{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:57:21Z","timestamp":1791395841169,"version":"4.3.3"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018553","name":"Science and Technology Plan Project of Wenzhou Municipality","doi-asserted-by":"publisher","award":["Y20210167"],"award-info":[{"award-number":["Y20210167"]}],"id":[{"id":"10.13039\/501100018553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017599","name":"Science and Technology Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2025C02152"],"award-info":[{"award-number":["2025C02152"]}],"id":[{"id":"10.13039\/501100017599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172117"],"award-info":[{"award-number":["82172117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201546"],"award-info":[{"award-number":["82201546"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372149"],"award-info":[{"award-number":["82372149"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2023KY307"],"award-info":[{"award-number":["2023KY307"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jconrel.2025.114080","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T23:43:52Z","timestamp":1753919032000},"page":"114080","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Engineered extracellular vesicles for targeted FGF20 delivery enhance neuroplasticity and functional recovery in ischemic stroke"],"prefix":"10.1016","volume":"386","author":[{"given":"Shufei","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengkai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchi","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaokun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.114080_bb0005","doi-asserted-by":"crossref","first-page":"102758","DOI":"10.1016\/j.eclinm.2024.102758","article-title":"Global, regional, and national burden of ischemic stroke, 1990\u20132021: an analysis of data from the global burden of disease study 2021","volume":"75","author":"Li","year":"2024","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.jconrel.2025.114080_bb0010","article-title":"Comorbidity and age in the modelling of stroke: are we still failing to consider the characteristics of stroke patients?","volume":"4","author":"McCann","year":"2020","journal-title":"BMJ Open Sci."},{"key":"10.1016\/j.jconrel.2025.114080_bb0015","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-019-1571-8","article-title":"Neuroinflammation as a target for treatment of stroke using mesenchymal stem cells and extracellular vesicles","volume":"16","author":"Dabrowska","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jconrel.2025.114080_bb0020","doi-asserted-by":"crossref","first-page":"1809065","DOI":"10.1080\/20013078.2020.1809065","article-title":"Characterization of brain-derived extracellular vesicles reveals changes in cellular origin after stroke and enrichment of the prion protein with a potential role in cellular uptake","volume":"9","author":"Brenna","year":"2020","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jconrel.2025.114080_bb0025","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1172\/JCI135530","article-title":"Immune responses to stroke: mechanisms, modulation, and therapeutic potential","volume":"130","author":"Iadecola","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2025.114080_bb0030","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.neuropharm.2008.01.005","article-title":"Mechanisms of ischemic brain damage","volume":"55","author":"Doyle","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jconrel.2025.114080_bb0035","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s10072-017-2938-1","article-title":"Pathogenic mechanisms following ischemic stroke","volume":"38","author":"Khoshnam","year":"2017","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.jconrel.2025.114080_bb0040","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1161\/STROKEAHA.119.028484","article-title":"Trends in stroke incidence in high-income countries in the 21st century","volume":"51","author":"Li","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.jconrel.2025.114080_bb0045","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41467-023-36008-y","article-title":"FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke","volume":"14","author":"Li","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.114080_bb0050","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/imcb.12191","article-title":"The immune system and stroke: from current targets to future therapy","volume":"97","author":"Malone","year":"2019","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.jconrel.2025.114080_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113325","article-title":"Moderate exercise has beneficial effects on mouse ischemic stroke by enhancing the functions of circulating endothelial progenitor cell-derived exosomes","volume":"330","author":"Wang","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jconrel.2025.114080_bb0060","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1177\/0963689718795424","article-title":"Transplanting mesenchymal stem cells for treatment of ischemic stroke","volume":"27","author":"Wang","year":"2018","journal-title":"Cell Transplant."},{"key":"10.1016\/j.jconrel.2025.114080_bb0065","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.addr.2021.01.015","article-title":"Targeting the blood-brain barrier for the delivery of stroke therapies","volume":"171","author":"D\u2019Souza","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.114080_bb0070","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1006\/bbrc.2000.3142","article-title":"Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22","volume":"274","author":"Kirikoshi","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jconrel.2025.114080_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.diff.2023.10.005","article-title":"FGF20","volume":"139","author":"Van Greenen","year":"2024","journal-title":"Differentiation"},{"key":"10.1016\/j.jconrel.2025.114080_bb0080","first-page":"3131","article-title":"Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis","volume":"61","author":"Jeffers","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2025.114080_bb0085","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/bbrc.2000.3675","article-title":"FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain","volume":"277","author":"Ohmachi","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jconrel.2025.114080_bb0090","doi-asserted-by":"crossref","first-page":"9750","DOI":"10.1523\/JNEUROSCI.2745-06.2006","article-title":"A specific survival response in dopamine neurons at most risk in Parkinson\u2019s disease","volume":"26","author":"Murase","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jconrel.2025.114080_bb0095","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.neuropharm.2012.07.029","article-title":"Fibroblast growth factor-20 protects against dopamine neuron loss in vitro and provides functional protection in the 6-hydroxydopamine-lesioned rat model of Parkinson\u2019s disease","volume":"63","author":"Sleeman","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jconrel.2025.114080_bb0100","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1080\/10717544.2018.1482972","article-title":"Efficient treatment of Parkinson\u2019s disease using ultrasonography-guided rhFGF20 proteoliposomes","volume":"25","author":"Niu","year":"2018","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jconrel.2025.114080_bb0105","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s40263-016-0405-9","article-title":"Crossing the blood-brain barrier: recent advances in drug delivery to the brain","volume":"31","author":"Patel","year":"2017","journal-title":"CNS Drugs"},{"key":"10.1016\/j.jconrel.2025.114080_bb0110","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jconrel.2017.07.001","article-title":"Extracellular vesicles: novel promising delivery systems for therapy of brain diseases","volume":"262","author":"Rufino-Ramos","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114080_bb0115","doi-asserted-by":"crossref","first-page":"1800222","DOI":"10.1080\/20013078.2020.1800222","article-title":"Quantification of extracellular vesicles in vitro and in vivo using sensitive bioluminescence imaging","volume":"9","author":"Gupta","year":"2020","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jconrel.2025.114080_bb0120","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41582-018-0126-4","article-title":"Exosomes - beyond stem cells for restorative therapy in stroke and neurological injury","volume":"15","author":"Zhang","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jconrel.2025.114080_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70031","article-title":"A simple polydopamine-based platform for engineering extracellular vesicles with brain-targeting peptide and imaging probes to improve stroke outcome","volume":"14","author":"Shi","year":"2025","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jconrel.2025.114080_bb0130","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1021\/acsbiomaterials.3c01622","article-title":"RVG29 peptide-modified exosomes loaded with Mir-133b mediate the RhoA-ROCK pathway to improve motor and neurological symptoms in Parkinson\u2019s disease","volume":"10","author":"Jiang","year":"2024","journal-title":"ACS Biomater Sci. Eng."},{"key":"10.1016\/j.jconrel.2025.114080_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121366","article-title":"Using genetically modified extracellular vesicles as a non-invasive strategy to evaluate brain-specific cargo","volume":"281","author":"Rufino-Ramos","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.114080_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12185","article-title":"Extracellular vesicle-mediated delivery of circDYM alleviates CUS-induced depressive-like behaviours","volume":"11","author":"Yu","year":"2022","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jconrel.2025.114080_bb0145","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nbt.1807","article-title":"Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes","volume":"29","author":"Alvarez-Erviti","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jconrel.2025.114080_bb0150","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1021\/bm401906p","article-title":"RVG-peptide-linked trimethylated chitosan for delivery of siRNA to the brain","volume":"15","author":"Gao","year":"2014","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2025.114080_bb0155","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1161\/CIRCULATIONAHA.120.045765","article-title":"Extracellular vesicle-mediated delivery of circular RNA SCMH1 promotes functional recovery in rodent and nonhuman primate ischemic stroke models","volume":"142","author":"Yang","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2025.114080_bb0160","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.omtn.2020.06.013","article-title":"Therapeutic effects of simultaneous delivery of nerve growth factor mRNA and protein via exosomes on cerebral ischemia","volume":"21","author":"Yang","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.jconrel.2025.114080_bb0165","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1007\/s12035-022-03192-9","article-title":"Extracellular vesicles derived from bone mesenchymal stem cells carrying circ_0000075 relieves cerebral ischemic injury by competitively inhibiting miR-218-5p and up-regulating E3 ubiquitin ligase SMURF2","volume":"60","author":"Liu","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jconrel.2025.114080_bb0170","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41419-023-05689-0","article-title":"CD11c+ microglia promote white matter repair after ischemic stroke","volume":"14","author":"Jia","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jconrel.2025.114080_bb0175","doi-asserted-by":"crossref","first-page":"eaaz0748","DOI":"10.1126\/sciadv.aaz0748","article-title":"Extracellular vesicle\u2013encapsulated IL-10 as novel nanotherapeutics against ischemic AKI","volume":"6","author":"Tang","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2025.114080_bb0180","first-page":"512","article-title":"Therapeutic effects of simultaneous delivery of nerve growth factor mRNA and protein via exosomes on cerebral ischemia","volume":"21","author":"Yang","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2025.114080_bb0185","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12975-021-00915-3","article-title":"Extracellular vesicle application as a novel therapeutic strategy for ischemic stroke","volume":"13","author":"Li","year":"2022","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.jconrel.2025.114080_bb0190","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J. Extracell. Vesicle"},{"key":"10.1016\/j.jconrel.2025.114080_bb0195","doi-asserted-by":"crossref","first-page":"447","DOI":"10.20517\/evcna.2023.14","article-title":"Advances in extracellular vesicle isolation methods: a path towards cell-type specific EV isolation","volume":"4","author":"Shami-shah","year":"2023","journal-title":"Extracell. Vesicles Circ. Nucl. Acids"},{"key":"10.1016\/j.jconrel.2025.114080_bb0200","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.7150\/thno.48761","article-title":"M2 microglial small extracellular vesicles reduce glial scar formation via the miR-124\/STAT3 pathway after ischemic stroke in mice","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2025.114080_bb0205","doi-asserted-by":"crossref","DOI":"10.1136\/svn-2023-002320","article-title":"STING mediates microglial pyroptosis via interaction with NLRP3 in cerebral ischaemic stroke","volume":"9","author":"Li","year":"2024","journal-title":"Stroke Vasc. Neurol."},{"key":"10.1016\/j.jconrel.2025.114080_bb0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2023.03.033","article-title":"Intranasal delivery of BDNF-loaded small extracellular vesicles for cerebral ischemia therapy","volume":"357","author":"Zhou","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114080_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109064","article-title":"Non-mitogenic fibroblast growth factor 1 protects against ischemic stroke by regulating microglia\/macrophage polarization through Nrf2 and NF-\u03baB pathways","volume":"212","author":"Dordoe","year":"2022","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jconrel.2025.114080_bb0220","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12974-023-02741-w","article-title":"TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair","volume":"20","author":"Xu","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jconrel.2025.114080_bb0225","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13937","article-title":"Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer\u2019s disease via reducing tau hyperphosphorylation and neuronal apoptosis","volume":"22","author":"Guo","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.jconrel.2025.114080_bb0230","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/1471-2105-15-293","article-title":"jvenn: an interactive Venn diagram viewer","volume":"15","author":"Bardou","year":"2014","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.jconrel.2025.114080_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113673","article-title":"A comprehensive evaluation of stability and safety for HEK293F-derived extracellular vesicles as promising drug delivery vehicles","volume":"382","author":"Chen","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114080_bb0240","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.jconrel.2023.10.003","article-title":"Bio-clickable, small extracellular vesicles-COCKTAIL therapy for ischemic stroke","volume":"363","author":"Haroon","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114080_bb0245","doi-asserted-by":"crossref","first-page":"22569","DOI":"10.1074\/jbc.274.32.22569","article-title":"Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase","volume":"274","author":"Hetman","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jconrel.2025.114080_bb0250","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1177\/0300060517734460","article-title":"Dexmedetomidine protects against oxygen-glucose deprivation\/reoxygenation injury-induced apoptosis via the p38 MAPK\/ERK signalling pathway","volume":"46","author":"Wang","year":"2018","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.jconrel.2025.114080_bb0255","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-025-04768-x","article-title":"CDC42 regulates the ERK pathway to improve oxygen\u2013glucose deprivation\/reoxygenation-induced neural oxidative stress and apoptosis","author":"Hao","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jconrel.2025.114080_bb0260","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.neuropharm.2018.04.017","article-title":"Fibroblast growth factor 20 is protective towards dopaminergic neurons in vivo in a paracrine manner","volume":"137","author":"Boshoff","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jconrel.2025.114080_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112200","article-title":"rhFGF20 promotes angiogenesis and vascular repair following traumatic brain injury by regulating Wnt\/\u03b2-catenin pathway","volume":"143","author":"Guo","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jconrel.2025.114080_bb0270","article-title":"FGF20 protected against BBB disruption after traumatic brain injury by upregulating junction protein expression and inhibiting the inflammatory response","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jconrel.2025.114080_bb0275","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70075","article-title":"Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles: a focus on inflammatory bowel disease","volume":"14","author":"Clua-Ferr\u00e9","year":"2024","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.114080_bb0280","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s13770-022-00441-9","article-title":"Mesenchymal stem cell-derived extracellular vesicles in the management of COVID19-associated lung injury: a review on publications, clinical trials and patent landscape","volume":"19","author":"Krishnan","year":"2022","journal-title":"Tissue Eng. Regen. Med."},{"key":"10.1016\/j.jconrel.2025.114080_bb0285","first-page":"16","article-title":"Mesenchymal stem cell secretome and extracellular vesicles for neurodegenerative diseases: risk-benefit profile and next steps for the market access","volume":"29","author":"Giovannelli","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2025.114080_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120467","article-title":"Extracellular vesicles: a bright star of nanomedicine","volume":"269","author":"Wu","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.114080_bb0295","doi-asserted-by":"crossref","first-page":"1324730","DOI":"10.1080\/20013078.2017.1324730","article-title":"Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells","volume":"6","author":"Zhu","year":"2017","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jconrel.2025.114080_bb0300","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/s13287-024-03955-2","article-title":"Genetically engineered human induced pluripotent stem cells for the production of brain-targeting extracellular vesicles","volume":"15","author":"Tang","year":"2024","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jconrel.2025.114080_bb0305","doi-asserted-by":"crossref","first-page":"53177","DOI":"10.1021\/acsami.3c08756","article-title":"Enhanced nose-to-brain delivery of combined small interfering RNAs using lesion-recognizing nanoparticles for the synergistic therapy of Alzheimer\u2019s disease","volume":"15","author":"Li","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2025.114080_bb0310","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1080\/1061186X.2021.1929257","article-title":"Genetically engineered exosomes display RVG peptide and selectively enrich a neprilysin variant: a potential formulation for the treatment of Alzheimer\u2019s disease","volume":"29","author":"Yu","year":"2021","journal-title":"J. Drug Target."},{"key":"10.1016\/j.jconrel.2025.114080_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113455","article-title":"Biliverdin modulates the long non-coding RNA H19\/microRNA-181b-5p\/endothelial cell specific molecule 1 axis to alleviate cerebral ischemia reperfusion injury","volume":"153","author":"Li","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jconrel.2025.114080_bb0320","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.neuroscience.2014.05.027","article-title":"PTEN degradation after ischemic stroke: a double-edged sword","volume":"274","author":"Li","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.jconrel.2025.114080_bb0325","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/s41419-020-03186-2","article-title":"YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation through destabilizing PTEN mRNA","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jconrel.2025.114080_bb0330","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.neuroscience.2012.11.050","article-title":"Delayed administration of a PTEN inhibitor bpv improves functional recovery after experimental stroke","volume":"231","author":"Mao","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.jconrel.2025.114080_bb0335","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1126\/science.aad2615","article-title":"Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2","volume":"350","author":"Jaworski","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2025.114080_bb0340","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/nature01790","article-title":"Semaphorin 7A promotes axon outgrowth through integrins and MAPKs","volume":"424","author":"Pasterkamp","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2025.114080_bb0345","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1242\/jcs.114.11.1973","article-title":"The Trio family of guanine-nucleotide-exchange factors: regulators of axon guidance","volume":"114","author":"Bateman","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jconrel.2025.114080_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2023.110734","article-title":"Electroacupuncture alleviates PTSD-like behaviors by modulating hippocampal synaptic plasticity via Wnt\/\u03b2-catenin signaling pathway","volume":"202","author":"Lv","year":"2023","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jconrel.2025.114080_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2021.107558","article-title":"Role of Wnt signaling in synaptic plasticity and memory","volume":"187","author":"Narvaes","year":"2022","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.jconrel.2025.114080_bb0360","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000460261","article-title":"Apelin-13 protects against ischemic blood-brain barrier damage through the effects of Aquaporin-4","volume":"44","author":"Chu","year":"2017","journal-title":"Cerebrovasc. Dis."},{"key":"10.1016\/j.jconrel.2025.114080_bb0365","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jconrel.2020.08.056","article-title":"Emerging strategies for labeling and tracking of extracellular vesicles","volume":"328","author":"Li","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114080_bb0370","doi-asserted-by":"crossref","first-page":"684","DOI":"10.20517\/evcna.2023.49","article-title":"Research progress in in vivo tracing technology for extracellular vesicles","volume":"4","author":"Shi","year":"2023","journal-title":"Extracell. Vesicles Circ. Nucl. Acids"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925007023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925007023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T08:42:53Z","timestamp":1777192973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925007023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":74,"alternative-id":["S0168365925007023"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114080","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineered extracellular vesicles for targeted FGF20 delivery enhance neuroplasticity and functional recovery in ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114080","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114080"}}