{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:59:51Z","timestamp":1781258391264,"version":"3.54.1"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015872","name":"Universit\u00e9 de Lille","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015872","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jconrel.2026.114977","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:35:18Z","timestamp":1777617318000},"page":"114977","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Intracochlear PLGA implants for simultaneous controlled release of multiple drugs"],"prefix":"10.1016","volume":"395","author":[{"given":"P.-K.","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Olivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Toulemonde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Verin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Danede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.F.","family":"Willart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Siepmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Siepmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.114977_bb0005","series-title":"World report on hearing","year":"2021"},{"key":"10.1016\/j.jconrel.2026.114977_bb0010","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2471\/BLT.13.128728","article-title":"The global burden of disabling hearing impairment: a call to action","volume":"92","author":"Olusanya","year":"2014","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.jconrel.2026.114977_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12901-018-0051-6","article-title":"Generic quality of life in persons with hearing loss: a systematic literature review","volume":"18","author":"Nordvik","year":"2018","journal-title":"BMC Ear, Nose and Throat Disord."},{"key":"10.1016\/j.jconrel.2026.114977_bb0020","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0196-0709(82)80016-1","article-title":"Transport characteristics of the blood\u2014perilymph barrier","volume":"3","author":"Juhn","year":"1982","journal-title":"Am. J. Otolaryngol."},{"key":"10.1016\/j.jconrel.2026.114977_bb0025","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.addr.2008.08.001","article-title":"Inner ear drug delivery for auditory applications","volume":"60","author":"Swan","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.114977_bb0030","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijpharm.2015.08.015","article-title":"Recent advances in local drug delivery to the inner ear","volume":"494","author":"El Kechai","year":"2015","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.114977_bb0035","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jconrel.2016.02.013","article-title":"Hyaluronic acid liposomal gel sustains delivery of a corticoid to the inner ear","volume":"226","author":"El Kechai","year":"2016","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114977_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120757","article-title":"Transtympanic injection of a liposomal gel loaded with N-acetyl-L-cysteine: a relevant strategy to prevent damage induced by cochlear implantation in guinea pigs?","volume":"604","author":"Jaudoin","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.114977_bb0045","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jmbbm.2019.05.007","article-title":"Coating stability and insertion forces of an alginate-cell-based drug delivery implant system for the inner ear","volume":"97","author":"H\u00fcgl","year":"2019","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jconrel.2026.114977_bb0050","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.heares.2015.04.019","article-title":"Effects of a dexamethasone-releasing implant on cochleae: a functional, morphological and pharmacokinetic study","volume":"327","author":"Liu","year":"2015","journal-title":"Hear. Res."},{"key":"10.1016\/j.jconrel.2026.114977_bb0055","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S1359-6446(05)03574-9","article-title":"Local inner ear drug delivery and pharmacokinetics","volume":"10","author":"Salt","year":"2005","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jconrel.2026.114977_bb0060","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.heares.2018.03.002","article-title":"Pharmacokinetic principles in the inner ear: influence of drug properties on intratympanic applications","volume":"368","author":"Salt","year":"2018","journal-title":"Hear. Res."},{"key":"10.1016\/j.jconrel.2026.114977_bb0065","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.7150\/thno.14858","article-title":"The smart drug delivery system and its clinical potential","volume":"6","author":"Liu","year":"2016","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2026.114977_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.120180","article-title":"Novel biodegradable round window disks for inner ear delivery of dexamethasone","volume":"594","author":"Lehner","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.114977_bb0075","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.heares.2018.03.006","article-title":"Controlled drug release to the inner ear: concepts, materials, mechanisms, and performance","volume":"368","author":"M\u00e4der","year":"2018","journal-title":"Hear. Res."},{"key":"10.1016\/j.jconrel.2026.114977_bb0080","article-title":"Long term behavior of dexamethasone-loaded cochlear implants: in vitro & in vivo","volume":"4","author":"Rongthong","year":"2022","journal-title":"Int. J. Pharmaceut. X"},{"key":"10.1016\/j.jconrel.2026.114977_bb0085","article-title":"EVA implants for controlled drug delivery to the inner ear","volume":"8","author":"Das Lages","year":"2024","journal-title":"Int. J. Pharm. X."},{"key":"10.1016\/j.jconrel.2026.114977_bb0090","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000320611","article-title":"Pharmacokinetics of dexamethasone solution following intratympanic injection in guinea pig and sheep","volume":"16","author":"Wang","year":"2011","journal-title":"Audiol. Neurotol."},{"key":"10.1016\/j.jconrel.2026.114977_bb0095","article-title":"Intratympanic injection of dexamethasone: time course of inner ear distribution and conversion to its active form","volume":"27","author":"Hargunani","year":"2006","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.jconrel.2026.114977_bb0100","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/AUD.0b013e3181c351f2","article-title":"Drug delivery for treatment of inner ear disease: current state of knowledge","volume":"31","author":"McCall","year":"2010","journal-title":"Ear Hear."},{"key":"10.1016\/j.jconrel.2026.114977_bb0105","doi-asserted-by":"crossref","DOI":"10.1186\/1916-0216-42-19","article-title":"Dexamethasone uptake in the murine organ of Corti with transtympanic versus systemic administration","volume":"42","author":"Grewal","year":"2013","journal-title":"J. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.jconrel.2026.114977_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2017.12.010","article-title":"Communication pathways to and from the inner ear and their contributions to drug delivery","volume":"362","author":"Salt","year":"2018","journal-title":"Hear. Res."},{"key":"10.1016\/j.jconrel.2026.114977_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2018.09.002","article-title":"A comparison of systemic and local dexamethasone administration: from perilymph\/cochlea concentration to cochlear distribution","volume":"370","author":"Wang","year":"2018","journal-title":"Hear. Res."},{"key":"10.1016\/j.jconrel.2026.114977_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123268","article-title":"Towards the optimization of drug delivery to the cochlear apex: influence of polymer and drug selection in biodegradable intracochlear implants","volume":"643","author":"Lehner","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.114977_bb0125","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/00016488609132823","article-title":"Morphometric comparison of endolymphatic and Perilymphatic spaces in human temporal bones","volume":"101","author":"Igarashi","year":"1986","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.jconrel.2026.114977_bb0130","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/000348940111000204","article-title":"Inner ear fluid volumes and the resolving power of magnetic resonance imaging: can it differentiate endolymphatic structures?","volume":"110","author":"Buckingham","year":"2001","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.jconrel.2026.114977_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2024.105972","article-title":"Characterization of PLGA versus PEG-PLGA intracochlear drug delivery implants: degradation kinetics, morphological changes, and pH alterations","volume":"99","author":"Lehner","year":"2024","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.jconrel.2026.114977_bb0140","article-title":"Intracochlear PLGA based implants for dexamethasone release: challenges and solutions","volume":"1","author":"Lehner","year":"2019","journal-title":"Int. J. Pharmaceut. X"},{"key":"10.1016\/j.jconrel.2026.114977_bb0145","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s13346-021-00914-9","article-title":"Microimaging of a novel intracochlear drug delivery device in combination with cochlear implants in the human inner ear","volume":"12","author":"Lehner","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.jconrel.2026.114977_bb0150","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1097\/MAO.0000000000000849","article-title":"Dexamethasone protects against apoptotic cell death of cisplatin-exposed auditory hair cells in vitro","volume":"36","author":"Dinh","year":"2015","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.jconrel.2026.114977_bb0155","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000441833","article-title":"The sustained-exposure dexamethasone formulation OTO-104 offers effective protection against cisplatin-induced hearing loss","volume":"21","author":"Fernandez","year":"2016","journal-title":"Audiol Neurotol"},{"key":"10.1016\/j.jconrel.2026.114977_bb0160","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1002\/lio2.508","article-title":"Autoimmune inner ear disease: a systematic review of management","volume":"5","author":"Breslin","year":"2020","journal-title":"Laryngosc. Investig Otolaryngol"},{"key":"10.1016\/j.jconrel.2026.114977_bb0165","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1007\/s00405-014-3288-8","article-title":"Intratympanic steroids as a salvage treatment for sudden sensorineural hearing loss? A meta-analysis","volume":"272","author":"Ng","year":"2015","journal-title":"Eur. Arch. Otorrinolaringol."},{"key":"10.1016\/j.jconrel.2026.114977_bb0170","series-title":"Drugs Affecting the Inner Ear","author":"Norris","year":"1988"},{"key":"10.1016\/j.jconrel.2026.114977_bb0175","first-page":"46","article-title":"Treatment of cochlear tinnitus with transtympanic infusion of 4% lidocaine into the tympanic cavity","volume":"7","author":"Sakata","year":"2001","journal-title":"Int. Tinnitus J."},{"key":"10.1016\/j.jconrel.2026.114977_bb0180","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00003446-199602000-00006","article-title":"Effects of intratympanically delivered lidocaine on the auditory system in humans","volume":"17","author":"Laurikainen","year":"1996","journal-title":"Ear Hear."},{"key":"10.1016\/j.jconrel.2026.114977_bb0185","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3109\/00016489709113432","article-title":"The mechanism and site of action of lidocaine hydrochloride in Guinea pig","volume":"117","author":"Laurikainen","year":"1997","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.jconrel.2026.114977_bb0190","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/lary.20713","article-title":"Sustained delivery of lidocaine into the cochlea using poly lactic\/glycolic acid microparticles","volume":"120","author":"Horie","year":"2010","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jconrel.2026.114977_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122474","article-title":"Anticancer potential of curcumin-cyclodextrin complexes and their pharmacokinetic properties","volume":"631","author":"Shahriari","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.114977_bb0200","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/bjc.2015.359","article-title":"Molecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: the role of curcumin on pSTAT3 and Nrf-2 signalling","volume":"113","author":"Fetoni","year":"2015","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jconrel.2026.114977_bb0205","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1097\/MAO.0000000000000302","article-title":"Curcuma longa (curcumin) decreases in vivo cisplatin-induced ototoxicity through Heme Oxygenase-1 induction","volume":"35","author":"Fetoni","year":"2014","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.jconrel.2026.114977_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111555","article-title":"Anti-oxidant and anti-inflammatory effects of caffeic acid: in vivo evidences in a model of noise-induced hearing loss","volume":"143","author":"Paciello","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jconrel.2026.114977_bb0215","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tips.2008.11.002","article-title":"Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets","volume":"30","author":"Aggarwal","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jconrel.2026.114977_bb0220","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/0142-9612(94)90271-2","article-title":"Biodegradation of PLA\/GA polymers: increasing complexity","volume":"15","author":"Vert","year":"1994","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.114977_bb0225","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0169-409X(97)00048-3","article-title":"Biodegradation and biocompatibility of PLA and PLGA microspheres","volume":"28","author":"Anderson","year":"1997","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.114977_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113758","article-title":"PLGA-based long-acting injectable (LAI) formulations","volume":"382","author":"Park","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114977_bb0235","doi-asserted-by":"crossref","first-page":"487","DOI":"10.31083\/ph.2010.9375","article-title":"Release of gentamicin sulphate from biodegradable PLGA-implants produced by hot melt extrusion","volume":"65","author":"Gosau","year":"2010","journal-title":"Pharmazie"},{"key":"10.1016\/j.jconrel.2026.114977_bb0240","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1208\/s12249-016-0548-5","article-title":"Hot melt extrusion for sustained protein release: matrix Erosion and in vitro release of PLGA-based implants","volume":"18","author":"Coss\u00e9","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jconrel.2026.114977_bb0245","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ijpharm.2007.11.012","article-title":"How to achieve sustained and complete protein release from PLGA-based microparticles?","volume":"350","author":"Giteau","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.114977_bb0250","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.jpba.2017.07.056","article-title":"Phase separation of in situ forming poly (lactide-co-glycolide acid) implants investigated using a hydrogel-based subcutaneous tissue surrogate and UV\u2013vis imaging","volume":"145","author":"Sun","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jconrel.2026.114977_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.126083","article-title":"Designing long-acting injectable formulations using PLGA via spray-drying","volume":"683","author":"Zhang","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.114977_bb0260","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ijpharm.2008.04.042","article-title":"Principles of encapsulating hydrophobic drugs in PLA\/PLGA microparticles","volume":"364","author":"Wischke","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.114977_bb0265","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0169-409X(97)00049-5","article-title":"Preparation of microspheres by the solvent evaporation technique","volume":"28","author":"O\u2019Donnell","year":"1997","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.114977_bb0270","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jconrel.2004.10.015","article-title":"Microencapsulation by solvent extraction\/evaporation: reviewing the state of the art of microsphere preparation process technology","volume":"102","author":"Freitas","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114977_bb0275","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jconrel.2020.06.023","article-title":"Continuous in-line homogenization process for scale-up production of naltrexone-loaded PLGA microparticles","volume":"325","author":"Sharifi","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114977_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122731","article-title":"Preparation and evaluation of sustained release formulation of PLGA using a new injection system based on ink-jet injection technology","volume":"635","author":"Sato","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.114977_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2019.04.023","article-title":"Encapsulation and release of doxycycline from electrospray-generated PLGA microspheres: effect of polymer end groups","volume":"564","author":"Wang","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.114977_bb0290","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijpharm.2011.05.049","article-title":"The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems\u2014a review","volume":"415","author":"Fredenberg","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.114977_bb0295","article-title":"Release mechanisms of PLGA-based drug delivery systems: a review","volume":"10","author":"Siepmann","year":"2025","journal-title":"Int. J. Pharmaceut. X"},{"key":"10.1016\/j.jconrel.2026.114977_bb0300","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijpharm.2013.04.044","article-title":"Mathematical modeling of drug dissolution","volume":"453","author":"Siepmann","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.114977_bb0305","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/andp.18551700105","article-title":"Ueber Diffusion","volume":"170","author":"Fick","year":"1855","journal-title":"Ann. Phys."},{"key":"10.1016\/j.jconrel.2026.114977_bb0310","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jconrel.2015.06.039","article-title":"Does PLGA microparticle swelling control drug release? New insight based on single particle swelling studies","volume":"213","author":"Gasmi","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114977_bb0315","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jconrel.2019.05.039","article-title":"Often neglected: PLGA\/PLA swelling orchestrates drug release: HME implants","volume":"306","author":"Bode","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114977_bb0320","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1021\/mp060041n","article-title":"Pore closing and opening in biodegradable polymers and their effect on the controlled release of proteins","volume":"4","author":"Kang","year":"2007","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2026.114977_bb0325","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1023\/A:1007582911958","article-title":"Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres","volume":"17","author":"Fu","year":"2000","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2026.114977_bb0330","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jconrel.2014.01.024","article-title":"Non-invasive in vivo characterization of microclimate pH inside in situ forming PLGA implants using multispectral fluorescence imaging","volume":"179","author":"Sch\u00e4dlich","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114977_bb0335","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1023\/A:1018822002353","article-title":"pH and osmotic pressure inside biodegradable microspheres during Erosion1","volume":"16","author":"Brunner","year":"1999","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2026.114977_bb0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2005.07.009","article-title":"Plasticizing effect of water on poly(lactide-co-glycolide)","volume":"108","author":"Blasi","year":"2005","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114977_bb0345","doi-asserted-by":"crossref","first-page":"E78","DOI":"10.1208\/pt0802037","article-title":"Ketoprofen poly(lactide-co-glycolide) physical interaction","volume":"8","author":"Blasi","year":"2007","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jconrel.2026.114977_bb0350","doi-asserted-by":"crossref","DOI":"10.5772\/33569","article-title":"The Mongolian gerbil as a model for the analysis of peripheral and central age-dependent hearing loss","author":"Otto","year":"2012","journal-title":"Hearing Loss"},{"key":"10.1016\/j.jconrel.2026.114977_bb0355","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.heares.2016.05.010","article-title":"Technical note for post-auricular route surgery in Mongolian gerbil","volume":"337","author":"Risoud","year":"2016","journal-title":"Hear. Res."},{"key":"10.1016\/j.jconrel.2026.114977_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2025.109188","article-title":"Perilymph sampling in Mongolian gerbil, technical note and procedure evaluation","volume":"458","author":"Olivier","year":"2025","journal-title":"Hear. Res."},{"key":"10.1016\/j.jconrel.2026.114977_bb0365","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijpharm.2007.10.030","article-title":"PLGA-based drug delivery systems: importance of the type of drug and device geometry","volume":"354","author":"Klose","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.114977_bb0370","article-title":"The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatininduced ototoxicity","volume":"10","author":"Paciello","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2026.114977_bb0375","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1021\/acs.cgd.7b01664","article-title":"Using milling to explore physical states: the amorphous and polymorphic forms of dexamethasone","volume":"18","author":"Oliveira","year":"2018","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.jconrel.2026.114977_bb0380","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ijpharm.2016.08.032","article-title":"Towards a better understanding of the different release phases from PLGA microparticles: dexamethasone-loaded systems","volume":"514","author":"Gasmi","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.114977_bb0385","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0928-0987(02)00023-4","article-title":"PLGA-based microparticles: elucidation of mechanisms and a new, simple mathematical model quantifying drug release","volume":"15","author":"Faisant","year":"2002","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2026.114977_bb0390","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jconrel.2022.01.028","article-title":"How agarose gels surrounding PLGA implants limit swelling and slow down drug release","volume":"343","author":"Bassand","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.114977_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.119009","article-title":"Sink conditions do not guarantee the absence of saturation effects","volume":"577","author":"Siepmann","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.114977_bb0400","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1097\/00005537-199910000-00021","article-title":"Cochlear fluid space dimensions for six species derived from reconstructions of three-dimensional magnetic resonance images","volume":"109","author":"Thorne","year":"1999","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jconrel.2026.114977_bb0405","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1016\/S0142-9612(02)00170-9","article-title":"Why degradable polymers undergo surface erosion or bulk erosion","volume":"23","author":"Burkersroda","year":"2002","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.114977_bb0410","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1007\/s11095-008-9594-3","article-title":"Acidic microclimate pH distribution in PLGA microspheres monitored by confocal laser scanning microscopy","volume":"25","author":"Ding","year":"2008","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2026.114977_bb0415","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1021\/bm050228k","article-title":"How autocatalysis accelerates drug Release from PLGA-based microparticles: a quantitative treatment","volume":"6","author":"Siepmann","year":"2005","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2026.114977_bb0420","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ijpharm.2005.07.031","article-title":"How porosity and size affect the drug release mechanisms from PLGA-based microparticles","volume":"314","author":"Klose","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.114977_bb0425","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jconrel.2017.03.009","article-title":"PLGA implants: how Poloxamer\/PEO addition slows down or accelerates polymer degradation and drug release","volume":"253","author":"Hamoudi-Ben Yelles","year":"2017","journal-title":"J. Control. Release"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926003809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926003809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:17:23Z","timestamp":1781255843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926003809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":85,"alternative-id":["S0168365926003809"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114977","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intracochlear PLGA implants for simultaneous controlled release of multiple drugs","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114977","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114977"}}