{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:09:36Z","timestamp":1792613376399,"version":"4.5.0"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE031476"],"award-info":[{"award-number":["R01DE031476"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jconrel.2025.114469","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:00:06Z","timestamp":1764086406000},"page":"114469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Bilayer gelatin-methacryloyl scaffold for pulp inflammation suppression and dentin-like tissue regeneration"],"prefix":"10.1016","volume":"389","author":[{"given":"Caroline","family":"Anselmi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renan","family":"Dal-Fabbro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisham","family":"Abada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor Paulino","family":"Mendes Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lais M.","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel H.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia C.","family":"Catalano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Beatriz","family":"Gomes de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabaha","family":"Sikder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Schwendeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josimeri","family":"Hebling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco C.","family":"Bottino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.114469_bb0005","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/230251","article-title":"Dental pulp defence and repair mechanisms in dental caries","volume":"2015","author":"Farges","year":"2015","journal-title":"Mediators Inflamm."},{"issue":"14","key":"10.1016\/j.jconrel.2025.114469_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11144016","article-title":"Vital pulp therapy of permanent teeth with reversible or irreversible pulpitis: an overview of the literature","volume":"11","author":"Iaculli","year":"2022","journal-title":"J. Clin. Med."},{"issue":"4","key":"10.1016\/j.jconrel.2025.114469_bb0015","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/iej.13449","article-title":"Efficacy of direct pulp capping for management of cariously exposed pulps in permanent teeth: a systematic review and meta-analysis","volume":"54","author":"Cushley","year":"2021","journal-title":"Int. Endod. J."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114469_bb0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.joen.2022.11.005","article-title":"Outcome of direct pulp capping using calcium hydroxide: a long-term retrospective study","volume":"49","author":"Ricucci","year":"2023","journal-title":"J Endod"},{"issue":"4","key":"10.1016\/j.jconrel.2025.114469_bb0025","first-page":"255","article-title":"Cytotoxic effects and pulpal response caused by a mineral trioxide aggregate formulation and calcium hydroxide","volume":"21","author":"de Souza Costa","year":"2008","journal-title":"Am. J. Dent."},{"issue":"10","key":"10.1016\/j.jconrel.2025.114469_bb0030","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/j.joen.2018.07.012","article-title":"Anti-inflammatory and mineralization effects of ProRoot MTA and endocem MTA in studies of human and rat dental pulps in vitro and in vivo","volume":"44","author":"Kim","year":"2018","journal-title":"J. Endod."},{"issue":"9","key":"10.1016\/j.jconrel.2025.114469_bb0035","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.joen.2021.07.015","article-title":"AAE position statement on vital pulp therapy","volume":"47","year":"2021","journal-title":"J. Endod."},{"issue":"4","key":"10.1016\/j.jconrel.2025.114469_bb0040","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.dental.2023.03.013","article-title":"Next-generation biomaterials for dental pulp tissue immunomodulation","volume":"39","author":"Dal-Fabbro","year":"2023","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jconrel.2025.114469_bb0045","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40824-016-0061-7","article-title":"Biomimetic microenvironments for regenerative endodontics","volume":"20","author":"Kaushik","year":"2016","journal-title":"Biomater. Res."},{"key":"10.1016\/j.jconrel.2025.114469_bb0050","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/978-1-0716-2780-8_30","article-title":"Methacrylated gelatin as an on-demand injectable vehicle for drug delivery in dentistry","volume":"2588","author":"Swanson","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jconrel.2025.114469_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2023.213427","article-title":"Multifunctional and biodegradable methacrylated gelatin\/Aloe vera nanofibers for endodontic disinfection and immunomodulation","volume":"150","author":"Namazi","year":"2023","journal-title":"Biomater. Adv."},{"issue":"22","key":"10.1016\/j.jconrel.2025.114469_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232213761","article-title":"Electrospun azithromycin-laden gelatin Methacryloyl fibers for endodontic infection control","volume":"23","author":"Ayoub","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2025.114469_bb0065","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.actbio.2023.11.005","article-title":"GelMA\/TCP nanocomposite scaffold for vital pulp therapy","volume":"173","author":"Han","year":"2024","journal-title":"Acta Biomater."},{"issue":"9","key":"10.1016\/j.jconrel.2025.114469_bb0070","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1016\/j.actbio.2011.05.022","article-title":"In vivo degradation of low temperature calcium and magnesium phosphate ceramics in a heterotopic model","volume":"7","author":"Klammert","year":"2011","journal-title":"Acta Biomater."},{"issue":"12","key":"10.1016\/j.jconrel.2025.114469_bb0075","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1007\/s10856-012-4743-y","article-title":"Microwave assisted synthesis of amorphous magnesium phosphate nanospheres","volume":"23","author":"Zhou","year":"2012","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.jconrel.2025.114469_bb0080","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.msec.2015.03.032","article-title":"Magnesium substitution in the structure of orthopedic nanoparticles: a comparison between amorphous magnesium phosphates, calcium magnesium phosphates, and hydroxyapatites","volume":"52","author":"Nabiyouni","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.jconrel.2025.114469_bb0085","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.actbio.2017.11.033","article-title":"Magnesium-based bioceramics in orthopedic applications","volume":"66","author":"Nabiyouni","year":"2018","journal-title":"Acta Biomater."},{"issue":"21","key":"10.1016\/j.jconrel.2025.114469_bb0090","doi-asserted-by":"crossref","first-page":"23752","DOI":"10.1021\/acsami.0c05311","article-title":"Extracellular matrix\/amorphous magnesium phosphate bioink for 3D bioprinting of Craniomaxillofacial bone tissue","volume":"12","author":"Dubey","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"11","key":"10.1016\/j.jconrel.2025.114469_bb0095","doi-asserted-by":"crossref","first-page":"6201","DOI":"10.1007\/s00784-021-03919-3","article-title":"Effect of non-steroidal anti-inflammatory drugs on pulpal and periapical inflammation induced by lipopolysaccharide","volume":"25","author":"Ribeiro-Santos","year":"2021","journal-title":"Clin. Oral Investig."},{"issue":"11","key":"10.1016\/j.jconrel.2025.114469_bb0100","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1016\/j.joms.2009.05.434","article-title":"Effect of ibuprofen on osteoblast differentiation of porcine bone marrow-derived progenitor cells","volume":"67","author":"Abukawa","year":"2009","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114469_bb0105","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/03008207.2022.2083613","article-title":"Effects of non-steroidal anti-inflammatory drug (ibuprofen) in low and high dose on stemness and biological characteristics of human dental pulp-derived mesenchymal stem cells","volume":"64","author":"Salkin","year":"2023","journal-title":"Connect. Tissue Res."},{"issue":"2","key":"10.1016\/j.jconrel.2025.114469_bb0110","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.xphs.2020.10.003","article-title":"Delivery of therapeutics from layer-by-layer electrospun nanofiber matrix for wound healing: an update","volume":"110","author":"Jeckson","year":"2021","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2025.114469_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.dental.2024.06.019","article-title":"Bifunctional naringenin-laden gelatin methacryloyl scaffolds with osteogenic and anti-inflammatory properties","author":"Cardoso","year":"2024","journal-title":"Dent. Mater."},{"issue":"7","key":"10.1016\/j.jconrel.2025.114469_bb0120","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1111\/iej.14243","article-title":"Quercetin-calcium hydroxide scaffolds modulate dental pulp stem cell response in vitro under a simulated inflammatory environment","volume":"58","author":"Anselmi","year":"2025","journal-title":"Int. Endod. J."},{"key":"10.1016\/j.jconrel.2025.114469_bb0125","doi-asserted-by":"crossref","DOI":"10.1590\/1678-7757-2023-0032","article-title":"Chronic exposure to lipopolysaccharides as an in vitro model to simulate the impaired odontogenic potential of dental pulp cells under pulpitis conditions","volume":"31","author":"Mendes Soares","year":"2023","journal-title":"J. Appl. Oral Sci."},{"key":"10.1016\/j.jconrel.2025.114469_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2025.214222","article-title":"Niche-inspired collagen infused melt electrowritten scaffolds for craniofacial bone regeneration","volume":"170","author":"Daghrery","year":"2025","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.jconrel.2025.114469_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2025.106929","article-title":"Electrospun SilkMA\/silicate-chlorinated cobalt-doped bioactive glass composite for bone regeneration","volume":"164","author":"de Souza","year":"2025","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"27","key":"10.1016\/j.jconrel.2025.114469_bb0140","doi-asserted-by":"crossref","first-page":"32121","DOI":"10.1021\/acsami.3c03059","article-title":"Nanoscale beta-TCP-laden GelMA\/PCL composite membrane for guided bone regeneration","volume":"15","author":"Mahmoud","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.jconrel.2025.114469_bb0145","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3390\/macromol4010004","article-title":"Electrospinning: processes, structures, and materials","volume":"4","author":"Ahmadi Bonakdar","year":"2024","journal-title":"Macromol"},{"issue":"7","key":"10.1016\/j.jconrel.2025.114469_bb0150","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.dental.2020.04.008","article-title":"Bioactive amorphous magnesium phosphate-polyetheretherketone composite filaments for 3D printing","volume":"36","author":"Sikder","year":"2020","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jconrel.2025.114469_bb0155","first-page":"2118","article-title":"Pre-formulation investigation and in vitro evaluation of directly compressed ibuprofen-ethocel oral controlled release matrix tablets: a kinetic approach","volume":"5","author":"Wahab","year":"2011","journal-title":"Afr. J. Pharm. Pharmacol"},{"issue":"2","key":"10.1016\/j.jconrel.2025.114469_bb0160","doi-asserted-by":"crossref","DOI":"10.1063\/1.4946867","article-title":"Attenuated total reflection-Fourier transform infrared spectroscopic imaging of pharmaceuticals in microfluidic devices","volume":"10","author":"Ewing","year":"2016","journal-title":"Biomicrofluidics"},{"key":"10.1016\/j.jconrel.2025.114469_bb0165","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.jmbbm.2016.09.004","article-title":"Relationships between mechanical properties and drug release from electrospun fibers of PCL and PLGA blends","volume":"65","author":"Chou","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"6","key":"10.1016\/j.jconrel.2025.114469_bb0170","doi-asserted-by":"crossref","DOI":"10.1115\/1.4033437","article-title":"Characterization of human dental pulp tissue under oscillatory shear and compression","volume":"138","author":"Ozcan","year":"2016","journal-title":"J. Biomech. Eng."},{"issue":"3","key":"10.1016\/j.jconrel.2025.114469_bb0175","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.dental.2024.12.003","article-title":"Guidance for evaluating biomaterials' properties and biological potential for dental pulp tissue engineering and regeneration research","volume":"41","author":"Rosa","year":"2025","journal-title":"Dent. Mater."},{"issue":"12","key":"10.1016\/j.jconrel.2025.114469_bb0180","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1111\/iej.13826","article-title":"Advances in scaffolds used for pulp-dentine complex tissue engineering: a narrative review","volume":"55","author":"Noohi","year":"2022","journal-title":"Int. Endod. J."},{"key":"10.1016\/j.jconrel.2025.114469_bb0185","doi-asserted-by":"crossref","first-page":"7938","DOI":"10.1016\/j.jmrt.2023.05.076","article-title":"Surface modifications of scaffolds for bone regeneration","volume":"24","author":"Teimouri","year":"2023","journal-title":"J. Mater. Res. Technol."},{"key":"10.1016\/j.jconrel.2025.114469_bb0190","article-title":"Metronidazole-laden silk fibroin methacrylated scaffolds for managing periapical lesions","author":"Silverberg","year":"2024","journal-title":"Odontology"},{"issue":"8","key":"10.1016\/j.jconrel.2025.114469_bb0195","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1177\/00220345960750081101","article-title":"Immunolocalization of fibronectin during reparative dentinogenesis in human teeth after pulp capping with calcium hydroxide","volume":"75","author":"Yoshiba","year":"1996","journal-title":"J. Dent. Res."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114469_bb0200","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.dental.2018.09.008","article-title":"Pulp capping materials modulate the balance between inflammation and regeneration","volume":"35","author":"Giraud","year":"2019","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jconrel.2025.114469_bb0205","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0168-3659(85)90051-3","article-title":"Kinetics of drug release from hydrogel matrices","volume":"2","author":"Lee","year":"1985","journal-title":"J. Control. Release"},{"issue":"50","key":"10.1016\/j.jconrel.2025.114469_bb0210","first-page":"35251","article-title":"Mohamady ghobashy, revolutionizing biomedicine: advancements, applications, and prospects of nanocomposite macromolecular carbohydrate-based hydrogel biomaterials: a review, RSC","volume":"13","author":"Alshangiti","year":"2023","journal-title":"Advances"},{"issue":"Pt 1","key":"10.1016\/j.jconrel.2025.114469_bb0215","article-title":"Dual scalable osteogenic microtissue engineering via GelMA microsphere-inspired mechanical training and autonomous assembling of dental pulp stem cell","volume":"282","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"12","key":"10.1016\/j.jconrel.2025.114469_bb0220","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1002\/jbm.a.37235","article-title":"3D printed hybrid bone constructs of PCL and dental pulp stem cells loaded GelMA","volume":"109","author":"Buyuksungur","year":"2021","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"4","key":"10.1016\/j.jconrel.2025.114469_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/jfb15040105","article-title":"Strontium-doped bioglass-laden gelatin Methacryloyl hydrogels for vital pulp therapy","volume":"15","author":"Aminmansour","year":"2024","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.jconrel.2025.114469_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102418","article-title":"3D bioprinting of DPSCs with GelMA hydrogel of various concentrations for bone regeneration","volume":"88","author":"Wang","year":"2024","journal-title":"Tissue Cell"},{"issue":"9","key":"10.1016\/j.jconrel.2025.114469_bb0235","doi-asserted-by":"crossref","DOI":"10.1007\/s00784-024-05877-y","article-title":"Anti-inflammatory potential of casein enzymatic hydrolysate\/gelatin methacryloyl scaffolds for vital pulp therapy","volume":"28","author":"Paymanpour","year":"2024","journal-title":"Clin. Oral Investig."},{"issue":"2","key":"10.1016\/j.jconrel.2025.114469_bb0240","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1177\/0022034516682005","article-title":"GelMA-encapsulated hDPSCs and HUVECs for dental pulp regeneration","volume":"96","author":"Khayat","year":"2017","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jconrel.2025.114469_bb0245","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.reth.2020.09.007","article-title":"Dental pulp stem cells response on the nanotopography of scaffold to regenerate dentin-pulp complex tissue","volume":"15","author":"Diana","year":"2020","journal-title":"Regen. Ther."},{"issue":"31","key":"10.1016\/j.jconrel.2025.114469_bb0250","doi-asserted-by":"crossref","first-page":"7822","DOI":"10.1016\/j.biomaterials.2011.04.034","article-title":"The effect of scaffold architecture on odontogenic differentiation of human dental pulp stem cells","volume":"32","author":"Wang","year":"2011","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.jconrel.2025.114469_bb0255","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cellimm.2010.03.010","article-title":"Prostaglandin E2 suppresses beta1-integrin expression via E-prostanoid receptor in human monocytes\/macrophages","volume":"263","author":"Hasegawa","year":"2010","journal-title":"Cell. Immunol."},{"issue":"5","key":"10.1016\/j.jconrel.2025.114469_bb0260","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.3892\/ijo.2013.1859","article-title":"Prostaglandin E(2) receptor EP1-mediated phosphorylation of focal adhesion kinase enhances cell adhesion and migration in hepatocellular carcinoma cells","volume":"42","author":"Bai","year":"2013","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.jconrel.2025.114469_bb0265","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.biomaterials.2015.02.097","article-title":"Magnesium modification of a calcium phosphate cement alters bone marrow stromal cell behavior via an integrin-mediated mechanism","volume":"53","author":"Zhang","year":"2015","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.jconrel.2025.114469_bb0270","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.joca.2010.06.005","article-title":"Magnesium enhances adherence and cartilage formation of synovial mesenchymal stem cells through integrins","volume":"18","author":"Shimaya","year":"2010","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114469_bb0275","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0014-4827(72)90480-6","article-title":"Roles of magnesium and calcium ions in cell-to-substrate adhesion","volume":"74","author":"Takeichi","year":"1972","journal-title":"Exp. Cell Res."},{"issue":"3","key":"10.1016\/j.jconrel.2025.114469_bb0280","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/bies.20183","article-title":"Magnesium: the missing element in molecular views of cell proliferation control","volume":"27","author":"Rubin","year":"2005","journal-title":"Bioessays"},{"issue":"4","key":"10.1016\/j.jconrel.2025.114469_bb0285","doi-asserted-by":"crossref","DOI":"10.3390\/nu13041376","article-title":"Assessment and imaging of intracellular magnesium in SaOS-2 osteosarcoma cells and its role in proliferation","volume":"13","author":"Cappadone","year":"2021","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.jconrel.2025.114469_bb0290","first-page":"4346","article-title":"The influence of biodegradable magnesium alloys on the osteogenic differentiation of human mesenchymal stem cells","volume":"102","author":"Li","year":"2014","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"7","key":"10.1016\/j.jconrel.2025.114469_bb0295","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.dental.2014.04.010","article-title":"Methods to evaluate and strategies to improve the biocompatibility of dental materials and operative techniques","volume":"30","author":"de Souza Costa","year":"2014","journal-title":"Dent. Mater."},{"issue":"8","key":"10.1016\/j.jconrel.2025.114469_bb0300","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1007\/s00784-021-04013-4","article-title":"Platform technologies for regenerative endodontics from multifunctional biomaterials to tooth-on-a-chip strategies","volume":"25","author":"Soares","year":"2021","journal-title":"Clin. Oral Investig."},{"issue":"5","key":"10.1016\/j.jconrel.2025.114469_bb0305","article-title":"Effects of ibuprofen and diclofenac pre-treatment on viability and apoptosis processes in human dental pulp stem cells","volume":"60","author":"Adamickova","year":"2024","journal-title":"Medicina (Kaunas)"},{"issue":"3","key":"10.1016\/j.jconrel.2025.114469_bb0310","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1042\/CBI20090211","article-title":"Effects of non-steroidal anti-inflammatory drugs on proliferation, differentiation and migration in equine mesenchymal stem cells","volume":"35","author":"Muller","year":"2011","journal-title":"Cell Biol. Int."},{"issue":"4 Suppl","key":"10.1016\/j.jconrel.2025.114469_bb0315","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1016\/j.joen.2014.01.021","article-title":"Inflammation and regeneration in the dentin-pulp complex: a double-edged sword","volume":"40","author":"Cooper","year":"2014","journal-title":"J. Endod."},{"key":"10.1016\/j.jconrel.2025.114469_bb0320","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.archoralbio.2017.05.008","article-title":"Inflammatory cytokines in normal and irreversibly inflamed pulps: a systematic review","volume":"82","author":"Hirsch","year":"2017","journal-title":"Arch. Oral Biol."},{"issue":"14","key":"10.1016\/j.jconrel.2025.114469_bb0325","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26144129","article-title":"ILs and MMPs levels in inflamed human dental pulp: a systematic review","volume":"26","author":"Kritikou","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.jconrel.2025.114469_bb0330","doi-asserted-by":"crossref","DOI":"10.3390\/biom12010138","article-title":"Role of lipopolysaccharide, derived from various bacterial species, in pulpitis-a systematic review","volume":"12","author":"Brodzikowska","year":"2022","journal-title":"Biomolecules"},{"issue":"51","key":"10.1016\/j.jconrel.2025.114469_bb0335","doi-asserted-by":"crossref","first-page":"7389","DOI":"10.1038\/sj.onc.1203160","article-title":"Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen","volume":"18","author":"Palayoor","year":"1999","journal-title":"Oncogene"},{"issue":"4","key":"10.1016\/j.jconrel.2025.114469_bb0340","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/sj.bjp.0701652","article-title":"Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen","volume":"123","author":"Scheuren","year":"1998","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114469_bb0345","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13287-017-0766-0","article-title":"Interleukin-6\/interleukin-6 receptor complex promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells","volume":"9","author":"Xie","year":"2018","journal-title":"Stem Cell Res. Ther."},{"issue":"9","key":"10.1016\/j.jconrel.2025.114469_bb0350","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S1074-7613(94)80014-6","article-title":"Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system","volume":"1","author":"Bernad","year":"1994","journal-title":"Immunity"},{"key":"10.1016\/j.jconrel.2025.114469_bb0355","doi-asserted-by":"crossref","DOI":"10.1111\/iej.13947","article-title":"Inflammatory response and odontogenic differentiation of inflamed dental pulp treated with different pulp capping materials: an in vivo study","author":"Chung","year":"2023","journal-title":"Int. Endod. J."},{"issue":"3","key":"10.1016\/j.jconrel.2025.114469_bb0360","first-page":"177","article-title":"Histologic evaluation of human pulp response to capping with Mta, Cem cement and biodentine","volume":"21","author":"Hoseinifar","year":"2020","journal-title":"J. Dent."},{"key":"10.1016\/j.jconrel.2025.114469_bb0365","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/002203458506400407","article-title":"Effects of calcium hydroxide-containing pulp-capping agents on pulp cell migration, proliferation, and differentiation","author":"Schroder","year":"1985","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jconrel.2025.114469_bb0370","first-page":"1061","article-title":"Adverse drug reactions and drug-drug interactions with over-the-counter NSAIDs","volume":"11","author":"Moore","year":"2015","journal-title":"Ther. Clin. Risk Manag."},{"key":"10.1016\/j.jconrel.2025.114469_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2022.212856","article-title":"Antibacterial amorphous magnesium phosphate\/graphene oxide for accelerating bone regeneration","volume":"138","author":"Pahlevanzadeh","year":"2022","journal-title":"Biomater. Adv."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114469_bb0380","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ydbio.2006.11.001","article-title":"Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo","volume":"303","author":"Lu","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.jconrel.2025.114469_bb0385","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3389\/fbioe.2018.00116","article-title":"Photocrosslinkable gelatin hydrogels modulate the production of the major pro-inflammatory cytokine, TNF-alpha, by human mononuclear cells","volume":"6","author":"Donaldson","year":"2018","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"6","key":"10.1016\/j.jconrel.2025.114469_bb0390","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.bone.2004.01.020","article-title":"Differential expression patterns of the dentin matrix proteins during mineralized tissue formation","volume":"34","author":"Hao","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.jconrel.2025.114469_bb0395","doi-asserted-by":"crossref","DOI":"10.1021\/acsami.4c09742","article-title":"Amino acid-based poly(ester urea) biodegradable membrane for guided bone regeneration","author":"Dal-Fabbro","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2025.114469_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.117819","article-title":"New formulation of ibuprofen-arginate reduces oxidative stress and prevents macrophage polarization toward M1 phenotype","volume":"183","author":"\u00c1lvarez","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jconrel.2025.114469_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113502","article-title":"Ibuprofen modulates macrophage polarization by downregulating poly (ADP-ribose) polymerase 1","volume":"143","author":"Wang","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.jconrel.2025.114469_bb0410","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.658","article-title":"Macrophage plasticity: signaling pathways, tissue repair, and regeneration","volume":"5","author":"Yan","year":"2024","journal-title":"MedComm"},{"key":"10.1016\/j.jconrel.2025.114469_bb0415","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.14053","article-title":"Macrophages play a key role in tissue repair and regeneration","volume":"10","author":"Yu","year":"2022","journal-title":"PeerJ"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925010831?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925010831?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:43:30Z","timestamp":1781325810000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925010831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":83,"alternative-id":["S0168365925010831"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114469","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bilayer gelatin-methacryloyl scaffold for pulp inflammation suppression and dentin-like tissue regeneration","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114469","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114469"}}