{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:08:34Z","timestamp":1792112914207,"version":"4.4.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ5597"],"award-info":[{"award-number":["2024JJ5597"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019054","name":"Changsha Science and Technology Project","doi-asserted-by":"publisher","award":["kh2205037"],"award-info":[{"award-number":["kh2205037"]}],"id":[{"id":"10.13039\/501100019054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030071"],"award-info":[{"award-number":["82030071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272495"],"award-info":[{"award-number":["82272495"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jconrel.2025.114308","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T17:00:52Z","timestamp":1760115652000},"page":"114308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"P1","title":["Engineered lesion-homing liposomes encapsulating Rosuvastatin enhance spinal cord injury repair by preventing the formation of foamy macrophages"],"prefix":"10.1016","volume":"388","author":[{"given":"Zhide","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haicheng","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rundong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aozhuo","family":"Zu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianding","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyue","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.114308_bb0005","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1474-4422(18)30415-0","article-title":"Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the global burden of disease study 2016","volume":"18","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jconrel.2025.114308_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113704","article-title":"Neuroimmunological therapies for treating spinal cord injury: evidence and future perspectives","volume":"341","author":"Chio","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jconrel.2025.114308_bb0015","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/brain\/awn334","article-title":"Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling","volume":"132","author":"Baer","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.jconrel.2025.114308_bb0020","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0896-6273(94)90247-X","article-title":"Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth","volume":"13","author":"McKerracher","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.jconrel.2025.114308_bb0025","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fnmol.2015.00051","article-title":"MAG, myelin and overcoming growth inhibition in the CNS","volume":"8","author":"McKerracher","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.jconrel.2025.114308_bb0030","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1111\/cns.13899","article-title":"Phagocytic microglia and macrophages in brain injury and repair","volume":"28","author":"Yu","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jconrel.2025.114308_bb0035","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s11011-014-9531-6","article-title":"The role of the microglia in acute CNS injury","volume":"30","author":"Kawabori","year":"2015","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.jconrel.2025.114308_bb0040","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/(SICI)1098-1136(200003)30:1<92::AID-GLIA10>3.0.CO;2-W","article-title":"Lysophosphatidylcholine induces rapid recruitment and activation of macrophages in the adult mouse spinal cord","volume":"30","author":"Ousman","year":"2000","journal-title":"Glia"},{"key":"10.1016\/j.jconrel.2025.114308_bb0045","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nn.3469","article-title":"M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination","volume":"16","author":"Miron","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jconrel.2025.114308_bb0050","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1093\/brain\/awab250","article-title":"Macrophage phagocytosis after spinal cord injury: when friends become foes","volume":"144","author":"Van Broeckhoven","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.jconrel.2025.114308_bb0055","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3389\/fimmu.2018.00127","article-title":"Macrophage clearance of apoptotic cells: a critical assessment","volume":"9","author":"Gordon","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.114308_bb0060","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/glia.22774","article-title":"Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris","volume":"63","author":"Wang","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.jconrel.2025.114308_bb0065","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.44702","article-title":"CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes","volume":"8","author":"Dimas","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jconrel.2025.114308_bb0070","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev-cellbio-100913-013101","article-title":"Myelination of the nervous system: mechanisms and functions","volume":"30","author":"Nave","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.jconrel.2025.114308_bb0075","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.neuron.2014.07.027","article-title":"TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord","volume":"83","author":"Kroner","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.jconrel.2025.114308_bb0080","doi-asserted-by":"crossref","first-page":"13435","DOI":"10.1523\/JNEUROSCI.3257-09.2009","article-title":"Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord","volume":"29","author":"Kigerl","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jconrel.2025.114308_bb0085","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12974-020-01735-2","article-title":"Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury","volume":"17","author":"Kong","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jconrel.2025.114308_bb0090","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12967-021-02727-3","article-title":"Rosuvastatin exerts anti-atherosclerotic effects by improving macrophage-related foam cell formation and polarization conversion via mediating autophagic activities","volume":"19","author":"Zhang","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.114308_bb0095","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1055\/s-2007-969031","article-title":"The evil in atherosclerosis: adherent platelets induce foam cell formation","volume":"33","author":"Daub","year":"2007","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.jconrel.2025.114308_bb0100","doi-asserted-by":"crossref","first-page":"I21","DOI":"10.1002\/clc.4960261307","article-title":"Treating hypercholesterolemia: looking forward","volume":"26","author":"Gotto","year":"2003","journal-title":"Clin. Cardiol."},{"key":"10.1016\/j.jconrel.2025.114308_bb0105","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/sc.2015.180","article-title":"Mortality benefit of statin use in traumatic spinal cord injury: a retrospective analysis","volume":"54","author":"Stillman","year":"2016","journal-title":"Spinal Cord"},{"key":"10.1016\/j.jconrel.2025.114308_bb0110","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejphar.2014.07.042","article-title":"Neuroprotective effects of rosuvastatin against traumatic spinal cord injury in rats","volume":"741","author":"Kahveci","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jconrel.2025.114308_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19041106","article-title":"A single dose of atorvastatin applied acutely after spinal cord injury suppresses inflammation, apoptosis, and promotes axon outgrowth, which might be essential for favorable functional outcome","volume":"19","author":"Bimbova","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.114308_bb0120","first-page":"722","article-title":"Simvastatin in an experimental spinal cord injury model: a histopathological and biochemical evidence based study","volume":"121","author":"Tascioglu","year":"2020","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.jconrel.2025.114308_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2016.02.012","article-title":"Rosuvastatin: beyond the cholesterol-lowering effect","volume":"107","author":"Cortese","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jconrel.2025.114308_bb0130","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.2147\/DDDT.S332352","article-title":"Combination therapy of ezetimibe and Rosuvastatin for dyslipidemia: current insights","volume":"16","author":"Chilbert","year":"2022","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.jconrel.2025.114308_bb0135","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/1440-1681.13040","article-title":"Unfolding the pleiotropic facades of rosuvastatin in therapeutic intervention of myriads of neurodegenerative disorders","volume":"46","author":"Husain","year":"2019","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.jconrel.2025.114308_bb0140","first-page":"328","article-title":"Engineered extracellular vesicles for delivery of siRNA promoting targeted repair of traumatic spinal cord injury","volume":"23","author":"Rong","year":"2023","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jconrel.2025.114308_bb0145","first-page":"427","article-title":"Targeted transplantation of engineered mitochondrial compound promotes functional recovery after spinal cord injury by enhancing macrophage phagocytosis","volume":"32","author":"Xu","year":"2024","journal-title":"Bioact Mater"},{"key":"10.1016\/j.jconrel.2025.114308_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113851","article-title":"Liposome composition in drug delivery design, synthesis, characterization, and clinical application","volume":"176","author":"Large","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.114308_bb0155","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.jconrel.2020.09.055","article-title":"Peptide-functionalized liposomes as therapeutic and diagnostic tools for cancer treatment","volume":"329","author":"Sonju","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114308_bb0160","article-title":"Barrier-penetrating liposome targeted delivery of basic fibroblast growth factor for spinal cord injury repair","volume":"18","author":"Wu","year":"2023","journal-title":"Mater Today Bio"},{"key":"10.1016\/j.jconrel.2025.114308_bb0165","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-0716-2954-3_4","article-title":"Thin-film hydration followed by extrusion method for liposome preparation","volume":"2622","author":"Zhang","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jconrel.2025.114308_bb0170","article-title":"Sphingosine 1-phosphate liposomes for targeted nitric oxide delivery to mediate anticancer effects against brain glioma tumors","volume":"33","author":"Liu","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2025.114308_bb0175","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.chroma.2015.09.048","article-title":"Size fractionation and size characterization of nanoemulsions of lipid droplets and large unilamellar lipid vesicles by asymmetric-flow field-flow fractionation\/multi-angle light scattering and dynamic light scattering","volume":"1418","author":"Vezo\u010dnik","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jconrel.2025.114308_bb0180","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1080\/02652048.2022.2131920","article-title":"Liposome and microemulsion loaded with ibuprofen: from preparation to mechanism of drug transport","volume":"39","author":"Xu","year":"2022","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.jconrel.2025.114308_bb0185","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s12974-021-02231-x","article-title":"Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression","volume":"18","author":"Cui","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jconrel.2025.114308_bb0190","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12951-020-00766-4","article-title":"TAT-modified serum albumin nanoparticles for sustained-release of tetramethylpyrazine and improved targeting to spinal cord injury","volume":"19","author":"Lin","year":"2021","journal-title":"J Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2025.114308_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.341434","article-title":"Quantitative biochemical phenotypic heterogeneity of macrophages after myelin debris phagocytosis at a single cell level by synchrotron radiation fourier transform infrared microspectroscopy","volume":"1271","author":"Sheng","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.jconrel.2025.114308_bb0200","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1016\/j.ymthe.2019.08.009","article-title":"UTX\/KDM6A deletion promotes recovery of spinal cord injury by epigenetically regulating vascular regeneration","volume":"27","author":"Ni","year":"2019","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2025.114308_bb0205","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.omtm.2020.12.004","article-title":"UTX\/KDM6A deletion promotes the recovery of spinal cord injury by epigenetically triggering intrinsic neural regeneration","volume":"20","author":"Guo","year":"2021","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1016\/j.jconrel.2025.114308_bb0210","doi-asserted-by":"crossref","first-page":"18008","DOI":"10.1021\/acsnano.3c04423","article-title":"Targeted delivery of RGD-CD146(+)CD271(+) human umbilical cord mesenchymal stem cell-derived exosomes promotes blood-spinal cord barrier repair after spinal cord injury","volume":"17","author":"Xie","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.114308_bb0215","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12974-023-02833-7","article-title":"Endothelial progenitor cell-derived exosomes promote anti-inflammatory macrophages via SOCS3\/JAK2\/STAT3 axis and improve the outcome of spinal cord injury","volume":"20","author":"Yuan","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jconrel.2025.114308_bb0220","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1523\/JNEUROSCI.2751-16.2017","article-title":"Macrophage transcriptional profile identifies lipid catabolic pathways that can be therapeutically targeted after spinal cord injury","volume":"37","author":"Zhu","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jconrel.2025.114308_bb0225","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s40820-019-0252-6","article-title":"Synthesis and characterization of a silica-based drug delivery system for spinal cord injury therapy","volume":"11","author":"Sun","year":"2019","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2025.114308_bb0230","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/2051-5960-1-43","article-title":"Myelin alters the inflammatory phenotype of macrophages by activating PPARs","volume":"1","author":"Bogie","year":"2013","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.jconrel.2025.114308_bb0235","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00441-021-03477-w","article-title":"New insights into glial scar formation after spinal cord injury","volume":"387","author":"Tran","year":"2022","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.jconrel.2025.114308_bb0240","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.conb.2014.02.011","article-title":"Nogo limits neural plasticity and recovery from injury","volume":"27","author":"Schwab","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.jconrel.2025.114308_bb0245","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1523\/JNEUROSCI.11-11-03398.1991","article-title":"Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes","volume":"11","author":"McKeon","year":"1991","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jconrel.2025.114308_bb0250","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21207533","article-title":"Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms","volume":"21","author":"Anjum","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.114308_bb0255","article-title":"Immune response following traumatic spinal cord injury: pathophysiology and therapies","volume":"13","author":"Sterner","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.114308_bb0260","article-title":"The role of foam cells in spinal cord injury: challenges and opportunities for intervention","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.114308_bb0265","doi-asserted-by":"crossref","first-page":"977","DOI":"10.4103\/1673-5374.184498","article-title":"Atorvastatin activates autophagy and promotes neurological function recovery after spinal cord injury","volume":"11","author":"Gao","year":"2016","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jconrel.2025.114308_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2022.102757","article-title":"Liposomes as biocompatible and smart delivery systems - the current state","volume":"309","author":"Dymek","year":"2022","journal-title":"Adv. Colloid Interf. Sci."},{"key":"10.1016\/j.jconrel.2025.114308_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120571","article-title":"Design of liposomes as drug delivery system for therapeutic applications","volume":"601","author":"Guimar\u00e3es","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.114308_bb0280","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.908401","article-title":"CAQK, a peptide associating with extracellular matrix components targets sites of demyelinating injuries","volume":"16","author":"Abi-Ghanem","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jconrel.2025.114308_bb0285","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s11671-018-2638-7","article-title":"Recent status of nanomaterial fabrication and their potential applications in neurological disease management","volume":"13","author":"Siddiqi","year":"2018","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.jconrel.2025.114308_bb0290","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1089\/neu.2020.7413","article-title":"Blood-spinal cord barrier in spinal cord injury: a review","volume":"38","author":"Jin","year":"2021","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.jconrel.2025.114308_bb0295","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.bbi.2024.04.013","article-title":"Targeting foamy macrophages by manipulating ABCA1 expression to facilitate lesion healing in the injured spinal cord","volume":"119","author":"Wang","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jconrel.2025.114308_bb0300","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41586-024-07185-7","article-title":"APOE4\/4 is linked to damaging lipid droplets in Alzheimer's disease microglia","volume":"628","author":"Haney","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2025.114308_bb0305","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2017.08.008","article-title":"The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases","volume":"47","author":"Krasemann","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.jconrel.2025.114308_bb0310","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925009216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925009216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T14:11:30Z","timestamp":1769868690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925009216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":62,"alternative-id":["S0168365925009216"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114308","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineered lesion-homing liposomes encapsulating Rosuvastatin enhance spinal cord injury repair by preventing the formation of foamy macrophages","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114308","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114308"}}