{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:52:11Z","timestamp":1789015931344,"version":"build-2803163510"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004106","name":"East China Normal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004106","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2024YFA1210100"],"award-info":[{"award-number":["2024YFA1210100"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jconrel.2026.114939","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T15:22:53Z","timestamp":1776525773000},"page":"114939","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Lipidized deferoxamine nanomedicines (DFOsomes) against iron overload"],"prefix":"10.1016","volume":"395","author":[{"given":"Yuhan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Echuan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.114939_bb0005","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41392-024-01969-z","article-title":"Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects","volume":"9","author":"Ru","year":"2024","journal-title":"Sig Transduct Target Ther"},{"key":"10.1016\/j.jconrel.2026.114939_bb0010","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3390\/cells12010090","article-title":"Ferroptosis and iron metabolism after intracerebral hemorrhage","volume":"12","author":"Sun","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2026.114939_bb0015","article-title":"Pharmacological inhibition of ferroptosis as a therapeutic target for neurodegenerative diseases and strokes","volume":"10","author":"Wang","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.114939_bb0020","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1056\/NEJMct1004810","article-title":"Iron-chelating therapy for transfusional iron overload","volume":"364","author":"Brittenham","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2026.114939_bb0025","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1182\/blood-2023-180898","article-title":"Oxidative stress damage of iron overload on bone marrow erythropoiesis, heart and liver in non-transfusion dependent thalassemia","volume":"142","author":"Pan","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.jconrel.2026.114939_bb0030","doi-asserted-by":"crossref","DOI":"10.1136\/svn-2016-000042","article-title":"Brain iron overload following intracranial haemorrhage","volume":"1","author":"Garton","year":"2016","journal-title":"Stroke Vasc Neurol"},{"key":"10.1016\/j.jconrel.2026.114939_bb0035","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/s41380-023-02399-z","article-title":"Iron imbalance in neurodegeneration","volume":"29","author":"Levi","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jconrel.2026.114939_bb0040","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/s41582-018-0020-0","article-title":"Haemoglobin scavenging in intracranial bleeding: biology and clinical implications","volume":"14","author":"Bulters","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jconrel.2026.114939_bb0045","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.brainresbull.2021.11.014","article-title":"Iron toxicity in intracerebral hemorrhage: Physiopathological and therapeutic implications","volume":"178","author":"Wei","year":"2022","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.jconrel.2026.114939_bb0050","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.expneurol.2019.05.003","article-title":"Deferoxamine therapy reduces brain hemin accumulation after intracerebral hemorrhage in piglets","volume":"318","author":"Hu","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jconrel.2026.114939_bb0055","first-page":"416","article-title":"Perihematomal brain tissue iron concentration measurement by MRI in patients with intracerebral hemorrhage","volume":"16","author":"Wei","year":"2009","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jconrel.2026.114939_bb0060","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1161\/STROKEAHA.110.602755","article-title":"Role of iron in brain injury after intraventricular hemorrhage","volume":"42","author":"Chen","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.jconrel.2026.114939_bb0065","first-page":"411","article-title":"An update on iron chelation therapy","volume":"10","author":"Poggiali","year":"2012","journal-title":"Blood Transfus."},{"key":"10.1016\/j.jconrel.2026.114939_bb0070","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1016\/S0140-6736(22)00536-0","article-title":"Thalassaemia","volume":"399","author":"Kattamis","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2026.114939_bb0075","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/ajh.21993","article-title":"Iron chelation adherence to deferoxamine and deferasirox in thalassemia","volume":"86","author":"Trachtenberg","year":"2011","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.jconrel.2026.114939_bb0080","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/ajh.21100","article-title":"Concepts and goals in the management of transfusional iron overload","volume":"82","author":"Porter","year":"2007","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.jconrel.2026.114939_bb0085","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1002\/pds.3657","article-title":"Safety of deferasirox: a retrospective cohort study on the risks of gastrointestinal, liver and renal events","volume":"23","author":"Huang","year":"2014","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"10.1016\/j.jconrel.2026.114939_bb0090","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/ajh.24479","article-title":"Deferiprone-induced agranulocytosis: 20 years of clinical observations","volume":"91","author":"Tricta","year":"2016","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.jconrel.2026.114939_bb0095","doi-asserted-by":"crossref","first-page":"5641","DOI":"10.1182\/bloodadvances.2023012316","article-title":"Rates of severe neutropenia and infection risk in patients treated with deferiprone: 28 years of data","volume":"8","author":"Badawy","year":"2024","journal-title":"Blood Advance"},{"key":"10.1016\/j.jconrel.2026.114939_bb0100","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.annemergmed.2010.11.020","article-title":"Effect of deferasirox on iron absorption in a randomized, placebo-controlled, crossover study in a human model of acute supratherapeutic iron ingestion","volume":"58","author":"Griffith","year":"2011","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.jconrel.2026.114939_bb0105","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ado3919","article-title":"In situ implantable DNA hydrogel for diagnosis and therapy of postoperative rehemorrhage following intracerebral hemorrhage surgery","volume":"10","author":"Yu","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2026.114939_bb0110","doi-asserted-by":"crossref","first-page":"10704","DOI":"10.1021\/nn4035074","article-title":"Design of long circulating nontoxic dendritic polymers for the removal of iron in vivo","volume":"7","author":"Imran Ul-Haq","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.114939_bb0115","doi-asserted-by":"crossref","first-page":"5134","DOI":"10.1038\/s41467-019-13143-z","article-title":"Renal clearable nanochelators for iron overload therapy","volume":"10","author":"Kang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.114939_bb0120","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1182\/blood.V128.22.2322.2322","article-title":"Twice monthly liposome encapsulated deferoxamine (LDFO) has a high molar efficiency in removing total body iron in an iron dextran-overloaded mouse model","volume":"128","author":"Tran","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jconrel.2026.114939_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202310178","article-title":"A semiconducting Iron-chelating nano-immunomodulator for specific and sensitized sono-metallo-immunotherapy of cancer","volume":"62","author":"He","year":"2023","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2026.114939_bb0130","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jconrel.2019.12.023","article-title":"The role of liposomes in clinical nanomedicine development. What now? Now what?","volume":"318","author":"Crommelin","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114939_bb0135","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.2042-7158.1994.tb03731.x","article-title":"Evaluation of a liposome system for the delivery of desferrioxamine to lungs in rats","volume":"46","author":"Tabak","year":"1994","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jconrel.2026.114939_bb0140","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1080\/10717540903141768","article-title":"An extended-release formulation of desferrioxamine for subcutaneous administration","volume":"16","author":"Toliyat","year":"2009","journal-title":"Drug Deliv."},{"key":"10.1016\/j.jconrel.2026.114939_bb0145","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1007\/s12035-015-9672-6","article-title":"Glucose transporters at the blood-brain barrier: function, regulation and gateways for drug delivery","volume":"54","author":"Patching","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jconrel.2026.114939_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1344039","article-title":"Bridging the gap: glucose transporters, alzheimers, and future therapeutic prospects","volume":"12","author":"Albaik","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jconrel.2026.114939_bb0155","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/acschemneuro.0c00076","article-title":"GLUT-1: an effective target to deliver brain-derived neurotrophic factor gene across the blood brain barrier","volume":"11","author":"Arora","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.jconrel.2026.114939_bb0160","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1021\/acsnano.3c09715","article-title":"Mannose-integrated nanoparticle hitchhike glucose transporter 1 recycling to overcome various barriers of oral delivery for alzheimers disease therapy","volume":"18","author":"Lei","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.114939_bb0165","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbrc.2017.04.004","article-title":"Mannose-conjugated platinum complexes reveals effective tumor targeting mediated by glucose transporter 1","volume":"487","author":"Liu","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jconrel.2026.114939_bb0170","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.201800219","article-title":"Liposomes actively recognizing the glucose transporter GLUT1 and integrin \u03b1v \u03b23 for dual-targeting of glioma","volume":"352","author":"Fu","year":"2019","journal-title":"Arch. Pharm."},{"key":"10.1016\/j.jconrel.2026.114939_bb0175","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202309517","article-title":"Alleviating recombinant tissue plasminogen activator-induced hemorrhagic transformation in ischemic stroke via targeted delivery of a ferroptosis inhibitor","volume":"11","author":"Geng","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.114939_bb0180","doi-asserted-by":"crossref","first-page":"8173","DOI":"10.1002\/anie.201914751","article-title":"Systemic brain delivery of antisense oligonucleotides across the blood\u2013brain barrier with a glucose-coated polymeric nanocarrier","volume":"59","author":"Min","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2026.114939_bb0185","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4149\/endo_2014_01_35","article-title":"Glucose transport in brain \u2013 effect of inflammation","volume":"48","author":"Jurcovicova","year":"2014","journal-title":"Endo"},{"key":"10.1016\/j.jconrel.2026.114939_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2022.212936","article-title":"Efficiently suppress of ferroptosis using deferoxamine nanoparticles as a new method for retinal ganglion cell protection after traumatic optic neuropathy","volume":"138","author":"Lin","year":"2022","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.jconrel.2026.114939_bb0195","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2023-181406","article-title":"Lipid nanoparticle library towards development of next generation genomic medicines","volume":"142","author":"Jain","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.jconrel.2026.114939_bb0200","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202303261","article-title":"Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy","volume":"35","author":"Zong","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.114939_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14030543","article-title":"Methods of liposomes preparation: formation and control factors of versatile nanocarriers for biomedical and nanomedicine application","volume":"14","author":"Lombardo","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2026.114939_bb0210","series-title":"Liposomes in Drug Delivery","first-page":"19","article-title":"Basic concepts of liposomes: Components, structures, properties and classification","year":"2024"},{"key":"10.1016\/j.jconrel.2026.114939_bb0215","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.apsusc.2014.01.046","article-title":"Theoretical estimation of the critical packing parameter of amphiphilic self-assembled aggregates","volume":"318","author":"Khalil","year":"2014","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.jconrel.2026.114939_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2024.110283","article-title":"A matrix metalloproteinase-sensitive hydrogel combined with photothermal therapy for transdermal delivery of deferoxamine to accelerate diabetic pressure ulcer healing","volume":"35","author":"Shen","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jconrel.2026.114939_bb0225","doi-asserted-by":"crossref","first-page":"10108","DOI":"10.1073\/pnas.86.24.10108","article-title":"Modulation of deferoxamine toxicity and clearance by covalent attachment to biocompatible polymers","volume":"86","author":"Hallaway","year":"1989","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jconrel.2026.114939_bb0230","doi-asserted-by":"crossref","first-page":"228","DOI":"10.7150\/thno.16638","article-title":"Comparison of 68Ga-HBED-CC PSMA-PET\/CT and multiparametric MRI for gross tumour volume detection in patients with primary prostate cancer based on slice by slice comparison with histopathology","volume":"7","author":"Zamboglou","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2026.114939_bb0235","first-page":"1","article-title":"Sonoafterglow nanoprobes for deep-tissue imaging of peroxynitrite","author":"Xu","year":"2025","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jconrel.2026.114939_bb0240","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.7150\/thno.20767","article-title":"Multimodality imaging of angiogenesis in a rabbit atherosclerotic model by GEBP11 peptide targeted nanoparticles","volume":"7","author":"Su","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2026.114939_bb0245","doi-asserted-by":"crossref","first-page":"7148","DOI":"10.1021\/jacs.5c00506","article-title":"Dual-locked fluorescence probe for monitoring the dynamic transition of pulmonary macrophages","volume":"147","author":"Hu","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2026.114939_bb0250","first-page":"1","article-title":"Molecular afterglow imaging for biomedical applications","author":"Xu","year":"2025","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jconrel.2026.114939_bb0255","doi-asserted-by":"crossref","first-page":"511","DOI":"10.7150\/thno.14261","article-title":"Evaluation of a 3-hydroxypyridin-2-one (2,3-HOPO) based macrocyclic chelator for 89Zr4+ and its use for ImmunoPET imaging of HER2 positive model of ovarian carcinoma in mice","volume":"6","author":"Tinianow","year":"2016","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2026.114939_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.supmat.2024.100080","article-title":"Fluorous-tagged bortezomib supramolecular nanomedicine for cancer therapy","volume":"3","author":"Wang","year":"2024","journal-title":"Supramolecular Materials"},{"key":"10.1016\/j.jconrel.2026.114939_bb0265","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.biomaterials.2019.01.025","article-title":"A disassembling strategy overcomes the EPR effect and renal clearance dilemma of the multifunctional theranostic nanoparticles for cancer therapy","volume":"197","author":"Wang","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.114939_bb0270","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0022-2143(00)70021-7","article-title":"First human studies with a high-molecular-weight iron chelator","volume":"135","author":"Dragsten","year":"2000","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.jconrel.2026.114939_bb0275","doi-asserted-by":"crossref","first-page":"25788","DOI":"10.1021\/acsami.6b09077","article-title":"Enzymatically biodegradable polyrotaxane\u2013deferoxamine conjugates for iron chelation","volume":"8","author":"Liu","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2026.114939_bb0280","first-page":"1842","article-title":"Iron overload disorders, hepatology","volume":"6","author":"Hsu","year":"2022","journal-title":"Communications"},{"key":"10.1016\/j.jconrel.2026.114939_bb0285","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1021\/jacs.4c15068","article-title":"In situ conversion of atherosclerotic plaques iron into nanotheranostics","volume":"147","author":"Pan","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2026.114939_bb0290","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an Iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2026.114939_bb0295","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.jconrel.2026.114939_bb0300","article-title":"System xc\u2212\/GSH\/GPX4 axis: an important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jconrel.2026.114939_bb0305","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1089\/ars.2017.7115","article-title":"GPx4, lipid peroxidation, and cell death: discoveries, rediscoveries, and open issues","volume":"29","author":"Maiorino","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.jconrel.2026.114939_bb0310","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41392-022-01090-z","article-title":"ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage","volume":"7","author":"Ma","year":"2022","journal-title":"Sig Transduct Target Ther"},{"key":"10.1016\/j.jconrel.2026.114939_bb0315","series-title":"Ion Channels","first-page":"169","article-title":"VDAC, a channel in the outer mitochondrial membrane","author":"Colombini","year":"1996"},{"key":"10.1016\/j.jconrel.2026.114939_bb0320","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2018.03.001","article-title":"Selenium and GPX4, a vital symbiosis","volume":"127","author":"Friedmann Angeli","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jconrel.2026.114939_bb0325","article-title":"FSP1 reduces exogenous coenzyme q10 and inhibits ferroptosis to alleviate intestinal ischemia\u2013reperfusion injury","author":"Shen","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.jconrel.2026.114939_bb0330","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.molmed.2023.05.013","article-title":"FSP1: a key regulator of ferroptosis","volume":"29","author":"Li","year":"2023","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jconrel.2026.114939_bb0335","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41419-023-05716-0","article-title":"The interaction between ferroptosis and inflammatory signaling pathways","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jconrel.2026.114939_bb0340","first-page":"420","article-title":"Autophagy-dependent ferroptosis: machinery and regulation, cell","volume":"27","author":"Liu","year":"2020","journal-title":"Chem. Biol."},{"key":"10.1016\/j.jconrel.2026.114939_bb0345","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/cr.2016.95","article-title":"Ferroptosis is an autophagic cell death process","volume":"26","author":"Gao","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.jconrel.2026.114939_bb0350","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.redox.2017.08.015","article-title":"Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis","volume":"14","author":"Masaldan","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.jconrel.2026.114939_bb0355","article-title":"Improving understanding of ferroptosis: molecular mechanisms, connection with cellular senescence and implications for aging","volume":"10","author":"Leon-Oliva","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.jconrel.2026.114939_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114961","article-title":"A new strategy for the treatment of intracerebral hemorrhage: Ferroptosis","volume":"382","author":"Sun","year":"2024","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jconrel.2026.114939_bb0365","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1186\/s12951-024-03023-0","article-title":"Polydopamine(PDA)-coated diselenide-bridged mesoporous silica-based nanoplatform for neuroprotection by reducing oxidative stress and targeting neuroinflammation in intracerebral hemorrhage","volume":"22","author":"Zhou","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2026.114939_bb0370","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41572-023-00424-7","article-title":"Intracerebral haemorrhage","volume":"9","author":"Puy","year":"2023","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.jconrel.2026.114939_bb0375","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1038\/s41591-023-02644-6","article-title":"Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain","volume":"29","author":"Sirko","year":"2023","journal-title":"Nat. Med."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926003421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926003421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:25:28Z","timestamp":1781256328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926003421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":75,"alternative-id":["S0168365926003421"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114939","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipidized deferoxamine nanomedicines (DFOsomes) against iron overload","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114939","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114939"}}