{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:51:30Z","timestamp":1792039890546,"version":"4.4.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2022YFC2304303"],"award-info":[{"award-number":["2022YFC2304303"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473856"],"award-info":[{"award-number":["82473856"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004572","name":"National Health Commission of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004572","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jconrel.2026.114703","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:29:50Z","timestamp":1770424190000},"page":"114703","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["A precision nitric oxide-releasing hydrogel promoting nanoparticles permeation for comprehensive nerve-vessel recovery and microenvironment regulation in diabetic wounds"],"prefix":"10.1016","volume":"392","author":[{"given":"Enhao","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuankuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruining","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianyi","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.jconrel.2026.114703_bb0005","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1056\/NEJMra1615439","article-title":"Diabetic foot ulcers and their recurrence","volume":"376","author":"Armstrong","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114703_bb0010","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2023.10578","article-title":"Diabetic foot ulcers: a review","volume":"330","author":"Armstrong","year":"2023","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.jconrel.2026.114703_bb0015","doi-asserted-by":"crossref","DOI":"10.1007\/s11892-019-1212-8","article-title":"Epidemiology of peripheral neuropathy and lower extremity disease in diabetes","volume":"19","author":"Hicks","year":"2019","journal-title":"Curr. Diab. Rep."},{"issue":"7","key":"10.1016\/j.jconrel.2026.114703_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101774","article-title":"Norepinephrine stimulates mobilization of endothelial progenitor cells after limb ischemia","volume":"9","author":"Jiang","year":"2014","journal-title":"PLoS One"},{"issue":"8008","key":"10.1016\/j.jconrel.2026.114703_bb0025","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/s41586-024-07237-y","article-title":"CGRP sensory neurons promote tissue healing via neutrophils and macrophages","volume":"628","author":"Lu","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2026.114703_bb0030","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/978-1-4614-5441-0_15","article-title":"Diabetic autonomic neuropathy","volume":"771","author":"Kamenov","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jconrel.2026.114703_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1265372","article-title":"Diabetic peripheral neuropathy: pathogenetic mechanisms and treatment","volume":"14","author":"Zhu","year":"2024","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114703_bb0040","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41577-018-0084-5","article-title":"The immunological anatomy of the skin","volume":"19","author":"Kabashima","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.jconrel.2026.114703_bb0045","doi-asserted-by":"crossref","first-page":"444","DOI":"10.2174\/1567201816666190201143457","article-title":"Topical and transdermal drug delivery: from simple potions to smart technologies","volume":"16","author":"Benson","year":"2019","journal-title":"Curr. Drug Deliv."},{"issue":"45","key":"10.1016\/j.jconrel.2026.114703_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202304250","article-title":"Biomimetic thermo-sensitive hydrogel encapsulating hemangiomas stem cell derived extracellular vesicles promotes microcirculation reconstruction in diabetic wounds","volume":"33","author":"Lu","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"Suppl. 1","key":"10.1016\/j.jconrel.2026.114703_bb0055","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s00508-023-02167-7","article-title":"Diabetic neuropathy and diabetic foot syndrome (update 2023)","volume":"135","author":"K\u00f6hler","year":"2023","journal-title":"Wien. Klin. Wochenschr."},{"key":"10.1016\/j.jconrel.2026.114703_bb0060","doi-asserted-by":"crossref","DOI":"10.1093\/burnst\/tkaf020","article-title":"Targeting oxidative damage in diabetic foot ulcers: integrative strategies involving antioxidant drugs and nanotechnologies","volume":"13","author":"Wang","year":"2025","journal-title":"Burns Trauma"},{"key":"10.1016\/j.jconrel.2026.114703_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112707","article-title":"Nitric oxide-releasing biomaterials for promoting wound healing in impaired diabetic wounds: state of the art and recent trends","volume":"149","author":"Ahmed","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.jconrel.2026.114703_bb0070","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ccc.2019.12.009","article-title":"Nitric oxide and endothelial dysfunction","volume":"36","author":"Cyr","year":"2020","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.jconrel.2026.114703_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2024.104078","article-title":"Neuroimmunomodulatory effect of nitric oxide on chronic wound healing after photodynamic therapy","volume":"47","author":"Nardini","year":"2024","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.jconrel.2026.114703_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpc.2023.107114","article-title":"Nitric oxide modulates NMDA receptor through a negative feedback mechanism and regulates the dynamical behavior of neuronal postsynaptic components","volume":"303","author":"Sharma","year":"2023","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.jconrel.2026.114703_bb0085","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.actbio.2024.05.012","article-title":"Pleiotropic effects of nitric oxide sustained-release system for peripheral nerve repair","volume":"182","author":"Huo","year":"2024","journal-title":"Acta Biomater."},{"issue":"9","key":"10.1016\/j.jconrel.2026.114703_bb0090","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.4103\/1673-5374.335160","article-title":"Delivery of nitric oxide-releasing silica nanoparticles for in vivo revascularization and functional recovery after acute peripheral nerve crush injury","volume":"17","author":"Lee","year":"2022","journal-title":"Neural Regen. Res."},{"issue":"6","key":"10.1016\/j.jconrel.2026.114703_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/antiox13060741","article-title":"Induction of nitric oxide and its role in facial nerve regeneration according to the method of facial nerve injury","volume":"13","author":"Oh","year":"2024","journal-title":"Antioxidants"},{"issue":"25","key":"10.1016\/j.jconrel.2026.114703_bb0100","article-title":"Sustained release of nitric oxide-mediated angiogenesis and nerve repair by mussel-inspired adaptable microreservoirs for brain traumatic injury therapy","volume":"13","author":"Liu","year":"2024","journal-title":"Adv. Healthc. Mate."},{"key":"10.1016\/j.jconrel.2026.114703_bb0105","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jcis.2024.11.167","article-title":"Near-infrared light-activated nanosystem endows scaffold with controllable nitric oxide release for peripheral nerve regeneration","volume":"682","author":"Qi","year":"2025","journal-title":"J. Colloid Interface Sci."},{"issue":"16","key":"10.1016\/j.jconrel.2026.114703_bb0110","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1097\/WNR.0b013e3282f03fff","article-title":"Regenerative arrest of inflamed peripheral nerves: role of nitric oxide","volume":"18","author":"McDonald","year":"2007","journal-title":"Neuroreport"},{"key":"10.1016\/j.jconrel.2026.114703_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105183","article-title":"Inhibition of nitric oxide production enhances the activity of facial nerve tubulin polymerization and the ability of tau to promote microtubule assembly after neurorrhaphy","volume":"150","author":"Yeh","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jconrel.2026.114703_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115912","article-title":"Advances in nitric oxide regulators for the treatment of ischemic stroke","volume":"262","author":"Wu","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"22","key":"10.1016\/j.jconrel.2026.114703_bb0125","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1177\/1535370221997052","article-title":"Nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells","volume":"246","author":"Liy","year":"2021","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.jconrel.2026.114703_bb0130","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8852759","article-title":"The role of oxidative stress and antioxidants in diabetic wound healing","volume":"2021","author":"Deng","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114703_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/nu15030660","article-title":"Supplementation with nitric oxide precursors for strength performance: a review of the current literature","volume":"15","author":"Gonzalez","year":"2023","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.jconrel.2026.114703_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/antiox13050602","article-title":"Cellular ROS and antioxidants: physiological and pathological role","volume":"13","author":"Kozlov","year":"2024","journal-title":"Antioxidants"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114703_bb0145","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3164\/jcbn.36.29","article-title":"Coenzyme Q10 as a front-line antioxidant against oxidative stress","volume":"36","author":"Yamamoto","year":"2005","journal-title":"J. Clin. Biochem. Nutr."},{"issue":"2","key":"10.1016\/j.jconrel.2026.114703_bb0150","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/08982104.2023.2268711","article-title":"Solid lipid nanoparticles: a versatile approach for controlled release and targeted drug delivery","volume":"34","author":"Munir","year":"2024","journal-title":"J. Liposome Res."},{"issue":"6","key":"10.1016\/j.jconrel.2026.114703_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24061089","article-title":"Recent advances in phenylboronic acid-based gels with potential for self-regulated drug delivery","volume":"24","author":"Wang","year":"2019","journal-title":"Molecules"},{"issue":"13","key":"10.1016\/j.jconrel.2026.114703_bb0160","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1039\/D3BM01792C","article-title":"Antibacterial polylysine-containing hydrogels for hemostatic and wound healing applications: preparation methods, current advances and future perspectives","volume":"12","author":"Pourshahrestani","year":"2024","journal-title":"Biomater. Sci."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114703_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/polym15030582","article-title":"Advances in the design of phenylboronic acid-based glucose-sensitive hydrogels","volume":"15","author":"Morariu","year":"2023","journal-title":"Polymers"},{"issue":"11","key":"10.1016\/j.jconrel.2026.114703_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28114498","article-title":"Preparation of biocompatible manganese selenium-based nanoparticles with antioxidant and catalytic functions","volume":"28","author":"Yu","year":"2023","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.jconrel.2026.114703_bb0175","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s12161-015-0306-4","article-title":"A highly sensitive and selective spectrofluorimetric method for the determination of nitrite in food products","volume":"9","author":"Wang","year":"2016","journal-title":"Food Anal. Methods"},{"key":"10.1016\/j.jconrel.2026.114703_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.154205","article-title":"A novel nitric oxide-driven nanomotor for synergistic treatment of ischaemic stroke: enhanced deep brain penetration and therapeutic efficacy","volume":"496","author":"Xiao","year":"2024","journal-title":"Chem. Eng. J."},{"issue":"21","key":"10.1016\/j.jconrel.2026.114703_bb0185","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202301440","article-title":"Biomimetic and NOS-responsive nanomotor deeply delivery a combination of MSC-EV and mitochondrial ROS scavenger and promote heart repair and regeneration","volume":"10","author":"Zhang","year":"2023","journal-title":"Adv. Sci."},{"issue":"5","key":"10.1016\/j.jconrel.2026.114703_bb0190","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202305063","article-title":"Dual-fuel propelled nanomotors with two-stage permeation for deep bacterial infection in the treatment of pulpitis","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.114703_bb0195","article-title":"Bio-inspired nitric-oxide-driven nanomotor","volume":"10","author":"Wan","year":"2019","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114703_bb0200","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202002525","article-title":"Nitric oxide-driven nanomotor for deep tissue penetration and multidrug resistance reversal in cancer therapy","volume":"8","author":"Wan","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.114703_bb0205","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jcis.2023.05.080","article-title":"Nanomotors-loaded microneedle patches for the treatment of bacterial biofilm-related infections of wound","volume":"647","author":"Chen","year":"2023","journal-title":"J. Colloid Interface Sci."},{"issue":"22","key":"10.1016\/j.jconrel.2026.114703_bb0210","doi-asserted-by":"crossref","first-page":"10132","DOI":"10.1021\/acs.nanolett.3c02291","article-title":"Visualizing facets asymmetry induced directional movement of cadmium chloride nanomotor","volume":"23","author":"Wan","year":"2023","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2026.114703_bb0215","first-page":"271","article-title":"An NIR-propelled janus nanomotor with enhanced ROS-scavenging, immunomodulating and biofilm-eradicating capacity for periodontitis treatment","volume":"41","author":"Bai","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2026.114703_bb0220","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.jcis.2024.10.028","article-title":"Dual responsive drug-loaded nanomotor based on zwitterionic materials for the treatment of peritoneal metastatic cancer","volume":"679","author":"Chen","year":"2025","journal-title":"J. Colloid Interface Sci."},{"issue":"52","key":"10.1016\/j.jconrel.2026.114703_bb0225","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202205252","article-title":"Cascade catalytically released nitric oxide-driven nanomotor with enhanced penetration for antibiofilm","volume":"18","author":"Zheng","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2026.114703_bb0230","article-title":"Biomimetic nanomotors for deep ischemia penetration and ferroptosis inhibition in neuroprotective therapy of ischemic stroke","author":"Wang","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114703_bb0235","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2121-14-22","article-title":"Constant or fluctuating hyperglycemias increases cytomembrane stiffness of human umbilical vein endothelial cells in culture: roles of cytoskeletal rearrangement and nitric oxide synthesis","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Cell Biol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114703_bb0240","doi-asserted-by":"crossref","first-page":"G109","DOI":"10.1152\/ajpgi.00331.2007","article-title":"Activated macrophages inhibit enterocyte gap junctions via the release of nitric oxide","volume":"294","author":"Anand","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"9","key":"10.1016\/j.jconrel.2026.114703_bb0245","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.2337\/db08-0381","article-title":"Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation - evidence for blunted responsiveness in diabetes","volume":"57","author":"Calzi","year":"2008","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114703_bb0250","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00004647-199902000-00003","article-title":"Nitric oxide modulates endothelin 1-induced Ca2+ mobilization and cytoskeletal F-actin filaments in human cerebromicrovascular endothelial cells","volume":"19","author":"Chen","year":"1999","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"8","key":"10.1016\/j.jconrel.2026.114703_bb0255","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.bbamem.2011.07.031","article-title":"Interaction between nitric oxide signaling and gap junctions: effects on vascular function","volume":"1818","author":"Looft-Wilson","year":"2012","journal-title":"BBA Biomembr."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114703_bb0260","first-page":"205","article-title":"Nitric oxide-gap junctional coupling of tracheal smooth-muscle excised from rats","volume":"11","author":"Miwa","year":"1995","journal-title":"Biog. Amines"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114703_bb0265","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/00001756-199601310-00046","article-title":"Nitric oxide-stimulated increase in intracellular cGMP modulates gap junction coupling in rat neocortex","volume":"7","author":"Rorig","year":"1996","journal-title":"Neuroreport"},{"issue":"10","key":"10.1016\/j.jconrel.2026.114703_bb0270","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1007\/s12274-018-2092-y","article-title":"Scavenging of reactive oxygen and nitrogen species with nanomaterials","volume":"11","author":"Ferreira","year":"2018","journal-title":"Nano Res."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114703_bb0275","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24031841","article-title":"Superoxide anion chemistry-its role at the core of the innate immunity","volume":"24","author":"Andres","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114703_bb0280","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.chemphyslip.2004.04.006","article-title":"Active oxygen chemistry within the liposomal bilayer part iv: locating 2\u2032,7\u2032-dichlorofluorescein (DCF), 2\u2032,7\u2032-dichlorodihydrofluorescein (DCFH) and 2\u2032,7\u2032-dichlorodihydrofluorescein diacetate (DCFH-DA) in the lipid bilayer","volume":"131","author":"Afri","year":"2004","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.jconrel.2026.114703_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2019.106637","article-title":"Comparison of three analytical methods for superoxide produced by activated immune cells","volume":"101","author":"Zhu","year":"2020","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"12","key":"10.1016\/j.jconrel.2026.114703_bb0290","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.1039\/C8NR08936A","article-title":"Leukocyte-mimicking Pluronic-lipid nanovesicle hybrids inhibit the growth and metastasis of breast cancer","volume":"11","author":"Chen","year":"2019","journal-title":"Nanoscale"},{"issue":"21","key":"10.1016\/j.jconrel.2026.114703_bb0295","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202212919","article-title":"Drug-free biomimetic oxygen supply nanovehicle promotes ischemia-reperfusion therapy in stroke","volume":"33","author":"He","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2026.114703_bb0300","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1226044","article-title":"ROS induced lipid peroxidation and their role in ferroptosis","volume":"11","author":"Endale","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jconrel.2026.114703_bb0305","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5080843","article-title":"Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis","volume":"2019","author":"Su","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"6","key":"10.1016\/j.jconrel.2026.114703_bb0310","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00204-023-03476-6","article-title":"ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis","volume":"97","author":"Wang","year":"2023","journal-title":"Arch. Toxicol."},{"issue":"7784","key":"10.1016\/j.jconrel.2026.114703_bb0315","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2026.114703_bb0320","series-title":"Reactive Oxygen Species: Methods and Protocols","first-page":"199","article-title":"Lipid Peroxidation Assay Using BODIPY-Phenylbutadiene Probes: A Methodological Overview","author":"Stockert","year":"2021"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114703_bb0325","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1023\/A:1007486022411","article-title":"Mitochondrial permeability transition in apoptosis and necrosis","volume":"14","author":"Hirsch","year":"1998","journal-title":"Cell Biol. Toxicol."},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2026.114703_bb0330","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0009-8981(02)00297-8","article-title":"Apoptosis: biochemical aspects and clinical implications","volume":"326","author":"Kiechle","year":"2002","journal-title":"Clin. Chim. Acta"},{"issue":"85","key":"10.1016\/j.jconrel.2026.114703_bb0335","doi-asserted-by":"crossref","first-page":"45128","DOI":"10.1039\/C4RA07577C","article-title":"Comparison of different probes based on labeled Annexin V for detection of apoptosis","volume":"4","author":"Nazari","year":"2014","journal-title":"RSC Adv."},{"issue":"8","key":"10.1016\/j.jconrel.2026.114703_bb0340","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1039\/c0ay00247j","article-title":"Detection of apoptosis: a review of conventional and novel techniques","volume":"2","author":"Martinez","year":"2010","journal-title":"Anal. Methods"},{"key":"10.1016\/j.jconrel.2026.114703_bb0345","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.188","article-title":"Eleostearic acid induces RIP1-mediated atypical apoptosis in a kinase-independent manner via ERK phosphorylation, ROS generation and mitochondrial dysfunction","volume":"4","author":"Obitsu","year":"2013","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.jconrel.2026.114703_bb0350","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1007\/s10517-014-2637-3","article-title":"Comparison of mitochondrial fluorescent dyes in stromal cells","volume":"157","author":"Buravkov","year":"2014","journal-title":"Bull. Exp. Biol. Med."},{"issue":"10","key":"10.1016\/j.jconrel.2026.114703_bb0355","first-page":"50","article-title":"Detection of apoptosis by YO-PRO-1\/PI staining","volume":"25","author":"Ye","year":"2005","journal-title":"J. Chin. Biotechnol."},{"key":"10.1016\/j.jconrel.2026.114703_bb0360","first-page":"259","article-title":"Methods for detecting and quantifying apoptosis","volume":"36","author":"McCarthy","year":"1998","journal-title":"Cell. Mole. Proced. Development. Biol."},{"issue":"9","key":"10.1016\/j.jconrel.2026.114703_bb0365","doi-asserted-by":"crossref","first-page":"7980","DOI":"10.3390\/molecules16097980","article-title":"Thymidine analogues for tracking DNA synthesis","volume":"16","author":"Cavanagh","year":"2011","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.jconrel.2026.114703_bb0370","doi-asserted-by":"crossref","first-page":"351","DOI":"10.4062\/biomolther.2010.18.4.351","article-title":"Therapeutic application of nitric oxide in human diseases","volume":"18","author":"Namkoong","year":"2010","journal-title":"Biomol. Ther."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114703_bb0375","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.smim.2015.05.004","article-title":"Gaseous mediators in resolution of inflammation","volume":"27","author":"Wallace","year":"2015","journal-title":"Semin. Immunol."},{"issue":"8","key":"10.1016\/j.jconrel.2026.114703_bb0380","doi-asserted-by":"crossref","DOI":"10.1111\/pim.12446","article-title":"Synergic and antagonistic relationship between MMP-2 and MMP-9 with fibrosis and inflammation in Chagas\u2019 cardiomyopathy","volume":"39","author":"Medeiros","year":"2017","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.jconrel.2026.114703_bb0385","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jconrel.2022.08.018","article-title":"In situ hydrogel capturing nitric oxide microbubbles accelerates the healing of diabetic foot","volume":"350","author":"Zhao","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114703_bb0390","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbae062","article-title":"Combined therapeutic strategy based on blocking the deleterious effects of AGEs for accelerating diabetic wound healing","volume":"11","author":"Yang","year":"2024","journal-title":"Regen. Biomater."},{"issue":"13","key":"10.1016\/j.jconrel.2026.114703_bb0395","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1039\/D4BM00351A","article-title":"Gases and gas-releasing materials for the treatment of chronic diabetic wounds","volume":"12","author":"Ye","year":"2024","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.jconrel.2026.114703_bb0400","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.niox.2018.11.001","article-title":"Nitric oxide regulates intussusceptive-like angiogenesis in wound repair in chicken embryo and transgenic zebrafish models","volume":"82","author":"Vimalraj","year":"2019","journal-title":"Nitric Oxide-Biol. Chem."},{"key":"10.1016\/j.jconrel.2026.114703_bb0405","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jconrel.2023.05.047","article-title":"A glucose-responsive nitric oxide release hydrogel for infected diabetic wounds treatment","volume":"359","author":"Zhou","year":"2023","journal-title":"J. Control. Release"},{"issue":"12","key":"10.1016\/j.jconrel.2026.114703_bb0410","doi-asserted-by":"crossref","first-page":"4972","DOI":"10.1021\/acs.biomac.0c01176","article-title":"Controlled nitric oxide release using poly(lactic-co-glycolic acid) nanoparticles for anti-inflammatory effects","volume":"21","author":"Oh","year":"2020","journal-title":"Biomacromolecules"},{"issue":"34","key":"10.1016\/j.jconrel.2026.114703_bb0415","doi-asserted-by":"crossref","first-page":"14628","DOI":"10.1002\/anie.202006117","article-title":"Sequential and timely combination of a cancer nanovaccine with immune checkpoint blockade effectively inhibits tumor growth and relapse","volume":"59","author":"Kim","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2026.114703_bb0420","doi-asserted-by":"crossref","unstructured":"Lee, J., P.E. Saw, V. Gujrati, et al., Mono-arginine cholesterol-based small lipid nanoparticles as a systemic siRNA delivery platform for effective cancer therapy. Theranostics, 2016. 6(2): 192\u2013203. doi:https:\/\/doi.org\/10.7150\/thno.13657.","DOI":"10.7150\/thno.13657"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926001057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926001057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T08:29:01Z","timestamp":1787128141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926001057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":84,"alternative-id":["S0168365926001057"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114703","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A precision nitric oxide-releasing hydrogel promoting nanoparticles permeation for comprehensive nerve-vessel recovery and microenvironment regulation in diabetic wounds","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114703","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114703"}}