{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:57:22Z","timestamp":1793235442445,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2025-00513566"],"award-info":[{"award-number":["RS-2025-00513566"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Korea Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2023-00218648"],"award-info":[{"award-number":["RS-2023-00218648"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003052","name":"Korea Ministry of Trade Industry and Energy","doi-asserted-by":"publisher","award":["20018412"],"award-info":[{"award-number":["20018412"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jconrel.2025.114389","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:13:32Z","timestamp":1762272812000},"page":"114389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"P2","title":["Focused ultrasound-triggered doxorubicin liposomes reshape tumor microenvironment to boost checkpoint depletion in triple-negative breast cancer model"],"prefix":"10.1016","volume":"388","author":[{"given":"Sang Nam","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungwon","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doyeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyoung","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak Jong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Taik","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2024","key":"10.1016\/j.jconrel.2025.114389_bb0005","first-page":"197","article-title":"A review of high-intensity focused ultrasound","volume":"4","author":"Turner","year":"2024","journal-title":"Int. J. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.114389_bb0010","first-page":"1","article-title":"High-intensity focused ultrasound therapy for pancreatic cancer","volume":"1","author":"Sofuni","year":"2022","journal-title":"J. Med. Ultrason."},{"key":"10.1016\/j.jconrel.2025.114389_bb0015","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1007\/s10439-021-02833-9","article-title":"High-intensity focused ultrasound: a review of mechanisms and clinical applications","volume":"49","author":"Bachu","year":"2021","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2025.114389_bb0020","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.4049\/jimmunol.1901430","article-title":"Focused ultrasound for immunomodulation of the tumor microenvironment","volume":"205","author":"Joiner","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2025.114389_bb0025","article-title":"Ultrasound-mediated immune regulation in tumor immunotherapy","volume":"14","author":"Sun","year":"2022","journal-title":"Mater. Today Adv."},{"key":"10.1016\/j.jconrel.2025.114389_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1038347","article-title":"Mechanical high-intensity focused ultrasound creates unique tumor debris enhancing dendritic cell-induced T cell activation","volume":"13","author":"van den Bijgaart","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.114389_bb0035","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-006226","article-title":"Novel combination strategy of high intensity focused ultrasound (HIFU) and checkpoint blockade boosted by bioinspired and oxygen-supplied nanoprobe for multimodal imaging-guided cancer therapy","volume":"11","author":"Tang","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jconrel.2025.114389_bb0040","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003717","article-title":"Combination of ultrasound-based mechanical disruption of tumor with immune checkpoint blockade modifies tumor microenvironment and augments systemic antitumor immunity","volume":"10","author":"Abe","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jconrel.2025.114389_bb0045","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1158\/1078-0432.CCR-19-1604","article-title":"High-intensity focused ultrasound (hIFU) triggers immune sensitization of refractory murine neuroblastoma to checkpoint inhibitor therapy","volume":"26","author":"Eranki","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jconrel.2025.114389_bb0050","doi-asserted-by":"crossref","DOI":"10.1080\/10717544.2024.2342844","article-title":"Application of high intensity focused ultrasound combined with nanomaterials in anti-tumor therapy","volume":"31","author":"Zhang","year":"2024","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jconrel.2025.114389_bb0055","doi-asserted-by":"crossref","DOI":"10.3892\/etm.2023.11869","article-title":"Nanomedicines for high-intensity focused ultrasound cancer treatment and theranostics (review)","volume":"25","author":"Zheng","year":"2023","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jconrel.2025.114389_bb0060","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.jconrel.2014.04.048","article-title":"Controlled release for local delivery of drugs: barriers and models","volume":"190","author":"Weiser","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114389_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2019.00418","article-title":"Local delivery of therapeutics to the inner ear: the state of the science","volume":"13","author":"Anderson","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jconrel.2025.114389_bb0070","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.1158\/0008-5472.CAN-15-3034","article-title":"Doxorubicin-induced systemic inflammation is driven by upregulation of toll-like receptor TLR4 and endotoxin leakage","volume":"76","author":"Wang","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2025.114389_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111708","article-title":"Doxorubicin-induced cardiotoxicity: an update on the molecular mechanism and novel therapeutic strategies for effective management","volume":"139","author":"Rawat","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jconrel.2025.114389_bb0080","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.lfs.2018.03.023","article-title":"Toxicity of doxorubicin (Dox) to different experimental organ systems","volume":"200","author":"Pugazhendhi","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.jconrel.2025.114389_bb0085","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00784","article-title":"The tumor microenvironment in the response to immune checkpoint blockade therapies","volume":"11","author":"Petitprez","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.114389_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14153788","article-title":"Checkpoint markers and tumor microenvironment: what do we know?","volume":"14","author":"Ephraim","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jconrel.2025.114389_bb0095","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.7150\/thno.42998","article-title":"Modulation of tumor microenvironment for immunotherapy: focus on nanomaterial-based strategies","volume":"10","author":"Liu","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2025.114389_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.600573","article-title":"Immune checkpoint inhibitors in triple negative breast Cancer treatment: promising future prospects","volume":"10","author":"Thomas","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jconrel.2025.114389_bb0105","doi-asserted-by":"crossref","DOI":"10.1038\/s41523-022-00486-y","article-title":"Immunotherapy in triple negative breast cancer: beyond checkpoint inhibitors","volume":"8","author":"Abdou","year":"2022","journal-title":"NPJ Breast Cancer"},{"key":"10.1016\/j.jconrel.2025.114389_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107876","article-title":"Immune checkpoint inhibitors for triple-negative breast cancer: from immunological mechanisms to clinical evidence","volume":"98","author":"Farshbafnadi","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jconrel.2025.114389_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.1095839","article-title":"Triple negative breast cancer: immunogenicity, tumor microenvironment, and immunotherapy","volume":"13","author":"Loizides","year":"2023","journal-title":"Front. Genet."},{"key":"10.1016\/j.jconrel.2025.114389_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104683","article-title":"Tumor microenvironment: challenges and opportunities in targeting metastasis of triple negative breast cancer","volume":"153","author":"Deepak","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jconrel.2025.114389_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/CMAR.S316700","article-title":"The characteristics of tumor microenvironment in triple negative breast cancer","volume":"14","author":"Fan","year":"2022","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.jconrel.2025.114389_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41523-022-00468-0","article-title":"Triple negative breast cancer: Pitfalls and progress","volume":"8","author":"Zagami","year":"2022","journal-title":"Npj Breast Cancer"},{"key":"10.1016\/j.jconrel.2025.114389_bb0135","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/s41571-021-00565-2","article-title":"Treatment landscape of triple-negative breast cancer \u2014 expanded options, evolving needs","volume":"19","author":"Bianchini","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2025.114389_bb0140","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.3390\/pharmaceutics14071512","article-title":"Effects of lipid shape and interactions on the conformation, dynamics, and curvature of ultrasound-responsive liposomes","volume":"14","author":"Lee","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.114389_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14071314","article-title":"Ultrasound-responsive liposomes for targeted drug delivery combined with focused ultrasound","volume":"14","author":"Kim","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.114389_bb0150","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1136\/jitc-2021-003717","article-title":"Combination of ultrasound-based mechanical disruption of tumor with immune checkpoint blockade modifies tumor microenvironment and augments systemic antitumor immunity","volume":"10","author":"Abe","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jconrel.2025.114389_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14122603","article-title":"Evading doxorubicin-induced systemic immunosuppression using ultrasound-responsive liposomes combined with focused ultrasound","volume":"14","author":"Lee","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.114389_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-45542-z","article-title":"Boiling histotripsy-induced partial mechanical ablation modulates tumour microenvironment by promoting immunogenic cell death of cancers","volume":"9","author":"Pahk","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.114389_bb0165","doi-asserted-by":"crossref","first-page":"322","DOI":"10.56434\/j.arch.esp.urol.20247704.44","article-title":"The impact of high intensity focused ultrasound (HIFU) on tumor-specific immune responses of prostate cancer","volume":"77","author":"Chen","year":"2024","journal-title":"Arch. Esp. Urol."},{"key":"10.1016\/j.jconrel.2025.114389_bb0170","first-page":"1","article-title":"Characterizing focused-ultrasound mediated drug delivery to the heterogeneous primate brain in vivo with acoustic monitoring","volume":"6","author":"Wu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.114389_bb0175","doi-asserted-by":"crossref","first-page":"36786","DOI":"10.1021\/acsami.8b15368","article-title":"Nanoparticle-mediated acoustic cavitation enables high intensity focused ultrasound ablation without tissue heating","volume":"10","author":"Yildirim","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2025.114389_bb0180","first-page":"1","article-title":"Cavitation dose painting for focused ultrasound-induced blood-brain barrier disruption","volume":"9","author":"Yang","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.114389_bb0185","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1109\/TBME.2023.3266952","article-title":"Real-time passive acoustic mapping with enhanced spatial resolution in neuronavigation-guided focused ultrasound for blood\u2013brain barrier opening","volume":"70","author":"Bae","year":"2023","journal-title":"IEEE Trans. Biomed. Eng."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836592501003X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836592501003X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T08:58:25Z","timestamp":1780822705000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016836592501003X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":37,"alternative-id":["S016836592501003X"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114389","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Focused ultrasound-triggered doxorubicin liposomes reshape tumor microenvironment to boost checkpoint depletion in triple-negative breast cancer model","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114389","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114389"}}