{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T09:26:04Z","timestamp":1787131564562,"version":"build-2736575974"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,6]],"date-time":"2027-02-06T00:00:00Z","timestamp":1801872000000},"content-version":"am","delay-in-days":311,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100002214","name":"McCarthy Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002214","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2 P30CA016042"],"award-info":[{"award-number":["2 P30CA016042"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016951","name":"UCLA AIDS Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016951","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007185","name":"University of California, Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010296","name":"James B. Pendleton Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010296","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA196266"],"award-info":[{"award-number":["R01CA196266"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA253215"],"award-info":[{"award-number":["R01CA253215"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jconrel.2026.114661","type":"journal-article","created":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T23:13:25Z","timestamp":1769382805000},"page":"114661","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A proimmunotoxin nanodrug targeting AIDS-associated non-Hodgkin lymphoma"],"prefix":"10.1016","volume":"392","author":[{"given":"Shilin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Kranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo R.","family":"Ancheta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Lappi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Yu","family":"Chiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy R.","family":"Daniels-Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel L.","family":"Penichet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.114661_bb0005","article-title":"Epidemiology of non-Hodgkin\u2019s lymphoma","volume":"9","author":"Thandra","year":"2021","journal-title":"Med. Sci. (Basel)"},{"issue":"2025","key":"10.1016\/j.jconrel.2026.114661_bb0010","first-page":"10","article-title":"Cancer statistics","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jconrel.2026.114661_bb0015","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1093\/cid\/ciaa1046","article-title":"Timing of antiretroviral therapy initiation and risk of cancer among persons living with human immunodeficiency virus","volume":"72","author":"Silverberg","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jconrel.2026.114661_bb0020","doi-asserted-by":"crossref","DOI":"10.4084\/mjhid.2019.004","article-title":"Hiv and lymphoma: from epidemiology to clinical management","volume":"11","author":"Re","year":"2019","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"10.1016\/j.jconrel.2026.114661_bb0025","first-page":"373","article-title":"Revision of the case definition of acquired immunodeficiency syndrome for national reporting--United States","volume":"34","author":"Centers for Disease Control (CDC)","year":"1985","journal-title":"MMWR Morb. Mortal Wkly. Rep."},{"key":"10.1016\/j.jconrel.2026.114661_bb0030","article-title":"Global and regional burden estimation of HIV-associated non-Hodgkin\u2019s lymphoma: a meta-analysis and modelling analysis protocol","volume":"14","author":"Chen","year":"2024","journal-title":"BMJ Open"},{"key":"10.1016\/j.jconrel.2026.114661_bb0035","doi-asserted-by":"crossref","first-page":"E240","DOI":"10.1016\/S2352-3018(18)30360-6","article-title":"Association of immunosuppression and HIV viraemia with non-Hodgkin lymphoma risk overall and by subtype in people living with HIV in Canada and the USA: a multicentre cohort study","volume":"6","author":"Hern\u00e1ndez-Ram\u00edrez","year":"2019","journal-title":"Lancet Hi"},{"key":"10.1016\/j.jconrel.2026.114661_bb0040","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.path.2019.03.005","article-title":"Human immunodeficiency virus-associated lymphoproliferative disorders","volume":"12","author":"Lilly","year":"2019","journal-title":"Surg. Pathol. Clin."},{"key":"10.1016\/j.jconrel.2026.114661_bb0045","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/bjh.13998","article-title":"Central nervous system involvement in AIDS-related lymphomas","volume":"173","author":"Barta","year":"2016","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.jconrel.2026.114661_bb0050","doi-asserted-by":"crossref","first-page":"e240","DOI":"10.1016\/S1470-2045(21)00137-6","article-title":"The effect of non-AIDS-defining cancers on people living with HIV","volume":"22","author":"Chiao","year":"2021","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.jconrel.2026.114661_bb0055","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s12026-010-8168-8","article-title":"HIV-associated immune dysfunction and viral infection: role in the pathogenesis of AIDS-related lymphoma","volume":"48","author":"Epeldegui","year":"2010","journal-title":"Immunol. Res."},{"key":"10.1016\/j.jconrel.2026.114661_bb0060","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.clim.2006.06.010","article-title":"The transferrin receptor part I: biology and targeting with cytotoxic antibodies for the treatment of cancer","volume":"121","author":"Daniels","year":"2006","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jconrel.2026.114661_bb0065","doi-asserted-by":"crossref","first-page":"991","DOI":"10.2217\/imt-2016-0050","article-title":"Transferrin receptor 1: a target for antibody-mediated cancer therapy","volume":"8","author":"Daniels-Wells","year":"2016","journal-title":"Immunotherapy"},{"key":"10.1016\/j.jconrel.2026.114661_bb0070","first-page":"916","article-title":"Transferrin receptor 1 in cancer: a new sight for cancer therapy","volume":"8","author":"Shen","year":"2018","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.jconrel.2026.114661_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.607692","article-title":"Antibodies targeting the transferrin receptor 1 (TfR1) as direct anti-cancer agents","volume":"12","author":"Candelaria","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2026.114661_bb0080","first-page":"37","article-title":"Correlation of transferrin receptor expression with histologic grade and immunophenotype in chronic lymphocytic leukemia and non-Hodgkin\u2019s lymphoma","volume":"4","author":"Das Gupta","year":"1990","journal-title":"Hematol. Pathol."},{"key":"10.1016\/j.jconrel.2026.114661_bb0085","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S0140-6736(83)92191-8","article-title":"Correlation of transferrin receptor expression with histological class and outcome in non-hodgkin lymphoma","volume":"321","author":"Habeshaw","year":"1983","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2026.114661_bb0090","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1309\/X8LBRRBBC43PL9HC","article-title":"The usefulness of CD71 expression by flow cytometry for differentiating indolent from aggressive CD10+ B-cell lymphomas","volume":"126","author":"Wu","year":"2006","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.jconrel.2026.114661_bb0095","series-title":"The American Society of Hematology Annual Meeting (November 13, 2019; Orlando, Florida, USA)","first-page":"2783","article-title":"Over-expression of transferrin receptor (TFRC\/CD71) and low expression of innate and adaptive immune cell subsets in HIV-associated, GCB-DLBCL by digital gene expression profiling","volume":"134","author":"Maguire","year":"2019"},{"key":"10.1016\/j.jconrel.2026.114661_bb0100","series-title":"International Confereence on Malignancies in HIV\/AIDS (October 21-22, 2019; Bethesda, Maryland, USA)","article-title":"Potential alternative survival mechanisms in HIV-associated diffuse large B-cell lymphoma (DLBCL) of germinal center (GCB) origin","author":"Maguire","year":"2019"},{"key":"10.1016\/j.jconrel.2026.114661_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039666","article-title":"A minimal connected network of transcription factors regulated in human tumors and its application to the quest for universal cancer biomarkers","volume":"7","author":"Essaghir","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2026.114661_bb0110","doi-asserted-by":"crossref","first-page":"10706","DOI":"10.1073\/pnas.162362999","article-title":"An anti-transferrin receptor-avidin fusion protein exhibits both strong proapoptotic activity and the ability to deliver various molecules into cancer cells","volume":"99","author":"Ng","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jconrel.2026.114661_bb0115","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1182\/blood-2006-04-020263","article-title":"Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor","volume":"108","author":"Ng","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jconrel.2026.114661_bb0120","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0076-6879(90)84259-J","article-title":"Avidin and streptavidin","volume":"184","author":"Green","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jconrel.2026.114661_bb0125","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1158\/1535-7163.MCT-07-0330","article-title":"Conjugation of an anti-transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells","volume":"6","author":"Daniels-Wells","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.jconrel.2026.114661_bb0130","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ddr.10347","article-title":"Design and engineering of human forms of monoclonal antibodies","volume":"61","author":"Penichet","year":"2004","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.jconrel.2026.114661_bb0135","series-title":"Reviews in Cell Biology and Molecular Medicine","first-page":"1","article-title":"Genetic engineering of antibody molecules","volume":"Vol. 1","author":"Payes","year":"2015"},{"key":"10.1016\/j.jconrel.2026.114661_bb0140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jconrel.2007.08.020","article-title":"Binding specificity and internalization properties of an antibody-avidin fusion protein targeting the human transferrin receptor","volume":"124","author":"Rodriguez","year":"2007","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114661_bb0145","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41467-021-27949-3","article-title":"Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections","volume":"13","author":"Hickerson","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.114661_bb0150","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.1128\/JVI.06397-11","article-title":"An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all New World hemorrhagic fever arenaviruses","volume":"86","author":"Helguera","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.jconrel.2026.114661_bb0155","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.3109\/10428194.2011.596964","article-title":"Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells","volume":"52","author":"Rodriguez","year":"2011","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.jconrel.2026.114661_bb0160","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/CJI.0b013e318222ffc8","article-title":"An antibody-based multifaceted approach targeting the human transferrin receptor for the treatment of B-cell malignancies","volume":"34","author":"Daniels","year":"2011","journal-title":"J. Immunother."},{"key":"10.1016\/j.jconrel.2026.114661_bb0165","first-page":"1380","article-title":"Biochemical modification of streptavidin and avidin: in vitro and in vivo analysis","volume":"37","author":"Rosebrough","year":"1996","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.jconrel.2026.114661_bb0170","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/CJI.0000000000000304","article-title":"An IgG1 version of the anti-transferrin receptor 1 antibody ch128.1 shows significant antitumor activity against different xenograft models of multiple myeloma: a brief communication","volume":"43","author":"Daniels-Wells","year":"2020","journal-title":"J. Immunother."},{"key":"10.1016\/j.jconrel.2026.114661_bb0175","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.4049\/jimmunol.1700787","article-title":"Efficacy and mechanism of antitumor activity of an antibody targeting transferrin receptor 1 in mouse models of human multiple myeloma","volume":"200","author":"Leoh","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.jconrel.2026.114661_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15061816","article-title":"Efficacy of antibodies targeting TfR1 in xenograft mouse models of AIDS-related non-Hodgkin lymphoma","volume":"15","author":"Daniels-Wells","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jconrel.2026.114661_bb0185","first-page":"291","article-title":"The transferrin receptor and the targeted delivery of therapeutic agents against cancer","volume":"2012","author":"Daniels","year":"1820","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jconrel.2026.114661_bb0190","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.1016\/S0021-9258(18)53284-1","article-title":"The expression of saporin, a ribosome-inactivating protein from the plant Saponaria officinalis, in Escherichia coli","volume":"268","author":"Barthelemy","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jconrel.2026.114661_bb0195","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1042\/bj2160617","article-title":"Ribosome-inactivating proteins from the seeds of Saponaria officinalis (soapwort), of Agrostemma githago (corn cockle) and of Asparagus officinalis (asparagus), and from the latex of Hura crepitans (sandbox tree)","volume":"216","author":"Stirpe","year":"1983","journal-title":"Biochem. J."},{"key":"10.1016\/j.jconrel.2026.114661_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/toxins14030184","article-title":"Saporin as a commercial reagent: its uses and unexpected impacts in the biological sciences-tools from the plant kingdom","volume":"14","author":"Ancheta","year":"2022","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.jconrel.2026.114661_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10020082","article-title":"Strategies to improve the clinical utility of Saporin-based targeted toxins","volume":"10","author":"Giansanti","year":"2018","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.jconrel.2026.114661_bb0210","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.3390\/toxins5101698","article-title":"Saporin-S6: a useful tool in cancer therapy","volume":"5","author":"Polito","year":"2013","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.jconrel.2026.114661_bb0215","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.tiv.2012.10.006","article-title":"Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1","volume":"27","author":"Daniels-Wells","year":"2013","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.jconrel.2026.114661_bb0220","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF02890252","article-title":"Hepatotoxicity of immunotoxins made with saporin, a ribosome-inactivating protein from Saponaria officinalis","volume":"53","author":"Stirpe","year":"1987","journal-title":"Virchows Arch. B Cell Pathol. Incl. Mol. Pathol."},{"key":"10.1016\/j.jconrel.2026.114661_bb0225","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0014-5793(00)01119-4","article-title":"Recombinant NeutraLite avidin: a non-glycosylated, acidic mutant of chicken avidin that exhibits high affinity for biotin and low non-specific binding properties","volume":"467","author":"Marttila","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jconrel.2026.114661_bb0230","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1021\/ac202375n","article-title":"Comparison of the energetics of avidin, streptavidin, neutrAvidin, and anti-biotin antibody binding to biotinylated lipid bilayer examined by second-harmonic generation","volume":"84","author":"Nguyen","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jconrel.2026.114661_bb0235","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/imr.12390","article-title":"Immunogenicity of therapeutic recombinant immunotoxins","volume":"270","author":"Mazor","year":"2016","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jconrel.2026.114661_bb0240","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1158\/1535-7163.MCT-19-0890","article-title":"Site-specific PEGylation of anti-Mesothelin recombinant immunotoxins increases half-life and antitumor activity","volume":"19","author":"Zheng","year":"2020","journal-title":"Mol. Cancer Ther."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114661_bb0245","first-page":"164","article-title":"Strategies to mitigate the on- and off-target toxicities of recombinant immunotoxins: an antibody engineering perspective","volume":"5","author":"Li","year":"2022","journal-title":"Antib. Ther."},{"key":"10.1016\/j.jconrel.2026.114661_bb0250","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jconrel.2008.03.010","article-title":"Preparation and characterization of PE38KDEL-loaded anti-HER2 nanoparticles for targeted cancer therapy","volume":"128","author":"Chen","year":"2008","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114661_bb0255","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001524","article-title":"Nanoencapsulated rituximab mediates superior cellular immunity against metastatic B-cell lymphoma in a complement competent humanized mouse model","volume":"9","author":"Wen","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jconrel.2026.114661_bb0260","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41551-019-0434-z","article-title":"Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice","volume":"3","author":"Wen","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2026.114661_bb0265","article-title":"A bioinspired platform for effective delivery of protein therapeutics to the central nervous system","volume":"31","author":"Wu","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114661_bb0270","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.03132","article-title":"Enhanced delivery of rituximab into brain and lymph nodes using timed-release nanocapsules in non-human Primates","volume":"10","author":"Qin","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2026.114661_bb0275","article-title":"Systemic delivery of monoclonal antibodies to the central nervous system for brain tumor therapy","volume":"31","author":"Han","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114661_bb0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072414","article-title":"Levels of murine, but not human, CXCL13 are greatly elevated in NOD-SCID mice bearing the AIDS-associated Burkitt lymphoma cell line, 2F7","volume":"8","author":"Widney","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2026.114661_bb0285","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jconrel.2026.114661_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/nu11102265","article-title":"Functional expression of choline transporters in the blood-brain barrier","volume":"11","author":"Inazu","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.jconrel.2026.114661_bb0295","doi-asserted-by":"crossref","first-page":"498","DOI":"10.2310\/7290.2006.00032","article-title":"Choline transporter as a novel target for molecular imaging of cancer","volume":"5","author":"Hara","year":"2006","journal-title":"Mol. Imaging"},{"key":"10.1016\/j.jconrel.2026.114661_bb0300","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/bjc.1985.252","article-title":"Pharmacokinetics, binding and distribution of Hoechst 33342 in spheroids and murine tumors, brit","volume":"52","author":"Olive","year":"1985","journal-title":"J. Cancer"},{"key":"10.1016\/j.jconrel.2026.114661_bb0305","series-title":"Pathological Anatomy and Histopathology","first-page":"25","author":"Virchows Archiv. A","year":"1982"},{"key":"10.1016\/j.jconrel.2026.114661_bb0310","article-title":"Applications of microfluidics and organ-on-a-Chip in cancer research","volume":"12","author":"Regmi","year":"2022","journal-title":"Biosensors (Basel)"},{"key":"10.1016\/j.jconrel.2026.114661_bb0315","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.cbpa.2010.08.016","article-title":"Tumors on chips: oncology meets microfluidics","volume":"14","author":"Wlodkowic","year":"2010","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.jconrel.2026.114661_bb0320","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.freeradbiomed.2018.06.037","article-title":"Transferrin and transferrin receptors update","volume":"133","author":"Kawabata","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jconrel.2026.114661_bb0325","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.3892\/or.2014.2981","article-title":"Overexpression of transferrin receptor CD71 and its tumorigenic properties in esophageal squamous cell carcinoma","volume":"31","author":"Chan","year":"2014","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jconrel.2026.114661_bb0330","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/cas.70195","article-title":"Overexpression of transferrin receptor in esophageal squamous cell cancer suggests poor prognosis and potential therapy","volume":"117","author":"Ikenaga","year":"2026","journal-title":"Cancer Sci"},{"key":"10.1016\/j.jconrel.2026.114661_bb0335","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10549-009-0345-x","article-title":"Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen","volume":"119","author":"Habashy","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.jconrel.2026.114661_bb0340","first-page":"541","article-title":"Expression of transferrin receptor and ferritin H-chain mRNA are associated with clinical and histopathological prognostic indicators in breast cancer","volume":"21","author":"Ding Cheng","year":"2001","journal-title":"Anticancer Res."},{"key":"10.1016\/j.jconrel.2026.114661_bb0345","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1038\/onc.2017.11","article-title":"Iron addiction: a novel therapeutic target in ovarian cancer","volume":"36","author":"Basuli","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.jconrel.2026.114661_bb0350","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1378\/chest.97.6.1367","article-title":"Transferrin receptor expression in adenocarcinoma of the lung as a histopathologic indicator of prognosis","volume":"97","author":"Kondo","year":"1990","journal-title":"Chest"},{"key":"10.1016\/j.jconrel.2026.114661_bb0355","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41417-019-0078-x","article-title":"Transferrin receptor-involved HIF-1 signaling pathway in cervical cancer","volume":"26","author":"Xu","year":"2019","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.jconrel.2026.114661_bb0360","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1464-410X.1990.tb14752.x","article-title":"Transferrin receptor expression in primary superficial human bladder tumours identifies patients who develop recurrences","volume":"65","author":"Smith","year":"1990","journal-title":"Br. J. Urol."},{"key":"10.1016\/j.jconrel.2026.114661_bb0365","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s13018-019-1301-z","article-title":"Transferrin receptor-1 and VEGF are prognostic factors for osteosarcoma","volume":"14","author":"Wu","year":"2019","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.jconrel.2026.114661_bb0370","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.ejca.2004.01.036","article-title":"Transferrin receptor is a marker of malignant phenotype in human pancreatic cancer and in neuroendocrine carcinoma of the pancreas","volume":"40","author":"Ryschich","year":"2004","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.jconrel.2026.114661_bb0375","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.bbrc.2016.02.023","article-title":"Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generation","volume":"471","author":"Jeong","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jconrel.2026.114661_bb0380","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10238-025-01847-0","article-title":"Elevated expression of transferrin receptor-1 in pancreatic cancer: clinical implications and prognostic significance","volume":"25","author":"Zhongqing","year":"2025","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.jconrel.2026.114661_bb0385","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317717655","article-title":"Upregulation of transferrin receptor-1 induces cholangiocarcinoma progression via induction of labile iron pool","volume":"39","author":"Jamnongkan","year":"2017","journal-title":"Tumour Biol."},{"key":"10.1016\/j.jconrel.2026.114661_bb0390","doi-asserted-by":"crossref","first-page":"107052","DOI":"10.18632\/oncotarget.22323","article-title":"Transferrin receptor 1 upregulation in primary tumor and downregulation in benign kidney is associated with progression and mortality in renal cell carcinoma patients","volume":"8","author":"Greene","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jconrel.2026.114661_bb0395","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/his.13847","article-title":"Transferrin receptor 1 overexpression is associated with tumour de-differentiation and acts as a potential prognostic indicator of hepatocellular carcinoma","volume":"75","author":"Adachi","year":"2019","journal-title":"Histopathology"},{"key":"10.1016\/j.jconrel.2026.114661_bb0400","doi-asserted-by":"crossref","first-page":"9178","DOI":"10.1002\/jcb.27184","article-title":"Iron metabolism gene expression and prognostic features of hepatocellular carcinoma","volume":"119","author":"Shen","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jconrel.2026.114661_bb0405","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0243812","article-title":"Transferrin receptor regulates malignancies and the stemness of hepatocellular carcinoma-derived cancer stem-like cells by affecting iron accumulation","volume":"15","author":"Xiao","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2026.114661_bb0410","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3803\/EnM.2020.35.1.132","article-title":"Protein expression of cyclin B1, transferrin receptor, and fibronectin is correlated with the prognosis of adrenal cortical carcinoma","volume":"35","author":"Moon","year":"2020","journal-title":"Endocrinol. Metab."},{"key":"10.1016\/j.jconrel.2026.114661_bb0415","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/BF01600299","article-title":"Transferrin receptor expression in tumours of the human nervous system: relation to tumour type, grading and tumour growth fraction","volume":"416","author":"Prior","year":"1990","journal-title":"Virchows Arch. A Pathol. Anat. Histopathol."},{"key":"10.1016\/j.jconrel.2026.114661_bb0420","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182954","article-title":"Transferrin receptor-1 and ferritin heavy and light chains in astrocytic brain tumors: expression and prognostic value","volume":"12","author":"Rosager","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2026.114661_bb0425","first-page":"226","article-title":"Transferrin receptor expression by blast cells in acute lymphoblastic leukemia correlates with white cell count & immunophenotype","volume":"104","author":"Das Gupta","year":"1996","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.jconrel.2026.114661_bb0430","doi-asserted-by":"crossref","first-page":"610","DOI":"10.2174\/1871530318666180605094706","article-title":"Prognostic value of transferrin receptor-1 (CD71) expression in acute lymphoblastic leukemia","volume":"18","author":"Hagag","year":"2018","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"10.1016\/j.jconrel.2026.114661_bb0435","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1007\/s12274-016-0991-3","article-title":"Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins","volume":"9","author":"Liang","year":"2016","journal-title":"Nano Res."},{"key":"10.1016\/j.jconrel.2026.114661_bb0440","doi-asserted-by":"crossref","first-page":"17073","DOI":"10.1021\/acs.chemrev.2c00344","article-title":"Zwitterionic biomaterials","volume":"122","author":"Li","year":"2022","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jconrel.2026.114661_bb0445","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1234887","article-title":"Choline metabolism and its implications in cancer","volume":"13","author":"Yao","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jconrel.2026.114661_bb0450","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1002\/adma.201101771","article-title":"Controlled protein delivery based on enzyme-responsive nanocapsules","volume":"23","author":"Wen","year":"2011","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114661_bb0455","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1163\/156856202317414384","article-title":"Preparation of cross-linked biocompatible poly(2-methacryloyloxyethyl phosphorylcholine) gel and its strange swelling behavior in water\/ethanol mixture","volume":"13","author":"Kiritoshi","year":"2002","journal-title":"J. Biomater. Sci. Polym. Ed."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926000623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926000623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T08:40:47Z","timestamp":1787128847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926000623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":91,"alternative-id":["S0168365926000623"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114661","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A proimmunotoxin nanodrug targeting AIDS-associated non-Hodgkin lymphoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114661","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114661"}}