{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:07:25Z","timestamp":1793200045538,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jconrel.2026.114809","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:52:28Z","timestamp":1773161548000},"page":"114809","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Dual-action nasal spray with mussel protein and xylitol restores epithelial barrier and attenuates type 2 inflammation in allergic rhinitis"],"prefix":"10.1016","volume":"393","author":[{"given":"Bin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaowen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jconrel.2026.114809_bb0005","first-page":"392","article-title":"Guideline for diagnosis and treatment of pediatric allergic rhinitis (2022, revision)","volume":"57","author":"Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of oOtorhinolaryngology hHead and nNeck sSurgery, sSubspecialty gGroups of rRhinology and Pediatrics, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association","year":"2022","journal-title":"Chin. J. Otorhinolaryngol. Head Neck Surg."},{"issue":"12","key":"10.1016\/j.jconrel.2026.114809_bb0010","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1111\/all.16318","article-title":"The epithelial barrier theory and its associated diseases","volume":"79","author":"Sun","year":"2024","journal-title":"Allergy"},{"issue":"9","key":"10.1016\/j.jconrel.2026.114809_bb0015","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1080\/1744666X.2022.2093188","article-title":"Comparing available treatments for pollen-induced allergic rhinitis in children","volume":"18","author":"Klain","year":"2022","journal-title":"Expert Rev. Clin. Immunol."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114809_bb0020","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2174\/1573396320666230912103108","article-title":"Treatment of allergic rhinitis in clinical practice","volume":"20","author":"Tosca","year":"2024","journal-title":"Curr. Pediatr. Rev."},{"issue":"4","key":"10.1016\/j.jconrel.2026.114809_bb0025","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.jaci.2024.01.015","article-title":"The mucosal concept in chronic rhinosinusitis: focus on the epithelial barrier","volume":"153","author":"Yan","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.jconrel.2026.114809_bb0030","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/mi.2015.32","article-title":"New developments in goblet cell mucus secretion and function","volume":"8","author":"Birchenough","year":"2015","journal-title":"Mucosal Immunol."},{"issue":"9","key":"10.1016\/j.jconrel.2026.114809_bb0035","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1542\/pir.2022-005618","article-title":"Allergic rhinitis","volume":"44","author":"Cohen","year":"2023","journal-title":"Pediatr. Rev."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114809_bb0040","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.jaip.2024.03.023","article-title":"Current management of allergic rhinitis","volume":"12","author":"Klimek","year":"2024","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"11","key":"10.1016\/j.jconrel.2026.114809_bb0045","first-page":"1786","article-title":"Oxidative stress and antioxidant pathway in allergic rhinitis","volume":"10","author":"Han","year":"2021","journal-title":"Antioxidants (Basel)"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114809_bb0050","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1021\/acs.biomac.3c01025","article-title":"Self-healable adhesive hydrogel with a preserved underwater adhesive ability based on histidine-zinc coordination and a bioengineered hybrid mussel protein","volume":"25","author":"Maeng","year":"2024","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2026.114809_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125773","article-title":"Mechanically tunable, antibacterial and bioactive mussel adhesive protein\/hyaluronic acid coacervates as bioadhesives","volume":"247","author":"Zhao","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.jconrel.2026.114809_bb0060","first-page":"256","article-title":"Anti-microbial activities of mussel-derived recombinant proteins against gram-negative bacteria","volume":"13","author":"Kim","year":"2024","journal-title":"Antibiotics (Basel)"},{"issue":"1","key":"10.1016\/j.jconrel.2026.114809_bb0065","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12865-025-00700-z","article-title":"Using gut microbiota and non-targeted metabolomics techniques to study the effect of xylitol on alleviating DSS-induced inflammatory bowel disease in mice","volume":"26","author":"Ma","year":"2025","journal-title":"BMC Immunol."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114809_bb0070","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1017\/S0022215121000542","article-title":"Non-steroid, non-antibiotic anti-biofilm therapy for the treatment of chronic rhinosinusitis: a systematic review","volume":"135","author":"Taylor","year":"2021","journal-title":"J. Laryngol. Otol."},{"issue":"2","key":"10.1016\/j.jconrel.2026.114809_bb0075","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1017\/S002221512100030X","article-title":"A historical review of the evolution of nasal lavage systems","volume":"135","author":"Fandino","year":"2021","journal-title":"J. Laryngol. Otol."},{"issue":"4","key":"10.1016\/j.jconrel.2026.114809_bb0080","doi-asserted-by":"crossref","first-page":"187","DOI":"10.5415\/apallergy.0000000000000120","article-title":"Application of nasal irrigation in the treatment of chronic rhinosinusitis","volume":"13","author":"Jin","year":"2023","journal-title":"Asia Pac. Allergy"},{"issue":"20","key":"10.1016\/j.jconrel.2026.114809_bb0085","first-page":"9738","article-title":"Analysis of the efficacy of azelastine nasal spray combined with mussel mucin in the treatment of allergic rhinitis and the influence of peripheral blood CCL26 and CCR3 levels","volume":"27","author":"Liu","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"12","key":"10.1016\/j.jconrel.2026.114809_bb0090","article-title":"Survey on use of local and systemic corticosteroids in the management of chronic rhinosinusitis with nasal polyps: identification of unmet clinical needs","volume":"12","author":"De Corso","year":"2022","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.jconrel.2026.114809_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122496","article-title":"Synthesis, characterization and evaluation of hyaluronic acid-based polymers for nasal delivery","volume":"631","author":"Laffleur","year":"2023","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114809_bb0100","doi-asserted-by":"crossref","first-page":"7672","DOI":"10.1038\/s41598-024-58317-y","article-title":"Insights from bioinformatics analysis reveal that lipopolysaccharide induces activation of chemokine-related signaling pathways in human nasal epithelial cells","volume":"14","author":"Tan","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2026.114809_bb0105","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2147\/JAA.S444923","article-title":"New insights into mechanisms of traditional Chinese medicine for allergic rhinitis by regulating inflammatory and oxidative stress pathways","volume":"17","author":"Qin","year":"2024","journal-title":"J. Asthma Allergy"},{"key":"10.1016\/j.jconrel.2026.114809_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.663626","article-title":"Nasal epithelial barrier integrity and tight junctions disruption in allergic rhinitis: overview and pathogenic insights","volume":"12","author":"Nur Husna","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2026.114809_bb0115","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2147\/JAA.S467774","article-title":"NLRP3 inflammasome deficiency alleviates inflammation and oxidative stress by promoting PINK1\/parkin-mediated mitophagy in allergic rhinitis mice and nasal epithelial cells","volume":"17","author":"Ding","year":"2024","journal-title":"J. Asthma Allergy"},{"issue":"6","key":"10.1016\/j.jconrel.2026.114809_bb0120","doi-asserted-by":"crossref","first-page":"53254","DOI":"10.1021\/acsami.5c13513","article-title":"Versatile polypeptide-anchored antifouling dip-coatings for common medical implant materials","volume":"17","author":"Nisal","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"5","key":"10.1016\/j.jconrel.2026.114809_bb0125","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3390\/biomedicines12061377","article-title":"Efficacy and safety of xylitol nasal irrigation after functional endoscopic sinus surgery: a randomized controlled study","volume":"12","author":"Jiang","year":"2024","journal-title":"Biomedicines"},{"issue":"5","key":"10.1016\/j.jconrel.2026.114809_bb0130","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1111\/all.15240","article-title":"Epithelial barrier hypothesis: effect of the external exposome on the microbiome and epithelial barriers in allergic disease","volume":"77","author":"Celebi Sozener","year":"2022","journal-title":"Allergy"},{"issue":"8","key":"10.1016\/j.jconrel.2026.114809_bb0135","doi-asserted-by":"crossref","first-page":"69086","DOI":"10.1021\/acsami.4c17855","article-title":"Injectable nanocomposite hydrogel with synergistic biofilm eradication and enhanced re-epithelialization for cccelerated diabetic wound healing","volume":"16","author":"Zhao","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"21","key":"10.1016\/j.jconrel.2026.114809_bb0140","first-page":"3448","article-title":"Targeting mast cells in allergic disease: current therapies and drug repurposing","volume":"11","author":"Burchett","year":"2022","journal-title":"Cells"},{"issue":"15","key":"10.1016\/j.jconrel.2026.114809_bb0145","first-page":"8433","article-title":"An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases","volume":"23","author":"Teleanu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.jconrel.2026.114809_bb0150","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.3390\/ijms19102871","article-title":"Hormesis: path and progression to significance","volume":"19","author":"Calabrese","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2026.114809_bb0155","first-page":"396","article-title":"A mussel-inspired, antibacterial, antioxidant, injectable composite hydrogel for the sustained delivery of salvianolic acid B for the treatment of frozen shoulder","volume":"40","author":"Yan","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2026.114809_bb0160","first-page":"368","article-title":"Rationally designed bioactive milk-derived protein scaffolds enhanced new bone formation","volume":"20","author":"Lee","year":"2023","journal-title":"Bioact. Mater."},{"issue":"12","key":"10.1016\/j.jconrel.2026.114809_bb0165","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1007\/s00405-019-05605-3","article-title":"Xylitol treats nasal mucosa in rhinitis medicamentosa: an experimental rat model study","volume":"276","author":"Cam","year":"2019","journal-title":"Eur. Arch. Otorrinolaringol."},{"key":"10.1016\/j.jconrel.2026.114809_bb0170","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.biopha.2017.04.133","article-title":"Bupleurum chinense extract ameliorates an OVA-induced murine allergic asthma through the reduction of the Th2 and Th17 cytokines production by inactivation of NF\u03baB pathway","volume":"91","author":"Bui","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114809_bb0175","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/alr.23090","article-title":"International consensus statement on allergy and rhinology: allergic rhinitis - 2023","volume":"13","author":"Wise","year":"2023","journal-title":"Int. Forum Allergy Rhinol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114809_bb0180","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13223-024-00905-8","article-title":"Role of Th2, Th17 and Treg cells and relevant cytokines in pathogenesis of allergic rhinitis","volume":"20","author":"Guo","year":"2024","journal-title":"Allergy, Asthma Clin. Immunol."},{"issue":"22","key":"10.1016\/j.jconrel.2026.114809_bb0185","article-title":"Evaluating the protective properties of a xyloglucan-based nasal spray in a mouse model of allergic rhinitis","volume":"22","author":"Lanza","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2026.114809_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmii.2025.05.004","article-title":"Molecular mechanisms of baicalein in treating recalcitrant chronic rhinosinusitis caused by Staphylococcus aureus: an in vitro study","author":"Lin","year":"2025","journal-title":"J. Microbiol. Immunol. Infect."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926002117?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926002117?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T17:02:58Z","timestamp":1781715778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926002117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":38,"alternative-id":["S0168365926002117"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114809","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual-action nasal spray with mussel protein and xylitol restores epithelial barrier and attenuates type 2 inflammation in allergic rhinitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114809","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114809"}}