{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:58:12Z","timestamp":1792205892771,"version":"4.4.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["YCJJ20252420"],"award-info":[{"award-number":["YCJJ20252420"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571623"],"award-info":[{"award-number":["32571623"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172757"],"award-info":[{"award-number":["82172757"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["W2512077"],"award-info":[{"award-number":["W2512077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32501266"],"award-info":[{"award-number":["32501266"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003397","name":"Huazhong University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008416","name":"Wuhan National Laboratory for Optoelectronics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jconrel.2026.114832","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T15:55:46Z","timestamp":1773676546000},"page":"114832","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A unified biochemical\u2013physical regulatory nanoparticle modulates tumor mechanics to augment nanomedicine penetration and antitumor efficacy"],"prefix":"10.1016","volume":"393","author":[{"given":"Tian","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leshu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyuan","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zitao","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longmei","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haochen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangliang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.114832_bb0005","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/s41568-024-00745-z","article-title":"Compressive stresses in cancer: characterization and implications for tumour progression and treatment","volume":"24","author":"Linke","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2026.114832_bb0010","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaz0868","article-title":"Physical traits of cancer","volume":"370","author":"Nia","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2026.114832_bb0015","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.semcancer.2015.09.001","article-title":"The mechanical microenvironment in cancer: how physics affects tumours","volume":"35","author":"Nagelkerke","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.jconrel.2026.114832_bb0020","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1158\/2159-8290.CD-24-0002","article-title":"The interplay between extracellular matrix remodeling and cancer therapeutics","volume":"14","author":"Prakash","year":"2024","journal-title":"Cancer Discov."},{"key":"10.1016\/j.jconrel.2026.114832_bb0025","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41568-020-00329-7","article-title":"The matrix in cancer","volume":"21","author":"Cox","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2026.114832_bb0030","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev-physiol-020518-114700","article-title":"Normalizing function of tumor vessels: progress, opportunities, and challenges","volume":"81","author":"Martin","year":"2019","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jconrel.2026.114832_bb0035","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1200\/JCO.2012.46.3653","article-title":"Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers","volume":"31","author":"Jain","year":"2013","journal-title":"JCO"},{"key":"10.1016\/j.jconrel.2026.114832_bb0040","doi-asserted-by":"crossref","first-page":"32045","DOI":"10.1021\/acsnano.4c10381","article-title":"Extracellular matrix limits nanoparticle diffusion and cellular uptake in a tissue-specific manner","volume":"18","author":"Cahn","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.114832_bb0045","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2209260120","article-title":"Extracellular matrix physical properties govern the diffusion of nanoparticles in tumor microenvironment","volume":"120","author":"He","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jconrel.2026.114832_bb0050","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.addr.2018.07.007","article-title":"Tumor targeting via EPR: strategies to enhance patient responses","volume":"130","author":"Golombek","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.114832_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114614","article-title":"The tumor EPR effect for cancer drug delivery: current status, limitations, and alternatives","volume":"191","author":"Sun","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.114832_bb0060","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13045-025-01688-0","article-title":"Cancer associated fibroblasts in cancer development and therapy","volume":"18","author":"Jia","year":"2025","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.jconrel.2026.114832_bb0065","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1042\/BST20160387","article-title":"Cancer-associated fibroblasts modulate growth factor signaling and extracellular matrix remodeling to regulate tumor metastasis","volume":"45","author":"Erdogan","year":"2017","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.jconrel.2026.114832_bb0070","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.trecan.2019.09.010","article-title":"CAF subpopulations: a new reservoir of stromal targets in pancreatic cancer","volume":"5","author":"Pereira","year":"2019","journal-title":"Trends Cancer"},{"key":"10.1016\/j.jconrel.2026.114832_bb0075","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12943-021-01428-1","article-title":"Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives","volume":"20","author":"Mao","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jconrel.2026.114832_bb0080","doi-asserted-by":"crossref","first-page":"0173","DOI":"10.34133\/bmr.0173","article-title":"Nanotension relief agent enhances tissue penetration by reducing solid stress in pancreatic ductal adenocarcinoma via rho\/ROCK pathway inhibition","volume":"29","author":"Yu","year":"2025","journal-title":"Biomater. Res."},{"key":"10.1016\/j.jconrel.2026.114832_bb0085","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41568-024-00740-4","article-title":"CAF-induced physical constraints controlling T cell state and localization in solid tumours","volume":"24","author":"Arpinati","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2026.114832_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108231","article-title":"Targeting cancer-associated fibroblasts: challenges, opportunities and future directions","volume":"240","author":"Jenkins","year":"2022","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jconrel.2026.114832_bb0095","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.trecan.2018.02.005","article-title":"Reengineering the physical microenvironment of tumors to improve drug delivery and efficacy: from mathematical modeling to bench to bedside","volume":"4","author":"Stylianopoulos","year":"2018","journal-title":"Trends Cancer"},{"key":"10.1016\/j.jconrel.2026.114832_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1467602","article-title":"Targeting extracellular matrix stiffness for cancer therapy","volume":"15","author":"Feng","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2026.114832_bb0105","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/intbio\/zyaa014","article-title":"Pirfenidone reduces immune-suppressive capacity of cancer-associated fibroblasts through targeting CCL17 and TNF-beta","volume":"12","author":"Aboulkheyr Es","year":"2020","journal-title":"Integr. Biol."},{"key":"10.1016\/j.jconrel.2026.114832_bb0110","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.phrs.2014.10.009","article-title":"Tranilast: a review of its therapeutic applications","volume":"91","author":"Darakhshan","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jconrel.2026.114832_bb0115","doi-asserted-by":"crossref","first-page":"7165","DOI":"10.1038\/s41467-022-34744-1","article-title":"Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models","volume":"13","author":"Panagi","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.114832_bb0120","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1186\/s12951-024-02871-0","article-title":"Losartan-based nanocomposite hydrogel overcomes chemo-immunotherapy resistance by remodeling tumor mechanical microenvironment","volume":"22","author":"Hou","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2026.114832_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202200608","article-title":"A space-time conversion vehicle for programmed multi-drugs delivery into pancreatic tumor to overcome matrix and reflux barriers","volume":"9","author":"Huo","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.114832_bb0130","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1021\/acs.nanolett.4c05625","article-title":"A PTT-induced feed-back carbon nanosystem for enhanced breast cancer therapy by extracellular matrix remodeling","volume":"25","author":"Zheng","year":"2025","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2026.114832_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2021.214330","article-title":"Low temperature photothermal therapy: advances and perspectives","volume":"454","author":"Yang","year":"2022","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.jconrel.2026.114832_bb0140","article-title":"Softness-aided mild hyperthermia boosts stiff nanomedicine by regulating tumor mechanics","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.114832_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101767","article-title":"Mild photothermal therapy boosts nanomedicine antitumor efficacy by disrupting DNA damage repair pathways and modulating tumor mechanics","volume":"49","author":"Xiong","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2026.114832_bb0150","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.apsb.2025.01.002","article-title":"Locally producing antibacterial peptide to deplete intratumoral pathogen for preventing metastatic breast cancer","volume":"15","author":"Geng","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2026.114832_bb0155","doi-asserted-by":"crossref","DOI":"10.34133\/2021\/9816594","article-title":"Low-temperature photothermal therapy: strategies and applications","volume":"2021","author":"Yi","year":"2021","journal-title":"Research"},{"key":"10.1016\/j.jconrel.2026.114832_bb0160","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s40580-017-0124-z","article-title":"Deep tissue penetration of nanoparticles using pulsed-high intensity focused ultrasound","volume":"4","author":"You","year":"2017","journal-title":"Nano Converg."},{"key":"10.1016\/j.jconrel.2026.114832_bb0165","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jconrel.2017.02.035","article-title":"Extracellular matrix remodeling in vivo for enhancing tumor-targeting efficiency of nanoparticle drug carriers using the pulsed high intensity focused ultrasound","volume":"263","author":"Lee","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114832_bb0170","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1038\/s41467-024-49156-6","article-title":"Hyperbaric oxygen enhances tumor penetration and accumulation of engineered bacteria for synergistic photothermal immunotherapy","volume":"15","author":"Xu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.114832_bb0175","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4103\/mgr.MEDGASRES-D-23-00028","article-title":"Hyperbaric oxygen: a multifaceted approach in cancer therapy","volume":"14","author":"Deng","year":"2024","journal-title":"Med. Gas Res."},{"key":"10.1016\/j.jconrel.2026.114832_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114181","article-title":"Hyperbaric oxygen augments Doxil antitumor efficacy by reducing tumor-induced lactate","volume":"387","author":"Li","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114832_bb0185","doi-asserted-by":"crossref","DOI":"10.1002\/EXP.20240080","article-title":"Hyperbaric oxygen regulates tumor pH to boost copper-doped hydroxyethyl starch conjugate nanoparticles against cancer stem cells","volume":"5","author":"Deng","year":"2025","journal-title":"Exploration"},{"key":"10.1016\/j.jconrel.2026.114832_bb0190","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202206370","article-title":"Nanoparticle-mediated radiotherapy remodels the tumor microenvironment to enhance antitumor efficacy","volume":"35","author":"Zhen","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114832_bb0195","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.1021\/acsnano.4c17229","article-title":"Actin-targeted magnetic nanomotors mechanically modulate the tumor mechanical microenvironment for cancer treatment","volume":"19","author":"Fan","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.114832_bb0200","article-title":"Microenvironment mechanical torque from ZnFe2O4 (ZFO) micromotors inhibiting tumor migration","volume":"37","author":"Jiang","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114832_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105200","article-title":"Boosting antitumor efficacy of nanoparticles by modulating tumor mechanical microenvironment","volume":"105","author":"Zhang","year":"2024","journal-title":"eBioMedicine"},{"key":"10.1016\/j.jconrel.2026.114832_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102624","article-title":"Targeting cancer-associated fibroblasts with pirfenidone: a novel approach for cancer therapy","volume":"91","author":"Rastegar-Pouyani","year":"2024","journal-title":"Tissue Cell"},{"key":"10.1016\/j.jconrel.2026.114832_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11050721","article-title":"Integrins, CAFs and mechanical forces in the progression of cancer","volume":"11","author":"Jang","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.jconrel.2026.114832_bb0220","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nmat2859","article-title":"Orally delivered thioketal nanoparticles loaded with TNF-\u03b1\u2013siRNA target inflammation and inhibit gene expression in the intestines","volume":"9","author":"Wilson","year":"2010","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jconrel.2026.114832_bb0225","doi-asserted-by":"crossref","first-page":"7373","DOI":"10.1021\/jacs.7b12025","article-title":"Biodegradable, hydrogen peroxide, and glutathione dual responsive nanoparticles for potential programmable paclitaxel release","volume":"140","author":"Chen","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2026.114832_bb0230","doi-asserted-by":"crossref","first-page":"16875","DOI":"10.1021\/acsnano.0c05722","article-title":"Reactive oxygen species activatable heterodimeric prodrug as tumor-selective nanotheranostics","volume":"14","author":"Jiang","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.114832_bb0235","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41467-019-14199-7","article-title":"Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.114832_bb0240","article-title":"Tetrasulfide bond boosts the anti-tumor efficacy of dimeric prodrug nanoassemblies","volume":"5","author":"Zuo","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.jconrel.2026.114832_bb0245","doi-asserted-by":"crossref","first-page":"7228","DOI":"10.1038\/s41467-022-35033-7","article-title":"Hybrid chalcogen bonds in prodrug nanoassemblies provides dual redox-responsivity in the tumor microenvironment","volume":"13","author":"Liu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.114832_bb0250","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.1002\/anie.201510844","article-title":"Biodegradable inorganic nanovector: passive versus active tumor targeting in siRNA transportation","volume":"55","author":"Park","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2026.114832_bb0255","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.addr.2019.05.009","article-title":"Towards more accurate bioimaging of drug nanocarriers: turning aggregation-caused quenching into a useful tool","volume":"143","author":"Qi","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.114832_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121180","article-title":"A novel prodrug and its nanoformulation suppress cancer stem cells by inducing immunogenic cell death and inhibiting indoleamine 2, 3-dioxygenase","volume":"279","author":"Guan","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.114832_bb0265","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.2147\/IJN.S171224","article-title":"Prior anti-CAFs break down the CAFs barrier and improve accumulation of docetaxel micelles in tumor","volume":"13","author":"Pang","year":"2018","journal-title":"IJN"},{"key":"10.1016\/j.jconrel.2026.114832_bb0270","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1158\/0008-5472.CAN-12-3180","article-title":"Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells","volume":"73","author":"Kozono","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2026.114832_bb0275","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.actbio.2019.04.022","article-title":"Near-infrared-light induced nanoparticles with enhanced tumor tissue penetration and intelligent drug release","volume":"90","author":"Zhang","year":"2019","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2026.114832_bb0280","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.ccell.2020.05.005","article-title":"Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer","volume":"37","author":"Shen","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jconrel.2026.114832_bb0285","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s12195-018-0544-9","article-title":"The role of desmoplasia and stromal fibroblasts on anti-cancer drug resistance in a microengineered tumor model","volume":"11","author":"Saini","year":"2018","journal-title":"Cell Mol. Bioeng."},{"key":"10.1016\/j.jconrel.2026.114832_bb0290","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.actbio.2022.10.021","article-title":"Nanomechanical properties of solid tumors as treatment monitoring biomarkers","volume":"154","author":"Stylianou","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2026.114832_bb0295","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1158\/0008-5472.CAN-12-4521","article-title":"Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse","volume":"73","author":"Stylianopoulos","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.jconrel.2026.114832_bb0300","doi-asserted-by":"crossref","first-page":"15101","DOI":"10.1073\/pnas.1213353109","article-title":"Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors","volume":"109","author":"Stylianopoulos","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jconrel.2026.114832_bb0305","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jconrel.2014.12.018","article-title":"Improving drug delivery to solid tumors: priming the tumor microenvironment","volume":"201","author":"Khawar","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114832_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101458","article-title":"Hyperbaric oxygen regulates tumor mechanics and augments Abraxane and gemcitabine antitumor effects against pancreatic ductal adenocarcinoma by inhibiting cancer-associated fibroblasts","volume":"44","author":"Wang","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2026.114832_bb0315","doi-asserted-by":"crossref","first-page":"8668","DOI":"10.1021\/acsnano.7b01026","article-title":"Designing liposomes to suppress extracellular matrix expression to enhance drug penetration and pancreatic tumor therapy","volume":"11","author":"Ji","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.114832_bb0320","doi-asserted-by":"crossref","first-page":"24654","DOI":"10.1021\/acsnano.3c03305","article-title":"Pirfenidone-loaded polymeric micelles as an effective mechanotherapeutic to potentiate immunotherapy in mouse tumor models","volume":"17","author":"Mpekris","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.114832_bb0325","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1016\/j.csbj.2023.04.024","article-title":"Sequential targeting biomimetic nano platform for enhanced mild photothermal therapy and chemotherapy of tumor","volume":"21","author":"Wang","year":"2023","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.jconrel.2026.114832_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.135712","article-title":"Tri-component programmable nanoregulator with three-pronged penetration boosts immunotherapy of triple-negative breast cancer","volume":"439","author":"Li","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jconrel.2026.114832_bb0335","doi-asserted-by":"crossref","first-page":"8193","DOI":"10.1039\/D2TB01812H","article-title":"Precise fibrin decomposition and tumor mechanics modulation with hydroxyethyl starch-based smart nanomedicine for enhanced antitumor efficacy","volume":"10","author":"Chen","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jconrel.2026.114832_bb0340","doi-asserted-by":"crossref","first-page":"7323","DOI":"10.1007\/s12274-023-5394-7","article-title":"Targeting cancer-associated fibroblasts with hydroxyethyl starch nanomedicine boosts cancer therapy","volume":"16","author":"Wang","year":"2023","journal-title":"Nano Res."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926002348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926002348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:59:11Z","timestamp":1781715551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926002348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":68,"alternative-id":["S0168365926002348"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114832","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A unified biochemical\u2013physical regulatory nanoparticle modulates tumor mechanics to augment nanomedicine penetration and antitumor efficacy","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114832","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114832"}}