{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T12:52:38Z","timestamp":1793710358270,"version":"4.6.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ21H180011"],"award-info":[{"award-number":["LQ21H180011"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["KYYW202303"],"award-info":[{"award-number":["KYYW202303"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271076"],"award-info":[{"award-number":["82271076"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jconrel.2025.114229","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:23:56Z","timestamp":1757607836000},"page":"114229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Alkaline phosphatase-responsive hydrogel for efficient management of autoimmune intraocular inflammation"],"prefix":"10.1016","volume":"387","author":[{"given":"Yijing","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanting","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanyu","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.114229_bb0005","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ophtha.2003.06.014","article-title":"Incidence and prevalence of uveitis in northern California; the northern California epidemiology of uveitis study","volume":"111","author":"Gritz","year":"2004","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jconrel.2025.114229_bb0010","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1136\/bjo.80.4.332","article-title":"Causes and frequency of blindness in patients with intraocular inflammatory disease","volume":"80","author":"Rothova","year":"1996","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.114229_bb0015","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.preteyeres.2011.06.005","article-title":"Understanding uveitis: the impact of research on visual outcomes","volume":"30","author":"de Smet","year":"2011","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.jconrel.2025.114229_bb0020","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s12016-014-8425-z","article-title":"Ocular involvement of Beh\u00e7et\u2019s syndrome: a comprehensive review","volume":"49","author":"Ozyazgan","year":"2015","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jconrel.2025.114229_bb0025","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.1167\/iovs.12-10981","article-title":"Vision-related functioning outcomes of dexamethasone intravitreal implant in noninfectious intermediate or posterior uveitis","volume":"54","author":"Lightman","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.114229_bb0030","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.otc.2010.04.003","article-title":"A comprehensive review of the adverse effects of systemic corticosteroids","volume":"43","author":"Poetker","year":"2010","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"10.1016\/j.jconrel.2025.114229_bb0035","first-page":"477","article-title":"Intravitreal injections: what do patients prefer? Analysis of patient\u2019s satisfaction and preferences about where to perform intravitreal injections","volume":"89","author":"Rodriguez Ramirez","year":"2014","journal-title":"Arch. Soc. Esp. Oftalmol."},{"key":"10.1016\/j.jconrel.2025.114229_bb0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1089\/jop.2015.0047","article-title":"Recent advances in topical ocular drug delivery","volume":"32","author":"Yellepeddi","year":"2016","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2025.114229_bb0045","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.2147\/OPTH.S118409","article-title":"Systemic side effects of eye drops: a pharmacokinetic perspective","volume":"10","author":"Farkouh","year":"2016","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.114229_bb0050","article-title":"Innovative Nanotechnology in Drug Delivery Systems for Advanced Treatment of Posterior Segment Ocular Diseases","volume":"vol. 11","author":"Wu","year":"2024","journal-title":"Advanced Science (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.jconrel.2025.114229_bb0055","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jconrel.2019.01.018","article-title":"Controlled release of corticosteroid with biodegradable nanoparticles for treating experimental autoimmune uveitis","volume":"296","author":"Luo","year":"2019","journal-title":"Journal of Controlled Release : Official Journal of the Controlled Release Society"},{"key":"10.1016\/j.jconrel.2025.114229_bb0060","series-title":"The Cochrane database of systematic reviews","article-title":"Corticosteroid implants for chronic non-infectious uveitis","volume":"8","author":"Reddy","year":"2023"},{"key":"10.1016\/j.jconrel.2025.114229_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114108","article-title":"A combination of inhibiting microglia activity and remodeling gut microenvironment suppresses the development and progression of experimental autoimmune uveitis","volume":"180","author":"Zhou","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jconrel.2025.114229_bb0070","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1167\/iovs.64.5.21","article-title":"Apigenin alleviates autoimmune uveitis by inhibiting microglia M1 pro-inflammatory polarization","volume":"64","author":"Shu","year":"2023","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.114229_bb0075","doi-asserted-by":"crossref","DOI":"10.1002\/cti2.1479","article-title":"Inflammatory cytokines as mediators of retinal endothelial barrier dysfunction in non-infectious uveitis","volume":"12","author":"Ferreira","year":"2023","journal-title":"Clinical & Translational Immunology"},{"key":"10.1016\/j.jconrel.2025.114229_bb0080","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/(SICI)1097-4547(19970801)49:3<268::AID-JNR2>3.0.CO;2-A","article-title":"Blood-retinal barrier (BRB) breakdown in experimental autoimmune uveoretinitis: comparison with vascular endothelial growth factor, tumor necrosis factor alpha, and interleukin-1beta-mediated breakdown","volume":"49","author":"Luna","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.jconrel.2025.114229_bb0085","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1365-2249.1992.tb06474.x","article-title":"Effect of lymphocytic infiltration on the blood-retinal barrier in experimental autoimmune uveoretinitis","volume":"88","author":"Lightman","year":"1992","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jconrel.2025.114229_bb0090","doi-asserted-by":"crossref","first-page":"20033","DOI":"10.1038\/s41598-024-68401-y","article-title":"Single-cell transcriptomic analysis of retinal immune regulation and blood-retinal barrier function during experimental autoimmune uveitis","volume":"14","author":"Quinn","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.114229_bb0095","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1167\/iovs.10-5768","article-title":"TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis","volume":"52","author":"Huang","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.114229_bb0100","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1089\/jop.2010.0079","article-title":"Effect of infliximab on tumor necrosis factor-alpha-induced alterations in retinal microvascular endothelial cells and retinal pigment epithelial cells","volume":"26","author":"Li","year":"2010","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2025.114229_bb0105","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1167\/iovs.16-21091","article-title":"TNF\u03b1-induced disruption of the blood-retinal barrier in vitro is regulated by intracellular 3\u2032,5\u2019-cyclic adenosine monophosphate levels","volume":"58","author":"van der Wijk","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.114229_bb0110","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3389\/fimmu.2020.00358","article-title":"Cytokine profiling in aqueous humor samples from patients with non-infectious uveitis associated with systemic inflammatory diseases","volume":"11","author":"Bonacini","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.114229_bb0115","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.clim.2011.01.014","article-title":"Cytokine Profiles in Aqueous Humor of Patients with Different Clinical Entities of Endogenous Uveitis","volume":"vol. 139","author":"El-Asrar","year":"2011","journal-title":"Clinical Immunology (Orlando, Fla.)"},{"key":"10.1016\/j.jconrel.2025.114229_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.740057","article-title":"TNF-\u03b1 in uveitis: from bench to clinic","volume":"12","author":"Jiang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jconrel.2025.114229_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15010205","article-title":"Ocular delivery of therapeutic proteins: a review","volume":"15","author":"Shastri","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.114229_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107430","article-title":"Comparative study of adalimumab versus conventional therapy in sight-threatening refractory Beh\u00e7et\u2019s uveitis with vasculitis","volume":"93","author":"Yang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jconrel.2025.114229_bb0135","first-page":"619","article-title":"Increased serum alkaline phosphatase activity in Beh\u00e7et\u2019s disease","volume":"7","author":"Takeuchi","year":"1989","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.jconrel.2025.114229_bb0140","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.actbio.2017.05.024","article-title":"Calcium ion coordinated dexamethasone supramolecular hydrogel as therapeutic alternative for control of non-infectious uveitis","volume":"61","author":"Wu","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2025.114229_bb0145","article-title":"Enhanced ocular delivery of Beva via ultra-small polymeric micelles for noninvasive anti-VEGF therapy","volume":"36","author":"Yang","year":"2024","journal-title":"Advanced materials (Deerfield Beach Fla)"},{"key":"10.1016\/j.jconrel.2025.114229_bb0150","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1038\/s41467-019-10296-9","article-title":"Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity","volume":"10","author":"Zhao","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.114229_bb0155","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jconrel.2022.03.011","article-title":"Enzyme-instructed self-assembly of peptide-drug conjugates in tear fluids for ocular drug delivery","volume":"344","author":"Hu","year":"2022","journal-title":"Journal of controlled release : official journal of the Controlled Release Society"},{"key":"10.1016\/j.jconrel.2025.114229_bb0160","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jconrel.2019.11.014","article-title":"Size and affinity kinetics of nanobodies influence targeting and penetration of solid tumours","volume":"317","author":"Debie","year":"2020","journal-title":"Journal of controlled release : official journal of the Controlled Release Society"},{"key":"10.1016\/j.jconrel.2025.114229_bb0165","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/978-1-60761-720-4_22","article-title":"Rodent Models of Experimental Autoimmune Uveitis","volume":"vol. 900","author":"Agarwal","year":"2012","journal-title":"Methods in Molecular Biology (Clifton, N.J.)"},{"key":"10.1016\/j.jconrel.2025.114229_bb0170","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4103\/0301-4738.156914","article-title":"Experimental autoimmune uveitis and other animal models of uveitis: an update","volume":"63","author":"Bansal","year":"2015","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.jconrel.2025.114229_bb0175","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41467-025-55904-z","article-title":"Injectable supramolecular hydrogel co-loading abemaciclib\/NLG919 for neoadjuvant immunotherapy of triple-negative breast cancer","volume":"16","author":"Zhu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.114229_bb0180","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1038\/s41467-019-09601-3","article-title":"Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation","volume":"10","author":"Zheng","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.114229_bb0185","doi-asserted-by":"crossref","first-page":"6680","DOI":"10.1002\/adma.201601147","article-title":"A Supramolecular Shear-Thinning Anti-Inflammatory Steroid Hydrogel","volume":"vol. 28","author":"Liu","year":"2016","journal-title":"Advanced Materials (Deerfield Beach, Fla.)"},{"key":"10.1016\/j.jconrel.2025.114229_bb0190","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1021\/acs.nanolett.0c02684","article-title":"Injectable anti-inflammatory nanofiber hydrogel to achieve systemic immunotherapy post local administration","volume":"20","author":"Chen","year":"2020","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2025.114229_bb0195","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1021\/acsbiomaterials.0c01600","article-title":"Metal-organic framework-based composites for protein delivery and therapeutics","volume":"8","author":"Guo","year":"2022","journal-title":"ACS Biomater Sci. Eng."},{"key":"10.1016\/j.jconrel.2025.114229_bb0200","doi-asserted-by":"crossref","first-page":"8209","DOI":"10.1021\/acsnano.3c12203","article-title":"Engineering matrix-free drug protein nanoparticles with promising penetration through biobarriers for treating corneal neovascularization","volume":"18","author":"Xu","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.114229_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052719","article-title":"The role of tumor necrosis factor alpha (TNF-\u03b1) in autoimmune disease and current TNF-\u03b1 inhibitors in therapeutics","volume":"22","author":"Jang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.114229_bb0210","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1167\/iovs.17-23127","article-title":"Local S100A8 levels correlate with recurrence of experimental autoimmune uveitis and promote pathogenic T cell activity","volume":"59","author":"Yun","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2025.114229_bb0215","doi-asserted-by":"crossref","first-page":"e780","DOI":"10.1016\/S2665-9913(24)00194-2","article-title":"Combinations of immunomodulatory agents for prevention of uveitis relapse in patients with severe Beh\u00e7et's disease already on corticosteroid therapy: a randomised, open-label, head-to-head trial","volume":"6","author":"Zhong","year":"2024","journal-title":"The Lancet Rheumatology"},{"key":"10.1016\/j.jconrel.2025.114229_bb0220","first-page":"667","article-title":"Combination therapy for Beh\u00e7et uveitis","volume":"20","author":"Webster","year":"2024","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jconrel.2025.114229_bb0225","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nri3391","article-title":"Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gates","volume":"13","author":"Shechter","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2025.114229_bb0230","doi-asserted-by":"crossref","unstructured":"X. Liu, Y.S. Lee, C.R. Yu, C.E. Egwuagu, Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases, Journal of immunology (Baltimore Md. : 1950), 180 (2008) 6070\u20136076.","DOI":"10.4049\/jimmunol.180.9.6070"},{"key":"10.1016\/j.jconrel.2025.114229_bb0235","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nm1585","article-title":"TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27\/STAT1","volume":"13","author":"Amadi-Obi","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2025.114229_bb0240","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.149346","article-title":"Endothelial STING controls T cell transmigration in an IFNI-dependent manner","volume":"6","author":"Anastasiou","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.jconrel.2025.114229_bb0245","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/abbs\/gmab019","article-title":"Elevated ZIPK is required for TNF-\u03b1-induced cell adhesion molecule expression and leucocyte adhesion in endothelial cells","volume":"53","author":"Zeng","year":"2021","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.jconrel.2025.114229_bb0250","doi-asserted-by":"crossref","first-page":"9989","DOI":"10.1073\/pnas.1820387116","article-title":"Retinal microglia initiate neuroinflammation in ocular autoimmunity","volume":"116","author":"Okunuki","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jconrel.2025.114229_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109726","article-title":"Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling","volume":"36","author":"Hu","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.jconrel.2025.114229_bb0260","doi-asserted-by":"crossref","first-page":"6693542","DOI":"10.1155\/2021\/6693542","article-title":"Cytokines that modulate the differentiation of Th17 cells in autoimmune uveitis","volume":"2021","author":"Guo","year":"2021","journal-title":"J Immunol Res"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925008417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925008417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:08:46Z","timestamp":1780477726000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925008417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":52,"alternative-id":["S0168365925008417"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114229","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alkaline phosphatase-responsive hydrogel for efficient management of autoimmune intraocular inflammation","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114229","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114229"}}