BMS-986263 in patients with advanced hepatic fibrosis: 36-week results from a randomized, placebo-controlled phase 2 trial","volume":"75","author":"Lawitz","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.jconrel.2025.114055_bb0230","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1016\/j.xphs.2017.04.042","article-title":"The delivery of small interfering RNA to hepatic stellate cells using a lipid nanoparticle composed of a vitamin A-scaffold lipid-like material","volume":"106","author":"Toriyabe","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2025.114055_bb0235","doi-asserted-by":"crossref","first-page":"7263","DOI":"10.1038\/s41467-024-51571-8","article-title":"RNA nanotherapeutics with fibrosis overexpression and retention for MASH treatment","volume":"15","author":"Shan","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.114055_bb0240","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1021\/bp049840y","article-title":"Preclinical manufacture of an anti-HER2 scFv-PEG-DSPE, liposome-inserting conjugate. 1. Gram-scale production and purification","volume":"21","author":"Nellis","year":"2005","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.jconrel.2025.114055_bb0245","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1021\/bp049839z","article-title":"Preclinical manufacture of anti-HER2 liposome-inserting, scFv-PEG-lipid conjugate. 2. Conjugate micelle identity, purity, stability, and potency analysis","volume":"21","author":"Nellis","year":"2005","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.jconrel.2025.114055_bb0250","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijpharm.2015.02.034","article-title":"Large-scale manufacturing of GMP-compliant anti-EGFR targeted nanocarriers: production of doxorubicin-loaded anti-EGFR-immunoliposomes for a first-in-man clinical trial","volume":"484","author":"Wicki","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.114055_bb0255","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1073\/pnas.0910603106","article-title":"Lipid-like materials for low-dose, in vivo gene silencing","volume":"107","author":"Love","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jconrel.2025.114055_bb0260","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jconrel.2022.12.020","article-title":"Self-homing nanocarriers for mRNA delivery to the activated hepatic stellate cells in liver fibrosis","volume":"353","author":"Younis","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114055_bb0265","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.tips.2021.03.002","article-title":"The importance of apparent pKa in the development of nanoparticles encapsulating siRNA and mRNA","volume":"42","author":"Patel","year":"2021","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jconrel.2025.114055_bb0270","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.omtn.2022.09.017","article-title":"Design and lyophilization of lipid nanoparticles for mRNA vaccine and its robust immune response in mice and nonhuman primates","volume":"30","author":"Suzuki","year":"2022","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.jconrel.2025.114055_bb0275","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jconrel.2016.05.059","article-title":"Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA","volume":"235","author":"Chen","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114055_bb0280","doi-asserted-by":"crossref","DOI":"10.1038\/mtna.2014.61","article-title":"Shielding of lipid nanoparticles for siRNA delivery: impact on physicochemical properties, cytokine induction, and efficacy","volume":"3","author":"Kumar","year":"2014","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.jconrel.2025.114055_bb0285","first-page":"12758","article-title":"Impact of lipid tail length on the organ selectivity of mRNA-lipid nanoparticles","volume":"24","author":"Hashiba","year":"2024","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2025.114055_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2019.183157","article-title":"Effect of dipole moment on amphiphile solubility and partition into liquid ordered and liquid disordered phases in lipid bilayers","volume":"1862","author":"Cardoso","year":"2020","journal-title":"Biochimica et Biophysica Acta (BBA) -Biomembranes"},{"key":"10.1016\/j.jconrel.2025.114055_bb0295","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1021\/acs.molpharmaceut.2c00033","article-title":"Comparison of DLin-MC3-DMA and ALC-0315 for siRNA delivery to hepatocytes and hepatic stellate cells","volume":"19","author":"Ferraresso","year":"2022","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2025.114055_bb0300","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2183\/pjab.82.155","article-title":"Hepatic stellate cells: three-dimensional structure, localization, heterogeneity and development","volume":"82","author":"Wake","year":"2006","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"10.1016\/j.jconrel.2025.114055_bb0305","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nbt.2634","article-title":"A window onto siRNA delivery","volume":"31","author":"Wang","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jconrel.2025.114055_bb0310","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nbt.2614","article-title":"Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling","volume":"31","author":"Sahay","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jconrel.2025.114055_bb0315","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1002\/jcp.24080","article-title":"Low density lipoprotein receptor-related protein 1 modulates the proliferation and migration of human hepatic stellate cells","volume":"227","author":"Llorente-Cortes","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jconrel.2025.114055_bb0320","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1111\/j.1476-5381.2009.00261.x","article-title":"Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells","volume":"157","author":"Kang","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jconrel.2025.114055_bb0325","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/hep.26604","article-title":"Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice","volume":"59","author":"Tomita","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jconrel.2025.114055_bb0330","unstructured":"https:\/\/www.livercellatlas.org\/index.php, Liver Cell Atlas, (2025; accessed 31 March 2025)."},{"key":"10.1016\/j.jconrel.2025.114055_bb0335","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cell.2021.12.018","article-title":"Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches","volume":"185","author":"Guilliams","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2025.114055_bb0340","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.omtn.2023.01.005","article-title":"Identification of potent siRNA targeting complement C5 and its robust activity in pre-clinical models of myasthenia gravis and collagen-induced arthritis","volume":"31","author":"Kuboi","year":"2023","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.jconrel.2025.114055_bb0345","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1097\/TP.0000000000004207","article-title":"Novel complement C5 small-interfering RNA lipid nanoparticle prolongs graft survival in a Hypersensitized rat kidney transplant model","volume":"106","author":"Ishigooka","year":"2022","journal-title":"Transplantation"},{"key":"10.1016\/j.jconrel.2025.114055_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtm.2025.101466","article-title":"Species-specific gene expression manipulation in humanized livers of chimeric mice via siRNA-encapsulated lipid nanoparticle treatment","volume":"33","author":"Yamazaki","year":"2025","journal-title":"Mol. Ther. Meth. Clin. Develop."},{"key":"10.1016\/j.jconrel.2025.114055_bb0355","series-title":"06 Chemical Computing Group ULC, 910\u20131010 Sherbrooke St. W., Montreal, QC H3A 2R7","first-page":"2024","author":"Molecular Operating Environment (MOE)","year":"2024"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925006777?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925006777?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:17:29Z","timestamp":1778944649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925006777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":71,"alternative-id":["S0168365925006777"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114055","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ionizable lipid chemistry in lipid nanoparticles determines delivery efficiency to hepatic stellate cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114055"}}