{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:20:02Z","timestamp":1792545602719,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1212100"],"award-info":[{"award-number":["2024YFA1212100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFE0114200"],"award-info":[{"award-number":["2025YFE0114200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32301121"],"award-info":[{"award-number":["32301121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52373166"],"award-info":[{"award-number":["52373166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471423"],"award-info":[{"award-number":["32471423"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52422318"],"award-info":[{"award-number":["52422318"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22277155"],"award-info":[{"award-number":["22277155"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024B1515020025"],"award-info":[{"award-number":["2024B1515020025"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004241","name":"China Primary Health Care Foundation","doi-asserted-by":"publisher","award":["2022\\u2212003"],"award-info":[{"award-number":["2022\\u2212003"]}],"id":[{"id":"10.13039\/501100004241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2025A04J7161"],"award-info":[{"award-number":["2025A04J7161"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2023A03J0218"],"award-info":[{"award-number":["2023A03J0218"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2024A04J6572"],"award-info":[{"award-number":["2024A04J6572"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jconrel.2025.114480","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T04:30:40Z","timestamp":1764390640000},"page":"114480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Nanovesicles integrating PD-1-mediated targeting and CRISPR\/Cas9-based CD47 editing for dual immune checkpoint blockade"],"prefix":"10.1016","volume":"390","author":[{"given":"Huimin","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenya","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingguo","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanteng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeh-Hsing","family":"Lao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixian","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2025.114480_bb0005","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41573-021-00345-8","article-title":"The foundations of immune checkpoint blockade and the ipilimumab approval decennial","volume":"21","author":"Korman","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2025.114480_bb0010","doi-asserted-by":"crossref","DOI":"10.59717\/j.xinn-life.2023.100016","article-title":"The role of extratumoral and intratumoral microorganisms in cancer immunotherapy","volume":"1","author":"Du","year":"2023","journal-title":"Innovation Life"},{"key":"10.1016\/j.jconrel.2025.114480_bb0015","doi-asserted-by":"crossref","first-page":"6","DOI":"10.15212\/bioi-2020-0002","article-title":"Immunoscore guided cold tumors to acquire \u201ctemperature\u201d through integrating physicochemical and biological methods","volume":"1","author":"Liu","year":"2020","journal-title":"BIO Integr."},{"key":"10.1016\/j.jconrel.2025.114480_bb0020","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201905751","article-title":"Dual-locking nanoparticles disrupt the PD-1\/PD-L1 pathway for efficient cancer immunotherapy","volume":"31","author":"Zhang","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2025.114480_bb0025","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba7365","article-title":"CRISPR-engineered T cells in patients with refractory cancer","volume":"367","author":"Stadtmauer","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2025.114480_bb0030","doi-asserted-by":"crossref","first-page":"10897","DOI":"10.1039\/D2SC03412C","article-title":"Rational development of molecularly imprinted nanoparticles for blocking PD-1\/PD-L1 axis","volume":"13","author":"Gu","year":"2022","journal-title":"Chem. Sci."},{"key":"10.1016\/j.jconrel.2025.114480_bb0035","doi-asserted-by":"crossref","first-page":"5309","DOI":"10.1016\/j.cell.2021.09.020","article-title":"Hallmarks of response, resistance, and toxicity to immune checkpoint blockade","volume":"184","author":"Morad","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2025.114480_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/EXP.20210106","article-title":"Recent advances in overcoming barriers to cell-based delivery systems for cancer immunotherapy","volume":"2","author":"Ding","year":"2022","journal-title":"Exploration"},{"key":"10.1016\/j.jconrel.2025.114480_bb0045","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adh2413","article-title":"Anti-phagocytosis-blocking repolarization-resistant membrane-fusogenic liposome (ARMFUL) for adoptive cell immunotherapy","volume":"9","author":"Zheng","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2025.114480_bb0050","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jconrel.2025.114480_bb0055","article-title":"Advances and applications of nanoparticles in cancer therapy","volume":"3","author":"Huang","year":"2024","journal-title":"MedComm \u2013 Oncol."},{"key":"10.1016\/j.jconrel.2025.114480_bb0060","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/s41467-024-44941-9","article-title":"Bacterial protoplast-derived nanovesicles carrying CRISPR-Cas9 tools re-educate tumor-associated macrophages for enhanced cancer immunotherapy","volume":"15","author":"Zhao","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.114480_bb0065","article-title":"Activation of RIG-I\/MDA5 signaling and inhibition of CD47-SIRPalpha checkpoint with a dual siRNA-assembled nanoadjuvant for robust cancer immunotherapy","volume":"63","author":"Xu","year":"2024","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.jconrel.2025.114480_bb0070","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202206213","article-title":"Microfluidics-enabled nanovesicle delivers CD47\/PD-L1 antibodies to enhance antitumor immunity and reduce immunotoxicity in lung adenocarcinoma","volume":"10","author":"Su","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2025.114480_bb0075","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1007\/s11427-022-2285-6","article-title":"Design of a novel chimeric peptide via dual blockade of CD47\/SIRPalpha and PD-1\/PD-L1 for cancer immunotherapy","volume":"66","author":"Hu","year":"2023","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.jconrel.2025.114480_bb0080","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/s41467-023-37328-9","article-title":"STING agonist-loaded, CD47\/PD-L1-targeting nanoparticles potentiate antitumor immunity and radiotherapy for glioblastoma","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.114480_bb0085","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1093\/cvr\/cvab369","article-title":"Loss of myeloid cell-specific SIRPalpha, but not CD47, attenuates inflammation and suppresses atherosclerosis","volume":"118","author":"Singla","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jconrel.2025.114480_bb0090","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1021\/acs.bioconjchem.2c00019","article-title":"Suppressing or enhancing macrophage engulfment through the use of CD47 and related peptides","volume":"33","author":"Jalil","year":"2022","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2025.114480_bb0095","doi-asserted-by":"crossref","first-page":"101359","DOI":"10.1016\/j.nantod.2021.101359","article-title":"CRISPR-based in situ engineering tumor cells to reprogram macrophages for effective cancer immunotherapy","volume":"42","author":"Lin","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2025.114480_bb0100","article-title":"Recent advances in nanomodulators for augmenting cancer immunotherapy in cold tumors: insights from drug delivery to drug-free strategies","volume":"34","author":"Zhang","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2025.114480_bb0105","doi-asserted-by":"crossref","first-page":"30332","DOI":"10.1021\/acsnano.4c07364","article-title":"Engineered outer membrane vesicles as nanosized immune cell engagers for enhanced solid tumor immunotherapy","volume":"18","author":"Sun","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.114480_bb0110","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.7150\/ijbs.72534","article-title":"Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance","volume":"18","author":"Zhang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jconrel.2025.114480_bb0115","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.addr.2020.04.010","article-title":"Delivery of CRISPR\/Cas systems for cancer gene therapy and immunotherapy","volume":"168","author":"Song","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.114480_bb0120","article-title":"Engineered nanomaterials to potentiate CRISPR\/Cas9 gene editing for Cancer therapy","volume":"36","author":"Yi","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2025.114480_bb0125","article-title":"Advanced nanotheranostics of CRISPR\/Cas for viral hepatitis and hepatocellular carcinoma","volume":"8","author":"Kong","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2025.114480_bb0130","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202407262","article-title":"CD47 knock-out using CRISPR-Cas9 RNA lipid nanocarriers results in reduced mesenchymal glioblastoma growth in vivo","volume":"12","author":"Rouatbi","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2025.114480_bb0135","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202004940","article-title":"Multistage sensitive nanoCRISPR enable efficient intracellular disruption of immune checkpoints for robust innate and adaptive immune coactivation","volume":"30","author":"Wang","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2025.114480_bb0140","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/s41573-023-00762-x","article-title":"Drug delivery systems for CRISPR-based genome editors","volume":"22","author":"Madigan","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2025.114480_bb0145","article-title":"Magnetic-activated nanosystem with liver-specific CRISPR nonviral vector to achieve spatiotemporal liver genome editing as hepatitis B therapeutics","volume":"33","author":"Zhuo","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2025.114480_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.102040","article-title":"Hepatocyte-confined CRISPR\/Cas9-based nanocleaver precisely eliminates viral DNA for efficient and safe treatment of hepatitis B virus infection","volume":"53","author":"Kong","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2025.114480_bb0155","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1039\/D3CC05375J","article-title":"CRISPR\/Cas detection with nanodevices: moving deeper into liquid biopsy","volume":"60","author":"Kong","year":"2024","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jconrel.2025.114480_bb0160","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41392-021-00645-w","article-title":"Spatiotemporal control of CRISPR\/Cas9 gene editing","volume":"6","author":"Zhuo","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2025.114480_bb0165","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2302910120","article-title":"Focused ultrasound-mediated brain genome editing","volume":"120","author":"Lao","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2025.114480_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2024.115346","article-title":"Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads","volume":"211","author":"Leandro","year":"2024","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.114480_bb0175","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202402445","article-title":"Revolutionizing neurocare: biomimetic nanodelivery via cell membranes","volume":"36","author":"Liao","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2025.114480_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/EXP.20230139","article-title":"Unveiling the promise: exosomes as game-changers in anti-infective therapy","volume":"4","author":"Chavda","year":"2024","journal-title":"Exploration"},{"key":"10.1016\/j.jconrel.2025.114480_bb0185","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1039\/D4BM00054D","article-title":"Functionalized extracellular nanovesicles as advanced CRISPR delivery systems","volume":"12","author":"Wang","year":"2024","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.jconrel.2025.114480_bb0190","article-title":"Proximity-activated DNA scanning encoded sequencing for massive access to membrane proteins nanoscale organization","volume":"122","author":"Zhao","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2025.114480_bb0195","doi-asserted-by":"crossref","first-page":"6606","DOI":"10.1021\/acs.nanolett.2c01863","article-title":"Engineered macrophage-membrane-coated nanoparticles with enhanced PD-1 expression induce immunomodulation for a synergistic and targeted antiglioblastoma activity","volume":"22","author":"Yin","year":"2022","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2025.114480_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113138","article-title":"Engineering of dendritic cell bispecific extracellular vesicles for tumor-targeting immunotherapy","volume":"42","author":"Xu","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.jconrel.2025.114480_bb0205","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41586-018-0392-8","article-title":"Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response","volume":"560","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2025.114480_bb0210","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/adma.201504288","article-title":"Fusogenic reactive oxygen species triggered charge-reversal vector for effective gene delivery","volume":"28","author":"Liu","year":"2016","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2025.114480_bb0215","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1038\/s41467-024-46533-z","article-title":"An antifouling membrane-fusogenic liposome for effective intracellular delivery in vivo","volume":"15","author":"Kong","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2025.114480_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122349","article-title":"A LIGHTFUL nanomedicine overcomes EGFR-mediated drug resistance for enhanced tyrosine-kinase-inhibitor-based hepatocellular carcinoma therapy","volume":"302","author":"Yi","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2025.114480_bb0225","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202370103","article-title":"Membrane-fusion-mediated multiplex engineering of tumor cell surface glycans for enhanced NK cell therapy","volume":"35","author":"Zheng","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2025.114480_bb0230","doi-asserted-by":"crossref","first-page":"6841","DOI":"10.1039\/D2TB00632D","article-title":"Membrane-fusogenic biomimetic particles: a new bioengineering tool learned from nature","volume":"10","author":"Kong","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jconrel.2025.114480_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2020.100895","article-title":"Harnessing nanoparticles for the efficient delivery of the CRISPR\/Cas9 system","volume":"34","author":"Rahimi","year":"2020","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2025.114480_bb0240","first-page":"251","article-title":"Engineered extracellular vesicles for concurrent anti-PDL1 immunotherapy and chemotherapy","volume":"9","author":"Chen","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2025.114480_bb0245","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41565-022-01261-7","article-title":"Targeting the activity of T cells by membrane surface redox regulation for cancer theranostics","volume":"18","author":"Shi","year":"2023","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2025.114480_bb0250","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev-immunol-070621-030155","article-title":"Resistance mechanisms to anti-PD cancer immunotherapy","volume":"40","author":"Vesely","year":"2022","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2025.114480_bb0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41392-023-01668-1","article-title":"Multifunctional nanoparticle-mediated combining therapy for human diseases","volume":"9","author":"Li","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2025.114480_bb0260","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003464","article-title":"Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes antitumor immunity","volume":"9","author":"Chen","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jconrel.2025.114480_bb0265","doi-asserted-by":"crossref","first-page":"2009116","DOI":"10.1002\/adfm.202009116","article-title":"A nano \u201cImmune-guide\u201d recruiting lymphocytes and modulating the ratio of macrophages from different origins to enhance cancer immunotherapy","volume":"31","author":"Sun","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2025.114480_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101606","article-title":"Engineered T cell extracellular vesicles displaying PD-1 boost anti-tumor immunity","volume":"46","author":"Li","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2025.114480_bb0275","doi-asserted-by":"crossref","first-page":"26320","DOI":"10.1002\/anie.202108342","article-title":"Genetically programmable fusion cellular vesicles for cancer immunotherapy","volume":"60","author":"Meng","year":"2021","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.jconrel.2025.114480_bb0280","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.cell.2024.01.042","article-title":"Past, present, and future of CRISPR genome editing technologies","volume":"187","author":"Pacesa","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2025.114480_bb0285","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41565-024-01747-6","article-title":"Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery","volume":"20","author":"Xue","year":"2025","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2025.114480_bb0290","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/s41565-022-01122-3","article-title":"Enhancing CRISPR\/Cas gene editing through modulating cellular mechanical properties for cancer therapy","volume":"17","author":"Zhang","year":"2022","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2025.114480_bb0295","article-title":"Oncolytic virus-like nanoparticles for tumor-specific gene delivery","volume":"34","author":"Li","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2025.114480_bb0300","doi-asserted-by":"crossref","first-page":"14532","DOI":"10.1021\/acsnano.3c01295","article-title":"Improvement of gene delivery by minimal bacteriophage particles","volume":"17","author":"Kao","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2025.114480_bb0305","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax5032","article-title":"Highly efficient and tumor-selective nanoparticles for dual-targeted immunogene therapy against cancer","volume":"6","author":"Huang","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2025.114480_bb0310","article-title":"In situ reprogramming of tumor-associated macrophages with internally and externally engineered exosomes","volume":"62","author":"Zhang","year":"2023","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.jconrel.2025.114480_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113891","article-title":"Nanotechnology-based delivery of CRISPR\/Cas9 for cancer treatment","volume":"176","author":"Xu","year":"2021","journal-title":"Adv. Drug Deliv. Rev."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925010946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925010946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:21:05Z","timestamp":1781702465000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925010946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":63,"alternative-id":["S0168365925010946"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114480","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanovesicles integrating PD-1-mediated targeting and CRISPR\/Cas9-based CD47 editing for dual immune checkpoint blockade","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114480","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114480"}}