{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T17:29:56Z","timestamp":1788715796276,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024A1515011550"],"award-info":[{"award-number":["2024A1515011550"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571333"],"award-info":[{"award-number":["82571333"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52003211"],"award-info":[{"award-number":["52003211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501423"],"award-info":[{"award-number":["82501423"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFF0508603"],"award-info":[{"award-number":["2024YFF0508603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20240813103605008"],"award-info":[{"award-number":["JCYJ20240813103605008"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2025AFD791"],"award-info":[{"award-number":["2025AFD791"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jconrel.2026.115055","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T15:00:47Z","timestamp":1779807647000},"page":"115055","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Poly(amino acid) nanoprodrugs mitigate cisplatin-induced ototoxicity"],"prefix":"10.1016","volume":"396","author":[{"given":"Xi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimin","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5191","key":"10.1016\/j.jconrel.2026.115055_bb0005","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/222385a0","article-title":"Platinum compounds: a new class of potent antitumour agents","volume":"222","author":"Rosenberg","year":"1969","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2026.115055_bb0010","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jconrel.2022.03.049","article-title":"Targeted nanomedicine in cisplatin-based cancer therapeutics","volume":"345","author":"Han","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115055_bb0015","article-title":"Oxaliplatin and its derivatives \u2013 an overview","volume":"497","author":"O\u2019Dowd","year":"2023","journal-title":"Coord. Chem. Rev."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115055_bb0020","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1038\/s41467-017-01837-1","article-title":"Cisplatin is retained in the cochlea indefinitely following chemotherapy","volume":"8","author":"Breglio","year":"2017","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115055_bb0025","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1620\/tjem.219.177","article-title":"Cisplatin ototoxicity and protection: clinical and experimental studies","volume":"219","author":"Rybak","year":"2009","journal-title":"Tohoku J. Exp. Med."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115055_bb0030","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/FTD.0000000000000298","article-title":"Clinical practice recommendations for the management and prevention of Cisplatin-induced hearing loss using pharmacogenetic markers","volume":"38","author":"Lee","year":"2016","journal-title":"Ther. Drug Monit."},{"issue":"22","key":"10.1016\/j.jconrel.2026.115055_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216545","article-title":"Molecular characteristics of cisplatin-induced ototoxicity and therapeutic interventions","volume":"24","author":"Tan","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115055_bb0040","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.apsb.2023.11.001","article-title":"Development of Chinese herbal medicine for sensorineural hearing loss","volume":"14","author":"Wu","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"issue":"38","key":"10.1016\/j.jconrel.2026.115055_bb0045","first-page":"26401","article-title":"Ototoxicity-alleviating and cytoprotective allomelanin nanomedicine for efficient sensorineural hearing loss treatment","volume":"18","author":"Chen","year":"2024","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115055_bb0050","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1186\/s12951-024-02686-z","article-title":"Crosslinked-hybrid nanoparticle embedded in thermogel for sustained co-delivery to inner ear","volume":"22","author":"Thakur","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"29","key":"10.1016\/j.jconrel.2026.115055_bb0055","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202407637","article-title":"Polydopamine nanohydrogel decorated adhesive and responsive hierarchical microcarriers for deafness protection","volume":"12","author":"Chen","year":"2025","journal-title":"Adv. Sci."},{"issue":"13","key":"10.1016\/j.jconrel.2026.115055_bb0060","doi-asserted-by":"crossref","first-page":"5512","DOI":"10.1021\/acs.jmedchem.7b01653","article-title":"Progress in the development of preventative drugs for cisplatin-induced hearing loss","volume":"61","author":"Hazlitt","year":"2018","journal-title":"J. Med. Chem."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115055_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202413371","article-title":"Functionalized nanozyme microcapsules targeting deafness prevention via mitochondrial homeostasis remodeling","volume":"37","author":"Ge","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115055_bb0070","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1146\/annurev-pharmtox-033123-114106","article-title":"Hear and now: ongoing clinical trials to prevent drug-induced hearing loss","volume":"64","author":"Lee","year":"2024","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"24","key":"10.1016\/j.jconrel.2026.115055_bb0075","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202407067","article-title":"Programmable NIR responsive nanocomposite enables noninvasive intratympanic delivery of dexamethasone to reverse cisplatin induced hearing loss","volume":"12","author":"Mustafa","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.115055_bb0080","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.addr.2016.01.004","article-title":"Advances in nano-based inner ear delivery systems for the treatment of sensorineural hearing loss","volume":"108","author":"Li","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.115055_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113728","article-title":"Bioadhesive drug-loaded microparticles prolong drug retention in the middle ear and ameliorate cisplatin-induced hearing loss","volume":"383","author":"Zhou","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115055_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2026.114938","article-title":"Thioether-functionalized polycarbonate nanosponges mitigate cisplatin-induced ototoxicity via ROS scavenging and cisplatin deactivation","volume":"395","author":"Yan","year":"2026","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115055_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.123026","article-title":"Advancements of ROS-based biomaterials for sensorineural hearing loss therapy","volume":"316","author":"Xu","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115055_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.progpolymsci.2024.101855","article-title":"Recent developments in synthetic approaches for macromolecular prodrugs","volume":"155","author":"Alex","year":"2024","journal-title":"Prog. Polym. Sci."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115055_bb0105","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41573-018-0005-0","article-title":"Polymer-drug conjugate therapeutics: advances, insights and prospects","volume":"18","author":"Ekladious","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115055_bb0110","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1021\/acs.nanolett.1c01201","article-title":"A nanoantidote alleviates glioblastoma chemotoxicity without efficacy compromise","volume":"21","author":"Tian","year":"2021","journal-title":"Nano Lett."},{"issue":"46","key":"10.1016\/j.jconrel.2026.115055_bb0115","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202408003","article-title":"2D catalytic niobium carbide MXenzyme for ameliorating noise-induced hearing loss","volume":"34","author":"Xu","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115055_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202305215","article-title":"Natural multifunctional silk microcarriers for noise-induced hearing loss therapy","volume":"11","author":"Zhang","year":"2024","journal-title":"Adv. Sci."},{"issue":"41","key":"10.1016\/j.jconrel.2026.115055_bb0125","doi-asserted-by":"crossref","first-page":"46212","DOI":"10.1021\/acsami.2c11647","article-title":"Microfluidic preparation of gelatin methacryloyl microgels as local drug delivery vehicles for hearing loss therapy","volume":"14","author":"Wang","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2026.115055_bb0130","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.2147\/IJN.S72555","article-title":"Enhanced local bioavailability of single or compound drugs delivery to the inner ear through application of PLGA nanoparticles via round window administration","volume":"9","author":"Cai","year":"2014","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2026.115055_bb0135","first-page":"3567","article-title":"A single dose of dexamethasone encapsulated in polyethylene glycol-coated polylactic acid nanoparticles attenuate cisplatin-induced hearing loss following round window membrane administration","volume":"10","author":"Sun","year":"2015","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2026.115055_bb0140","doi-asserted-by":"crossref","first-page":"7517","DOI":"10.2147\/IJN.S170130","article-title":"A666-conjugated nanoparticles target prestin of outer hair cells preventing cisplatin-induced hearing loss","volume":"13","author":"Wang","year":"2018","journal-title":"Int. J. Nanomedicine"},{"issue":"35","key":"10.1016\/j.jconrel.2026.115055_bb0145","doi-asserted-by":"crossref","first-page":"24189","DOI":"10.1021\/jacs.4c05382","article-title":"Recent advances and future developments in the preparation of polypeptides via N-carboxyanhydride (NCA) ring-opening polymerization","volume":"146","author":"Wu","year":"2024","journal-title":"J Am Chem Soc"},{"issue":"7","key":"10.1016\/j.jconrel.2026.115055_bb0150","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1039\/D4NR04481A","article-title":"Recent advances in poly(amino acids), polypeptides, and their derivatives in drug delivery","volume":"17","author":"Yuan","year":"2025","journal-title":"Nanoscale"},{"issue":"47","key":"10.1016\/j.jconrel.2026.115055_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202211136","article-title":"Spatiotemporally targeted polypeptide nanoantidotes improve chemotherapy tolerance of cisplatin","volume":"61","author":"Yang","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115055_bb0160","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2174\/187152007779314062","article-title":"The role of sulfur in platinum anticancer chemotherapy","volume":"7","author":"Wang","year":"2007","journal-title":"Anti Cancer Agents Med. Chem."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836592600458X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836592600458X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:58:10Z","timestamp":1787579890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016836592600458X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":32,"alternative-id":["S016836592600458X"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115055","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Poly(amino acid) nanoprodrugs mitigate cisplatin-induced ototoxicity","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115055"}}