{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:11:57Z","timestamp":1792685517045,"version":"4.5.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LZ22H060001"],"award-info":[{"award-number":["LZ22H060001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473857"],"award-info":[{"award-number":["82473857"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jconrel.2025.114406","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T05:50:41Z","timestamp":1763185841000},"page":"114406","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Sunitinib lipid nanoparticles remodel tumor vasculature to synergize with two-stage radiotherapy for enhanced radiosensitivity in breast Cancer"],"prefix":"10.1016","volume":"389","author":[{"given":"Peirong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhefan","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caini","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renxiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihe","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jconrel.2025.114406_bb0005","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.soc.2023.03.002","article-title":"Advances in radiotherapy for breast cancer","volume":"32","author":"Upadhyay","year":"2023","journal-title":"Surg. Oncol. Clin. N. Am."},{"key":"10.1016\/j.jconrel.2025.114406_bb0010","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/S0140-6736(20)32381-3","article-title":"Breast cancer","volume":"397","author":"Loibl","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2025.114406_bb0015","doi-asserted-by":"crossref","DOI":"10.1200\/EDBK_432442","article-title":"Systemic therapy in breast Cancer","volume":"44","author":"Corti","year":"2024","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"key":"10.1016\/j.jconrel.2025.114406_bb0020","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ejca.2017.06.014","article-title":"Preoperative breast radiation therapy: indications and perspectives","volume":"82","author":"Lightowlers","year":"2017","journal-title":"Eur. J. Cancer"},{"issue":"1","key":"10.1016\/j.jconrel.2025.114406_bb0025","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s13046-021-01932-8","article-title":"ALG3 contributes to stemness and radioresistance through regulating glycosylation of TGF-\u03b2 receptor II in breast cancer","volume":"40","author":"Sun","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jconrel.2025.114406_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2025.102351","article-title":"Mechanisms of radioresistance and radiosensitization strategies for triple negative breast Cancer","volume":"55","author":"Wang","year":"2025","journal-title":"Transl. Oncol."},{"issue":"6","key":"10.1016\/j.jconrel.2025.114406_bb0035","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/s12276-021-00640-9","article-title":"Tumor microenvironment and radioresistance","volume":"53","author":"Suwa","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jconrel.2025.114406_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116783","article-title":"Survival strategies: how tumor hypoxia microenvironment orchestrates angiogenesis","volume":"176","author":"Yang","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"10","key":"10.1016\/j.jconrel.2025.114406_bb0045","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41568-024-00736-0","article-title":"Targeting the tumour vasculature: from vessel destruction to promotion","volume":"24","author":"Guelfi","year":"2024","journal-title":"Nat. Rev. Cancer"},{"issue":"9","key":"10.1016\/j.jconrel.2025.114406_bb0050","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s00018-019-03351-7","article-title":"Tumor angiogenesis: causes, consequences, challenges and opportunities","volume":"77","author":"Lugano","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"issue":"4","key":"10.1016\/j.jconrel.2025.114406_bb0055","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10456-017-9562-9","article-title":"Tumor angiogenesis and vascular normalization: alternative therapeutic targets","volume":"20","author":"Viallard","year":"2017","journal-title":"Angiogenesis"},{"issue":"5706","key":"10.1016\/j.jconrel.2025.114406_bb0060","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.1104819","article-title":"Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy","volume":"307","author":"Jain","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2025.114406_bb0065","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jconrel.2024.06.052","article-title":"Environmentally responsive hydrogel promotes vascular normalization to enhance STING anti-tumor immunity","volume":"372","author":"Wang","year":"2024","journal-title":"J. Control. Release"},{"issue":"761","key":"10.1016\/j.jconrel.2025.114406_bb0070","doi-asserted-by":"crossref","first-page":"eadn0904","DOI":"10.1126\/scitranslmed.adn0904","article-title":"Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies","volume":"16","author":"Lu","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2025.114406_bb0075","article-title":"Research progress of HIF-1\u03b1 on immunotherapy outcomes in immune vascular microenvironment","volume":"16","author":"Shi","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.114406_bb0080","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/978-3-030-34461-0_18","article-title":"Hypoxia compromises anti-cancer immune responses","volume":"1232","author":"Multhoff","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114406_bb0085","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13045-024-01559-0","article-title":"Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy","volume":"17","author":"Toledo","year":"2024","journal-title":"J. Hematol. Oncol."},{"issue":"9","key":"10.1016\/j.jconrel.2025.114406_bb0090","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1002\/jcp.25726","article-title":"The sabotaging role of myeloid cells in anti-angiogenic therapy: coordination of angiogenesis and immune suppression by hypoxia","volume":"232","author":"Li","year":"2017","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114406_bb0095","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13045-021-01102-5","article-title":"The relationship between expression of PD-L1 and HIF-1\u03b1 in glioma cells under hypoxia","volume":"14","author":"Ding","year":"2021","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114406_bb0100","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41392-023-01462-z","article-title":"Radiation-induced tumor immune microenvironments and potential targets for combination therapy","volume":"8","author":"Guo","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114406_bb0105","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41392-022-01102-y","article-title":"Radiotherapy combined with immunotherapy: the dawn of cancer treatment","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"47","key":"10.1016\/j.jconrel.2025.114406_bb0110","doi-asserted-by":"crossref","first-page":"19059","DOI":"10.1073\/pnas.1318022110","article-title":"Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation","volume":"110","author":"Batchelor","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.jconrel.2025.114406_bb0115","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/s41571-024-00886-y","article-title":"Antiangiogenic-immune-checkpoint inhibitor combinations: lessons from phase III clinical trials","volume":"21","author":"Kuo","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.jconrel.2025.114406_bb0120","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s11060-011-0748-5","article-title":"Relation between bevacizumab dose intensity and high-grade glioma survival: a retrospective study in two large cohorts","volume":"107","author":"Lorgis","year":"2012","journal-title":"J. Neuro-Oncol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114406_bb0125","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11060-014-1693-x","article-title":"Impact of bevacizumab administered dose on overall survival of patients with progressive glioblastoma","volume":"122","author":"Levin","year":"2015","journal-title":"J. Neuro-Oncol."},{"issue":"5","key":"10.1016\/j.jconrel.2025.114406_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e09403","article-title":"Lipid-based nanoparticles for treatment of cancer","volume":"8","author":"Sheoran","year":"2022","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.jconrel.2025.114406_bb0135","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3390\/pharmaceutics15010216","article-title":"Lipid nanoparticles functionalized with antibodies for anticancer drug therapy","volume":"15","author":"Marques","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.114406_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114416","article-title":"The role of lipid components in lipid nanoparticles for vaccines and gene therapy","volume":"188","author":"Hald Albertsen","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.114406_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2023.102871","article-title":"Lipid-core nanoparticles: classification, preparation methods, routes of administration and recent advances in cancer treatment","volume":"314","author":"Grav\u00e1n","year":"2023","journal-title":"Adv. Colloid Interf. Sci."},{"issue":"11","key":"10.1016\/j.jconrel.2025.114406_bb0150","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/s41571-023-00811-9","article-title":"Targeting cancer with mRNA-lipid nanoparticles: key considerations and future prospects","volume":"20","author":"Kon","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"51","key":"10.1016\/j.jconrel.2025.114406_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202303261","article-title":"Lipid nanoparticle (LNP) enables mRNA delivery for Cancer therapy","volume":"35","author":"Zong","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2025.114406_bb0160","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-bioeng-071813-105259","article-title":"The role of mechanical forces in tumor growth and therapy","volume":"16","author":"Jain","year":"2014","journal-title":"Annu. Rev. Biomed. Eng."},{"issue":"40","key":"10.1016\/j.jconrel.2025.114406_bb0165","doi-asserted-by":"crossref","first-page":"8193","DOI":"10.1039\/D2TB01812H","article-title":"Precise fibrin decomposition and tumor mechanics modulation with hydroxyethyl starch-based smart nanomedicine for enhanced antitumor efficacy","volume":"10","author":"Chen","year":"2022","journal-title":"J. Mater. Chem. B"},{"issue":"7","key":"10.1016\/j.jconrel.2025.114406_bb0170","article-title":"Modulating cancer mechanopathology to restore vascular function and enhance immunotherapy","volume":"5","author":"Mpekris","year":"2024","journal-title":"Cell Rep. Med."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114406_bb0175","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-022-01569-x","article-title":"Targeting TGF-\u03b2 signal transduction for fibrosis and cancer therapy","volume":"21","author":"Peng","year":"2021","journal-title":"Mol. Cancer"},{"issue":"41","key":"10.1016\/j.jconrel.2025.114406_bb0180","doi-asserted-by":"crossref","first-page":"16618","DOI":"10.1073\/pnas.1117610109","article-title":"TGF-\u03b2 blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma","volume":"109","author":"Liu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.jconrel.2025.114406_bb0185","article-title":"Therapeutic Remodeling of the tumor microenvironment enhances nanoparticle delivery","volume":"6","author":"Chen","year":"2019","journal-title":"Adv. Sci. (Weinh)."},{"key":"10.1016\/j.jconrel.2025.114406_bb0190","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.actbio.2015.12.002","article-title":"A dual strategy to improve the penetration and treatment of breast cancer by combining shrinking nanoparticles with collagen depletion by losartan","volume":"31","author":"Cun","year":"2016","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114406_bb0195","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12943-023-01744-8","article-title":"Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments","volume":"22","author":"Yuan","year":"2023","journal-title":"Mol. Cancer"},{"issue":"10","key":"10.1016\/j.jconrel.2025.114406_bb0200","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.molmed.2021.07.009","article-title":"Extracellular matrix-based cancer targeting","volume":"27","author":"Karamanos","year":"2021","journal-title":"Trends Mol. Med."},{"issue":"50","key":"10.1016\/j.jconrel.2025.114406_bb0205","doi-asserted-by":"crossref","first-page":"43493","DOI":"10.1021\/acsami.8b17684","article-title":"Collagenase-encapsulated pH-responsive nanoscale coordination polymers for tumor microenvironment modulation and enhanced photodynamic nanomedicine","volume":"10","author":"Liu","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"26","key":"10.1016\/j.jconrel.2025.114406_bb0210","article-title":"Softness-aided mild hyperthermia boosts stiff nanomedicine by regulating tumor mechanics","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci (Weinh)."},{"issue":"12","key":"10.1016\/j.jconrel.2025.114406_bb0215","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1080\/17425247.2020.1814735","article-title":"Vascular and extracellular matrix remodeling by physical approaches to improve drug delivery at the tumor site","volume":"17","author":"Gouarderes","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"issue":"3","key":"10.1016\/j.jconrel.2025.114406_bb0220","doi-asserted-by":"crossref","DOI":"10.1063\/1.5018327","article-title":"Clinical doses of radiation reduce collagen matrix stiffness","volume":"2","author":"Miller","year":"2018","journal-title":"APL Bioeng."},{"key":"10.1016\/j.jconrel.2025.114406_bb0225","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jconrel.2017.02.035","article-title":"Extracellular matrix remodeling in vivo for enhancing tumor-targeting efficiency of nanoparticle drug carriers using the pulsed high intensity focused ultrasound","volume":"263","author":"Lee","year":"2017","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.jconrel.2025.114406_bb0230","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1080\/09205063.2020.1825304","article-title":"PEGYLATION: an important approach for novel drug delivery system","volume":"32","author":"Yadav","year":"2021","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.jconrel.2025.114406_bb0235","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1078\/0171-9335-00363","article-title":"PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles","volume":"83","author":"Mishra","year":"2004","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.jconrel.2025.114406_bb0240","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00280-008-0917-1","article-title":"Single- and multiple-dose disposition kinetics of sunitinib malate, a multitargeted receptor tyrosine kinase inhibitor: comparative plasma kinetics in non-clinical species","volume":"64","author":"Haznedar","year":"2009","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.jconrel.2025.114406_bb0245","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jconrel.2025.114406_bb0250","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10549-010-0788-0","article-title":"Phase III randomized trial of sunitinib versus capecitabine in patients with previously treated HER2-negative advanced breast cancer","volume":"121","author":"Barrios","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"issue":"15","key":"10.1016\/j.jconrel.2025.114406_bb0255","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.1039\/D2BM00600F","article-title":"Combination of tumor vessel normalization and immune checkpoint blockade for breast cancer treatment via multifunctional nanocomplexes","volume":"10","author":"Zeng","year":"2022","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.jconrel.2025.114406_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.121805","article-title":"Intelligent porphyrin nano-delivery system for photostimulated and targeted inhibition of angiogenesis","volume":"621","author":"Jiao","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"7","key":"10.1016\/j.jconrel.2025.114406_bb0265","doi-asserted-by":"crossref","first-page":"7591","DOI":"10.1021\/acsnano.9b00467","article-title":"Carrier-enhanced anticancer efficacy of sunitinib-loaded green tea-based micellar nanocomplex beyond tumor-targeted delivery","volume":"13","author":"Yongvongsoontorn","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.114406_bb0270","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jconrel.2016.11.013","article-title":"Tumor-targeted delivery of sunitinib base enhances vaccine therapy for advanced melanoma by remodeling the tumor microenvironment","volume":"245","author":"Huo","year":"2017","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.jconrel.2025.114406_bb0275","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1152\/physrev.00038.2010","article-title":"Normalization of the vasculature for treatment of cancer and other diseases","volume":"91","author":"Goel","year":"2011","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.jconrel.2025.114406_bb0280","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3390\/cells8050471","article-title":"Role of Angiopoietin-2 in vascular physiology and pathophysiology","volume":"8","author":"Akwii","year":"2019","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.jconrel.2025.114406_bb0285","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/s41565-019-0570-3","article-title":"Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies","volume":"14","author":"Sung","year":"2019","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2025.114406_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123512","article-title":"\u201ctargeted plus controlled\u201d - composite nano delivery system opens the tumor vascular and microenvironment normalization window for anti-tumor therapy","volume":"647","author":"Shen","year":"2023","journal-title":"Int. J. Pharm."},{"issue":"8","key":"10.1016\/j.jconrel.2025.114406_bb0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11033-021-06607-3","article-title":"The PI3K\/AKT\/mTOR signaling pathway inhibitors enhance radiosensitivity in cancer cell lines","volume":"48","author":"Mardanshahi","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jconrel.2025.114406_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.111828","article-title":"CKS1B regulates the radiosensitivity of lung cancer via activating the PI3K\/AKT signaling pathway","volume":"132","author":"Lu","year":"2025","journal-title":"Cell. Signal."},{"issue":"7","key":"10.1016\/j.jconrel.2025.114406_bb0305","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1111\/cas.13650","article-title":"Synergy between peroxisome proliferator-activated receptor \u03b3 agonist and radiotherapy in cancer","volume":"109","author":"Huang","year":"2018","journal-title":"Cancer Sci."},{"key":"10.1016\/j.jconrel.2025.114406_bb0310","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cyto.2016.08.003","article-title":"TNF activity and T cells","volume":"101","author":"Mehta","year":"2018","journal-title":"Cytokine"},{"issue":"1","key":"10.1016\/j.jconrel.2025.114406_bb0315","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/s12951-024-02612-3","article-title":"Photosensitive and dual-targeted chromium nanoparticle delivering small interfering RNA YTHDF1 for molecular-targeted immunotherapy in liver cancer","volume":"22","author":"Chen","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2025.114406_bb0320","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40364-020-00228-x","article-title":"Roles of IFN-\u03b3 in tumor progression and regression: a review","volume":"8","author":"Jorgovanovic","year":"2020","journal-title":"Biomark. Res."},{"issue":"4","key":"10.1016\/j.jconrel.2025.114406_bb0325","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3390\/toxins15040298","article-title":"Natriuretic-like peptide Lebetin 2 mediates M2 macrophage polarization in LPS-activated RAW264.7 cells in an IL-10-dependent manner","volume":"15","author":"Bouzazi","year":"2023","journal-title":"Toxins (Basel)"},{"issue":"10","key":"10.1016\/j.jconrel.2025.114406_bb0330","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1172\/JCI137552","article-title":"HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer","volume":"130","author":"de Heer","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.jconrel.2025.114406_bb0335","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1200\/JCO.2005.12.017","article-title":"Angiogenesis of breast cancer","volume":"23","author":"Schneider","year":"2005","journal-title":"J. Clin. Oncol."},{"issue":"2","key":"10.1016\/j.jconrel.2025.114406_bb0340","doi-asserted-by":"crossref","first-page":"446","DOI":"10.7150\/ijbs.86085","article-title":"VEGFA\/NRP-1\/GAPVD1 axis promotes progression and cancer stemness of triple-negative breast cancer by enhancing tumor cell-macrophage crosstalk","volume":"20","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114406_bb0345","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-024-02108-4","article-title":"Breast cancer: pathogenesis and treatments","volume":"10","author":"Xiong","year":"2025","journal-title":"Signal Transduction Targeted Ther."},{"issue":"10","key":"10.1016\/j.jconrel.2025.114406_bb0350","doi-asserted-by":"crossref","first-page":"5078","DOI":"10.1021\/acs.molpharmaceut.3c00381","article-title":"Normalizing tumor blood vessels to improve chemotherapy and inhibit breast Cancer metastasis by multifunctional nanoparticles","volume":"20","author":"Zeng","year":"2023","journal-title":"Mol. Pharm."},{"issue":"3","key":"10.1016\/j.jconrel.2025.114406_bb0355","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202001917","article-title":"Normalizing the microenvironment overcomes vessel compression and resistance to Nano-immunotherapy in breast Cancer lung metastasis","volume":"8","author":"Mpekris","year":"2020","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2025.114406_bb0360","first-page":"1200","article-title":"Combination of sunitinib and PD-L1 blockade enhances anticancer efficacy of TLR7\/8 agonist-based Nanovaccine","volume":"16","author":"Kim","year":"2019","journal-title":"Molecularpharmaceutics"},{"key":"10.1016\/j.jconrel.2025.114406_bb0365","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1007\/s11864-024-01251-y","article-title":"Neoadjuvant therapy: current landscape and future horizons for ER-positive\/HER2-negative and triple-negative early breast Cancer","volume":"25","author":"Bischoff","year":"2024","journal-title":"Curr.Treat. Options in Oncol."},{"issue":"9","key":"10.1016\/j.jconrel.2025.114406_bb0370","doi-asserted-by":"crossref","DOI":"10.1172\/JCI159473","article-title":"Cross-talk between HIF and PD-1\/PD-L1 pathways in carcinogenesis and therapy","volume":"132","author":"Shurin","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2025.114406_bb0375","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.canlet.2021.09.022","article-title":"Plasmacytoid dendritic cells recruited by HIF-1\u03b1\/eADO\/ADORA1 signaling induce immunosuppression in hepatocellular carcinoma","volume":"522","author":"Pang","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jconrel.2025.114406_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173235","article-title":"Silencing of HIF-1\u03b1\/CD73 axis by siRNA-loaded TAT-chitosan-spion nanoparticles robustly blocks cancer cell progression","volume":"882","author":"Hajizadeh","year":"2020","journal-title":"Eur. J. Pharmacol."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836592501020X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836592501020X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:49:46Z","timestamp":1781326186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016836592501020X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":76,"alternative-id":["S016836592501020X"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114406","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sunitinib lipid nanoparticles remodel tumor vasculature to synergize with two-stage radiotherapy for enhanced radiosensitivity in breast Cancer","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114406","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114406"}}