{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:46:02Z","timestamp":1790102762812,"version":"4.0.1"},"reference-count":199,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515011738"],"award-info":[{"award-number":["2023A1515011738"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515011039"],"award-info":[{"award-number":["2023A1515011039"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515011845"],"award-info":[{"award-number":["2025A1515011845"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51932002"],"award-info":[{"award-number":["51932002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471431"],"award-info":[{"award-number":["32471431"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20160"],"award-info":[{"award-number":["U22A20160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2023A03J0383"],"award-info":[{"award-number":["2023A03J0383"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2024A03J0935"],"award-info":[{"award-number":["2024A03J0935"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jconrel.2026.114617","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:07:26Z","timestamp":1768320446000},"page":"114617","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Adaptive smart hydrogels driving precision bone healing in pathological contexts"],"prefix":"10.1016","volume":"391","author":[{"given":"Hongkai","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhua","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyun","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0005","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7837837","article-title":"Differential lung protective capacity of exosomes derived from human adipose tissue, bone marrow, and umbilical cord mesenchymal stem cells in sepsis-induced acute lung injury","volume":"2022","author":"Deng","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"7","key":"10.1016\/j.jconrel.2026.114617_bb0010","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3390\/ph15070879","article-title":"Bone tissue engineering in the treatment of bone defects","volume":"15","author":"Xue","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jconrel.2026.114617_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124258","article-title":"Lignin-enriched tricalcium phosphate\/sodium alginate 3D scaffolds for application in bone tissue regeneration","volume":"239","author":"Silva-Barroso","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"21","key":"10.1016\/j.jconrel.2026.114617_bb0020","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.3390\/cells12212576","article-title":"A brief review of bone cell function and importance","volume":"12","author":"\u0160romov\u00e1","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41413-021-00180-y","article-title":"Recent advances in smart stimuli-responsive biomaterials for bone therapeutics and regeneration","volume":"10","author":"Wei","year":"2022","journal-title":"Bone Res."},{"issue":"2","key":"10.1016\/j.jconrel.2026.114617_bb0030","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41584-022-00887-0","article-title":"The decisive early phase of bone regeneration","volume":"19","author":"Duda","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"issue":"52","key":"10.1016\/j.jconrel.2026.114617_bb0035","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202301670","article-title":"Hydrogels and bioprinting in bone tissue engineering: creating artificial stem-cell niches for in vitro models","volume":"35","author":"Lewns","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmatsci.2022.100963","article-title":"Additive manufacturing of biomaterials for bone tissue engineering\u2013A critical review of the state of the art and new concepts","volume":"130","author":"Germaini","year":"2022","journal-title":"Prog. Mater. Sci."},{"key":"10.1016\/j.jconrel.2026.114617_bb0045","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41413-022-00190-4","article-title":"Mechanical regulation of bone remodeling","volume":"10","author":"Wang","year":"2022","journal-title":"Bone Res."},{"key":"10.1016\/j.jconrel.2026.114617_bb0050","article-title":"The treatment efficacy of bone tissue engineering strategy for repairing segmental bone defects under diabetic condition","volume":"12","author":"Wang","year":"2024","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jconrel.2026.114617_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1052592","article-title":"A narrative review of diabetic bone disease: characteristics, pathogenesis, and treatment","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"5","key":"10.1016\/j.jconrel.2026.114617_bb0060","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1089\/ten.teb.2020.0168","article-title":"Injectable hydrogels as three-dimensional network reservoirs for osteoporosis treatment","volume":"27","author":"Zheng","year":"2021","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.jconrel.2026.114617_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102422","article-title":"The role of TNF-\u03b1 in osteoporosis, bone repair and inflammatory bone diseases: a review","volume":"89","author":"Yao","year":"2024","journal-title":"Tissue Cell"},{"issue":"32","key":"10.1016\/j.jconrel.2026.114617_bb0070","doi-asserted-by":"crossref","first-page":"2401507","DOI":"10.1002\/adhm.202401507","article-title":"Controlled release of ceria and ferric oxide nanoparticles via collagen hydrogel for enhanced osteoarthritis therapy","volume":"13","author":"Chen","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.138086","article-title":"Injectable tumor microenvironment-modulated hydrogels with enhanced chemosensitivity and osteogenesis for tumor-associated bone defects closed-loop management","volume":"450","author":"Cai","year":"2022","journal-title":"Chem. Eng. J."},{"issue":"10","key":"10.1016\/j.jconrel.2026.114617_bb0080","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.3390\/bioengineering10101187","article-title":"Mesenchymal stem\/stromal cells: immunomodulatory and bone regeneration potential after tumor excision in osteosarcoma patients","volume":"10","author":"Baron","year":"2023","journal-title":"Bioengineering"},{"issue":"4","key":"10.1016\/j.jconrel.2026.114617_bb0085","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/BOT.0000000000001420","article-title":"Autograft, allograft, and bone graft substitutes: clinical evidence and indications for use in the setting of orthopaedic trauma surgery","volume":"33","author":"Baldwin","year":"2019","journal-title":"J. Orthop. Trauma"},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0090","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-18772-x","article-title":"Allograft versus autograft for reconstruction after resection of primary bone tumors: a comparative study of long-term clinical outcomes and risk factors for failure of reconstruction","volume":"12","author":"Wisanuyotin","year":"2022","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.jconrel.2026.114617_bb0095","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.3390\/ma16114117","article-title":"Bone grafts in dental medicine: an overview of autografts, allografts and synthetic materials","volume":"16","author":"Ferraz","year":"2023","journal-title":"Materials"},{"issue":"3","key":"10.1016\/j.jconrel.2026.114617_bb0100","article-title":"Evaluation of osseointegration of trabecular titanium implants produced with porous metal technology: an experimental study","volume":"35","author":"Ozcan","year":"2025","journal-title":"Rev. Cient. Facult. Vet."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114617_bb0105","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.prosdent.2020.12.010","article-title":"Peri-implant marginal bone changes with implant-supported metal-ceramic or monolithic zirconia single crowns: a retrospective clinical study of 1 to 5 years","volume":"128","author":"Shen","year":"2022","journal-title":"J. Prosthet. Dent."},{"key":"10.1016\/j.jconrel.2026.114617_bb0110","article-title":"Progress in dentin-derived bone graft materials: a new xenogeneic dentin-derived material with retained organic component allows for broader and easier application","volume":"13","author":"Humphrey","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2026.114617_bb0115","first-page":"1","article-title":"Histological analysis of new bone formation using bone substitutes, with and without autograft. A systematic review","author":"Hosseini Hooshiar","year":"2025","journal-title":"J. Maxillofacial Oral Surg."},{"issue":"14","key":"10.1016\/j.jconrel.2026.114617_bb0120","doi-asserted-by":"crossref","first-page":"8471","DOI":"10.3390\/app13148471","article-title":"Current options and future perspectives on bone graft and biomaterials substitutes for bone repair, from clinical needs to advanced biomaterials research","volume":"13","author":"Georgeanu","year":"2023","journal-title":"Appl. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0125","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3390\/ijms24010529","article-title":"Existing and novel biomaterials for bone tissue engineering","volume":"24","author":"Dec","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.jconrel.2026.114617_bb0130","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202005941","article-title":"Stimuli-responsive nanocomposite hydrogels for biomedical applications","volume":"31","author":"Lavrador","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fbiom.2022.948493","article-title":"Injectable hydrogel with immobilized BMP-2 mimetic peptide for local bone regeneration","volume":"1","author":"Gultian","year":"2022","journal-title":"Front. Biomater. Sci."},{"key":"10.1016\/j.jconrel.2026.114617_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.apsusc.2020.146961","article-title":"Assessing the effects of cellulose-inorganic nanofillers on thermo\/pH-dual responsive hydrogels","volume":"528","author":"Yue","year":"2020","journal-title":"Appl. Surf. Sci."},{"issue":"5","key":"10.1016\/j.jconrel.2026.114617_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202206545","article-title":"A MgFe-LDH nanosheet-incorporated smart thermo-responsive hydrogel with controllable growth factor releasing capability for bone regeneration","volume":"35","author":"Lv","year":"2023","journal-title":"Adv. Mater."},{"issue":"15","key":"10.1016\/j.jconrel.2026.114617_bb0150","article-title":"Regulating type H vessel formation and bone metabolism via bone-targeting oral micro\/nano-hydrogel microspheres to prevent bone loss","volume":"10","author":"Li","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.114617_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2025.112252","article-title":"Enhancing bone healing through immunological microenvironment modulation via a smart-responsive multifunctional therapeutic system","volume":"297","author":"Wang","year":"2025","journal-title":"Compos. Part B"},{"issue":"3","key":"10.1016\/j.jconrel.2026.114617_bb0160","article-title":"Photosensitive and conductive hydrogel induced innerved bone regeneration for infected bone defect repair","volume":"12","author":"Jing","year":"2023","journal-title":"Adv. Healthc. Mater."},{"issue":"7","key":"10.1016\/j.jconrel.2026.114617_bb0165","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3390\/gels9070533","article-title":"Advancements and applications of injectable hydrogel composites in biomedical research and therapy","volume":"9","author":"Omidian","year":"2023","journal-title":"Gels"},{"key":"10.1016\/j.jconrel.2026.114617_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110343","article-title":"Injectable and thermosensitive nanofibrous hydrogel for bone tissue engineering","volume":"107","author":"Wasupalli","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"issue":"6","key":"10.1016\/j.jconrel.2026.114617_bb0175","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1007\/s11914-023-00824-4","article-title":"Inflammatory processes affecting bone health and repair","volume":"21","author":"Torres","year":"2023","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.jconrel.2026.114617_bb0180","series-title":"Seminars in Plastic Surgery","first-page":"198","article-title":"Bone healing and inflammation: principles of fracture and repair","author":"ElHawary","year":"2021"},{"issue":"4","key":"10.1016\/j.jconrel.2026.114617_bb0185","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s13577-022-00711-7","article-title":"Regulation of osteogenic differentiation by the pro-inflammatory cytokines IL-1\u03b2 and TNF-\u03b1: current conclusions and controversies","volume":"35","author":"Mo","year":"2022","journal-title":"Hum. Cell"},{"issue":"6","key":"10.1016\/j.jconrel.2026.114617_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e16530","article-title":"Enoxaparin sodium bone cement displays local anti-inflammatory effects by regulating the expression of IL-6 and TNF-\u03b1","volume":"9","author":"Hao","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.jconrel.2026.114617_bb0195","article-title":"TNF-\u03b1 driven inflammation in bone tissues using an anatomical-and bio-integrated hydroxyapatite-enriched spongy-like hydrogel 3D model","volume":"214526","author":"Bastos","year":"2025","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.jconrel.2026.114617_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2022.116349","article-title":"Bone mass and adaptation to mechanical loading are sexually dimorphic in adult osteoblast-specific ER\u03b1 knockout mice","volume":"158","author":"Rooney","year":"2022","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.jconrel.2026.114617_bb0205","doi-asserted-by":"crossref","first-page":"11755","DOI":"10.1021\/acsnano.2c03776","article-title":"Effects of scaffold shape on bone regeneration: tiny shape differences affect the entire system","volume":"16","author":"Hayashi","year":"2022","journal-title":"ACS Nano"},{"issue":"6","key":"10.1016\/j.jconrel.2026.114617_bb0210","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba0776","article-title":"A combinational chemo-immune therapy using an enzyme-sensitive nanoplatform for dual-drug delivery to specific sites by cascade targeting","volume":"7","author":"He","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2026.114617_bb0215","doi-asserted-by":"crossref","first-page":"117484","DOI":"10.1016\/j.bone.2025.117484","article-title":"Influences and strategies for bone regeneration based on microenvironment pH adjustment","volume":"196","author":"Zhang","year":"2025","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0220","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1113\/JP280572","article-title":"Regulation of glycolysis by the hypoxia\u2010inducible factor (HIF): implications for cellular physiology","volume":"599","author":"Kierans","year":"2021","journal-title":"J. Physiol."},{"issue":"7","key":"10.1016\/j.jconrel.2026.114617_bb0225","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41584-021-00621-2","article-title":"The role of HIF proteins in maintaining the metabolic health of the intervertebral disc","volume":"17","author":"Silagi","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"issue":"9","key":"10.1016\/j.jconrel.2026.114617_bb0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0332494","article-title":"PDK1, associated with glycolytic metabolism, is a potential prognostic biomarker in osteosarcoma","volume":"20","author":"Qi","year":"2025","journal-title":"PLoS ONE"},{"issue":"8","key":"10.1016\/j.jconrel.2026.114617_bb0235","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1093\/cvr\/cvaf032","article-title":"Targeting the pyruvate dehydrogenase kinase\/pyruvate dehydrogenase axis modulates neutrophil and smooth muscle cell pathological responses and prevents abdominal aortic aneurysm formation","volume":"121","author":"Griepke","year":"2025","journal-title":"Cardiovasc. Res."},{"issue":"10","key":"10.1016\/j.jconrel.2026.114617_bb0240","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1093\/rheumatology\/keab022","article-title":"Glycolysis-derived acidic microenvironment as a driver of endothelial dysfunction in systemic sclerosis","volume":"60","author":"Andreucci","year":"2021","journal-title":"Rheumatology"},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0245","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41413-024-00342-8","article-title":"Wnt\/\u03b2-catenin signaling components and mechanisms in bone formation, homeostasis, and disease","volume":"12","author":"Hu","year":"2024","journal-title":"Bone Res."},{"issue":"2","key":"10.1016\/j.jconrel.2026.114617_bb0250","doi-asserted-by":"crossref","first-page":"64","DOI":"10.21037\/atm-21-6742","article-title":"Cistanoside A promotes osteogenesis of primary osteoblasts by alleviating apoptosis and activating autophagy through involvement of the Wnt\/\u03b2-catenin signal pathway","volume":"10","author":"Chen","year":"2022","journal-title":"Ann. Transl. Med."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0255","first-page":"C257","article-title":"Ion channels involved in inflammation and pain in osteoarthritis and related musculoskeletal disorders","volume":"325","author":"Matta","year":"2023","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.jconrel.2026.114617_bb0260","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.678532","article-title":"Acid-induced inflammatory cytokines in osteoblasts: a guided path to osteolysis in bone metastasis","volume":"9","author":"Di Pompo","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114617_bb0265","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.kint.2020.10.023","article-title":"Deletion of the proton receptor OGR1 in mouse osteoclasts impairs metabolic acidosis-induced bone resorption","volume":"99","author":"Krieger","year":"2021","journal-title":"Kidney Int."},{"key":"10.1016\/j.jconrel.2026.114617_bb0270","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkaf052","article-title":"From injury to integrity: tissue engineering solutions in combined bone repair and regeneration and muscle repair","volume":"13","author":"Jin","year":"2025","journal-title":"Burns Trauma"},{"issue":"28","key":"10.1016\/j.jconrel.2026.114617_bb0275","doi-asserted-by":"crossref","first-page":"33972","DOI":"10.1021\/acsami.3c02961","article-title":"pH-responsive gallol-functionalized hyaluronic acid-based tissue adhesive hydrogels for injection and three-dimensional bioprinting","volume":"15","author":"Jongprasitkul","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"9","key":"10.1016\/j.jconrel.2026.114617_bb0280","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.3390\/pharmaceutics15092270","article-title":"Injectable pH and thermo-responsive hydrogel scaffold with enhanced osteogenic differentiation of preosteoblasts for bone regeneration","volume":"15","author":"King","year":"2023","journal-title":"Pharmaceutics"},{"issue":"8","key":"10.1016\/j.jconrel.2026.114617_bb0285","doi-asserted-by":"crossref","first-page":"6999","DOI":"10.3390\/ijms24086999","article-title":"Construction of bone hypoxic microenvironment based on bone-on-a-chip platforms","volume":"24","author":"Li","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2026.114617_bb0290","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.658893","article-title":"Hypoxia-inducible factors regulate osteoclasts in health and disease","volume":"9","author":"Meng","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"10","key":"10.1016\/j.jconrel.2026.114617_bb0295","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200329RR","article-title":"Spatiotemporal correlation between HIF-1\u03b1 and bone regeneration","volume":"36","author":"Tao","year":"2022","journal-title":"FASEB J."},{"issue":"9","key":"10.1016\/j.jconrel.2026.114617_bb0300","doi-asserted-by":"crossref","first-page":"8029","DOI":"10.3390\/ijms24098029","article-title":"The role of HIF-1\u03b1 in bone regeneration: a new direction and challenge in bone tissue engineering","volume":"24","author":"You","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jconrel.2026.114617_bb0305","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/odi.13745","article-title":"HIF-1\u03b1 regulates osteoclast activation and mediates osteogenesis during mandibular bone repair via CT-1","volume":"28","author":"Tian","year":"2022","journal-title":"Oral Dis."},{"issue":"8","key":"10.1016\/j.jconrel.2026.114617_bb0310","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1007\/s10439-022-02970-9","article-title":"Effect of angiogenesis in bone tissue engineering","volume":"50","author":"Huang","year":"2022","journal-title":"Ann. Biomed. Eng."},{"issue":"14","key":"10.1016\/j.jconrel.2026.114617_bb0315","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abo7868","article-title":"Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression","volume":"9","author":"Zhang","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2026.114617_bb0320","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.actbio.2022.09.018","article-title":"Injectable temperature-sensitive hydrogel system incorporating deferoxamine-loaded microspheres promotes H-type blood vessel-related bone repair of a critical size femoral defect","volume":"153","author":"Zeng","year":"2022","journal-title":"Acta Biomater."},{"issue":"4","key":"10.1016\/j.jconrel.2026.114617_bb0325","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3390\/jfb15040112","article-title":"Deferoxamine-loaded chitosan-based hydrogel on bone implants showing enhanced bond strength and pro-angiogenic effects","volume":"15","author":"Liu","year":"2024","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.112433","article-title":"Insights into oxidative stress in bone tissue and novel challenges for biomaterials","volume":"130","author":"Cerqueni","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.jconrel.2026.114617_bb0335","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jmst.2023.01.055","article-title":"Regulation of hypoxic stress and oxidative stress in bone grafting: current trends and future perspectives","volume":"157","author":"Hu","year":"2023","journal-title":"J. Mater. Sci. Technol."},{"issue":"12","key":"10.1016\/j.jconrel.2026.114617_bb0340","doi-asserted-by":"crossref","first-page":"7314","DOI":"10.1021\/acsbiomaterials.4c01279","article-title":"Treatment of bone defects and nonunion via novel delivery mechanisms, growth factors, and stem cells: a review","volume":"10","author":"Ehlen","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"4","key":"10.1016\/j.jconrel.2026.114617_bb0345","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.3390\/ijms24043772","article-title":"Oxidative stress and inflammation in osteoporosis: molecular mechanisms involved and the relationship with microRNAs","volume":"24","author":"Iantomasi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2026.114617_bb0350","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.809397","article-title":"Local application of mineral-coated microparticles loaded with VEGF and BMP-2 induces the healing of murine atrophic non-unions","volume":"9","author":"Orth","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"5","key":"10.1016\/j.jconrel.2026.114617_bb0355","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1021\/acs.bioconjchem.2c00094","article-title":"Redox-responsive hydrogels for tunable and \u201con-demand\u201d release of biomacromolecules","volume":"33","author":"Kilic Boz","year":"2022","journal-title":"Bioconjug. Chem."},{"issue":"4","key":"10.1016\/j.jconrel.2026.114617_bb0360","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1021\/acs.biomac.3c01443","article-title":"High-density dynamic bonds cross-linked hydrogel with tissue adhesion, highly efficient self-healing behavior, and NIR photothermal antibacterial ability as dressing for wound repair","volume":"25","author":"Lu","year":"2024","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2026.114617_bb0365","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jconrel.2017.02.021","article-title":"Revisiting structure-property relationship of pH-responsive polymers for drug delivery applications","volume":"253","author":"Bazban-Shotorbani","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114617_bb0370","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jmst.2022.10.008","article-title":"3D printed porous titanium filled with mineralized UV-responsive chitosan hydrogel promotes cell proliferation and osteogenesis in vitro","volume":"142","author":"Yang","year":"2023","journal-title":"J. Mater. Sci. Technol."},{"key":"10.1016\/j.jconrel.2026.114617_bb0375","article-title":"Recent development in near infrared light-responsive polymeric materials for smart drug-delivery systems","volume":"25","author":"Sana","year":"2022","journal-title":"Mater. Today Chem."},{"issue":"2","key":"10.1016\/j.jconrel.2026.114617_bb0380","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1080\/09205063.2020.1827923","article-title":"Experimental study on bone defect repair by BMSCs combined with a light-sensitive material: g-C3N4\/rGO","volume":"32","author":"Liang","year":"2021","journal-title":"J. Biomater. Sci. Polym. Ed."},{"issue":"12","key":"10.1016\/j.jconrel.2026.114617_bb0385","doi-asserted-by":"crossref","first-page":"6567","DOI":"10.1021\/acsbiomaterials.3c01132","article-title":"Photo-cross-linked hydrogels for cartilage and osteochondral repair","volume":"9","author":"Zhu","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"4","key":"10.1016\/j.jconrel.2026.114617_bb0390","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3390\/gels8040216","article-title":"Current understanding of the applications of photocrosslinked hydrogels in biomedical engineering","volume":"8","author":"Liu","year":"2022","journal-title":"Gels"},{"issue":"51","key":"10.1016\/j.jconrel.2026.114617_bb0395","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202403003","article-title":"Photoactivated hydrogel therapeutic system with MXene-based nanoarchitectonics potentiates endogenous bone repair through reshaping the osteo-vascularization network","volume":"20","author":"Wu","year":"2024","journal-title":"Small"},{"issue":"47","key":"10.1016\/j.jconrel.2026.114617_bb0400","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202105383","article-title":"Injectable hydrogel with NIR light-responsive, dual-mode PTH release for osteoregeneration in osteoporosis","volume":"31","author":"Kuang","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmps.2022.105045","article-title":"Mechanics of multi-stimuli temperature-responsive hydrogels","volume":"169","author":"Brighenti","year":"2022","journal-title":"J. Mech. Phys. Solids"},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0410","first-page":"68","article-title":"A temperature responsive adhesive hydrogel for fabrication of flexible electronic sensors, npj Flexible","volume":"6","author":"Liu","year":"2022","journal-title":"Electronics"},{"issue":"40","key":"10.1016\/j.jconrel.2026.114617_bb0415","doi-asserted-by":"crossref","first-page":"9197","DOI":"10.1039\/D0TB01814G","article-title":"Temperature-responsive supramolecular hydrogels","volume":"8","author":"Xian","year":"2020","journal-title":"J. Mater. Chem. B"},{"issue":"8","key":"10.1016\/j.jconrel.2026.114617_bb0420","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s10965-024-04073-6","article-title":"Synthesis and properties of N-isopropylacrylamide and benzylmethacrylate-based amphiphilic block copolymers on different interphase surfaces","volume":"31","author":"Zamyshlyayeva","year":"2024","journal-title":"J. Polym. Res."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114617_bb0425","first-page":"300","article-title":"Injectable body temperature responsive hydrogel for encephalitis treatment via sustained release of nano-anti-inflammatory agents","volume":"5","author":"Gai","year":"2024","journal-title":"Biomater. Transl."},{"key":"10.1016\/j.jconrel.2026.114617_bb0430","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.actbio.2021.08.033","article-title":"Temperature-responsive biodegradable injectable polymers with tissue adhesive properties","volume":"135","author":"Fujiwara","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118925","article-title":"Design of a dual pH and temperature responsive hydrogel based on esterified cellulose nanocrystals for potential drug release","volume":"278","author":"Emam","year":"2022","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0440","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3390\/polym15010167","article-title":"pH and thermoresponsive PNIPAm-co-polyacrylamide hydrogel for dual stimuli-responsive controlled drug delivery","volume":"15","author":"Thirupathi","year":"2022","journal-title":"Polymers"},{"key":"10.1016\/j.jconrel.2026.114617_bb0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.153597","article-title":"An intelligent controlled release hydrogel with photothermal effect for the treatment of bone defects","volume":"495","author":"Wei","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jconrel.2026.114617_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123191","article-title":"Novel \u201chot spring\u201d-mimetic scaffolds for sequential neurovascular network reconstruction and osteoporosis reversion","volume":"320","author":"Zhao","year":"2025","journal-title":"Biomaterials"},{"issue":"19","key":"10.1016\/j.jconrel.2026.114617_bb0455","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202010779","article-title":"Injectable in situ induced robust hydrogel for photothermal therapy and bone fracture repair","volume":"31","author":"Liu","year":"2021","journal-title":"Adv. Funct. Mater."},{"issue":"12","key":"10.1016\/j.jconrel.2026.114617_bb0460","article-title":"Endogenous electric field-coupled pd@ bp biomimetic periosteum promotes bone regeneration through sensory nerve via fanconi anemia signaling pathway","volume":"12","author":"Su","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0465","article-title":"Electrosensitive polymer gels: controlling size and shape by means of red\u2013ox processes\u2013outlook and prospects","volume":"29","author":"Marcisz","year":"2022","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.jconrel.2026.114617_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122266","article-title":"A nano-conductive osteogenic hydrogel to locally promote calcium influx for electro-inspired bone defect regeneration","volume":"301","author":"Yu","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.114617_bb0475","first-page":"1","article-title":"Electrical stimulation of bone regeneration in infected defects: biomaterial approaches","author":"Na","year":"2025","journal-title":"Macromol. Res."},{"key":"10.1016\/j.jconrel.2026.114617_bb0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.144305","article-title":"Ultrasound-driven electrical stimulation based on 3D hierarchical porous piezoelectric nanofiber-aerogel scaffold promotes bone defect repair","volume":"470","author":"Chen","year":"2023","journal-title":"Chem. Eng. J."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0485","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12951-024-02320-y","article-title":"Injectable ultrasound-powered bone-adhesive nanocomposite hydrogel for electrically accelerated irregular bone defect healing","volume":"22","author":"Zhou","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2026.114617_bb0490","first-page":"1","article-title":"An electrostatic encapsulation strategy to motivate 3D-printed polyelectrolyte scaffolds for repair of osteoporotic bone defects","volume":"46","author":"Gao","year":"2025","journal-title":"Bioact. Mater."},{"issue":"6","key":"10.1016\/j.jconrel.2026.114617_bb0495","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202403837","article-title":"Bioelectrically reprogramming hydrogels rejuvenate vascularized bone regeneration in senescence","volume":"14","author":"Wu","year":"2025","journal-title":"Adv. Healthc. Mater."},{"issue":"24","key":"10.1016\/j.jconrel.2026.114617_bb0500","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232416190","article-title":"Advanced 3D magnetic scaffolds for tumor-related bone defects","volume":"23","author":"Cojocaru","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"32","key":"10.1016\/j.jconrel.2026.114617_bb0505","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202301724","article-title":"Biomimetic structural protein based magnetic responsive scaffold for enhancing bone regeneration by physical stimulation on intracellular calcium homeostasis","volume":"12","author":"Liang","year":"2023","journal-title":"Adv. Healthc. Mater."},{"issue":"26","key":"10.1016\/j.jconrel.2026.114617_bb0510","doi-asserted-by":"crossref","first-page":"6095","DOI":"10.1039\/D3TB00852E","article-title":"Magnetically actuated hydrogel-based capsule microrobots for intravascular targeted drug delivery","volume":"11","author":"Qiao","year":"2023","journal-title":"J. Mater. Chem. B"},{"issue":"4","key":"10.1016\/j.jconrel.2026.114617_bb0515","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3390\/pharmaceutics15041045","article-title":"Magnetic bone tissue engineering: reviewing the effects of magnetic stimulation on bone regeneration and angiogenesis","volume":"15","author":"Ribeiro","year":"2023","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0520","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1038\/s41467-023-39744-3","article-title":"In situ activation of flexible magnetoelectric membrane enhances bone defect repair","volume":"14","author":"Liu","year":"2023","journal-title":"Nat. Commun."},{"issue":"52","key":"10.1016\/j.jconrel.2026.114617_bb0525","doi-asserted-by":"crossref","first-page":"35575","DOI":"10.1021\/acsnano.4c13562","article-title":"Engineered magneto-piezoelectric nanoparticles-enhanced scaffolds disrupt biofilms and activate oxidative phosphorylation in Icam1+ macrophages for infectious bone defect regeneration","volume":"18","author":"Wu","year":"2024","journal-title":"ACS Nano"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114617_bb0530","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s40883-022-00281-y","article-title":"Effect of therapeutic ultrasound on the mechanical and biological properties of fibroblasts","volume":"9","author":"C\u00e1rdenas-Sandoval","year":"2023","journal-title":"Regener. Eng. Transl. Med."},{"issue":"19","key":"10.1016\/j.jconrel.2026.114617_bb0535","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911222","article-title":"Landscape of cellular bioeffects triggered by ultrasound-induced sonoporation","volume":"23","author":"Przystupski","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"47","key":"10.1016\/j.jconrel.2026.114617_bb0540","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202003214","article-title":"Recent advances in nanomaterial-assisted combinational sonodynamic cancer therapy","volume":"32","author":"Liang","year":"2020","journal-title":"Adv. Mater."},{"issue":"34","key":"10.1016\/j.jconrel.2026.114617_bb0545","doi-asserted-by":"crossref","first-page":"14212","DOI":"10.1002\/anie.201906823","article-title":"Ultrasound-activated sensitizers and applications","volume":"59","author":"Lin","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2026.114617_bb0550","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2024.102206","article-title":"Remotely disturbing bioelectrical homeostasis by nanoparticle-enabled intracellular electrical stimulation for wireless cancer therapy","volume":"55","author":"Xiao","year":"2024","journal-title":"Nano Today"},{"issue":"12","key":"10.1016\/j.jconrel.2026.114617_bb0555","doi-asserted-by":"crossref","first-page":"20770","DOI":"10.1021\/acsnano.2c07900","article-title":"One-dimensional ferroelectric nanoarrays with wireless switchable static and dynamic electrical stimulation for selective regulating osteogenesis and antiosteosarcoma","volume":"16","author":"Xiao","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.114617_bb0560","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.actbio.2023.07.025","article-title":"pH-responsive scaffolds for tissue regeneration: in vivo performance","volume":"168","author":"Zarur","year":"2023","journal-title":"Acta Biomater."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114617_bb0565","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1007\/s10853-022-08103-w","article-title":"A pH-responsive CaO2@ ZIF-67 system endows a scaffold with chemodynamic therapy properties","volume":"58","author":"Qian","year":"2023","journal-title":"J. Mater. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0570","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3390\/bios12010040","article-title":"Optical hydrogel detector for pH measurements","volume":"12","author":"Alqurashi","year":"2022","journal-title":"Biosensors"},{"issue":"21","key":"10.1016\/j.jconrel.2026.114617_bb0575","doi-asserted-by":"crossref","first-page":"31357","DOI":"10.1021\/acsami.5c02776","article-title":"Injectable pH-responsive hydrogel adapted to gingival crevicular fluid microenvironment for periodontitis therapy","volume":"17","author":"Xia","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2026.114617_bb0580","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jconrel.2024.11.055","article-title":"pH-responsive hydrogel with gambogic acid and calcium nanowires for promoting mitochondrial apoptosis in osteosarcoma","volume":"377","author":"Yang","year":"2025","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.jconrel.2026.114617_bb0585","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1080\/02648725.2023.2199244","article-title":"Redox signaling regulates the skeletal tissue development and regeneration","volume":"40","author":"Zhang","year":"2024","journal-title":"Biotechnol. Genet. Eng. Rev."},{"issue":"8","key":"10.1016\/j.jconrel.2026.114617_bb0590","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1039\/D4BM01345J","article-title":"Oxidation-responsive, settable bone substitute composites for regenerating critically-sized bone defects","volume":"13","author":"Dos Santos","year":"2025","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.jconrel.2026.114617_bb0595","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.actbio.2020.04.003","article-title":"Redox injectable gel protects osteoblastic function against oxidative stress and suppresses alveolar bone loss in a rat peri-implantitis model","volume":"110","author":"Ozawa","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0600","doi-asserted-by":"crossref","DOI":"10.1016\/j.polymer.2022.125240","article-title":"Synergistic effect of multiple hydrogen bond and disulfide bond on healing waterborne conductive polyurethane composite","volume":"258","author":"Wu","year":"2022","journal-title":"Polymer"},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0605","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-024-54894-8","article-title":"Biodegradable Janus sonozyme with continuous reactive oxygen species regulation for treating infected critical-sized bone defects","volume":"15","author":"Ou","year":"2024","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.jconrel.2026.114617_bb0610","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s13770-023-00561-w","article-title":"Reactive oxygen species scavenging hydrogel regulates stem cell behavior and promotes bone healing in osteoporosis","volume":"20","author":"Ye","year":"2023","journal-title":"Tissue Eng. Regener. Med."},{"key":"10.1016\/j.jconrel.2026.114617_bb0615","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.123059","article-title":"Injectable bioresponsive bone adhesive hydrogels inhibit NLRP3 inflammasome on demand to accelerate diabetic fracture healing","volume":"317","author":"Xing","year":"2025","journal-title":"Biomaterials"},{"issue":"20","key":"10.1016\/j.jconrel.2026.114617_bb0620","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202100883","article-title":"ROS-responsive boronate-stabilized polyphenol\u2013poloxamer 188 assembled dexamethasone nanodrug for macrophage repolarization in osteoarthritis treatment","volume":"10","author":"Li","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0625","article-title":"Immunologically modified enzyme-responsive micelles regulate the tumor microenvironment for cancer immunotherapy","volume":"13","author":"Han","year":"2022","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.jconrel.2026.114617_bb0630","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121061","article-title":"Enhanced chemo-photodynamic therapy of an enzyme-responsive prodrug in bladder cancer patient-derived xenograft models","volume":"277","author":"Tan","year":"2021","journal-title":"Biomaterials"},{"issue":"23","key":"10.1016\/j.jconrel.2026.114617_bb0635","doi-asserted-by":"crossref","first-page":"5889","DOI":"10.1158\/0008-5472.CAN-21-1538","article-title":"A PLCB1\u2013PI3K\u2013AKT Signaling Axis activates EMT to promote cholangiocarcinoma progression","volume":"81","author":"Liang","year":"2021","journal-title":"Cancer Res."},{"issue":"46","key":"10.1016\/j.jconrel.2026.114617_bb0640","doi-asserted-by":"crossref","first-page":"51249","DOI":"10.1021\/acsami.0c15211","article-title":"Pd@ Pt-GOx\/HA as a novel enzymatic cascade nanoreactor for high-efficiency starving-enhanced chemodynamic cancer therapy","volume":"12","author":"Ming","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"50","key":"10.1016\/j.jconrel.2026.114617_bb0645","doi-asserted-by":"crossref","first-page":"59708","DOI":"10.1021\/acsami.1c19058","article-title":"Intracellular enzyme-responsive profluorophore and prodrug nanoparticles for tumor-specific imaging and precise chemotherapy","volume":"13","author":"Pei","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2026.114617_bb0650","doi-asserted-by":"crossref","first-page":"101874","DOI":"10.1016\/j.mtbio.2025.101874","article-title":"Curcumin-encapsulated exosomes in bisphosphonate-modified hydrogel microspheres promote bone repair through macrophage polarization and DNA damage mitigation","volume":"32","author":"Si","year":"2025","journal-title":"Mater. Today Bio."},{"issue":"5","key":"10.1016\/j.jconrel.2026.114617_bb0655","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaw1228","article-title":"Lysostaphin and BMP-2 co-delivery reduces S. aureus infection and regenerates critical-sized segmental bone defects","volume":"5","author":"Johnson","year":"2019","journal-title":"Sci. Adv."},{"issue":"11","key":"10.1016\/j.jconrel.2026.114617_bb0660","doi-asserted-by":"crossref","first-page":"15403","DOI":"10.1021\/acsnano.0c06000","article-title":"Microenvironment-triggered degradable hydrogel for imaging diagnosis and combined treatment of intraocular choroidal melanoma","volume":"14","author":"Li","year":"2020","journal-title":"ACS Nano"},{"issue":"25","key":"10.1016\/j.jconrel.2026.114617_bb0665","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202300313","article-title":"A unified therapeutic\u2013prophylactic tissue-engineering scaffold demonstrated to prevent tumor recurrence and overcoming infection toward bone remodeling","volume":"35","author":"Huang","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0670","first-page":"381","article-title":"Piezo-enhanced near infrared photocatalytic nanoheterojunction integrated injectable biopolymer hydrogel for anti-osteosarcoma and osteogenesis combination therapy","volume":"34","author":"Xiao","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0675","doi-asserted-by":"crossref","first-page":"101773","DOI":"10.1016\/j.mtbio.2025.101773","article-title":"Multiscale metal-based nanocomposites for bone and joint disease therapies","volume":"32","author":"Wang","year":"2025","journal-title":"Mater. Today Bio."},{"key":"10.1016\/j.jconrel.2026.114617_bb0680","article-title":"A dual peptide sustained-release system based on nanohydroxyapatite\/polyamide 66 scaffold for synergistic-enhancing diabetic rats\u2019 fracture healing in osteogenesis and angiogenesis","volume":"9","author":"Li","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.jconrel.2026.114617_bb0685","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.biomaterials.2016.04.013","article-title":"Sulfated hyaluronan improves bone regeneration of diabetic rats by binding sclerostin and enhancing osteoblast function","volume":"96","author":"Picke","year":"2016","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.jconrel.2026.114617_bb0690","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s10856-020-06435-0","article-title":"Incorporation of nanosized calcium silicate improved osteointegration of polyetheretherketone under diabetic conditions","volume":"31","author":"Ma","year":"2020","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.jconrel.2026.114617_bb0695","doi-asserted-by":"crossref","DOI":"10.1016\/j.compositesb.2021.109550","article-title":"Lithium-containing bioactive glasses enhanced 3D-printed PLGA scaffolds for bone regeneration in diabetes","volume":"230","author":"Chen","year":"2022","journal-title":"Compos. Part B"},{"key":"10.1016\/j.jconrel.2026.114617_bb0700","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jmst.2021.10.053","article-title":"Injectable composite hydrogel based on carbon particles for photothermal therapy of bone tumor and bone regeneration","volume":"118","author":"Wei","year":"2022","journal-title":"J. Mater. Sci. Technol."},{"issue":"2","key":"10.1016\/j.jconrel.2026.114617_bb0705","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1021\/acsami.2c18545","article-title":"Janus-inspired core\u2013shell structure hydrogel programmatically releases melatonin for reconstruction of postoperative bone tumor","volume":"15","author":"Huang","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2026.114617_bb0710","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.141855","article-title":"3D printed hydrogel\/bioceramics core\/shell scaffold with NIR-II triggered drug release for chemo-photothermal therapy of bone tumors and enhanced bone repair","volume":"461","author":"Zhang","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jconrel.2026.114617_bb0715","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135723","article-title":"Development of a zoledronate-modified functional alginate hydrogel with effects of promoting osteogenesis for potential osteoporosis treatment","volume":"280","author":"Zuo","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"19","key":"10.1016\/j.jconrel.2026.114617_bb0720","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202212669","article-title":"Self-mineralizing dnazyme hydrogel as a multifaceted bone microenvironment amendment for promoting osteogenesis in osteoporosis","volume":"33","author":"Wu","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"9","key":"10.1016\/j.jconrel.2026.114617_bb0725","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202101479","article-title":"Injectable natural polymer hydrogels for treatment of knee osteoarthritis","volume":"11","author":"Lin","year":"2022","journal-title":"Adv. Healthc. Mater."},{"issue":"10","key":"10.1016\/j.jconrel.2026.114617_bb0730","doi-asserted-by":"crossref","first-page":"14983","DOI":"10.1021\/acsami.4c21021","article-title":"Self-sorted chiral nanofibrous hydrogels for enhanced osteoarthritis cartilage regeneration","volume":"17","author":"Xing","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"15","key":"10.1016\/j.jconrel.2026.114617_bb0735","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.1016\/j.cell.2024.06.029","article-title":"Diabetes mellitus\u2014progress and opportunities in the evolving epidemic","volume":"187","author":"Abel","year":"2024","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.jconrel.2026.114617_bb0740","doi-asserted-by":"crossref","DOI":"10.1002\/hsr2.2004","article-title":"Diabetes mellitus, the fastest growing global public health concern: early detection should be focused","volume":"7","author":"Hossain","year":"2024","journal-title":"Health Sci. Rep."},{"issue":"11","key":"10.1016\/j.jconrel.2026.114617_bb0745","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202108430","article-title":"A logic-based diagnostic and therapeutic hydrogel with multistimuli responsiveness to orchestrate diabetic bone regeneration","volume":"34","author":"Li","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0750","article-title":"Hydrogel-based drug delivery systems for diabetes bone defects","volume":"154436","author":"Ye","year":"2024","journal-title":"Chem. Eng. J."},{"issue":"36","key":"10.1016\/j.jconrel.2026.114617_bb0755","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202206919","article-title":"Functionalized metal\u2013organic framework-modified hydrogel that breaks the vicious cycle of inflammation and ROS for repairing of diabetic bone defects","volume":"19","author":"Lao","year":"2023","journal-title":"Small"},{"issue":"31","key":"10.1016\/j.jconrel.2026.114617_bb0760","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202101611","article-title":"Safeguarding osteointegration in diabetic patients: a potent \u201cChain armor\u201d coating for scavenging ROS and macrophage reprogramming in a microenvironment-responsive manner","volume":"31","author":"He","year":"2021","journal-title":"Adv. Funct. Mater."},{"issue":"9","key":"10.1016\/j.jconrel.2026.114617_bb0765","doi-asserted-by":"crossref","first-page":"6376","DOI":"10.1002\/jcp.30312","article-title":"Mechanical stretch induces osteogenesis through the alternative activation of macrophages","volume":"236","author":"Dong","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jconrel.2026.114617_bb0770","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.138945","article-title":"Methacrylated silk fibroin based composite hydrogel with ROS-scavenging and osteogenic ability to orchestrate diabetic bone regeneration","volume":"294","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.jconrel.2026.114617_bb0775","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.dental.2023.03.014","article-title":"Sustained delivery of IL-10 by self-assembling peptide hydrogel to reprogram macrophages and promote diabetic alveolar bone defect healing","volume":"39","author":"Wang","year":"2023","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0780","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.ijbiomac.2022.09.236","article-title":"3D printing of reduced glutathione grafted gelatine methacrylate hydrogel scaffold promotes diabetic bone regeneration by activating PI3K\/Akt signaling pathway","volume":"222","author":"Wang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"13","key":"10.1016\/j.jconrel.2026.114617_bb0785","article-title":"Regulating macrophage polarization in high glucose microenvironment using lithium-modified bioglass-hydrogel for diabetic bone regeneration","volume":"11","author":"Wu","year":"2022","journal-title":"Adv. Healthc. Mater."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0790","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12943-024-02161-1","article-title":"Nanoparticles and bone microenvironment: a comprehensive review for malignant bone tumor diagnosis and treatment","volume":"23","author":"Guan","year":"2024","journal-title":"Mol. Cancer"},{"issue":"18","key":"10.1016\/j.jconrel.2026.114617_bb0795","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.3390\/cancers14184527","article-title":"Surgical site infection after bone tumor surgery: risk factors and new preventive techniques","volume":"14","author":"Miwa","year":"2022","journal-title":"Cancers"},{"issue":"11","key":"10.1016\/j.jconrel.2026.114617_bb0800","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.3390\/cancers14112694","article-title":"Surgical treatment of bone sarcoma","volume":"14","author":"Bl\u00e4sius","year":"2022","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.jconrel.2026.114617_bb0805","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1089\/ten.teb.2019.0302","article-title":"Modeling the tumor microenvironment and pathogenic signaling in bone sarcoma","volume":"26","author":"Molina","year":"2020","journal-title":"Tissue Eng. B Rev."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0810","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1080\/10717544.2022.2075983","article-title":"Bone tumors effective therapy through functionalized hydrogels: current developments and future expectations","volume":"29","author":"Shao","year":"2022","journal-title":"Drug Deliv."},{"issue":"6","key":"10.1016\/j.jconrel.2026.114617_bb0815","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1177\/08853282211035236","article-title":"Progress of biomaterials for bone tumor therapy","volume":"36","author":"Chen","year":"2022","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.jconrel.2026.114617_bb0820","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122637","article-title":"Injectable rhein-assisted crosslinked hydrogel for efficient local osteosarcoma chemotherapy","volume":"634","author":"Zhang","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.114617_bb0825","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112995","article-title":"Novel application of rhein and its prodrug diacerein for reversing cancer-related multidrug resistance through the dual inhibition of P-glycoprotein efflux and STAT3-mediated P-glycoprotein expression","volume":"150","author":"Teng","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0830","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s11658-022-00371-3","article-title":"Osteoporosis pathogenesis and treatment: existing and emerging avenues","volume":"27","author":"Liang","year":"2022","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"10329","key":"10.1016\/j.jconrel.2026.114617_bb0835","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S0140-6736(21)02646-5","article-title":"Drug therapy for osteoporosis in older adults","volume":"399","author":"Reid","year":"2022","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0840","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/13697137.2021.1951697","article-title":"Medical treatment of osteoporosis","volume":"25","author":"Palacios","year":"2022","journal-title":"Climacteric"},{"key":"10.1016\/j.jconrel.2026.114617_bb0845","article-title":"Romosozumab for the treatment of osteoporosis in women: efficacy, safety, and cardiovascular risk","volume":"18","author":"Lim","year":"2022","journal-title":"Women Health"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114617_bb0850","doi-asserted-by":"crossref","DOI":"10.1002\/marc.202400653","article-title":"Polyphenols and functionalized hydrogels for osteoporotic bone regeneration","volume":"46","author":"Xv","year":"2025","journal-title":"Macromol. Rapid Commun."},{"key":"10.1016\/j.jconrel.2026.114617_bb0855","article-title":"High-strength gelatin hydrogel scaffold with drug loading remodels the inflammatory microenvironment to enhance osteoporotic bone repair","volume":"2501051","author":"Huang","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0860","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.146743","article-title":"Bioactive composite hydrogel with effects of robust promoting osteogenesis and immunomodulation for osteoporotic bone regeneration","volume":"476","author":"Sun","year":"2023","journal-title":"Chem. Eng. J."},{"issue":"41","key":"10.1016\/j.jconrel.2026.114617_bb0865","doi-asserted-by":"crossref","first-page":"17543","DOI":"10.1021\/jacs.0c07309","article-title":"Smart nanosacrificial layer on the bone surface prevents osteoporosis through acid\u2013base neutralization regulated biocascade effects","volume":"142","author":"Lin","year":"2020","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0870","doi-asserted-by":"crossref","first-page":"5679","DOI":"10.1038\/s41467-025-60853-8","article-title":"Injectable magnesium-bisphosphonate MOF-based bone adhesive prevents excessive fibrosis for osteoporotic fracture repair","volume":"16","author":"Xiao","year":"2025","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.jconrel.2026.114617_bb0875","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.joca.2023.06.005","article-title":"Fundamentals of osteoarthritis: inflammatory mediators in osteoarthritis","volume":"31","author":"De Roover","year":"2023","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114617_bb0880","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.joca.2021.04.020","article-title":"Epidemiology of osteoarthritis","volume":"30","author":"Allen","year":"2022","journal-title":"Osteoarthr. Cartil."},{"issue":"10","key":"10.1016\/j.jconrel.2026.114617_bb0885","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.joca.2023.06.005","article-title":"Fundamentals of osteoarthritis: inflammatory mediators in osteoarthritis","volume":"31","author":"De Roover","year":"2023","journal-title":"Osteoarthr. Cartil."},{"issue":"2","key":"10.1016\/j.jconrel.2026.114617_bb0890","first-page":"293","article-title":"Osteoarthritis: pathology, diagnosis, and treatment options","volume":"104","author":"Abramoff","year":"2020","journal-title":"Med. Clin."},{"issue":"4","key":"10.1016\/j.jconrel.2026.114617_bb0895","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.joca.2022.11.005","article-title":"Pharmaceutical treatment of osteoarthritis","volume":"31","author":"Richard","year":"2023","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.jconrel.2026.114617_bb0900","article-title":"Injectable hydrogel with selenium nanoparticles delivery for sustained glutathione peroxidase activation and enhanced osteoarthritis therapeutics","volume":"23","author":"Hu","year":"2023","journal-title":"Mater. Today Bio"},{"issue":"4","key":"10.1016\/j.jconrel.2026.114617_bb0905","doi-asserted-by":"crossref","first-page":"923","DOI":"10.3390\/biomedicines12040923","article-title":"Applications of hydrogels in osteoarthritis treatment","volume":"12","author":"Gan","year":"2024","journal-title":"Biomedicines"},{"issue":"36","key":"10.1016\/j.jconrel.2026.114617_bb0910","doi-asserted-by":"crossref","first-page":"40711","DOI":"10.1021\/acsami.2c12703","article-title":"Nanoarchitectonics of cartilage-targeting hydrogel microspheres with reactive oxygen species responsiveness for the repair of osteoarthritis","volume":"14","author":"Yu","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"43","key":"10.1016\/j.jconrel.2026.114617_bb0915","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202304829","article-title":"Magnesium gradient-based hierarchical scaffold for dual-lineage regeneration of osteochondral defect","volume":"33","author":"Gao","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0920","doi-asserted-by":"crossref","unstructured":"G. Baima, M. Minoli, D.S. Michaud, M. Aimetti, M. Sanz, B.G. Loos, M. Romandini, Periodontitis and risk of cancer: mechanistic evidence, Periodontology 2000 96(1) (2024) 83-94.","DOI":"10.1111\/prd.12540"},{"issue":"5","key":"10.1016\/j.jconrel.2026.114617_bb0925","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1021\/acsbiomaterials.4c00220","article-title":"Advances in hydrogels for periodontitis treatment","volume":"10","author":"Li","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114617_bb0930","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jcpe.13189","article-title":"Periodontitis and cardiovascular diseases: consensus report","volume":"47","author":"Sanz","year":"2020","journal-title":"J. Clin. Periodontol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114617_bb0935","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/prd.12313","article-title":"New developments in neutrophil biology and periodontitis","volume":"82","author":"Hajishengallis","year":"2000","journal-title":"Periodontology"},{"key":"10.1016\/j.jconrel.2026.114617_bb0940","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.actbio.2022.03.046","article-title":"ZIF-8 modified multifunctional injectable photopolymerizable GelMA hydrogel for the treatment of periodontitis","volume":"146","author":"Liu","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0945","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.147195","article-title":"A sequential sustained-release hydrogel with potent antimicrobial, anti-inflammatory, and osteogenesis-promoting properties for the treatment of periodontitis","volume":"477","author":"Xu","year":"2023","journal-title":"Chem. Eng. J."},{"issue":"18","key":"10.1016\/j.jconrel.2026.114617_bb0950","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1039\/D3SC00980G","article-title":"Oxidization enhances type I ROS generation of AIE-active zwitterionic photosensitizers for photodynamic killing of drug-resistant bacteria","volume":"14","author":"Gong","year":"2023","journal-title":"Chem. Sci."},{"key":"10.1016\/j.jconrel.2026.114617_bb0955","first-page":"346","article-title":"Piezoelectric hydrogel for treatment of periodontitis through bioenergetic activation","volume":"35","author":"Liu","year":"2024","journal-title":"Bioact. Mater."},{"issue":"20","key":"10.1016\/j.jconrel.2026.114617_bb0960","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202203337","article-title":"Alleviate periodontitis and its comorbidity hypertension using a nanoparticle-embedded functional hydrogel system","volume":"12","author":"Xu","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0965","first-page":"213","article-title":"Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes","volume":"18","author":"Li","year":"2022","journal-title":"Bioact. Mater."},{"issue":"10","key":"10.1016\/j.jconrel.2026.114617_bb0970","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202305594","article-title":"Multifunctional DNA-based hydrogel promotes diabetic alveolar bone defect reconstruction","volume":"20","author":"Peng","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2026.114617_bb0975","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.134625","article-title":"Multifunctional hydrogel as wound dressing for intelligent wound monitoring","volume":"433","author":"Wang","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jconrel.2026.114617_bb0980","first-page":"313","article-title":"Enhancing bone repair with \u03b2-TCP-based composite scaffolds: a review of design strategies and biological mechanisms","author":"Ni","year":"2025","journal-title":"Orthop. Res. Rev."},{"key":"10.1016\/j.jconrel.2026.114617_bb0985","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.859920","article-title":"Evaluation of osseointegration and bone healing using pure-phase \u03b2-TCP ceramic implant in bone critical defects. A systematic review","volume":"9","author":"Garcia","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.jconrel.2026.114617_bb0990","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.actbio.2023.05.045","article-title":"A conductive multifunctional hydrogel dressing with the synergistic effect of ROS-scavenging and electroactivity for the treatment and sensing of chronic diabetic wounds","volume":"167","author":"Zhang","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2026.114617_bb0995","first-page":"111","article-title":"Multiscale design of stiffening and ROS scavenging hydrogels for the augmentation of mandibular bone regeneration","volume":"20","author":"Wu","year":"2023","journal-title":"Bioact. Mater."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926000180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926000180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T08:37:21Z","timestamp":1781771841000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926000180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":199,"alternative-id":["S0168365926000180"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114617","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adaptive smart hydrogels driving precision bone healing in pathological contexts","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114617","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114617"}}