{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:54:55Z","timestamp":1790830495845,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019065","name":"Tianjin Municipal Science and Technology Program","doi-asserted-by":"publisher","award":["24ZXZSSS00270"],"award-info":[{"award-number":["24ZXZSSS00270"]}],"id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32171386"],"award-info":[{"award-number":["32171386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32201157"],"award-info":[{"award-number":["32201157"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20488"],"award-info":[{"award-number":["U23A20488"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jconrel.2026.114868","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:55:46Z","timestamp":1774486546000},"page":"114868","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Long-acting triamcinolone acetonide prodrug microcrystals for sustained intra-articular treatment of osteoarthritis"],"prefix":"10.1016","volume":"394","author":[{"given":"Xiaoyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanliang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyue","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shutao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.114868_bb0005","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41572-025-00594-6","article-title":"Osteoarthritis","volume":"11","author":"Tang","year":"2025","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.jconrel.2026.114868_bb0010","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0140-6736(05)71086-2","article-title":"Pathogenesis and management of pain in osteoarthritis","volume":"365","author":"Dieppe","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2026.114868_bb0015","doi-asserted-by":"crossref","first-page":"e195","DOI":"10.1016\/S2665-9913(24)00006-7","article-title":"When should we treat knee osteoarthritis and with which treatments?","volume":"6","author":"Haber","year":"2024","journal-title":"Lancet Rheumatol."},{"key":"10.1016\/j.jconrel.2026.114868_bb0020","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.joca.2025.08.015","article-title":"Osteoarthritis year in review 2025: epidemiology and therapy","volume":"33","author":"Dell\u2019Isola","year":"2025","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.jconrel.2026.114868_bb0025","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrrheum.2013.159","article-title":"Progress in intra-articular therapy","volume":"10","author":"Evans","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jconrel.2026.114868_bb0030","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41584-018-0123-4","article-title":"Intra-articular treatment options for knee osteoarthritis","volume":"15","author":"Jones","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jconrel.2026.114868_bb0035","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12891-022-05048-8","article-title":"The comparison of dexamethasone and triamcinolone periarticular administration in total knee arthroplasty: retrospective cohort study","volume":"23","author":"Oshima","year":"2022","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.jconrel.2026.114868_bb0040","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1093\/rheumatology\/key265","article-title":"Triamcinolone acetonide extended-release in patients with osteoarthritis and type 2 diabetes: a randomized, phase 2 study","volume":"57","author":"Russell","year":"2018","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jconrel.2026.114868_bb0045","doi-asserted-by":"crossref","DOI":"10.1002\/jeo2.12060","article-title":"Intra-articular corticosteroids for the treatment of osteoarthritis: a systematic review and meta-analysis on the comparison of different molecules and doses","volume":"11","author":"Bensa","year":"2024","journal-title":"J. Exp. Orthop."},{"key":"10.1016\/j.jconrel.2026.114868_bb0050","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s40265-019-01083-3","article-title":"Triamcinolone acetonide extended-release: a review in osteoarthritis pain of the knee","volume":"79","author":"Paik","year":"2019","journal-title":"Drugs"},{"key":"10.1016\/j.jconrel.2026.114868_bb0055","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2106\/JBJS.N.00918","article-title":"An intra-articular, extended-release formulation of triamcinolone acetonide prolongs and amplifies analgesic effect in patients with osteoarthritis of the knee: a randomized clinical trial","volume":"97","author":"Bodick","year":"2015","journal-title":"J. Bone Joint Surg."},{"key":"10.1016\/j.jconrel.2026.114868_bb0060","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/art.40364","article-title":"Brief report: a phase IIb trial of a novel extended-release microsphere formulation of triamcinolone acetonide for intraarticular injection in knee osteoarthritis","volume":"70","author":"Conaghan","year":"2018","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jconrel.2026.114868_bb0065","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.1167\/iovs.16-21334","article-title":"Evaluation of the toxicity of intravitreally injected PLGA microspheres and rods in monkeys and rabbits: effects of depot size on inflammatory response","volume":"58","author":"Thackaberry","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jconrel.2026.114868_bb0070","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.jconrel.2022.06.015","article-title":"Assessment of joint pharmacokinetics and consequences for the intraarticular delivery of biologics","volume":"348","author":"Siefen","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114868_bb0075","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jconrel.2023.04.039","article-title":"Emerging nanoparticle platforms to improve the administration of glucocorticoids","volume":"358","author":"Tessier","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114868_bb0080","doi-asserted-by":"crossref","first-page":"eadh9751","DOI":"10.1126\/scitranslmed.adh9751","article-title":"Chondrocyte membrane-coated nanoparticles promote drug retention and halt cartilage damage in rat and canine osteoarthritis","volume":"16","author":"Deng","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2026.114868_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114860","article-title":"Prodrug approaches for the development of a long-acting drug delivery systems","volume":"198","author":"Chien","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.114868_bb0090","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.xphs.2020.01.003","article-title":"Diclofenac Prodrugs for Intra-articular Depot Injectables: In Vitro Hydrolysis and Species Variation","volume":"109","author":"Storgaard","year":"2020","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2026.114868_bb0095","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jddst.2018.11.012","article-title":"Simulated synovial fluids for in vitro drug and prodrug release testing of depot injectables intended for joint injection","volume":"49","author":"Thing","year":"2019","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.jconrel.2026.114868_bb0100","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1021\/acs.molpharmaceut.4c00665","article-title":"Patient-centric long-acting injectable and implantable platformsan industrial perspective","volume":"21","author":"Alidori","year":"2024","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2026.114868_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/cells14201605","article-title":"Joint acidosis and acid-sensing receptors and ion channels in osteoarthritis pathobiology and therapy","volume":"14","author":"Martin","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2026.114868_bb0110","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.3390\/ijms23084466","article-title":"AcidoCEST-UTE MRI reveals an acidic microenvironment in knee osteoarthritis","volume":"23","author":"Lombardi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2026.114868_bb0115","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jconrel.2024.11.046","article-title":"Subconjunctival injection of microcrystalline prodrug of dexamethasone for long-acting anti-inflammation after phacoemulsification surgery","volume":"377","author":"Zhou","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114868_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2024.102552","article-title":"Advances in acid-degradable and enzyme-cleavable linkers for drug delivery","volume":"84","author":"Zhao","year":"2025","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.jconrel.2026.114868_bb0125","doi-asserted-by":"crossref","first-page":"5532","DOI":"10.1038\/s41467-021-25856-1","article-title":"Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols","volume":"12","author":"Yu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.114868_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.supflu.2023.106119","article-title":"Solubility measurement of triamcinolone acetonide (steroid medication) in supercritical CO2: experimental and thermodynamic modeling","volume":"204","author":"Sodeifian","year":"2024","journal-title":"J. Supercrit. Fluids"},{"key":"10.1016\/j.jconrel.2026.114868_bb0135","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1021\/acs.molpharmaceut.2c00348","article-title":"Microcrystals of ketal-linked paliperidone prodrugs for long-acting antipsychotics","volume":"19","author":"Xu","year":"2022","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2026.114868_bb0140","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jpba.2014.11.028","article-title":"Simultaneous determination of triamcinolone acetonide palmitate and triamcinolone acetonide in beagle dog plasma by UPLC-MS\/MS and its application to a long-term pharmacokinetic study of triamcinolone acetonide palmitate lipid emulsion injection","volume":"104","author":"Liu","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jconrel.2026.114868_bb0145","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1021\/bc050176w","article-title":"Polyketal nanoparticles: a new pH-sensitive biodegradable drug delivery vehicle","volume":"16","author":"Heffernan","year":"2005","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2026.114868_bb0150","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1248\/cpb.40.2169","article-title":"Esterase-like activity of human serum albumin. VIII. Reaction with amino acid p-nitrophenyl esters","volume":"40","author":"Kurono","year":"1992","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.jconrel.2026.114868_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e07906","article-title":"Dynamic weight-bearing test during jumping: a sensitive outcome measure of chronic osteoarthritis pain in rats","volume":"7","author":"Westhof","year":"2021","journal-title":"Heliyon"},{"key":"10.1016\/j.jconrel.2026.114868_bb0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2016.06.049","article-title":"Intraarticular slow-release triamcinolone acetate reduces allodynia in an experimental mouse knee osteoarthritis model","volume":"591","author":"Kroin","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.jconrel.2026.114868_bb0165","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.3390\/ijms22041742","article-title":"Overview of MMP-13 as a promising target for the treatment of osteoarthritis","volume":"22","author":"Hu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2026.114868_bb0170","first-page":"99","article-title":"Cyasterone inhibits IL-1\u03b2-mediated apoptosis and inflammation via the NF-\u03baB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo","volume":"21","author":"Teng","year":"2023","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.jconrel.2026.114868_bb0175","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s13075-020-02274-0","article-title":"Association between knee alignment, osteoarthritis disease severity, and subchondral trabecular bone microarchitecture in patients with knee osteoarthritis: a cross-sectional study","volume":"22","author":"Han","year":"2020","journal-title":"Arthritis Res. Ther."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926002701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926002701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:49:17Z","timestamp":1779756557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926002701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":35,"alternative-id":["S0168365926002701"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114868","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-acting triamcinolone acetonide prodrug microcrystals for sustained intra-articular treatment of osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114868","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114868"}}