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Control. Release"},{"key":"10.1016\/j.jconrel.2025.114058_bb0735","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jcis.2022.03.040","article-title":"Multifunctional hydrogel platform for biofilm scavenging and O2 generating with photothermal effect on diabetic chronic wound healing","volume":"617","author":"Wang","year":"2022","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jconrel.2025.114058_bb0740","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202302073","article-title":"Bioactive glasses-based nanozymes composite macroporous cryogel with antioxidative, antibacterial, and pro-healing properties for diabetic infected wound repair","volume":"12","author":"Zhu","year":"2023","journal-title":"Adv. Healthc. 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Mater."},{"key":"10.1016\/j.jconrel.2025.114058_bb0760","article-title":"Injectable hydrogel based on defect-rich multi-nanozymes for diabetic wound healing via an oxygen self-supplying cascade reaction","volume":"18","author":"Li","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2025.114058_bb0765","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24129900","article-title":"Innovative functional biomaterials as therapeutic wound dressings for chronic diabetic foot ulcers","volume":"24","author":"Da Silva","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.114058_bb0770","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.actbio.2020.09.035","article-title":"Sulfated chitosan rescues dysfunctional macrophages and accelerates wound healing in diabetic mice","volume":"117","author":"Shen","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2025.114058_bb0775","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.ijbiomac.2021.08.154","article-title":"Chitosan for biomedical applications, promising antidiabetic drug delivery system, and new diabetes mellitus treatment based on stem cell","volume":"190","author":"Othman","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jconrel.2025.114058_bb0780","doi-asserted-by":"crossref","first-page":"784","DOI":"10.3390\/md20120784","article-title":"Antidiabetic properties of chitosan and its derivatives","volume":"20","author":"Tzeng","year":"2022","journal-title":"Mar. 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Mater."},{"key":"10.1016\/j.jconrel.2025.114058_bb0800","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1111\/j.1538-7836.2006.01861.x","article-title":"Fibrin structure and wound healing","volume":"4","author":"Laurens","year":"2006","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.jconrel.2025.114058_bb0805","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.actbio.2019.03.011","article-title":"Preparation of fibrin hydrogels to promote the recruitment of anti-inflammatory macrophages","volume":"89","author":"Tanaka","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2025.114058_bb0810","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202417314","article-title":"Biomolecular microneedle initiates Fe3O4\/MXene heterojunction-mediated nanozyme-like reactions and bacterial ferroptosis to repair diabetic wounds","volume":"12","author":"You","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2025.114058_bb0815","first-page":"4592","article-title":"An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing","volume":"6","author":"Hu","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2025.114058_bb0820","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2020.126273","article-title":"Hierarchical micro\/nanofibrous scaffolds incorporated with curcumin and zinc ion eutectic metal organic frameworks for enhanced diabetic wound healing via anti-oxidant and anti-inflammatory activities","volume":"402","author":"Wang","year":"2020","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jconrel.2025.114058_bb0825","article-title":"Mechanical force induced self-assembly of chinese herbal hydrogel with synergistic effects of antibacterial activity and immune regulation for wound healing","volume":"18","author":"Chen","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2025.114058_bb0830","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12951-025-03193-5","article-title":"Inflammatory memory - activited biomimetic nanovesicles regulateneutrophil plasticity and metabolic reprogramming for rapid diabetic wound healing via targeting miR-193a-5p\/TLR4\/JNK\/P38 MAPK pathways","volume":"23","author":"Fan","year":"2025","journal-title":"J. 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Mater."},{"key":"10.1016\/j.jconrel.2025.114058_bb0845","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107282","article-title":"Activation and modulation of the AGEs-RAGE axis: implications for inflammatory pathologies and therapeutic interventions - a review","volume":"206","author":"Zhou","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jconrel.2025.114058_bb0850","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jconrel.2021.03.032","article-title":"Self-assembled elastin-like polypeptide fusion protein coacervates as competitive inhibitors of advanced glycation end-products enhance diabetic wound healing","volume":"333","author":"Kang","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114058_bb0855","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1021\/acsnano.2c10039","article-title":"Infected diabetic wound regeneration using peptide-modified chiral dressing to target revascularization","volume":"17","author":"Xing","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.114058_bb0860","first-page":"1","article-title":"Glucose and MMP-9 dual-responsive hydrogel with temperature sensitive self-adaptive shape and controlled drug release accelerates diabetic wound healing","volume":"17","author":"Zhou","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2025.114058_bb0865","article-title":"Antibacterial coaxial hydro-membranes accelerate diabetic wound healing by tuning surface immunomodulatory functions","volume":"16","author":"Zhang","year":"2022","journal-title":"Mater. Today. Bio."},{"key":"10.1016\/j.jconrel.2025.114058_bb0870","article-title":"Controllable adaptive molybdate-oligosaccharide nanoparticles regulate M2 macrophage mitochondrial function and promote angiogenesis via PI3K\/HIF-1alpha\/VEGF pathway to accelerate diabetic wound healing","volume":"13","author":"Huang","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2025.114058_bb0875","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.cell.2019.01.021","article-title":"VEGF in signaling and disease: beyond discovery and development","volume":"176","author":"Apte","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2025.114058_bb0880","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11154-019-09492-1","article-title":"Role of growth factors and cytokines in diabetic foot ulcer healing: a detailed review","volume":"20","author":"Zubair","year":"2019","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.jconrel.2025.114058_bb0885","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.2337\/db20-0188","article-title":"Integrated skin transcriptomics and serum multiplex assays reveal nnovel mechanisms of wound healing in diabetic foot ulcers","volume":"69","author":"Theocharidis","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.jconrel.2025.114058_bb0890","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jconrel.2015.10.028","article-title":"Heparin desulfation modulates VEGF release and angiogenesis in diabetic wounds","volume":"220","author":"Freudenberg","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114058_bb0895","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/s12951-023-02073-0","article-title":"An injectable, activated neutrophil-derived exosome mimetics\/extracellular matrix hybrid hydrogel with antibacterial activity and wound healing promotion effect for diabetic wound therapy","volume":"21","author":"Yu","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2025.114058_bb0900","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202105749","article-title":"Engineering bacteria-activated multifunctionalized hydrogel for promoting diabetic wound healing","volume":"31","author":"Lu","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2025.114058_bb0905","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202104229","article-title":"All-in-one: multifunctional hydrogel accelerates oxidative diabetic wound healing through timed-release of exosome and fibroblast growth factor","volume":"18","author":"Xiong","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2025.114058_bb0910","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1093\/bib\/bby054","article-title":"Trends in the development of miRNA bioinformatics tools","volume":"20","author":"Chen","year":"2019","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.jconrel.2025.114058_bb0915","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/nsmb.2296","article-title":"The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC","volume":"19","author":"Fabian","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jconrel.2025.114058_bb0920","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109613","article-title":"Accelerated wound healing in diabetic mice by miRNA-497 and its anti-inflammatory activity","volume":"121","author":"Ban","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jconrel.2025.114058_bb0925","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1001\/jama.2016.17822","article-title":"Stem cell treatments","volume":"317","author":"Jin","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jconrel.2025.114058_bb0930","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1186\/s13287-022-03132-3","article-title":"ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C\/VEGFR-3-dependent mechanism and inhibiting the NF-kappaB pathway by the secretome","volume":"13","author":"Zhang","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jconrel.2025.114058_bb0935","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.biomaterials.2017.03.021","article-title":"Development of a UV crosslinked biodegradable hydrogel containing adipose derived stem cells to promote vascularization for skin wounds and tissue engineering","volume":"129","author":"Eke","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.114058_bb0940","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120020","article-title":"Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing","volume":"249","author":"Shiekh","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.114058_bb0945","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s12951-021-00942-0","article-title":"Hypoxia adipose stem cell-derived exosomes promote high-quality healing of diabetic wound involves activation of PI3K\/Akt pathways","volume":"19","author":"Wang","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2025.114058_bb0950","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202103317","article-title":"Polydopamine decorated microneedles with Fe-MSC-derived nanovesicles encapsulation for wound healing","volume":"9","author":"Ma","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2025.114058_bb0955","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2025.114058_bb0960","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s12274-016-1265-9","article-title":"Optimizing surface-engineered ultra-small gold nanoparticles for highly efficient miRNA delivery to enhance osteogenic differentiation of bone mesenchymal stromal cells","volume":"10","author":"Yu","year":"2017","journal-title":"Nano Res"},{"key":"10.1016\/j.jconrel.2025.114058_bb0965","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev-biochem-013118-111902","article-title":"Exosomes","volume":"88","author":"Pegtel","year":"2019","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jconrel.2025.114058_bb0970","doi-asserted-by":"crossref","first-page":"10279","DOI":"10.1021\/acsnano.9b03656","article-title":"Efficient angiogenesis-based diabetic wound healing\/skin reconstruction through bioactive antibacterial adhesive ultraviolet shielding nanodressing with exosome release","author":"Wang","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.114058_bb0975","doi-asserted-by":"crossref","first-page":"378S","DOI":"10.3945\/an.112.003483","article-title":"Magnesium in disease prevention and overall health","volume":"4","author":"Volpe","year":"2013","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.jconrel.2025.114058_bb0980","doi-asserted-by":"crossref","first-page":"12196","DOI":"10.1039\/D2NR03411E","article-title":"MOF-derived nanoarrays as advanced electrocatalysts for water splitting","volume":"14","author":"Zhang","year":"2022","journal-title":"Nanoscale"},{"key":"10.1016\/j.jconrel.2025.114058_bb0985","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cis.2008.10.004","article-title":"Cerium oxide nanoparticles prepared in self-assembled systems","volume":"147-148","author":"Bumajdad","year":"2009","journal-title":"Adv. Colloid Interf. Sci."},{"key":"10.1016\/j.jconrel.2025.114058_bb0990","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201902956","article-title":"Ceria nanoparticles meet hepatic ischemia-reperfusion injury: the perfect imperfection","volume":"31","author":"Ni","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2025.114058_bb0995","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-021-01151-5","article-title":"A thermoreversible antibacterial zeolite-based nanoparticles loaded hydrogel promotes diabetic wound healing via detrimental factor neutralization and ROS scavenging","volume":"19","author":"Qi","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2025.114058_bb1000","first-page":"17","article-title":"A nanoenzyme-modified hydrogel targets macrophage reprogramming-angiogenesis crosstalk to boost diabetic wound repair","volume":"35","author":"He","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2025.114058_bb1005","article-title":"Glucose\/ROS cascade-responsive ceria nanozymes for diabetic wound healing","volume":"15","author":"Yu","year":"2022","journal-title":"Mater. Today. Bio."},{"key":"10.1016\/j.jconrel.2025.114058_bb1010","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202417774","article-title":"Amyloid-templated ceria nanozyme reinforced microneedle for diabetic wound treatments","volume":"37","author":"Xuan","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2025.114058_bb1015","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202303229","article-title":"Enhanced .OH-scavenging activity of Cu-CeOx nanozyme via resurrecting macrophage Nrf2 transcriptional activity facilitates diabetic wound healing","volume":"13","author":"Zhu","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2025.114058_bb1020","doi-asserted-by":"crossref","first-page":"18520","DOI":"10.1039\/C8NR04748K","article-title":"All-in-one NIR-activated nanoplatforms for enhanced bacterial biofilm eradication","volume":"10","author":"Dai","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.jconrel.2025.114058_bb1025","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbad072","article-title":"Photothermal effective CeO2NPs combined in thermosensitive hydrogels with enhanced antibacterial, antioxidant and vascularization performance to accelerate infected diabetic wound healing","volume":"10","author":"Zheng","year":"2023","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.jconrel.2025.114058_bb1030","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.actbio.2018.12.048","article-title":"Cobalt-mediated multi-functional dressings promote bacteria-infected wound healing","volume":"86","author":"Shi","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2025.114058_bb1035","first-page":"298","article-title":"Double hits with bioactive nanozyme based on cobalt-doped nanoglass for acute and diabetic wound therapies through anti-inflammatory and pro-angiogenic functions","volume":"31","author":"Mandakhbayar","year":"2024","journal-title":"Bioact. 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Endocrinol. Investig."},{"key":"10.1016\/j.jconrel.2025.114058_bb1125","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1039\/C7TB02342A","article-title":"Enhanced diabetic wound healing by electrospun core-sheath fibers loaded with dimethyloxalylglycine","volume":"6","author":"Gao","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jconrel.2025.114058_bb1130","doi-asserted-by":"crossref","first-page":"7950","DOI":"10.1021\/acsami.6b15815","article-title":"Effects of dimethyloxalylglycine-embedded poly(epsilon-caprolactone) fiber meshes on wound healing in diabetic rats","volume":"9","author":"Zhang","year":"2017","journal-title":"ACS Appl. Mater. 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