{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:24:49Z","timestamp":1789503889107,"version":"build-2803163510"},"reference-count":132,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk A\/S","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2141064"],"award-info":[{"award-number":["2141064"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jconrel.2026.114914","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:08:21Z","timestamp":1775840901000},"page":"114914","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Cryopreservation of stem cell-derived aggregates for type 1 diabetes cell therapy: Considerations and challenges"],"prefix":"10.1016","volume":"395","author":[{"given":"Anita Dey","family":"Barsukova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindong","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Szymanska-Vandendriessche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Langer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Traverso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.114914_bb0005","series-title":"IDF Diabetes Atlas Reports: Type 1 Diabetes Estimates in Children and Adults","author":"Ogle","year":"2022"},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0010","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.ecl.2010.05.009","article-title":"Complications of type 1 diabetes","volume":"39","author":"Melendez-Ramirez","year":"2010","journal-title":"Endocrinol. Metab. Clin."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114914_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nrdp.2017.16","article-title":"Type 1 diabetes mellitus","volume":"3","author":"Katsarou","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.jconrel.2026.114914_bb0020","series-title":"The Islets of Langerhans","first-page":"1","article-title":"Microscopic Anatomy of the Human Islet of Langerhans","author":"In\u2019t Veld","year":"2010"},{"issue":"5","key":"10.1016\/j.jconrel.2026.114914_bb0025","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.2337\/db09-1177","article-title":"Unique arrangement of \u03b1- and \u03b2-cells in human islets of langerhans","volume":"59","author":"Bosco","year":"2010","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.jconrel.2026.114914_bb0030","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1073\/pnas.0510790103","article-title":"The unique cytoarchitecture of human pancreatic islets has implications for islet cell function","volume":"103","author":"Cabrera","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114914_bb0035","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/scientificamerican0192-86","article-title":"How cells absorb glucose","volume":"266","author":"Lienhard","year":"1992","journal-title":"Sci. Am."},{"issue":"5","key":"10.1016\/j.jconrel.2026.114914_bb0040","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s00125-021-05398-3","article-title":"Current and future therapies for type 1 diabetes","volume":"64","author":"von Scholten","year":"2021","journal-title":"Diabetologia"},{"issue":"Supplement_1","key":"10.1016\/j.jconrel.2026.114914_bb0045","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.2337\/dc20-S009","article-title":"9. Pharmacologic approaches to glycemic treatment: standards of medical care in diabetes\u20142020","volume":"43","author":"American Diabetes Association","year":"2019","journal-title":"Diabetes Care"},{"issue":"5","key":"10.1016\/j.jconrel.2026.114914_bb0050","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nrendo.2016.178","article-title":"Clinical pancreatic islet transplantation","volume":"13","author":"Shapiro","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"issue":"4","key":"10.1016\/j.jconrel.2026.114914_bb0055","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nri1332","article-title":"Clinical islet transplantation: advances and immunological challenges","volume":"4","author":"Ricordi","year":"2004","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.jconrel.2026.114914_bb0060","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","article-title":"Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen","volume":"343","author":"Shapiro","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2026.114914_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.631463","article-title":"Stem cell-based clinical trials for diabetes mellitus","volume":"12","author":"de Klerk","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"6","key":"10.1016\/j.jconrel.2026.114914_bb0070","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.stem.2018.05.016","article-title":"Stem cell therapies for treating diabetes: Progress and remaining challenges","volume":"22","author":"Sneddon","year":"2018","journal-title":"Cell Stem Cell"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114914_bb0075","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cell.2014.09.040","article-title":"Generation of functional human pancreatic \u03b2 cells in vitro","volume":"159","author":"Pagliuca","year":"2014","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.jconrel.2026.114914_bb0080","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/sctm.21-0161","article-title":"Process parameter development for the scaled generation of stem cell-derived pancreatic endocrine cells","volume":"10","author":"Iworima","year":"2021","journal-title":"Stem Cells Transl. Med."},{"issue":"12","key":"10.1016\/j.jconrel.2026.114914_bb0085","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/s41573-021-00262-w","article-title":"Engineering islets from stem cells for advanced therapies of diabetes","volume":"20","author":"Siehler","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2026.114914_bb0090","doi-asserted-by":"crossref","DOI":"10.1177\/09636897261417623","article-title":"Advances in stem cell-derived Beta-cell therapy: a new frontier in type 1 diabetes treatment","volume":"35","author":"Upadhye","year":"2026","journal-title":"Cell Transplant."},{"issue":"5","key":"10.1016\/j.jconrel.2026.114914_bb0095","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s00125-009-1653-8","article-title":"Rat islet cell aggregates are superior to islets for transplantation in microcapsules","volume":"53","author":"O\u2019Sullivan","year":"2010","journal-title":"Diabetologia"},{"issue":"5","key":"10.1016\/j.jconrel.2026.114914_bb0100","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.stem.2023.04.002","article-title":"Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes","volume":"30","author":"Hogrebe","year":"2023","journal-title":"Cell Stem Cell"},{"issue":"12","key":"10.1016\/j.jconrel.2026.114914_bb0105","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/bjs.6391","article-title":"Optimal implantation site for pancreatic islet transplantation","volume":"95","author":"Merani","year":"2008","journal-title":"Br. J. Surg."},{"issue":"11","key":"10.1016\/j.jconrel.2026.114914_bb0110","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1111\/j.1600-6143.2009.02815.x","article-title":"Endoscopic gastric submucosal transplantation of islets (ENDO-STI): technique and initial results in diabetic pigs","volume":"9","author":"Echeverri","year":"2009","journal-title":"Am. J. Transplant."},{"issue":"2","key":"10.1016\/j.jconrel.2026.114914_bb0115","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1177\/1932296819868495","article-title":"Considerations for an alternative site of islet cell transplantation","volume":"14","author":"Addison","year":"2020","journal-title":"J. Diabetes Sci. Technol."},{"issue":"12","key":"10.1016\/j.jconrel.2026.114914_bb0120","article-title":"Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device","volume":"2","author":"Shapiro","year":"2021","journal-title":"Cell Rep. Med."},{"issue":"10","key":"10.1016\/j.jconrel.2026.114914_bb0125","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/s41587-023-02055-5","article-title":"Encapsulated stem cell\u2013derived \u03b2 cells exert glucose control in patients with type 1 diabetes","volume":"42","author":"Keymeulen","year":"2024","journal-title":"Nat. Biotechnol."},{"issue":"9","key":"10.1016\/j.jconrel.2026.114914_bb0135","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1056\/NEJMoa2506549","article-title":"Stem cell\u2013derived, fully differentiated islets for type 1 diabetes","volume":"393","author":"Reichman","year":"2025","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0155","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.stem.2024.02.001","article-title":"Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate","volume":"31","author":"Hu","year":"2024","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.jconrel.2026.114914_bb0160","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s44222-023-00045-5","article-title":"Re-considering quantity requirements in islet transplantation","volume":"1","author":"Owyang","year":"2023","journal-title":"Nat. Rev. Bioeng."},{"issue":"9","key":"10.1016\/j.jconrel.2026.114914_bb0165","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1038\/s41596-021-00560-y","article-title":"Generation of insulin-producing pancreatic \u03b2 cells from multiple human stem cell lines","volume":"16","author":"Hogrebe","year":"2021","journal-title":"Nat. Protoc."},{"issue":"5","key":"10.1016\/j.jconrel.2026.114914_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037004","article-title":"A scalable system for production of functional pancreatic progenitors from human embryonic stem cells","volume":"7","author":"Schulz","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jconrel.2026.114914_bb0175","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10616-006-9005-8","article-title":"Reactor engineering in large scale animal cell culture","volume":"50","author":"Nienow","year":"2006","journal-title":"Cytotechnology"},{"issue":"10","key":"10.1016\/j.jconrel.2026.114914_bb0180","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1016\/j.xphs.2023.08.001","article-title":"Cell therapy drug product development: technical considerations and challenges","volume":"112","author":"Weng","year":"2023","journal-title":"J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0185","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1159\/000497289","article-title":"Technical considerations in the freezing, low-temperature storage and thawing of stem cells for cellular therapies","volume":"46","author":"Hunt","year":"2019","journal-title":"Transfus. Med. Hemother."},{"issue":"4","key":"10.1016\/j.jconrel.2026.114914_bb0190","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10047-014-0777-x","article-title":"Optimal method for short-term or long-term islet preservation: comparison of islet culture, cold preservation and cryopreservation","volume":"17","author":"Liu","year":"2014","journal-title":"J. Artif. Organs"},{"issue":"4","key":"10.1016\/j.jconrel.2026.114914_bb0195","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/s41591-022-01718-1","article-title":"Pancreatic islet cryopreservation by vitrification achieves high viability, function, recovery and clinical scalability for transplantation","volume":"28","author":"Zhan","year":"2022","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114914_bb0200","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1080\/19382014.2017.1405202","article-title":"Systematic review of islet cryopreservation","volume":"10","author":"Kojayan","year":"2018","journal-title":"Islets"},{"issue":"4","key":"10.1016\/j.jconrel.2026.114914_bb0205","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41551-022-00987-y","article-title":"Challenges in the clinical advancement of cell therapies for parkinsons disease","volume":"7","author":"Skidmore","year":"2023","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2026.114914_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2020.592242","article-title":"Cryopreservation as a key element in the successful delivery of cell-based therapies\u2014a review","volume":"7","author":"Meneghel","year":"2020","journal-title":"Front. Med."},{"key":"10.1016\/j.jconrel.2026.114914_bb0220","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.cryobiol.2017.04.004","article-title":"Cryoprotectants: a review of the actions and applications of cryoprotective solutes that modulate cell recovery from ultra-low temperatures","volume":"76","author":"Elliott","year":"2017","journal-title":"Cryobiology"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114914_bb0230","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000326083","article-title":"Packaging considerations for biopreservation","volume":"38","author":"Woods","year":"2011","journal-title":"Transfus. Med. Hemother."},{"key":"10.1016\/j.jconrel.2026.114914_bb0235","series-title":"Practical Pharmaceutics: An International Guideline for the Preparation, Care and Use of Medicinal Products","first-page":"749","article-title":"Aseptic Handling","author":"Boom","year":"2023"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114914_bb0240","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10561-005-1966-x","article-title":"Survival of Micro-organisms in cryostorage of human sperm","volume":"7","author":"Mazzilli","year":"2006","journal-title":"Cell Tissue Bank."},{"key":"10.1016\/j.jconrel.2026.114914_bb0245","series-title":"Cell Engineering and Regeneration","first-page":"1","article-title":"Preservation and Storage of Cells for Therapy: Current Applications and Protocols","author":"Acker","year":"2022"},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0250","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1159\/000497289","article-title":"Technical considerations in the freezing, low-temperature storage and thawing of stem cells for cellular therapies","volume":"46","author":"Hunt","year":"2019","journal-title":"Transfus. Med. Hemother."},{"key":"10.1016\/j.jconrel.2026.114914_bb0255","series-title":"Cryopreservation and Freeze-Drying Protocols","first-page":"3","article-title":"Principles of Cryopreservation","author":"Pegg","year":"2015"},{"key":"10.1016\/j.jconrel.2026.114914_bb0260","series-title":"Cryopreservation and Freeze-Drying Protocols","first-page":"3","article-title":"Principles Underlying Cryopreservation and Freeze-Drying of Cells and Tissues","author":"Wolkers","year":"2021"},{"key":"10.1016\/j.jconrel.2026.114914_bb0265","doi-asserted-by":"crossref","DOI":"10.1177\/0963689721999617","article-title":"Cryopreservation: an overview of principles and cell-specific considerations","volume":"30","author":"Whaley","year":"2021","journal-title":"Cell Transplant."},{"key":"10.1016\/j.jconrel.2026.114914_bb0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-bioeng-060418-052130","article-title":"Exploring dynamics and structure of biomolecules, cryoprotectants, and water using molecular dynamics simulations: implications for biostabilization and biopreservation","volume":"21","author":"Weng","year":"2019","journal-title":"Annu. Rev. Biomed. Eng."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0275","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/0011-2240(83)90018-4","article-title":"Ice nucleation and freezing in undercooled cells","volume":"20","author":"Franks","year":"1983","journal-title":"Cryobiology"},{"issue":"5","key":"10.1016\/j.jconrel.2026.114914_bb0280","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/j.1537-2995.2007.01212.x","article-title":"Cryopreservation of living cells: principles and practice","volume":"47","author":"Meryman","year":"2007","journal-title":"Transfusion (Paris)"},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0285","doi-asserted-by":"crossref","first-page":"C125","DOI":"10.1152\/ajpcell.1984.247.3.C125","article-title":"Freezing of living cells: mechanisms and implications","volume":"247","author":"Mazur","year":"1984","journal-title":"Am. J. Physiol.-Cell Physiol."},{"issue":"3934","key":"10.1016\/j.jconrel.2026.114914_bb0290","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1126\/science.168.3934.939","article-title":"Cryobiology: the freezing of biological systems","volume":"168","author":"Mazur","year":"1970","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114914_bb0295","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0014-4827(72)90303-5","article-title":"A two-factor hypothesis of freezing injury","volume":"71","author":"Mazur","year":"1972","journal-title":"Exp. Cell Res."},{"issue":"4","key":"10.1016\/j.jconrel.2026.114914_bb0300","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0011-2240(87)90033-2","article-title":"Vitrification of mouse islets of langerhans: comparison with a more conventional freezing method","volume":"24","author":"Jutte","year":"1987","journal-title":"Cryobiology"},{"issue":"5","key":"10.1016\/j.jconrel.2026.114914_bb0305","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0011-2240(87)90043-5","article-title":"Vitrification of human islets of langerhans","volume":"24","author":"Jutte","year":"1987","journal-title":"Cryobiology"},{"issue":"6003","key":"10.1016\/j.jconrel.2026.114914_bb0310","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/313573a0","article-title":"Ice-free cryopreservation of mouse embryos at \u2212196\u00b0c by vitrification","volume":"313","author":"Rall","year":"1985","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0315","first-page":"3","article-title":"How cryoprotectants work","volume":"28","author":"Wowk","year":"2007","journal-title":"Cryonics"},{"issue":"4","key":"10.1016\/j.jconrel.2026.114914_bb0320","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0011-2240(84)90079-8","article-title":"Vitrification as an approach to cryopreservation","volume":"21","author":"Fahy","year":"1984","journal-title":"Cryobiology"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114914_bb0325","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000326623","article-title":"Cryopreservation of human stem cells for clinical application: a review","volume":"38","author":"Hunt","year":"2011","journal-title":"Transfus. Med. Hemother."},{"issue":"4","key":"10.1016\/j.jconrel.2026.114914_bb0330","first-page":"185","article-title":"Critical cooling and warming rates as a function of cpa concentration","volume":"41","author":"Han","year":"2020","journal-title":"Cryo-Letters"},{"issue":"4","key":"10.1016\/j.jconrel.2026.114914_bb0335","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1006\/cryo.1998.2135","article-title":"Membrane permeability modeling: Kedem\u2013Katchalsky vs a two-parameter formalism","volume":"37","author":"Kleinhans","year":"1998","journal-title":"Cryobiology"},{"key":"10.1016\/j.jconrel.2026.114914_bb0340","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0006-3002(58)90330-5","article-title":"Thermodynamic analysis of the permeability of biological membranes to non-electrolytes","volume":"27","author":"Kedem","year":"1958","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114914_bb0345","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1177\/096368979700600210","article-title":"Comparison of methods used for the removal of dmso following cryopreservation and the development of an automated protocol","volume":"6","author":"Lakey","year":"1997","journal-title":"Cell Transplant."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114914_bb0350","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1749-6632.1999.tb08504.x","article-title":"Islet cryopreservation protocols","volume":"875","author":"Rajotte","year":"1999","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"5","key":"10.1016\/j.jconrel.2026.114914_bb0355","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1089\/bio.2017.0044","article-title":"Nylon mesh device for vitrification of large quantities of rat pancreatic islets","volume":"15","author":"Yamanaka","year":"2017","journal-title":"Biopreservation Biobanking"},{"issue":"10","key":"10.1016\/j.jconrel.2026.114914_bb0360","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1063\/1.1699435","article-title":"Formation of crystal nuclei in liquid metals","volume":"21","author":"Turnbull","year":"1950","journal-title":"J. Appl. Phys."},{"issue":"8","key":"10.1016\/j.jconrel.2026.114914_bb0365","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41570-022-00407-4","article-title":"Chemical approaches to cryopreservation","volume":"6","author":"Murray","year":"2022","journal-title":"Nat. Rev. Chem."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0370","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4161\/org.5.3.9583","article-title":"The cryopreservation of composite tissues","volume":"5","author":"Bakhach","year":"2009","journal-title":"Organogenesis"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114914_bb0375","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1085\/jgp.47.2.347","article-title":"Kinetics of water loss from cells at subzero temperatures and the likelihood of intracellular freezing","volume":"47","author":"Mazur","year":"1963","journal-title":"J. Gen. Physiol."},{"issue":"49","key":"10.1016\/j.jconrel.2026.114914_bb0380","doi-asserted-by":"crossref","first-page":"14721","DOI":"10.1021\/jp2054348","article-title":"Kinetics of coupling water and cryoprotectant transport across cell membranes and applications to cryopreservation","volume":"115","author":"Weng","year":"2011","journal-title":"J. Phys. Chem. B"},{"issue":"9","key":"10.1016\/j.jconrel.2026.114914_bb0385","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1063\/1.355959","article-title":"A model of diffusion-limited ice growth inside biological cells during freezing","volume":"75","author":"Karlsson","year":"1994","journal-title":"J. Appl. Phys."},{"issue":"5","key":"10.1016\/j.jconrel.2026.114914_bb0390","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0011-2240(81)90206-6","article-title":"Simplified calculation of cell water content during freezing and thawing in nonideal solutions of cryoprotective agents and its possible application to the study of \u2018solution effects\u2019 injury","volume":"18","author":"Fahy","year":"1981","journal-title":"Cryobiology"},{"issue":"14","key":"10.1016\/j.jconrel.2026.114914_bb0395","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.1021\/jp807274z","article-title":"Comparison between ideal and nonideal solution models for single-cell cryopreservation protocols","volume":"113","author":"Saenz","year":"2009","journal-title":"J. Phys. Chem. B"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114914_bb0400","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.cryobiol.2010.07.004","article-title":"Kinetics of osmotic water flow across cell membranes in non-ideal solutions during freezing and thawing","volume":"61","author":"Weng","year":"2010","journal-title":"Cryobiology"},{"issue":"7","key":"10.1016\/j.jconrel.2026.114914_bb0405","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1021\/jp0680342","article-title":"A multisolute osmotic virial equation for solutions of interest in biology","volume":"111","author":"Elliott","year":"2007","journal-title":"J. Phys. Chem. B"},{"issue":"4","key":"10.1016\/j.jconrel.2026.114914_bb0410","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.2042-7158.1969.tb08235.x","article-title":"Cryoprotectants\u2014a new class of drugs","volume":"21","author":"Karow","year":"1969","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114914_bb0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2020.129749","article-title":"The need for novel cryoprotectants and cryopreservation protocols: insights into the importance of biophysical investigation and cell permeability","volume":"1865","author":"Raju","year":"2021","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.jconrel.2026.114914_bb0420","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cryobiol.2020.08.012","article-title":"Review of non-permeating cryoprotectants as supplements for vitrification of mammalian tissues","volume":"96","author":"Yong","year":"2020","journal-title":"Cryobiology"},{"issue":"4","key":"10.1016\/j.jconrel.2026.114914_bb0425","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1089\/bio.2020.0130","article-title":"Technologies and applications toward preservation of cells in a dry state for therapies","volume":"19","author":"Weng","year":"2021","journal-title":"Biopreservation Biobanking"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114914_bb0430","doi-asserted-by":"crossref","DOI":"10.1063\/1.5144617","article-title":"Ultrasound-induced molecular delivery to erythrocytes using a microfluidic system","volume":"14","author":"Centner","year":"2020","journal-title":"Biomicrofluidics"},{"issue":"28","key":"10.1016\/j.jconrel.2026.114914_bb0435","doi-asserted-by":"crossref","first-page":"11585","DOI":"10.1073\/pnas.0702538104","article-title":"Trehalose transporter 1, a facilitated and high-capacity trehalose transporter, allows exogenous trehalose uptake into cells","volume":"104","author":"Kikawada","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jconrel.2026.114914_bb0440","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cryobiol.2019.10.002","article-title":"Me2SO- and serum-free cryopreservation of human umbilical cord mesenchymal stem cells using electroporation-assisted delivery of sugars","volume":"91","author":"Mutsenko","year":"2019","journal-title":"Cryobiology"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114914_bb0445","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/72608","article-title":"Intracellular trehalose improves the survival of cryopreserved mammalian cells","volume":"18","author":"Eroglu","year":"2000","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114914_bb0450","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00232-016-9916-z","article-title":"Cryopreservation of human adipose-derived stem cells in combination with trehalose and reversible electroporation","volume":"250","author":"Dovgan","year":"2017","journal-title":"J. Membr. Biol."},{"issue":"2","key":"10.1016\/j.jconrel.2026.114914_bb0455","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cryobiol.2009.06.003","article-title":"An experimental study of the use of ultrasound to facilitate the loading of trehalose into platelets","volume":"59","author":"Zhang","year":"2009","journal-title":"Cryobiology"},{"issue":"39","key":"10.1016\/j.jconrel.2026.114914_bb0460","doi-asserted-by":"crossref","first-page":"11911","DOI":"10.1021\/jp3035538","article-title":"Molecular dynamics simulations of the interactions of DMSO with DPPC and DOPC phospholipid membranes","volume":"116","author":"Hughes","year":"2012","journal-title":"J. Phys. Chem. B"},{"issue":"35","key":"10.1016\/j.jconrel.2026.114914_bb0465","doi-asserted-by":"crossref","first-page":"10453","DOI":"10.1021\/jp073113e","article-title":"Modulating the structure and properties of cell membranes: the molecular mechanism of action of dimethyl sulfoxide","volume":"111","author":"Gurtovenko","year":"2007","journal-title":"J. Phys. Chem. B"},{"issue":"43","key":"10.1016\/j.jconrel.2026.114914_bb0470","doi-asserted-by":"crossref","first-page":"13982","DOI":"10.1021\/ja063363t","article-title":"Molecular basis for dimethylsulfoxide (DMSO) action on lipid membranes","volume":"128","author":"Notman","year":"2006","journal-title":"J. Am. Chem. Soc."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0475","article-title":"Advances in the regulated pharmaceutical use of Dimethyl Sulfoxide USP","volume":"2016 Supplement","author":"Strub","year":"2016","journal-title":"Ph.Eur. Pharm. Technol."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0480","doi-asserted-by":"crossref","first-page":"123","DOI":"10.54680\/fr23310110112","article-title":"Perspective: the role of cryopreservation techniques in manufacturing, transport, and storage of Car-T therapy products","volume":"44","author":"Jandov\u00e1","year":"2023","journal-title":"Cryoletters"},{"issue":"7","key":"10.1016\/j.jconrel.2026.114914_bb0485","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/sj.bmt.1705100","article-title":"Variation in dimethyl sulfoxide use in stem cell transplantation: a survey of EBMT centres","volume":"36","author":"Windrum","year":"2005","journal-title":"Bone Marrow Transplant."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0490","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.2217\/rme-2019-0145","article-title":"Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity?","volume":"15","author":"Awan","year":"2020","journal-title":"Regen. Med."},{"key":"10.1016\/j.jconrel.2026.114914_bb0495","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.12688\/f1000research.16642.2","article-title":"Adverse reactions of dimethyl sulfoxide in humans: a systematic review","volume":"7","author":"Kollerup Madsen","year":"2019","journal-title":"F1000Research"},{"issue":"1","key":"10.1016\/j.jconrel.2026.114914_bb0500","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1038\/s41598-019-40660-0","article-title":"DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro","volume":"9","author":"Verheijen","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0505","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1096\/fj.13-235440","article-title":"Unexpected low-dose toxicity of the universal solvent DMSO","volume":"28","author":"Galvao","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.jconrel.2026.114914_bb0510","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cryobiol.2017.04.010","article-title":"Long-term cryopreservation of reaggregated pancreatic islets resulting in successful transplantation in rats","volume":"76","author":"Rawal","year":"2017","journal-title":"Cryobiology"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114914_bb0515","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/00006676-199608000-00008","article-title":"Improved insulin secretion of cryopreserved human islets by antioxidant treatment","volume":"13","author":"Janjic","year":"1996","journal-title":"Pancreas"},{"issue":"5","key":"10.1016\/j.jconrel.2026.114914_bb0520","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4161\/isl.26304","article-title":"Human islet mass, morphology, and survival after cryopreservation using the Edmonton protocol","volume":"5","author":"Miranda","year":"2013","journal-title":"Islets"},{"issue":"7","key":"10.1016\/j.jconrel.2026.114914_bb0525","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1177\/0963689718779898","article-title":"The flaws and future of islet volume measurements","volume":"27","author":"Huang","year":"2018","journal-title":"Cell Transplant."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0530","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00592-003-0100-4","article-title":"Size of pancreatic islets ofLangerhans: a key parameter for viability aftercryopreservation","volume":"40","author":"von Mach","year":"2003","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.jconrel.2026.114914_bb0535","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.mbs.2014.06.003","article-title":"Mathematical model formulation and validation of water and solute transport in whole hamster pancreatic islets","volume":"254","author":"Benson","year":"2014","journal-title":"Math. Biosci."},{"issue":"8","key":"10.1016\/j.jconrel.2026.114914_bb0540","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183780","article-title":"Oxygen environment and islet size are the primary limiting factors of isolated pancreatic islet survival","volume":"12","author":"Komatsu","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2026.114914_bb0545","doi-asserted-by":"crossref","first-page":"10418","DOI":"10.1038\/s41598-021-89853-6","article-title":"Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets","volume":"11","author":"Dolezalova","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2026.114914_bb0550","doi-asserted-by":"crossref","DOI":"10.1038\/s41536-025-00409-y","article-title":"Scale up manufacturing approach for production of human induced pluripotent stem cell-derived islets using vertical wheel\u00ae bioreactors","volume":"10","author":"Dadheech","year":"2025","journal-title":"npj Regener. Med."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114914_bb0555","doi-asserted-by":"crossref","first-page":"5221","DOI":"10.1038\/s41598-022-09124-w","article-title":"Microwell bag culture for large-scale production of homogeneous islet-like clusters","volume":"12","author":"Suenaga","year":"2022","journal-title":"Sci. Rep."},{"issue":"7756","key":"10.1016\/j.jconrel.2026.114914_bb0560","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/s41586-019-1168-5","article-title":"Charting cellular identity during human in vitro \u03b2-cell differentiation","volume":"569","author":"Veres","year":"2019","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.jconrel.2026.114914_bb0565","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/s41587-022-01219-z","article-title":"Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells","volume":"40","author":"Balboa","year":"2022","journal-title":"Nat. Biotechnol."},{"issue":"6","key":"10.1016\/j.jconrel.2026.114914_bb0570","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s00018-023-04815-7","article-title":"Pancreatic \u03b2-cell heterogeneity in adult human islets and stem cell-derived islets","volume":"80","author":"Aldous","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0575","doi-asserted-by":"crossref","first-page":"709","DOI":"10.2337\/db14-1662","article-title":"Cadherins in islet \u03b2-cells: more than meets the eye","volume":"64","author":"Cirulli","year":"2015","journal-title":"Diabetes"},{"issue":"4\u20135","key":"10.1016\/j.jconrel.2026.114914_bb0580","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3727\/000000001783986576","article-title":"Development of a cryopreservation procedure employing a freezer bag for pancreatic islets using a newly developed cryoprotectant","volume":"10","author":"Miyamoto","year":"2001","journal-title":"Cell Transplant."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0585","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10047-012-0635-7","article-title":"Cryopreservation of rat islets of langerhans by vitrification","volume":"15","author":"Sasamoto","year":"2012","journal-title":"J. Artif. Organs"},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0590","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cryobiol.2016.09.003","article-title":"Direct comparison of cryotop\u00ae vitrification and bicell\u00ae freezing on recovery of functional rat pancreatic islets","volume":"73","author":"Yamanaka","year":"2016","journal-title":"Cryobiology"},{"issue":"1","key":"10.1016\/j.jconrel.2026.114914_bb0595","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s001090050330","article-title":"Viability and recovery of frozen-thawed human islets and in vivo quality control by xenotransplantation","volume":"77","author":"Langer","year":"1999","journal-title":"J. Mol. Med."},{"issue":"6","key":"10.1016\/j.jconrel.2026.114914_bb0600","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/19382014.2020.1849928","article-title":"Transplantation of rat pancreatic islets vitrified-warmed on the nylon mesh device and the silk fibroin sponge disc","volume":"12","author":"Nakayama-Iwatsuki","year":"2020","journal-title":"Islets"},{"issue":"8","key":"10.1016\/j.jconrel.2026.114914_bb0605","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1055\/s-0042-102628","article-title":"An effective new cryopreservation procedure for pancreatic islets using hollow fiber vitrification","volume":"48","author":"Nagaya","year":"2016","journal-title":"Horm. Metab. Res."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114914_bb0610","doi-asserted-by":"crossref","first-page":"8511","DOI":"10.1038\/s41467-025-63483-2","article-title":"Physical vitrification and nanowarming at Liter-scale CPA volumes: toward organ cryopreservation","volume":"16","author":"Gangwar","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.114914_bb0615","doi-asserted-by":"crossref","unstructured":"Wakabayashi, T., Kaneko, M., Nakai, T., Horie, M., Fujimoto, H., Takahashi, M., Tanoue, S., and Ito, A., \u201cNanowarming of vitrified pancreatic islets as a cryopreservation technology for transplantation,\u201d Bioeng. Transl. Med., n\/a(n\/a), p. e10416. doi:https:\/\/doi.org\/10.1002\/btm2.10416.","DOI":"10.1002\/btm2.10416"},{"issue":"8","key":"10.1016\/j.jconrel.2026.114914_bb0620","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1016\/j.ajt.2025.07.146","article-title":"Clinical scale cryopreservation of human deceased donor islet and stem cell-derived beta clusters by vitrification for allotransplantation in type i diabetes","volume":"25","author":"Rao","year":"2025","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.jconrel.2026.114914_bb0625","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cryobiol.2019.04.004","article-title":"Improved cryopreservation yield of pancreatic islets using combination of lower dose permeable cryoprotective agents","volume":"88","author":"Kojayan","year":"2019","journal-title":"Cryobiology"},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0630","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4161\/org.5.3.9812","article-title":"Review of vitreous islet cryopreservation","volume":"5","author":"Taylor","year":"2009","journal-title":"Organogenesis"},{"issue":"1","key":"10.1016\/j.jconrel.2026.114914_bb0635","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0263005","article-title":"Cryopreservation and post-thaw characterization of dissociated human islet cells","volume":"17","author":"Marquez-Curtis","year":"2022","journal-title":"PLoS One"},{"issue":"50","key":"10.1016\/j.jconrel.2026.114914_bb0640","article-title":"Cold-responsive nanocapsules enable the sole-cryoprotectant-trehalose cryopreservation of \u03b2 cell\u2013laden hydrogels for diabetes treatment","volume":"15","author":"Cheng","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2026.114914_bb0645","doi-asserted-by":"crossref","DOI":"10.1177\/2155179019876641","article-title":"Cryopreserved alginate-encapsulated islets can restore euglycemia in a diabetic animal model better than cryopreserved non-encapsulated islets","volume":"11","author":"Kojayan","year":"2019","journal-title":"Cell Med."},{"key":"10.1016\/j.jconrel.2026.114914_bb0650","article-title":"The effect of hydroxyethyl starch as a cryopreservation agent during freezing of mouse pancreatic islets","volume":"38","author":"Shin","year":"2024","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.jconrel.2026.114914_bb0655","author":"Pagliuca"},{"key":"10.1016\/j.jconrel.2026.114914_bb0660","author":"Pagliuca"},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0665","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/btpr.358","article-title":"Enhancement of cell recovery for dissociated human embryonic stem cells after cryopreservation","volume":"26","author":"Xu","year":"2010","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.jconrel.2026.114914_bb0670","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.imlet.2017.09.012","article-title":"Natural killer-92 cells maintain cytotoxic activity after long-term cryopreservation in novel DMSO-free media","volume":"192","author":"Pasley","year":"2017","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jconrel.2026.114914_bb0680","article-title":"Natural zwitterionic betaine enables cells to survive ultrarapid cryopreservation","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2026.114914_bb0685","series-title":"Cell encapsulation and cryostorage in PVA\u2013gelatin cryogels: incorporation of carboxylated \u03b5-poly-L-lysine as cryoprotectant - Vrana - 2012 - Journal of Tissue Engineering and Regenerative Medicine","year":"2026"},{"issue":"3","key":"10.1016\/j.jconrel.2026.114914_bb0690","doi-asserted-by":"crossref","first-page":"594","DOI":"10.2337\/db06-0779","article-title":"Superiority of small islets in human islet transplantation","volume":"56","author":"Lehmann","year":"2007","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.jconrel.2026.114914_bb0695","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001565","article-title":"Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregates","volume":"3","author":"Ungrin","year":"2008","journal-title":"PLoS One"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926003160?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926003160?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:12:56Z","timestamp":1781255576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926003160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":132,"alternative-id":["S0168365926003160"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114914","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cryopreservation of stem cell-derived aggregates for type 1 diabetes cell therapy: Considerations and challenges","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114914","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114914"}}