{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T09:24:21Z","timestamp":1787131461071,"version":"build-2736575974"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471525"],"award-info":[{"award-number":["32471525"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52403185"],"award-info":[{"award-number":["52403185"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004024","name":"Jinan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515010529"],"award-info":[{"award-number":["2025A1515010529"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515011493"],"award-info":[{"award-number":["2023A1515011493"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515012871"],"award-info":[{"award-number":["2025A1515012871"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jconrel.2026.114707","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:31:09Z","timestamp":1770507069000},"page":"114707","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A versatile self-adjuvanting macro-microporous ZIF-8@Mn MOF platform for efficient antigen capture and presentation to boost antitumor immunity"],"prefix":"10.1016","volume":"392","author":[{"given":"Qinhua","family":"Zuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanxu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zonghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.114707_rf0005","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41591-018-0014-x","volume":"24","author":"Binnewies","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2026.114707_rf0010","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41577-019-0127-6","volume":"19","author":"DeNardo","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2026.114707_rf0015","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.aar4060","volume":"359","author":"Ribas","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2026.114707_rf0020","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-019-0052-1","volume":"19","author":"Shimasaki","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2026.114707_rf0025","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41408-021-00459-7","volume":"11","author":"Sterner","year":"2021","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.jconrel.2026.114707_rf0030","volume":"37","author":"Chen","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114707_rf0035","volume":"37","author":"Sun","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114707_rf0040","doi-asserted-by":"crossref","first-page":"21170","DOI":"10.1021\/jacs.5c06776","volume":"147","author":"Yang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2026.114707_rf0045","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1016\/j.cclet.2020.12.055","volume":"32","author":"Hu","year":"2021","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jconrel.2026.114707_rf0050","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/ot9.0000000000000014","volume":"9","author":"Qin","year":"2023","journal-title":"Oncol. Transla. Med."},{"key":"10.1016\/j.jconrel.2026.114707_bb0015","volume":"12","author":"Rivero-Hinojosa","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.114707_rf0060","volume":"8","author":"Fan","year":"2023","journal-title":"Signal Transduct Tar"},{"key":"10.1016\/j.jconrel.2026.114707_rf0065","volume":"32","author":"Jiang","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114707_rf0070","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202309843","volume":"36","author":"Pal","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114707_rf0075","doi-asserted-by":"crossref","first-page":"9017","DOI":"10.1021\/acs.nanolett.4c02113","volume":"24","author":"Shao","year":"2024","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2026.114707_rf0080","doi-asserted-by":"crossref","DOI":"10.4028\/b-XDTcg5","volume":"11","author":"Wang","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2026.114707_rf0085","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.1016\/j.cclet.2022.01.071","volume":"33","author":"Zhang","year":"2022","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jconrel.2026.114707_rf0090","volume":"34","author":"Li","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2026.114707_rf0095","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201900996","volume":"9","author":"Cai","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2026.114707_rf0100","volume":"64","author":"Dai","year":"2025","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.jconrel.2026.114707_rf0105","volume":"37","author":"Guo","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114707_rf0110","volume":"19","author":"Zhang","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2026.114707_rf0115","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-immunol-032712-100008","volume":"31","author":"Kroemer","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2026.114707_rf0120","volume":"36","author":"Wang","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114707_rf0125","volume":"11","author":"Chen","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.114707_rf0130","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1021\/acs.accounts.1c00239","volume":"54","author":"Saw","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.jconrel.2026.114707_rf0135","volume":"6","author":"Ni","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2026.114707_rf0140","volume":"64","author":"Xu","year":"2025","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.jconrel.2026.114707_rf0145","doi-asserted-by":"crossref","first-page":"7136","DOI":"10.1021\/acsnano.3c11637","volume":"18","author":"Zhang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.114707_rf0150","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41551-021-00834-6","volume":"6","author":"Wang","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2026.114707_rf0155","author":"Li","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114707_rf0160","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adk6484","volume":"17","author":"Tavakolpour","year":"2025","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2026.114707_rf0165","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.114707_rf0170","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1126\/science.aao3403","volume":"359","author":"Shen","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2026.114707_rf0175","doi-asserted-by":"crossref","first-page":"31186","DOI":"10.1021\/jacs.4c11243","volume":"146","author":"Zou","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2026.114707_rf0180","author":"Liao","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2026.114707_rf0185","volume":"62","author":"Ding","year":"2023","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.jconrel.2026.114707_rf0190","volume":"417","author":"Guo","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jconrel.2026.114707_rf0195","volume":"420","author":"Lu","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jconrel.2026.114707_bb0070","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1021\/acs.molpharmaceut.7b00905","volume":"15","author":"Wang","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2026.114707_bb0075","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.immuni.2020.05.013","volume":"53","author":"Zhang","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jconrel.2026.114707_rf0210","author":"Wang","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2026.114707_rf0215","doi-asserted-by":"crossref","first-page":"2504253","DOI":"10.1002\/adma.202504253","volume":"37","author":"Xu","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114707_rf0220","volume":"36","author":"Li","year":"2025","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jconrel.2026.114707_bb0085","volume":"34","author":"Chen","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2026.114707_rf0230","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.cclet.2021.10.074","volume":"33","author":"Fu","year":"2022","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jconrel.2026.114707_rf0235","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1021\/acsnano.1c08232","volume":"16","author":"Wang","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.114707_rf0240","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.addr.2017.04.010","volume":"114","author":"Ngambenjawong","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.114707_rf0245","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jconrel.2017.03.395","volume":"254","author":"Singh","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114707_rf0250","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/ot9.0000000000000063","volume":"10","author":"Chen","year":"2024","journal-title":"Oncol. Transla. Med."},{"key":"10.1016\/j.jconrel.2026.114707_rf0255","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-58289-1","volume":"16","author":"Heras-Murillo","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.114707_rf0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120678","volume":"270","author":"Luo","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.114707_rf0265","volume":"6","author":"Yu","year":"2019","journal-title":"Adv. Sci."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926001094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926001094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T08:28:43Z","timestamp":1787128123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926001094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":53,"alternative-id":["S0168365926001094"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114707","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A versatile self-adjuvanting macro-microporous ZIF-8@Mn MOF platform for efficient antigen capture and presentation to boost antitumor immunity","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114707","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114707"}}