{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:10:17Z","timestamp":1793315417652,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017958","name":"Health Commission of Hubei Province","doi-asserted-by":"publisher","award":["ZY2025Q028"],"award-info":[{"award-number":["ZY2025Q028"]}],"id":[{"id":"10.13039\/100017958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404548"],"award-info":[{"award-number":["82404548"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["YCJJ20252432"],"award-info":[{"award-number":["YCJJ20252432"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003397","name":"Huazhong University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2025AFA042"],"award-info":[{"award-number":["2025AFA042"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012261","name":"Federation of Canadian Municipalities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jconrel.2026.114827","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:25:39Z","timestamp":1773825939000},"page":"114827","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Immunogenic cell death\u2013primed autophagosome vaccines drive dendritic cell cross-presentation and suppress colon cancer metastasis"],"prefix":"10.1016","volume":"393","author":[{"given":"Hongbo","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianzi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianya","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conglian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.114827_bb0005","doi-asserted-by":"crossref","first-page":"1309635","DOI":"10.3389\/fimmu.2023.1309635","article-title":"Programmed cell death in tumor immunity: mechanistic insights and clinical implications","volume":"14","author":"Wang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2026.114827_bb0010","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41420-025-02376-1","article-title":"Cell death in tumor microenvironment: an insight for exploiting novel therapeutic approaches","volume":"11","author":"Wang","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.jconrel.2026.114827_bb0015","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.ccell.2025.03.030","article-title":"Cell death, IL-1 cytokines, and tumor progression","volume":"43","author":"Cheng","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jconrel.2026.114827_bb0020","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/s41573-024-00920-9","article-title":"Targeting immunogenic cell stress and death for cancer therapy","volume":"23","author":"Galluzzi","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2026.114827_bb0025","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41568-024-00674-x","article-title":"Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity","volume":"24","author":"Meier","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2026.114827_bb0030","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41590-022-01132-2","article-title":"Immunogenic cell stress and death","volume":"23","author":"Kroemer","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jconrel.2026.114827_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2025.216846","article-title":"Immunogenic cell death inducers: current advances and future perspectives","volume":"542","author":"Lv","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.jconrel.2026.114827_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2025.102678","article-title":"An immunogenic cell death dual-nanoamplifier for the reverse of chemotherapy resistance and immune escape in metastatic colon cancer","volume":"62","author":"Zhang","year":"2025","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2026.114827_bb0045","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jconrel.2024.07.030","article-title":"A laponite-based immunologically active gel delivery system for long-acting tumor vaccine","volume":"373","author":"Zhang","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114827_bb0050","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jconrel.2023.05.044","article-title":"Dying tumor cells-inspired vaccine for boosting humoral and cellular immunity against cancer","volume":"359","author":"Qin","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114827_bb0055","article-title":"Rational design of ICD-inducing nanoparticles for cancer immunotherapy","volume":"10","author":"Zhang","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2026.114827_bb0060","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.jconrel.2024.10.060","article-title":"A personalized vaccine combining immunogenic cell death-induced cells and nanosized antigens for enhanced antitumor immunity","volume":"376","author":"Yang","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114827_bb0065","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41419-024-06644-3","article-title":"Turning anecdotal irradiation-induced anticancer immune responses into reproducible in situ cancer vaccines via disulfiram\/copper-mediated enhanced immunogenic cell death of breast cancer cells","volume":"15","author":"Guo","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jconrel.2026.114827_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122065","article-title":"Genetically engineered cellular nanoparticles for biomedical applications","volume":"296","author":"Krishnan","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.114827_bb0075","first-page":"211","article-title":"CD47KO\/CRT dual-bioengineered cell membrane-coated nanovaccine combined with anti-PD-L1 antibody for boosting tumor immunotherapy","volume":"22","author":"Liu","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2026.114827_bb0080","article-title":"Click-chemistry-mediated cell membrane glycopolymer engineering to potentiate dendritic cell vaccines","volume":"63","author":"Yang","year":"2024","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2026.114827_bb0085","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1285","article-title":"Cell membrane-coated nanoparticles for the treatment of cancer","volume":"13","author":"Krishnan","year":"2023","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.jconrel.2026.114827_bb0090","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1021\/nl500618u","article-title":"Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery","volume":"14","author":"Fang","year":"2014","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2026.114827_bb0095","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.biomaterials.2018.08.016","article-title":"PEGylated tumor cell membrane vesicles as a new vaccine platform for cancer immunotherapy","volume":"182","author":"Ochyl","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.114827_bb0100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2023.07.043","article-title":"Logistics and distribution of small extracellular vesicles from the subcutaneous space to the lymphatic system","volume":"361","author":"Sakurai","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114827_bb0105","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12483","article-title":"Cell dehydration enables massive production of engineered membrane vesicles with therapeutic functions","volume":"13","author":"Liu","year":"2024","journal-title":"J. Extracell. Vesicle"},{"key":"10.1016\/j.jconrel.2026.114827_bb0110","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1038\/s41467-024-48200-9","article-title":"PD-1\/CD80+ small extracellular vesicles from immunocytes induce cold tumours featured with enhanced adaptive immunosuppression","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.114827_bb0115","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202300121","article-title":"Rethinking antigen source: cancer vaccines based on whole tumor cell\/tissue lysate or whole tumor cell","author":"Diao","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.114827_bb0120","article-title":"Immunotherapy and prevention of cancer by nanovaccines loaded with whole-cell components of tumor tissues or cells","volume":"33","author":"Ma","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114827_bb0125","article-title":"Pathogen-mimicking cancer vaccine with self-generated dsRNA potentiates innate immunity against colon cancer","author":"Zhou","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2026.114827_bb0130","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1142\/S0192415X20500962","article-title":"Autophagy impairment through lysosome dysfunction by brucine induces immunogenic cell death (ICD)","volume":"48","author":"Ishimwe","year":"2020","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.jconrel.2026.114827_bb0135","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s41419-023-06154-8","article-title":"Autophagy: regulator of cell death","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jconrel.2026.114827_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121651","article-title":"Autophagy inhibition recovers deficient ICD-based cancer immunotherapy","volume":"287","author":"Li","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.114827_bb0145","first-page":"47","article-title":"Immunogenic cell death: a step ahead of autophagy in cancer therapy","volume":"3","author":"Gupta","year":"2021","journal-title":"J. Cancer Immunol. (Wilmington)"},{"key":"10.1016\/j.jconrel.2026.114827_bb0150","article-title":"Radiation-based immunogenic vaccine combined with a macrophage \u201ccheckpoint inhibitor\u201d for boosting innate and adaptive immunity against metastatic colon cancers","author":"Xu","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2026.114827_bb0155","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth","volume":"41","author":"De Visser","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jconrel.2026.114827_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217385","article-title":"Tumor microenvironment: nurturing cancer cells for immunoevasion and druggable vulnerabilities for cancer immunotherapy","volume":"611","author":"Yu","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jconrel.2026.114827_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115432","article-title":"The tumor microenvironment is an ecosystem sustained by metabolic interactions","volume":"44","author":"Kay","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.jconrel.2026.114827_bb0170","first-page":"1","article-title":"The tumour microenvironment in pancreatic cancer \u2014 new clinical challenges, but more opportunities","author":"Kung","year":"2025","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2026.114827_bb0175","doi-asserted-by":"crossref","first-page":"40437","DOI":"10.18632\/oncotarget.9624","article-title":"A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy","volume":"7","author":"Yan","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jconrel.2026.114827_bb0180","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41541-025-01084-2","article-title":"Exploring Clec9a in dendritic cell-based tumor immunotherapy for molecular insights and therapeutic potentials","volume":"10","author":"Hussain","year":"2025","journal-title":"npj Vaccin."},{"key":"10.1016\/j.jconrel.2026.114827_bb0185","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.molimm.2022.05.058","article-title":"The dendritic cell receptor Clec9A: receptor regulation and immune modulation","volume":"150","author":"Tullett","year":"2022","journal-title":"Mol. Immunol."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926002294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926002294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T17:08:47Z","timestamp":1781716127000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926002294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":37,"alternative-id":["S0168365926002294"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114827","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunogenic cell death\u2013primed autophagosome vaccines drive dendritic cell cross-presentation and suppress colon cancer metastasis","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114827","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114827"}}