{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:20:55Z","timestamp":1788546055524,"version":"build-2803163510"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T00:00:00Z","timestamp":1763769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016386","name":"Government of Valencia Ministry of Innovation Universities Science and Society","doi-asserted-by":"publisher","award":["CIACIF\/2022\/341"],"award-info":[{"award-number":["CIACIF\/2022\/341"]}],"id":[{"id":"10.13039\/501100016386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Espa\u00f1a Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["MS21-126"],"award-info":[{"award-number":["MS21-126"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Espa\u00f1a Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["UV-INV-PREDOC-18F2-743816"],"award-info":[{"award-number":["UV-INV-PREDOC-18F2-743816"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Espa\u00f1a Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020-114530GA-I00"],"award-info":[{"award-number":["PID2020-114530GA-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003551","name":"American Concrete Institute Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003551","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003508","name":"Universitat de Val\u00e8ncia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003508","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023561","name":"Ministerio de Universidades","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023561","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jconrel.2025.114461","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T16:02:59Z","timestamp":1763827379000},"page":"114461","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Ultraflexible lipid vesicles loaded with cyanocobalamin or cyclosporin A downregulate acute and chronic immuno-inflammatory skin states"],"prefix":"10.1016","volume":"389","author":[{"given":"Miquel","family":"Mart\u00ednez-Navarrete","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Carmen","family":"Recio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Mar\u00eda","family":"Giner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Mart\u00ed-Quijal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Jos\u00e9","family":"Guillot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Melero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.114461_bb0005","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1177\/1203475416685078","article-title":"Atopic dermatitis, depression, and suicidality","volume":"21","author":"Nicholas","year":"2017","journal-title":"J. Cutan. Med. Surg."},{"key":"10.1016\/j.jconrel.2025.114461_bb0010","doi-asserted-by":"crossref","first-page":"320","DOI":"10.2340\/00015555-3510","article-title":"Prevalence and incidence of atopic dermatitis: a systematic review","volume":"100","author":"Bylund","year":"2020","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0015","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s13555-021-00519-7","article-title":"Clinical and economic burden of mild-to-moderate atopic dermatitis in the UK: a propensity-score-matched case-control study","volume":"11","author":"Toron","year":"2021","journal-title":"Dermatol. Ther. (Heidelb.)"},{"key":"10.1016\/j.jconrel.2025.114461_bb0020","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jaad.2014.03.023","article-title":"Guidelines of care for the management of atopic dermatitis","volume":"71","author":"Eichenfield","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0025","first-page":"337","article-title":"Topical corticosteroids: choice and application","volume":"103","author":"Stacey","year":"2021","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.jconrel.2025.114461_bb0030","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12887-016-0607-9","article-title":"Systematic review of published trials: long-term safety of topical corticosteroids and topical calcineurin inhibitors in pediatric patients with atopic dermatitis","volume":"16","author":"Siegfried","year":"2016","journal-title":"BMC Pediatr."},{"key":"10.1016\/j.jconrel.2025.114461_bb0035","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1001\/jamadermatol.2020.4968","article-title":"Association of Potent and Very Potent Topical Corticosteroids and the risk of osteoporosis and major osteoporotic fractures","volume":"157","author":"Egeberg","year":"2021","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0040","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0140-6736(91)90134-B","article-title":"Double-blind, controlled, crossover study of cyclosporin in adults with severe refractory atopic dermatitis","volume":"338","author":"Sowden","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2025.114461_bb0045","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-2133.1993.tb15154.x","article-title":"Can cyclosporin a induce permanent remission of atopic dermatitis?","volume":"128","author":"Sepp","year":"1993","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0050","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000018065","article-title":"Comparison of two formulations of cyclosporin a in the treatment of severe atopic dermatitis. A double-blind, single-centre, cross-over pilot study","volume":"198","author":"Zurbriggen","year":"1999","journal-title":"Dermatology"},{"key":"10.1016\/j.jconrel.2025.114461_bb0055","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1159\/000514535","article-title":"Biological therapies for atopic dermatitis: a systematic review","volume":"237","author":"Zhou","year":"2021","journal-title":"Dermatology"},{"key":"10.1016\/j.jconrel.2025.114461_bb0060","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s40257-022-00683-2","article-title":"Long-term efficacy and safety of dupilumab in adolescents with moderate-to-severe atopic dermatitis: results through week 52 from a phase III open-label extension trial (LIBERTY AD PED-OLE)","volume":"23","author":"Blauvelt","year":"2022","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1884","article-title":"Microneedle-assisted transdermal delivery of nanoparticles: recent insights and prospects","volume":"15","author":"Guillot","year":"2023","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0070","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/wnan.147","article-title":"Drug delivery through the skin: molecular simulations of barrier lipids to design more effective noninvasive dermal and transdermal delivery systems for small molecules, biologics, and cosmetics","volume":"3","author":"Torin Huzil","year":"2011","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0075","first-page":"295","article-title":"The important role of stratum corneum lipids for the cutaneous barrier function","volume":"1841","author":"van Smeden","year":"2014","journal-title":"Biochimica et Biophys. Acta (BBA) Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.jconrel.2025.114461_bb0080","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1034\/j.1600-0625.2000.009003165.x","article-title":"The 500 Dalton rule for the skin penetration of chemical compounds and drugs","volume":"9","author":"Bos","year":"2000","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics12060569","article-title":"Microneedle-based delivery: an overview of current applications and trends","volume":"12","author":"Guillot","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.114461_bb0090","doi-asserted-by":"crossref","first-page":"169","DOI":"10.15171\/apb.2018.021","article-title":"Chemical enhancer: a simplistic way to modulate barrier function of the stratum corneum","volume":"8","author":"Haque","year":"2018","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.jconrel.2025.114461_bb0095","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1615\/CritRevTherDrugCarrierSyst.v17.i6.20","article-title":"Enhancement of transdermal drug delivery: chemical and physical approaches","volume":"17","author":"Asbill","year":"2000","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"10.1016\/j.jconrel.2025.114461_bb0100","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3762\/bjnano.10.16","article-title":"Targeting strategies for improving the efficacy of nanomedicine in oncology","volume":"10","author":"Villaverde","year":"2019","journal-title":"Beilstein J. Nanotechnol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0105","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ymthe.2020.11.030","article-title":"Plant exosome-like nanovesicles: emerging therapeutics and drug delivery nanoplatforms","volume":"29","author":"Dad","year":"2021","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2025.114461_bb0110","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2015.10.049","article-title":"Nanoparticles and nanofibers for topical drug delivery","volume":"240","author":"Goyal","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114461_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics13020291","article-title":"Naringenin nano-delivery systems and their therapeutic applications","volume":"13","author":"Bhia","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.114461_bb0120","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0923-1811(96)00508-7","article-title":"Topical liposomal system for localized and controlled drug delivery","volume":"13","author":"Singh","year":"1996","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jconrel.2025.114461_bb0125","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.jconrel.2023.02.006","article-title":"Skin drug delivery using lipid vesicles: a starting guideline for their development","volume":"355","author":"Guillot","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114461_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13030418","article-title":"Cyanocobalamin ultraflexible lipid vesicles: characterization and in vitro evaluation of drug-skin depth profiles","volume":"13","author":"Guillot","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.114461_bb0135","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s13346-019-00693-4","article-title":"Ultraflexible lipid vesicles allow topical absorption of cyclosporin A","volume":"10","author":"Carreras","year":"2020","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.jconrel.2025.114461_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e09394","article-title":"Liposomes: structure, composition, types, and clinical applications","volume":"8","author":"Nsairat","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.jconrel.2025.114461_bb0145","doi-asserted-by":"crossref","DOI":"10.1100\/2012\/134876","article-title":"Influence of the flexible liposomes on the skin deposition of a hydrophilic model drug, carboxyfluorescein: dependency on their composition","volume":"2012","author":"Badran","year":"2012","journal-title":"Sci. World J."},{"key":"10.1016\/j.jconrel.2025.114461_bb0150","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1773-2247(07)50046-8","article-title":"Ethosomes for skin delivery","volume":"17","author":"Touitou","year":"2007","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0155","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jconrel.2024.09.032","article-title":"Cyanocobalamin-loaded dissolving microneedles diminish skin inflammation in vivo","volume":"375","author":"Guillot","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114461_bb0160","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1007\/s13346-024-01542-9","article-title":"Cyclosporin A-loaded dissolving microneedles for dermatitis therapy: development, characterisation and efficacy in a delayed-type hypersensitivity in vivo model","volume":"14","author":"Mart\u00ednez-Navarrete","year":"2024","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.jconrel.2025.114461_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2020.183361","article-title":"The effect of lipid phase on liposome stability upon exposure to the mechanical stress","volume":"1862","author":"Doskocz","year":"2020","journal-title":"BBA-Biomembranes"},{"key":"10.1016\/j.jconrel.2025.114461_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14030543","article-title":"Methods of liposomes preparation: formation and control factors of versatile nanocarriers for biomedical and nanomedicine application","volume":"14","author":"Lombardo","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.114461_bb0175","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ejcb.2007.03.008","article-title":"Procathepsin D secreted by HaCaT keratinocyte cells - a novel regulator of keratinocyte growth","volume":"86","author":"Vashishta","year":"2007","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0180","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jdermsci.2018.04.013","article-title":"Non-invasive bioluminescence imaging as a standardized assessment measure in mouse models of dermal inflammation","volume":"91","author":"Hofmann","year":"2018","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jconrel.2025.114461_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-9255-5-1","article-title":"Topical anti-inflammatory activity of Polygonum cuspidatum extract in the TPA model of mouse ear inflammation","volume":"5","author":"Bralley","year":"2008","journal-title":"J. Inflamm. (Lond.)"},{"key":"10.1016\/j.jconrel.2025.114461_bb0190","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0014-2999(02)02554-2","article-title":"Effects of FK506 (tacrolimus hydrate) on chronic oxazolone-induced dermatitis in rats","volume":"456","author":"Fujii","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0195","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.jid.5701011","article-title":"Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges","volume":"128","author":"Man","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124764","article-title":"In vivo reduction of skin inflammation using ferulic acid-loaded lipid vesicles derived from brewer\u2019s spent grain","volume":"666","author":"Bucci","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.114461_bb0205","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/exd.12461","article-title":"Topical application of the adenosine A2A receptor agonist CGS-21680 prevents phorbol-induced epidermal hyperplasia and inflammation in mice","volume":"23","author":"Arasa","year":"2014","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0210","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0378-5173(03)00183-2","article-title":"Particle size of liposomes influences dermal delivery of substances into skin","volume":"258","author":"Verma","year":"2003","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.114461_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics10020057","article-title":"Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems","volume":"10","author":"Danaei","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.114461_bb0220","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/cpr.12192","article-title":"Independent effect of polymeric nanoparticle zeta potential\/surface charge, on their cytotoxicity and affinity to cells","volume":"48","author":"Shao","year":"2015","journal-title":"Cell Prolif."},{"key":"10.1016\/j.jconrel.2025.114461_bb0225","doi-asserted-by":"crossref","first-page":"813","DOI":"10.3109\/1061186X.2012.716845","article-title":"Nanostructured lipid carriers system: recent advances in drug delivery","volume":"20","author":"Iqbal","year":"2012","journal-title":"J. Drug Target."},{"key":"10.1016\/j.jconrel.2025.114461_bb0230","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ejpb.2022.06.015","article-title":"Exploration of microneedle-assisted skin delivery of cyanocobalamin formulated in ultraflexible lipid vesicles","volume":"177","author":"Guillot","year":"2022","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2025.114461_bb0235","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-1-4939-7352-1_8","article-title":"Imaging of liposomes by transmission electron microscopy","volume":"1682","author":"Baxa","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.123903","article-title":"Surfactants for stabilization of dermal emulsions and their skin compatibility under UVA irradiation: diacyl phospholipids and polysorbate 80 result in high viability rates of primary human skin cells","volume":"653","author":"Steiner","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.114461_bb0245","doi-asserted-by":"crossref","first-page":"570","DOI":"10.2174\/1567201817666200826093102","article-title":"Recent developments in the principles, modification and application prospects of functionalized Ethosomes for topical delivery","volume":"18","author":"Lu","year":"2021","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.jconrel.2025.114461_bb0250","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s11095-021-03053-5","article-title":"Ethosomes as nanocarriers for the development of skin delivery formulations","volume":"38","author":"Paiva-Santos","year":"2021","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2025.114461_bb0255","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1365-2133.1996.tb03884.x","article-title":"Ethanol enhances the IFN-gamma, TGF-alpha and IL-6 secretion in psoriatic co-cultures","volume":"135","author":"Ockenfels","year":"1996","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0260","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0741-8329(02)00198-2","article-title":"Ethanol signals for apoptosis in cultured skin cells","volume":"26","author":"Neuman","year":"2002","journal-title":"Alcohol"},{"key":"10.1016\/j.jconrel.2025.114461_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-025-18487-9","article-title":"A pilot study on the cutaneous effects of ethanol in a moisturizing cream on non-lesional skin of patients with atopic dermatitis","volume":"15","author":"Celikoglu","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.114461_bb0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-88072-3","article-title":"Effect of commonly used cosmetic preservatives on skin resident microflora dynamics","volume":"11","author":"Pinto","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2025.114461_bb0275","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1538\/expanim.60.373","article-title":"Usefulness of rat skin as a substitute for human skin in the in vitro skin permeation study","volume":"60","author":"Takeuchi","year":"2011","journal-title":"Exp. Anim."},{"key":"10.1016\/j.jconrel.2025.114461_bb0280","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ijpharm.2009.09.028","article-title":"Wistar rat skin as surrogate for human skin in nortriptyline hydrochloride patch studies","volume":"384","author":"Melero","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.114461_bb0285","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3109\/10717544.2012.724472","article-title":"Comparative study of liposomes, transfersomes and ethosomes as carriers for improving topical delivery of celecoxib","volume":"19","author":"Bragagni","year":"2012","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jconrel.2025.114461_bb0290","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.585393","article-title":"Predicting transdermal fentanyl delivery using mechanistic simulations for tailored therapy","volume":"11","author":"Defraeye","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0295","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1080\/10837450.2017.1330345","article-title":"Formulation and characterization of Phospholipon 90 G and tween 80 based transfersomes for transdermal delivery of eprosartan mesylate","volume":"23","author":"Ahad","year":"2018","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0300","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1016\/j.bbamem.2018.05.018","article-title":"Cholesterol modulates curcumin partitioning and membrane effects","volume":"1860","author":"Leite","year":"2018","journal-title":"BBA \u2013 Biomembr."},{"key":"10.1016\/j.jconrel.2025.114461_bb0305","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/0975-7406.92724","article-title":"Status of surfactants as penetration enhancers in transdermal drug delivery","volume":"4","author":"Som","year":"2012","journal-title":"J. Pharm. Bioallied Sci."},{"key":"10.1016\/j.jconrel.2025.114461_bb0310","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.cis.2018.04.002","article-title":"Interactions between surfactants and the skin \u2013 theory and practice","volume":"256","author":"Seweryn","year":"2018","journal-title":"Adv. Colloid Interf. Sci."},{"key":"10.1016\/j.jconrel.2025.114461_bb0315","article-title":"Mechanism investigation of ethosomes transdermal permeation","volume":"1","author":"Niu","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2025.114461_bb0320","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jconrel.2004.02.028","article-title":"Synergistic penetration enhancement effect of ethanol and phospholipids on the topical delivery of cyclosporin a","volume":"97","author":"Verma","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114461_bb0325","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3390\/bioengineering10010088","article-title":"Portable iontophoresis device for efficient drug delivery","volume":"10","author":"Bok","year":"2023","journal-title":"Bioengineering"},{"key":"10.1016\/j.jconrel.2025.114461_bb0330","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3390\/pharmaceutics12060569","article-title":"Microneedle-based delivery\u00a0: an overview of current applications and trends","volume":"12","author":"Guillot","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.114461_bb0335","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16030309","article-title":"Liposomes and other nanocarriers for the treatment of acne vulgaris: improved therapeutic efficacy and skin tolerability","volume":"16","author":"Dragicevic","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.114461_bb0340","series-title":"Microneedle-assisted transdermal delivery of nanoparticles: Recent insights and prospects","first-page":"1","author":"Guillot","year":"2023"},{"key":"10.1016\/j.jconrel.2025.114461_bb0345","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cbi.2018.02.019","article-title":"Topical delivery of l-theanine ameliorates TPA-induced acute skin inflammation via downregulating endothelial PECAM-1 and neutrophil infiltration and activation","volume":"284","author":"Zeng","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jconrel.2025.114461_bb0350","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/890151","article-title":"Antinociceptive and anti-inflammatory activities of bridelia retusa methanolic fruit extract in experimental animals","volume":"2014","author":"Kumar","year":"2014","journal-title":"Sci. World J."},{"key":"10.1016\/j.jconrel.2025.114461_bb0355","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.bcp.2006.01.005","article-title":"Involvement of tumor necrosis factor (TNF)-alpha in phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin edema in mice","volume":"71","author":"Murakawa","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0360","doi-asserted-by":"crossref","DOI":"10.1111\/1523-1747.ep12505705","article-title":"The role of epidermal cytokines in inflammatory skin diseases","volume":"95","author":"Sauder","year":"1990","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0365","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12895-016-0046-1","article-title":"Effect of 12-O-tetradecanoylphorbol-13-acetate-induced psoriasis-like skin lesions on systemic inflammation and atherosclerosis in hypercholesterolaemic apolipoprotein E deficient mice","volume":"16","author":"Madsen","year":"2016","journal-title":"BMC Dermatol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0370","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.bbrc.2006.07.079","article-title":"Inhibition of the TPA-induced cutaneous inflammation and hyperplasia by EC-SOD","volume":"348","author":"Ha","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jconrel.2025.114461_bb0375","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/exd.14270","article-title":"Mouse models of atopic dermatitis: a critical reappraisal","volume":"30","author":"Gilhar","year":"2021","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0380","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099297","article-title":"Oxazolone-induced contact hypersensitivity reduces lymphatic drainage but enhances the induction of adaptive immunity","volume":"9","author":"Aebischer","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2025.114461_bb0385","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1163\/1568569042664521","article-title":"Nitric oxide levels in atopic dermatitis","volume":"16","author":"Akdeniz","year":"2004","journal-title":"Pain Clinic"},{"key":"10.1016\/j.jconrel.2025.114461_bb0390","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1152\/physrev.00063.2017","article-title":"Mechanisms of insulin action and insulin resistance","volume":"98","author":"Petersen","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jconrel.2025.114461_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112351","article-title":"Formulation of liposomes loading lentisk oil to ameliorate topical delivery, attenuate oxidative stress damage and improve cell migration in scratch assay","volume":"144","author":"Allaw","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jconrel.2025.114461_bb0400","series-title":"Molecular Mechanisms of Atopic Dermatitis Pathogenesis","author":"Sroka-tomaszewska","year":"2021"},{"key":"10.1016\/j.jconrel.2025.114461_bb0405","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics12090789","article-title":"Advanced characterization of imiquimod-induced psoriasis-like mouse model","volume":"12","author":"Jabeen","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.114461_bb0410","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1046\/j.1523-1747.1998.00239.x","article-title":"Intralesional cytokines in chronic oxazolone-induced contact sensitivity suggest roles for tumor necrosis factor alpha and interleukin-4","volume":"111","author":"Webb","year":"1998","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0415","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.fct.2013.02.038","article-title":"Role of oxidative stress in chemical allergens induced skin cells activation","volume":"61","author":"Corsini","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jconrel.2025.114461_bb0420","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1084\/jem.20160417","article-title":"IL-6 IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells","volume":"213","author":"Yang","year":"2016","journal-title":"J. Exp. Med."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925010752?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925010752?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:44:56Z","timestamp":1781325896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925010752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":84,"alternative-id":["S0168365925010752"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114461","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ultraflexible lipid vesicles loaded with cyanocobalamin or cyclosporin A downregulate acute and chronic immuno-inflammatory skin states","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114461","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114461"}}