{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:37:02Z","timestamp":1784547422019,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006469","name":"Fundo para o Desenvolvimento das Ci\u00eancias e da Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jconrel.2026.114985","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:58:53Z","timestamp":1777931933000},"page":"114985","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["IFN-\u03b3-primed MSC extracellular vesicles attenuate rheumatoid arthritis via PD-L1-driven T-cell suppression and bone preservation"],"prefix":"10.1016","volume":"395","author":[{"given":"Xi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan Qing","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linna","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan-Tian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty Yuen Kwan","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Kam Wai","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jconrel.2026.114985_bb0005","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s13045-021-01208-w","article-title":"Mesenchymal stem\/stromal cells in cancer therapy","volume":"14","author":"Lan","year":"2021","journal-title":"J. Hematol. Oncol."},{"issue":"13","key":"10.1016\/j.jconrel.2026.114985_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25136979","article-title":"Mesenchymal stem cells and their derived products in ageing and diseases","volume":"25","author":"Vizoso","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114985_bb0015","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s10020-024-00967-9","article-title":"Mesenchymal stem cells lineage and their role in disease development","volume":"30","author":"Xu","year":"2024","journal-title":"Mol. Med."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114985_bb0020","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1186\/s13287-024-04078-4","article-title":"Impact of mesenchymal stem cell size and adhesion modulation on in vivo distribution: insights from quantitative PET imaging","volume":"15","author":"Ji","year":"2024","journal-title":"Stem Cell Res. Ther."},{"issue":"6","key":"10.1016\/j.jconrel.2026.114985_bb0025","doi-asserted-by":"crossref","first-page":"779","DOI":"10.2174\/1574888X17666220823092202","article-title":"Review of the published literature confirms the safety of intravenous infusion of mesenchymal stem cells","volume":"18","author":"Barmada","year":"2023","journal-title":"Curr. Stem Cell Res. Ther."},{"issue":"22","key":"10.1016\/j.jconrel.2026.114985_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212429","article-title":"Mesenchymal stem cell: a friend or foe in anti-tumor immunity","volume":"22","author":"Harrell","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2026.114985_bb0035","article-title":"Exosomal long non-coding RNA: interaction between cancer cells and non-cancer cells","volume":"10","author":"Han","year":"2020","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114985_bb0040","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13287-021-02138-7","article-title":"Advances in mesenchymal stem cell exosomes: a review","volume":"12","author":"Tang","year":"2021","journal-title":"Stem Cell Res. Ther."},{"issue":"3","key":"10.1016\/j.jconrel.2026.114985_bb0045","doi-asserted-by":"crossref","first-page":"5338","DOI":"10.3390\/ijms14035338","article-title":"Exosomes as intercellular signaling organelles involved in health and disease: basic science and clinical applications","volume":"14","author":"Corrado","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2026.114985_bb0050","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jare.2024.05.004","article-title":"Mesenchymal stem cell secretome for regenerative medicine: where do we stand?","volume":"70","author":"Trigo","year":"2025","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114985_bb0055","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12951-025-03216-1","article-title":"MSCs-EVs harboring OA immune memory reprogram macrophage phenotype via modulation of the mt-ND3\/NADH-CoQ axis for OA treatment","volume":"23","author":"Zhan","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114985_bb0060","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1089\/scd.2018.0015","article-title":"Human Fetal liver mesenchymal stem cell-derived exosomes impair natural killer cell function","volume":"28","author":"Fan","year":"2019","journal-title":"Stem Cells Dev."},{"issue":"8","key":"10.1016\/j.jconrel.2026.114985_bb0065","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.4049\/jimmunol.1800304","article-title":"Therapeutic potential of mesenchymal cell-derived miRNA-150-5p-expressing exosomes in rheumatoid arthritis mediated by the modulation of MMP14 and VEGF","volume":"201","author":"Chen","year":"2018","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.jconrel.2026.114985_bb0070","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2174\/1566523220666200916120708","article-title":"miRNA-146a improves immunomodulatory effects of MSC-derived exosomes in rheumatoid arthritis","volume":"20","author":"Tavasolian","year":"2020","journal-title":"Curr. Gene Ther."},{"issue":"4","key":"10.1016\/j.jconrel.2026.114985_bb0075","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/a-1995-6365","article-title":"Interferon-gamma-treated mesenchymal stem cells modulate the T cell-related chemokines and chemokine receptors in an animal model of experimental autoimmune encephalomyelitis","volume":"73","author":"Ahmadifard","year":"2023","journal-title":"Drug Res. (Stuttg.)"},{"issue":"10","key":"10.1016\/j.jconrel.2026.114985_bb0080","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1136\/annrheumdis-2020-217798","article-title":"Combination of human umbilical cord mesenchymal stem (stromal) cell transplantation with IFN-gamma treatment synergistically improves the clinical outcomes of patients with rheumatoid arthritis","volume":"79","author":"He","year":"2020","journal-title":"Ann. Rheum. Dis."},{"issue":"2","key":"10.1016\/j.jconrel.2026.114985_bb0085","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jaci.2014.12.1926","article-title":"Culture medium from TNF-\u03b1\u2013stimulated mesenchymal stem cells attenuates allergic conjunctivitis through multiple antiallergic mechanisms","volume":"136","author":"Su","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6","key":"10.1016\/j.jconrel.2026.114985_bb0090","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1021\/acsnano.9b01004","article-title":"Stem cell-derived exosomes as nanotherapeutics for autoimmune and neurodegenerative disorders","volume":"13","author":"Riazifar","year":"2019","journal-title":"ACS Nano"},{"issue":"7","key":"10.1016\/j.jconrel.2026.114985_bb0095","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41419-020-02788-0","article-title":"IFN-gamma promoted exosomes from mesenchymal stem cells to attenuate colitis via miR-125a and miR-125b","volume":"11","author":"Yang","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jconrel.2026.114985_bib211","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4939-8802-0_1","article-title":"Collagen-Induced Arthritis Models","volume":"1868","author":"Miyoshi","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"12","key":"10.1016\/j.jconrel.2026.114985_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12279","article-title":"Suppression of PD-L1 release from small extracellular vesicles promotes systemic anti-tumor immunity by targeting ORAI1 calcium channels","volume":"11","author":"Chen","year":"2022","journal-title":"J. Extracell. Vesicles"},{"issue":"11","key":"10.1016\/j.jconrel.2026.114985_bb0105","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1038\/s41423-020-0380-4","article-title":"Sirtuin 5 deficiency increases disease severity in rats with adjuvant-induced arthritis","volume":"17","author":"Zhang","year":"2020","journal-title":"Cell. Mol. Immunol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114985_bb0110","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41590-020-00816-x","article-title":"The immunology of rheumatoid arthritis","volume":"22","author":"Weyand","year":"2021","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.jconrel.2026.114985_bb0115","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00441-018-2967-y","article-title":"Vascularized composite allograft rejection is delayed by infusion of IFN-gamma-conditioned BMSCs through upregulating PD-L1","volume":"376","author":"Wang","year":"2019","journal-title":"Cell Tissue Res."},{"issue":"7718","key":"10.1016\/j.jconrel.2026.114985_bb0120","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41586-018-0392-8","article-title":"Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response","volume":"560","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2026.114985_bb0125","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jss.2019.02.038","article-title":"IFN-gamma promotes epithelial-mesenchymal transition and the expression of PD-L1 in pancreatic cancer","volume":"240","author":"Imai","year":"2019","journal-title":"J. Surg. Res."},{"issue":"2","key":"10.1016\/j.jconrel.2026.114985_bb0130","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/art.41417","article-title":"Rheumatoid arthritis pathogenesis, prediction, and prevention: an emerging paradigm shift","volume":"73","author":"Deane","year":"2021","journal-title":"Arthritis Rheumatol."},{"issue":"13","key":"10.1016\/j.jconrel.2026.114985_bb0135","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMp2310178","article-title":"What is rheumatoid arthritis?","volume":"390","author":"Gravallese","year":"2024","journal-title":"N. Engl. J. Med."},{"issue":"5_Supplement","key":"10.1016\/j.jconrel.2026.114985_bb0140","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.7326\/M24-0678","article-title":"Rheumatology: what you may have missed in 2023","volume":"177","author":"Jalali","year":"2024","journal-title":"Ann. Intern. Med."},{"issue":"7","key":"10.1016\/j.jconrel.2026.114985_bb0145","doi-asserted-by":"crossref","first-page":"10018","DOI":"10.1002\/jcp.27860","article-title":"Strategies toward rheumatoid arthritis therapy; the old and the new","volume":"234","author":"Abbasi","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.jconrel.2026.114985_bb0150","doi-asserted-by":"crossref","first-page":"e252","DOI":"10.1016\/S2665-9913(24)00234-0","article-title":"Sustained DMARD-free remission in subgroups of patients with rheumatoid arthritis: an analysis of two prospective cohorts with early arthritis","volume":"7","author":"Heutz","year":"2025","journal-title":"Lancet Rheumatol."},{"key":"10.1016\/j.jconrel.2026.114985_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2023.104771","article-title":"Interactions of mesenchymal stromal\/stem cells and immune cells following MSC-based therapeutic approaches in rheumatoid arthritis","volume":"393-394","author":"Dehnavi","year":"2023","journal-title":"Cell. Immunol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114985_bb0160","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13287-025-04184-x","article-title":"Efficacy and safety of mesenchymal stromal cell transplantation in the treatment of autoimmune and rheumatic immune diseases: a systematic review and meta-analysis of randomized controlled trials","volume":"16","author":"Zeng","year":"2025","journal-title":"Stem Cell Res. Ther."},{"issue":"11","key":"10.1016\/j.jconrel.2026.114985_bb0165","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1038\/s41423-021-00764-y","article-title":"TGF-beta-induced CD4+ FoxP3+ regulatory T cell-derived extracellular vesicles modulate Notch1 signaling through miR-449a and prevent collagen-induced arthritis in a murine model","volume":"18","author":"Chen","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114985_bb0170","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s13287-023-03523-0","article-title":"Exosomes derived from mesenchymal stem cells primed with disease-condition-serum improved therapeutic efficacy in a mouse rheumatoid arthritis model via enhanced TGF-beta1 production","volume":"14","author":"Choi","year":"2023","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114985_bb0175","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/s41467-024-45213-2","article-title":"Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission","volume":"15","author":"Baker","year":"2024","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.jconrel.2026.114985_bb0180","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1002\/med.21842","article-title":"The immunosuppressive activity of artemisinin-type drugs towards inflammatory and autoimmune diseases","volume":"41","author":"Efferth","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jconrel.2026.114985_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00851","article-title":"Extracellular vesicles transfer the receptor programmed death-1 in rheumatoid arthritis","volume":"8","author":"Greisen","year":"2017","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114985_bb0190","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12865-021-00460-6","article-title":"Soluble programmed death molecule 1 (sPD-1) as a predictor of interstitial lung disease in rheumatoid arthritis","volume":"22","author":"Xu","year":"2021","journal-title":"BMC Immunol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114985_bb0195","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13075-023-03041-7","article-title":"Stratified distribution of Th17 and Treg cells in patients with multi-stage rheumatoid arthritis","volume":"25","author":"Su","year":"2023","journal-title":"Arthritis Res. Ther."},{"issue":"5","key":"10.1016\/j.jconrel.2026.114985_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25052688","article-title":"Osteoimmunology: the crosstalk between T cells, B cells, and osteoclasts in rheumatoid arthritis","volume":"25","author":"Yang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2026.114985_bb0205","doi-asserted-by":"crossref","first-page":"218","DOI":"10.7150\/thno.38198","article-title":"Mononuclear phagocyte system blockade improves therapeutic exosome delivery to the myocardium","volume":"10","author":"Wan","year":"2020","journal-title":"Theranostics"},{"issue":"24","key":"10.1016\/j.jconrel.2026.114985_bb0210","doi-asserted-by":"crossref","first-page":"10748","DOI":"10.1039\/D1NR02065J","article-title":"Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery","volume":"13","author":"Shi","year":"2021","journal-title":"Nanoscale"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926003883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926003883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:15:16Z","timestamp":1781255716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926003883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":43,"alternative-id":["S0168365926003883"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114985","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IFN-\u03b3-primed MSC extracellular vesicles attenuate rheumatoid arthritis via PD-L1-driven T-cell suppression and bone preservation","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.114985","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114985"}}