{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:56:19Z","timestamp":1793476579762,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2025C02134"],"award-info":[{"award-number":["2025C02134"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272296"],"award-info":[{"award-number":["82272296"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402927"],"award-info":[{"award-number":["82402927"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472552"],"award-info":[{"award-number":["82472552"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jconrel.2025.114127","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T15:12:59Z","timestamp":1755097979000},"page":"114127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Apoptotic neutrophil membrane-modified nanoparticles promote wound healing by enhancing efferocytotic capacity of dendritic cells"],"prefix":"10.1016","volume":"386","author":[{"given":"Kai","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danfeng","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengtai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexue","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jindan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengwei","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenggang","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jconrel.2025.114127_bb0005","article-title":"The global and regional burden of diabetic peripheral neuropathy","volume":"21","author":"Masha","year":"2024","journal-title":"Nat. Rev. Neurol."},{"issue":"8","key":"10.1016\/j.jconrel.2025.114127_bb0010","article-title":"The wound microbiota: microbial mechanisms of impaired wound healing and infection","volume":"22","author":"Aayushi","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"issue":"45","key":"10.1016\/j.jconrel.2025.114127_bb0015","article-title":"Engineered enucleated mesenchymal stem cells regulating immune microenvironment and promoting wound healing","volume":"36","author":"Zhengtai","year":"2024","journal-title":"Adv. Mater."},{"issue":"9","key":"10.1016\/j.jconrel.2025.114127_bb0020","article-title":"Metabolic orchestration of the wound healing response","volume":"33","author":"Sabine","year":"2021","journal-title":"Cell Metab."},{"issue":"7","key":"10.1016\/j.jconrel.2025.114127_bb0025","article-title":"The clearance of dead cells by efferocytosis","volume":"21","author":"Emilio","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.jconrel.2025.114127_bb0030","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cmet.2018.12.004","article-title":"Efferocytosis fuels requirements of fatty acid oxidation and the Electron transport chain to polarize macrophages for tissue repair","volume":"29","author":"Zhang","year":"2019","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.jconrel.2025.114127_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009539","article-title":"Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice","volume":"5","author":"Khanna","year":"2010","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jconrel.2025.114127_bb0040","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.immuni.2016.01.002","article-title":"Erythropoeitin signaling in macrophages promotes dying cell clearance and immune tolerance","volume":"44","author":"Luo","year":"2016","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.jconrel.2025.114127_bb0045","article-title":"The cell biology of inflammation: from common traits to remarkable immunological adaptations","volume":"219","author":"Helen","year":"2020","journal-title":"J. Cell Biol."},{"issue":"9","key":"10.1016\/j.jconrel.2025.114127_bb0050","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1021\/acsmacrolett.7b00592","article-title":"Apoptotic cell membrane-inspired polymer for immunosuppression","volume":"6","author":"Nakagawa","year":"2017","journal-title":"ACS Macro Lett."},{"issue":"8008","key":"10.1016\/j.jconrel.2025.114127_bb0060","article-title":"CGRP sensory neurons promote tissue healing via neutrophils and macrophages","volume":"628","author":"Yen-Zhen","year":"2024","journal-title":"Nature"},{"issue":"7915","key":"10.1016\/j.jconrel.2025.114127_bb0065","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41586-022-04754-6","article-title":"Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes","volume":"606","author":"Maschalidi","year":"2022","journal-title":"Nature"},{"issue":"26","key":"10.1016\/j.jconrel.2025.114127_bb0070","article-title":"Inhaled pro-Efferocytic Nanozymes promote resolution of acute lung injury","volume":"9","author":"Haiying","year":"2022","journal-title":"Adv. Sci. (Weinh.)."},{"issue":"0","key":"10.1016\/j.jconrel.2025.114127_bb0075","article-title":"Elucidating the dual roles of apoptosis and necroptosis in diabetic wound healing: implications for therapeutic intervention","volume":"13","author":"Xingqian","year":"2025","journal-title":"Burns & trauma."},{"issue":"33","key":"10.1016\/j.jconrel.2025.114127_bb0080","article-title":"Apoptotic neutrophil membrane-camouflaged liposomes for dually targeting synovial macrophages and fibroblasts to attenuate osteoarthritis","volume":"15","author":"Caifeng","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.jconrel.2025.114127_bb0085","article-title":"Neutrophil-like pH-responsive pro-efferocytic nanoparticles improve neurological recovery by promoting erythrophagocytosis after intracerebral hemorrhage","volume":"14","author":"Linfeng","year":"2024","journal-title":"Theranostics"},{"issue":"21","key":"10.1016\/j.jconrel.2025.114127_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242115903","article-title":"The Tolerogenic influence of dexamethasone on dendritic cells is accompanied by the induction of Efferocytosis, promoted by MERTK","volume":"24","author":"Li","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.114127_bb0095","doi-asserted-by":"crossref","first-page":"1415573","DOI":"10.3389\/fimmu.2024.1415573","article-title":"Efferocytosis in dendritic cells: an overlooked immunoregulatory process","volume":"15","author":"Ma","year":"2024","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114127_bb0100","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1038\/s41467-023-40519-z","article-title":"Cas9-mediated knockout of Ndrg2 enhances the regenerative potential of dendritic cells for wound healing","volume":"14","author":"Henn","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.114127_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122908","article-title":"Electrically-driven drug delivery into deep cutaneous tissue by conductive microneedles for fungal infection eradication and protective immunity","volume":"314","author":"Ghosh","year":"2025","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.jconrel.2025.114127_bb0110","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s41563-023-01689-9","article-title":"Pro-regenerative biomaterials recruit immunoregulatory dendritic cells after traumatic injury","volume":"23","author":"Lokwani","year":"2024","journal-title":"Nat. Mater."},{"issue":"4","key":"10.1016\/j.jconrel.2025.114127_bb0115","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI124049","article-title":"Suppression of the SLC7A11\/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma","volume":"130","author":"Hu","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2025.114127_bb0120","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.actbio.2023.05.016","article-title":"Reduction of neutrophil extracellular traps accelerates inflammatory resolution and increases bone formation on titanium implants","volume":"166","author":"Morandini","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2025.114127_bb0125","first-page":"183","article-title":"Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution","volume":"9","author":"Bao","year":"2022","journal-title":"Bioact Mater."},{"key":"10.1016\/j.jconrel.2025.114127_bb0130","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.actbio.2024.03.030","article-title":"A multi-mode Rhein-based nano-platform synergizing ferrotherapy\/chemotherapy-induced immunotherapy for enhanced tumor therapy","volume":"180","author":"Zhu","year":"2024","journal-title":"Acta Biomater."},{"issue":"45","key":"10.1016\/j.jconrel.2025.114127_bb0135","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202412253","article-title":"Engineered enucleated mesenchymal stem cells regulating immune microenvironment and promoting wound healing","volume":"36","author":"Chen","year":"2024","journal-title":"Adv. Mater."},{"issue":"29","key":"10.1016\/j.jconrel.2025.114127_bb0140","article-title":"Synthetic biomimetic liposomes harness efferocytosis machinery for highly efficient macrophages-targeted drug delivery to alleviate inflammation","volume":"11","author":"Run","year":"2024","journal-title":"Adv. Sci. (Weinh.)."},{"issue":"6","key":"10.1016\/j.jconrel.2025.114127_bb0145","article-title":"A+T rich interaction domain protein 3a (Arid3a) impairs Mertk-mediated efferocytosis in cholestasis","volume":"79","author":"Ruiling","year":"2023","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114127_bb0150","article-title":"Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment","volume":"18","author":"Kaylav","year":"2019","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.jconrel.2025.114127_bb0155","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1038\/s41467-024-46564-6","article-title":"Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis","volume":"15","author":"Nerviani","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114127_bb0160","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.12529","article-title":"Efferocytosis in multisystem diseases (review)","volume":"25","author":"Zhang","year":"2022","journal-title":"Mol. Med. Rep."},{"issue":"4","key":"10.1016\/j.jconrel.2025.114127_bb0165","article-title":"Efferocytosis in health and disease","volume":"20","author":"Amanda","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"0","key":"10.1016\/j.jconrel.2025.114127_bb0170","article-title":"SLC7A11-ROS\/\u03b1KG-AMPK axis regulates liver inflammation through mitophagy and impairs liver fibrosis and NASH progression","volume":"72","author":"Tingting","year":"2024","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.jconrel.2025.114127_bb0175","article-title":"Cell death, IL-1 cytokines, and tumor progression","volume":"43","author":"Long","year":"2025","journal-title":"Cancer Cell"},{"issue":"0","key":"10.1016\/j.jconrel.2025.114127_bb0180","article-title":"Efferocytosis of vascular cells in cardiovascular disease","volume":"229","author":"Tori","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2025.114127_bb0185","article-title":"Lymph node macrophages drive immune tolerance and resistance to cancer therapy by induction of the immune-regulatory cytokine IL-33","volume":"0","author":"Sara","year":"2025","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.jconrel.2025.114127_bb0190","article-title":"Lactobacillus intestinalis facilitates tumor-derived CCL5 to recruit dendritic cell and suppress colorectal tumorigenesis","volume":"17","author":"Yong","year":"2025","journal-title":"Gut Microbes"},{"issue":"3","key":"10.1016\/j.jconrel.2025.114127_bb0195","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/imm.12731","article-title":"Distinctive role of efferocytosis in dendritic cell maturation and migration in sterile or infectious conditions","volume":"151","author":"Penteado","year":"2017","journal-title":"Immunology"},{"issue":"0","key":"10.1016\/j.jconrel.2025.114127_bb0200","article-title":"Convergence of nanomedicine and neutrophils for drug delivery","volume":"35","author":"Sichen","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2025.114127_bb0205","first-page":"461","article-title":"Construction of multifunctional hydrogel based on the tannic acid-metal coating decorated MoS dual nanozyme for bacteria-infected wound healing","volume":"9","author":"Li","year":"2022","journal-title":"Bioact Mater."},{"key":"10.1016\/j.jconrel.2025.114127_bb0210","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.actbio.2025.02.046","article-title":"A calcitonin gene-related peptide co-crosslinked hydrogel promotes diabetic wound healing by regulating M2 macrophage polarization and angiogenesis","volume":"196","author":"Li","year":"2025","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.jconrel.2025.114127_bb0215","first-page":"E21","article-title":"Efficacy of a nanofabricated electrospun wound matrix in treating full-thickness cutaneous wounds in a porcine model","volume":"30","author":"MacEwan","year":"2018","journal-title":"Wounds"},{"issue":"4","key":"10.1016\/j.jconrel.2025.114127_bb0220","article-title":"Nanodrug-engineered exosomes achieve a jointly dual-pathway inhibition on Cuproptosis","volume":"12","author":"Sun","year":"2025","journal-title":"Adv Sci (Weinh)."},{"issue":"2","key":"10.1016\/j.jconrel.2025.114127_bb0225","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/s41418-019-0380-z","article-title":"ATF3 promotes erastin-induced ferroptosis by suppressing system xc","volume":"27","author":"Wang","year":"2020","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.jconrel.2025.114127_bb0230","article-title":"Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target","volume":"24","author":"Luika","year":"2013","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.jconrel.2025.114127_bb0235","article-title":"Natural product triptolide induces GSDME-mediated pyroptosis in head and neck cancer through suppressing mitochondrial hexokinase-\u0399\u0399","volume":"40","author":"Jing","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114127_bb0240","article-title":"Augmented ERO1\u03b1 upon mTORC1 activation induces ferroptosis resistance and tumor progression via upregulation of SLC7A11","volume":"43","author":"Zixi","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"0","key":"10.1016\/j.jconrel.2025.114127_bb0245","article-title":"Soft apoptotic-cell-inspired nanoparticles persistently bind to macrophage membranes and promote anti-inflammatory and pro-healing effects","volume":"131","author":"Guanglin","year":"2021","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114127_bb0250","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41571-022-00699-x","article-title":"Targeting drugs to tumours using cell membrane-coated nanoparticles","volume":"20","author":"Fang","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"9","key":"10.1016\/j.jconrel.2025.114127_bb0255","article-title":"pH-responsive hybrid platelet membrane-coated nanobomb with deep tumor penetration ability and enhanced cancer thermal\/chemodynamic therapy","volume":"12","author":"Huang","year":"2022","journal-title":"Theranostics"},{"issue":"0","key":"10.1016\/j.jconrel.2025.114127_bb0260","article-title":"Black phosphorus nanoplatform coated with platelet membrane improves inhibition of atherosclerosis progression through macrophage targeting and efferocytosis","volume":"192","author":"Jiahui","year":"2024","journal-title":"Acta Biomater."},{"issue":"13","key":"10.1016\/j.jconrel.2025.114127_bb0265","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202304304","article-title":"Efferocytosis-inspired biomimetic Nanoplatform for targeted acute lung injury therapy","volume":"13","author":"Huang","year":"2024","journal-title":"Adv. Healthc. Mater."},{"issue":"0","key":"10.1016\/j.jconrel.2025.114127_bb0270","article-title":"A bioactive composite hydrogel dressing that promotes healing of both acute and chronic diabetic skin wounds","volume":"34","author":"Shunlai","year":"2024","journal-title":"Bioact Mater."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114127_bb0275","article-title":"CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer","volume":"15","author":"Maosheng","year":"2024","journal-title":"Nat. Commun."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925007382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925007382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T08:43:23Z","timestamp":1777193003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925007382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":54,"alternative-id":["S0168365925007382"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114127","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apoptotic neutrophil membrane-modified nanoparticles promote wound healing by enhancing efferocytotic capacity of dendritic cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114127","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114127"}}