{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T07:11:07Z","timestamp":1782889867747,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010790","name":"Erasmus+","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003061","name":"Erasmus MC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jconrel.2025.114544","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T17:24:03Z","timestamp":1765560243000},"page":"114544","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The effect of hyperthermic cycling on intratumoral liposome accumulation and triggered drug release"],"prefix":"10.1016","volume":"390","author":[{"given":"Li","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein I.","family":"Priester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Rossmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hossann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard C.","family":"van Rhoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann L.B.","family":"Seynhaeve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Haemmerich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo L.M.","family":"ten Hagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.jconrel.2025.114544_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics9020012","article-title":"Liposomal formulations in clinical use: An Updated Review","volume":"9","author":"Bulbake","year":"2017","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2025.114544_bb0010","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.addr.2020.02.004","article-title":"Hyperthermia and smart drug delivery systems for solid tumor therapy","volume":"163","author":"Seynhaeve","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2025.114544_bb0015","doi-asserted-by":"crossref","unstructured":"Seynhaeve AL, Hoving S, Schipper D, Vermeulen CE, de Wiel-Ambagtsheer GA, van Tiel ST, Eggermont AM, Ten Hagen TL. Tumor necrosis factor alpha mediates homogeneous distribution of liposomes in murine melanoma that contributes to a better tumor response. Cancer Res. 2007 Oct 1;67(19):9455\u201362.","DOI":"10.1158\/0008-5472.CAN-07-1599"},{"issue":"1","key":"10.1016\/j.jconrel.2025.114544_bb0020","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jconrel.2013.08.034","article-title":"Intact Doxil is taken up intracellularly and released doxorubicin sequesters in the lysosome: evaluated by in vitro\/in vivo live cell imaging","volume":"172","author":"Seynhaeve","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114544_bb0025","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2174\/1875933501103010038","article-title":"Nanoscale drug delivery and hyperthermia: the materials design and preclinical and clinical testing of low temperature-sensitive liposomes used in combination with mild hyperthermia in the treatment of local Cancer","volume":"3","author":"Landon","year":"2011","journal-title":"Open Nanomed J."},{"key":"10.1016\/j.jconrel.2025.114544_bb0030","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.addr.2020.03.006","article-title":"A moderate thermal dose is sufficient for effective free and TSL based thermochemotherapy","volume":"163-164","author":"van Rhoon","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"7","key":"10.1016\/j.jconrel.2025.114544_bb0035","first-page":"3027","article-title":"Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature","volume":"61","author":"Kong","year":"2001","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.jconrel.2025.114544_bb0040","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jconrel.2013.01.026","article-title":"Improved intratumoral nanoparticle extravasation and penetration by mild hyperthermia","volume":"167","author":"Li","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114544_bb0045","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.addr.2020.01.003","article-title":"Molecular and biological rationale of hyperthermia as radio- and chemosensitizer","volume":"163-164","author":"Oei","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"24","key":"10.1016\/j.jconrel.2025.114544_bb0050","doi-asserted-by":"crossref","first-page":"9851","DOI":"10.1073\/pnas.1101053108","article-title":"Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition","volume":"108","author":"Krawczyk","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"16","key":"10.1016\/j.jconrel.2025.114544_bb0055","doi-asserted-by":"crossref","first-page":"1487296","DOI":"10.3389\/fimmu.2025.1487296","article-title":"From cold to hot: mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy","volume":"28","author":"Abreu","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2025.114544_bb0060","first-page":"2728","article-title":"European Society for Medical Oncology Congress","author":"Di Gioia","year":"2025","journal-title":"Poster"},{"issue":"1","key":"10.1016\/j.jconrel.2025.114544_bb0065","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1080\/02656736.2020.1779357","article-title":"Heating technology for malignant tumors: a review","volume":"37","author":"Kok","year":"2020","journal-title":"Int. J. Hyperth."},{"key":"10.1016\/j.jconrel.2025.114544_bb0070","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jconrel.2016.12.033","article-title":"Sequential HIFU heating and nanobubble encapsulation provide efficient drug penetration from stealth and temperature sensitive liposomes in colon cancer","volume":"247","author":"Van Osdol","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114544_bb0075","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jconrel.2018.04.047","article-title":"Image-guided thermosensitive liposomes for focused ultrasound drug delivery: using NIRF-labelled lipids and topotecan to visualise the effects of hyperthermia in tumours","volume":"280","author":"Centelles","year":"2018","journal-title":"J. Control. Release"},{"issue":"36","key":"10.1016\/j.jconrel.2025.114544_bb0080","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba5684","article-title":"Novel fractionated ultrashort thermal exposures with MRI-guided focused ultrasound for treating tumors with thermosensitive drugs","volume":"6","author":"Santos","year":"2020","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.jconrel.2025.114544_bb0085","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jconrel.2010.01.006","article-title":"Triggered content release from optimized stealth thermosensitive liposomes using mild hyperthermia","volume":"143","author":"Li","year":"2010","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.jconrel.2025.114544_bb0090","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jconrel.2013.03.011","article-title":"Mild hyperthermia triggered doxorubicin release from optimized stealth thermosensitive liposomes improves intratumoral drug delivery and efficacy","volume":"168","author":"Li","year":"2013","journal-title":"J. Control. Release"},{"issue":"5","key":"10.1016\/j.jconrel.2025.114544_bb0095","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/BF02531316","article-title":"Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots","volume":"5","author":"Rouser","year":"1970","journal-title":"Lipids"},{"key":"10.1016\/j.jconrel.2025.114544_bb0100","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jconrel.2013.11.012","article-title":"A novel two-step mild hyperthermia for advanced liposomal chemotherapy","volume":"174","author":"Li","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2025.114544_bb0105","article-title":"Intravital microscopy of tumor-associated vasculature using advanced dorsal skinfold window chambers on transgenic fluorescent mice","volume":"131","author":"Seynhaeve","year":"2018","journal-title":"J. Vis. Exp."},{"issue":"1","key":"10.1016\/j.jconrel.2025.114544_bb0110","doi-asserted-by":"crossref","first-page":"20389","DOI":"10.1038\/s41598-021-99939-w","article-title":"An adapted dorsal skinfold model used for 4D intravital followed by whole-mount imaging to reveal endothelial cell-pericyte association","volume":"11","author":"Seynhaeve","year":"2021","journal-title":"Sci. Rep."},{"issue":"20","key":"10.1016\/j.jconrel.2025.114544_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13205146","article-title":"Preclinical studies in small animals for advanced drug delivery using hyperthermia and intravital microscopy","volume":"13","author":"Priester","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.jconrel.2025.114544_bb0120","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/s42003-021-02428-z","article-title":"Drug transport kinetics of intravascular triggered drug delivery systems","volume":"4","author":"Ten Hagen","year":"2021","journal-title":"Commun Biol."},{"key":"10.1016\/j.jconrel.2025.114544_bb0125","series-title":"Methods in Molecular Medicine","first-page":"227","article-title":"Tumor Vascular Therapy With TNF","volume":"98","author":"Ten Hagen","year":"2004"},{"issue":"18","key":"10.1016\/j.jconrel.2025.114544_bb0130","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.3390\/cancers13184628","article-title":"External basic hyperthermia devices for preclinical studies in small animals","volume":"13","author":"Priester","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.jconrel.2025.114544_bb0135","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jconrel.2015.12.004","article-title":"Method of hyperthermia and tumor size influence effectiveness of doxorubicin release from thermosensitive liposomes in experimental tumors","volume":"222","author":"Willerding","year":"2016","journal-title":"J. Control. Release"},{"issue":"10","key":"10.1016\/j.jconrel.2025.114544_bb0140","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1016\/j.bbamem.2007.05.021","article-title":"In vitro stability and content release properties of phosphatidylglyceroglycerol containing thermosensitive liposomes","volume":"1768","author":"Hossann","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.jconrel.2025.114544_bb0145","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/bjc.1994.301","article-title":"Daunorubicin pharmacokinetics and the correlation with P-glycoprotein and response in patients with acute leukaemia","volume":"70","author":"Galettis","year":"1994","journal-title":"Br. J. Cancer"},{"issue":"8","key":"10.1016\/j.jconrel.2025.114544_bb0150","first-page":"1837","article-title":"Adriamycin and daunorubicin: a comparison of antitumor activities and tissue uptake in mice following immunosuppression","volume":"33","author":"Schwarz","year":"1973","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.jconrel.2025.114544_bb0155","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/0360-3016(84)90379-1","article-title":"Thermal dose determination in cancer therapy","volume":"10","author":"Sapareto","year":"1984","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.jconrel.2025.114544_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2021.104250","article-title":"Thermal therapy induced fluid pressure and stress reductions in a solid tumor","volume":"139","author":"Jin","year":"2022","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.jconrel.2025.114544_bb0165","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.addr.2020.07.007","article-title":"Hyperthermia can alter tumor physiology and improve chemo- and radio-therapy efficacy","volume":"163-164","author":"Dunne","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.jconrel.2025.114544_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16030505","article-title":"Hyperthermia in combination with emerging targeted and immunotherapies as a new approach in Cancer treatment","volume":"16","author":"Logghe","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"7","key":"10.1016\/j.jconrel.2025.114544_bb0175","doi-asserted-by":"crossref","DOI":"10.1002\/adtp.202000267","article-title":"The effects of localized heat on the hallmarks of Cancer","volume":"4","author":"Hannon","year":"2021","journal-title":"Adv. Therapeut."},{"issue":"4","key":"10.1016\/j.jconrel.2025.114544_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035489","article-title":"Acute and long-term effects of hyperthermia in B16-F10 melanoma cells","volume":"7","author":"Garcia","year":"2012","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jconrel.2025.114544_bb0185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0217676","article-title":"Thermal cycling-hyperthermia in combination with polyphenols, epigallocatechin gallate and chlorogenic acid, exerts synergistic anticancer effect against human pancreatic cancer PANC-1 cells","volume":"14","author":"Lu","year":"2019","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.jconrel.2025.114544_bb0190","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.7150\/thno.14960","article-title":"Investigation of particle accumulation, chemosensitivity and Thermosensitivity for effective solid tumor therapy using thermosensitive liposomes and hyperthermia","volume":"6","author":"Lokerse","year":"2016","journal-title":"Theranostics"},{"issue":"Pt A","key":"10.1016\/j.jconrel.2025.114544_bb0195","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jconrel.2015.10.056","article-title":"Formulation and optimization of idarubicin thermosensitive liposomes provides ultrafast triggered release at mild hyperthermia and improves tumor response","volume":"220","author":"Lu","year":"2015","journal-title":"J. Control. Release"},{"issue":"12","key":"10.1016\/j.jconrel.2025.114544_bb0200","doi-asserted-by":"crossref","first-page":"5700","DOI":"10.7150\/thno.55163","article-title":"Externally triggered smart drug delivery system encapsulating idarubicin shows superior kinetics and enhances tumoral drug uptake and response","volume":"11","author":"Lu","year":"2021","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.jconrel.2025.114544_bb0205","first-page":"617","article-title":"Thermal cycling as a novel thermal therapy to synergistically enhance the anticancer effect of propolis on PANC-1 cells","volume":"55","author":"Chen","year":"2019","journal-title":"Int. J. Oncol."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925011587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365925011587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:24:49Z","timestamp":1781702689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365925011587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":41,"alternative-id":["S0168365925011587"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114544","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of hyperthermic cycling on intratumoral liposome accumulation and triggered drug release","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2025.114544","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114544"}}