{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T16:26:46Z","timestamp":1793896006342,"version":"4.8.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013066","name":"Key Scientific Research Project of Colleges and Universities in Henan Province","doi-asserted-by":"publisher","award":["24A350005"],"award-info":[{"award-number":["24A350005"]}],"id":[{"id":"10.13039\/501100013066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015402","name":"Innovative Team and Outstanding Talent Program of Colleges and Universities in Guangxi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470351"],"award-info":[{"award-number":["82470351"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82 202321"],"award-info":[{"award-number":["82 202321"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304427"],"award-info":[{"award-number":["82304427"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jconrel.2026.115062","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T23:23:14Z","timestamp":1780356194000},"page":"115062","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Engineering ROS-responsive size-transformable nanoassemblies to reprogram plaque microenvironment and activate autophagy for atherosclerosis therapy"],"prefix":"10.1016","volume":"396","author":[{"given":"Yanyan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaishun","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youyou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruirui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanda","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjiang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.115062_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105169","article-title":"Apoptosis, autophagy and atherosclerosis: relationships and the role of Hsp27","volume":"166","author":"Shan","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jconrel.2026.115062_bb0010","doi-asserted-by":"crossref","first-page":"8943","DOI":"10.1021\/acsnano.8b02037","article-title":"Targeted therapy of atherosclerosis by a broad-Spectrum reactive oxygen species scavenging nanoparticle with intrinsic anti-inflammatory activity","volume":"12","author":"Wang","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115062_bb0015","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s11883-024-01229-z","article-title":"Targeting macrophage phenotypes and metabolism as novel therapeutic approaches in atherosclerosis and related cardiovascular diseases","volume":"26","author":"Wang","year":"2024","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.jconrel.2026.115062_bb0020","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cmet.2012.01.022","article-title":"Macrophage autophagy plays a protective role in advanced atherosclerosis","volume":"15","author":"Liao","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.jconrel.2026.115062_bb0025","article-title":"Targeting the microenvironment of vulnerable atherosclerotic plaques: An emerging diagnosis and therapy strategy for atherosclerosis","volume":"34","author":"Zhang","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115062_bb0030","doi-asserted-by":"crossref","first-page":"14555","DOI":"10.1021\/acsnano.3c01420","article-title":"Design of a Multifunctional Nanozyme for resolving the Proinflammatory plaque microenvironment and attenuating atherosclerosis","volume":"17","author":"He","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115062_bb0035","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/biom13010015","article-title":"Autophagy in atherosclerotic plaque cells: targeting NLRP3 inflammasome for self-rescue","volume":"13","author":"Li","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.jconrel.2026.115062_bb0040","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1111\/jcmm.12859","article-title":"Autophagy dysfunction and regulatory cystatin C in macrophage death of atherosclerosis","volume":"20","author":"Li","year":"2016","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.jconrel.2026.115062_bb0045","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.3390\/ijms26073252","article-title":"Autophagy and its association with macrophages in clonal hematopoiesis leading to atherosclerosis","volume":"26","author":"Li","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2026.115062_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202105875","article-title":"Plaque-targeted rapamycin spherical nucleic acids for synergistic atherosclerosis treatment","volume":"9","author":"Guo","year":"2022","journal-title":"Adv Sci"},{"key":"10.1016\/j.jconrel.2026.115062_bb0055","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.jconrel.2024.10.051","article-title":"Targeted delivery of rapamycin and inhibition of platelet adhesion with multifunctional peptide nanoparticles for atherosclerosis treatment","volume":"376","author":"Wang","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115062_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2024.102530","article-title":"ROS-responsive biomimetic nanovesicles to plaque microenvironment in targeted therapy of atherosclerosis","volume":"59","author":"Zhou","year":"2024","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2026.115062_bb0065","doi-asserted-by":"crossref","first-page":"6819","DOI":"10.3390\/ijms25136819","article-title":"Effect of mTORC Agonism via MHY1485 with and without Rapamycin on C2C12 Myotube Metabolism","volume":"25","author":"Cook","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2026.115062_bb0070","doi-asserted-by":"crossref","first-page":"e152","DOI":"10.1016\/S2666-7568(23)00258-1","article-title":"Targeting ageing with rapamycin and its derivatives in humans: a systematic review","volume":"5","author":"Lee","year":"2024","journal-title":"Lancet Healthy Longev."},{"key":"10.1016\/j.jconrel.2026.115062_bb0075","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1021\/acsnano.9b08434","article-title":"Size-transformable Hyaluronan stacked self-assembling peptide nanoparticles for improved transcellular tumor penetration and photo-chemo combination therapy","volume":"14","author":"Cong","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115062_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.114854","article-title":"Design of disintegrable nanoassemblies to release multiple small-sized nanoparticles","volume":"197","author":"Zhu","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.115062_bb0085","article-title":"Lesional macrophage-targeted nanomedicine regulating cholesterol homeostasis for the treatment of atherosclerosis","volume":"37","author":"Liu","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115062_bb0090","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jconrel.2018.05.041","article-title":"Co-delivery of LOX-1 siRNA and statin to endothelial cells and macrophages in the atherosclerotic lesions by a dual-targeting core-shell nanoplatform: a dual cell therapy to regress plaques","volume":"283","author":"Zhao","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115062_bb0095","doi-asserted-by":"crossref","first-page":"104404","DOI":"10.1016\/j.jddst.2023.104404","article-title":"Pharmacokinetics and tumor delivery of nanoparticles","volume":"83","author":"Yuan","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.jconrel.2026.115062_bb0100","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1021\/nn506750r","article-title":"Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging","volume":"9","author":"Lobatto","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115062_bb0105","doi-asserted-by":"crossref","first-page":"1427651","DOI":"10.3389\/fphar.2024.1427651","article-title":"Nanoparticle-based approaches for treating restenosis after vascular injury","volume":"15","author":"Zhao","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jconrel.2026.115062_bb0110","article-title":"Site-specific MicroRNA-33 antagonism by pH-responsive Nanotherapies for treatment of atherosclerosis via regulating cholesterol efflux and adaptive immunity","volume":"30","author":"Li","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2026.115062_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119632","article-title":"Cyclodextrin boostered-high density lipoprotein for antiatherosclerosis by regulating cholesterol efflux and efferocytosis","volume":"292","author":"Wang","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.jconrel.2026.115062_bb0120","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/eurheartj\/ehad796","article-title":"Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase c\u03b2\/store-operated calcium entry\/calreticulin\/scavenger receptor a pathways","volume":"45","author":"Li","year":"2024","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jconrel.2026.115062_bb0125","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.jconrel.2025.02.053","article-title":"Combining oxygen delivery and generation for targeted atherosclerosis therapy","volume":"380","author":"Wang","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115062_bb0130","article-title":"Duplex responsive nanoplatform with cascade targeting for atherosclerosis photoacoustic diagnosis and multichannel combination therapy","volume":"35","author":"Xu","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115062_bb0135","article-title":"Endocytic recycling as cellular trafficking fate of simvastatin-loaded discoidal reconstituted high-density lipoprotein to coordinate cholesterol efflux and drug influx","volume":"32","author":"Qi","year":"2021","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2026.115062_bb0140","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nrm2256","article-title":"ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis","volume":"8","author":"D\u2019Autr\u00e9aux","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jconrel.2026.115062_bb0145","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1038\/s41467-020-16439-7","article-title":"Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines","volume":"11","author":"Gao","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115062_bb0150","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s12951-021-00897-2","article-title":"Reactive oxygen species scavenging and inflammation mitigation enabled by biomimetic prussian blue analogues boycott atherosclerosis","volume":"19","author":"Zhang","year":"2021","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.jconrel.2026.115062_bb0155","first-page":"115","article-title":"Reactive oxygen species (ROS)-responsive size-reducible nanoassemblies for deeper atherosclerotic plaque penetration and enhanced macrophage-targeted drug delivery","volume":"19","author":"He","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2026.115062_bb0160","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.trsl.2017.10.008","article-title":"Development of mannose functionalized dendrimeric nanoparticles for targeted delivery to macrophages: use of this platform to modulate atherosclerosis","volume":"193","author":"He","year":"2018","journal-title":"Transl. Res."},{"key":"10.1016\/j.jconrel.2026.115062_bb0165","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12933-025-02715-7","article-title":"AGE induced macrophage-derived exosomes induce endothelial dysfunction in diabetes via miR-22-5p\/FOXP1","volume":"24","author":"Ji","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.jconrel.2026.115062_bb0170","doi-asserted-by":"crossref","first-page":"108606","DOI":"10.1016\/j.biotechadv.2025.108606","article-title":"Biomimetic high-density lipoprotein nanoparticles for the delivery of nucleic acid-based therapeutics","volume":"83","author":"Ihnatsyeu-Kachan","year":"2025","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.jconrel.2026.115062_bb0175","doi-asserted-by":"crossref","first-page":"17845","DOI":"10.1021\/acsnano.3c03390","volume":"17","author":"Sun","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115062_bb0180","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.coph.2007.12.012","article-title":"Hydrogen peroxide as an endogenous mediator and exogenous tool in cardiovascular research: issues and considerations","volume":"8","author":"Schr\u00f6der","year":"2008","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.jconrel.2026.115062_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11122343","article-title":"Interleukin-33 induces neutrophil extracellular trap (NET) formation and macrophage necroptosis via enhancing oxidative stress and secretion of Proatherogenic factors in advanced atherosclerosis","volume":"11","author":"Tembhre","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.jconrel.2026.115062_bb0190","article-title":"Reprogramming macrophage polarization, depleting ROS by Astaxanthin and Thioketal-containing polymers delivering rapamycin for osteoarthritis treatment","volume":"11","author":"Li","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.jconrel.2026.115062_bb0195","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s13105-024-01039-6","article-title":"Role of ROS and autophagy in the pathological process of atherosclerosis","volume":"80","author":"Zhu","year":"2024","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.jconrel.2026.115062_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121734","article-title":"ROS responsive nanoparticles loaded with lipid-specific AIEgen for atherosclerosis-targeted diagnosis and bifunctional therapy","volume":"288","author":"Xu","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115062_bb0205","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/aps.2015.87","article-title":"The roles of macrophage autophagy in atherosclerosis","volume":"37","author":"Shao","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jconrel.2026.115062_bb0210","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1021\/acs.molpharmaceut.9b00445","article-title":"Rational design of lovastatin-loaded spherical reconstituted high density lipoprotein for efficient and safe anti-atherosclerotic therapy","volume":"16","author":"Jiang","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2026.115062_bb0215","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.7150\/thno.87416","article-title":"Tet1 deficiency exacerbates oxidative stress in acute kidney injury by regulating superoxide dismutase","volume":"13","author":"Fan","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2026.115062_bb0220","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.freeradbiomed.2018.10.412","article-title":"A novel antioxidant Mito-Tempol inhibits ox-LDL-induced foam cell formation through restoration of autophagy flux","volume":"129","author":"Ma","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jconrel.2026.115062_bb0225","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1010248","article-title":"Rapamycin and FTY720 alleviate atherosclerosis by cross talk of macrophage polarization and autophagy","volume":"2018","author":"Sun","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jconrel.2026.115062_bb0230","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1080\/14728222.2023.2288272","article-title":"Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets","volume":"27","author":"Galindo","year":"2023","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.jconrel.2026.115062_bb0235","doi-asserted-by":"crossref","first-page":"1378990","DOI":"10.3389\/fimmu.2024.1378990","article-title":"ROS induced pyroptosis in inflammatory disease and cancer","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2026.115062_bb0240","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.2174\/0113816128303026240514111200","article-title":"Reactive Oxygen Species and Mitochondrial Calcium\u2019s Roles in the Development of Atherosclerosis","volume":"30","author":"Priya","year":"2024","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jconrel.2026.115062_bb0245","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1053\/j.semnuclmed.2022.08.009","article-title":"Vulnerable plaque imaging","volume":"53","author":"Nakahara","year":"2023","journal-title":"Semin. Nucl. Med."},{"key":"10.1016\/j.jconrel.2026.115062_bb0250","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1093\/cvr\/cvad079","article-title":"Transforming growth factor-\u03b22 is associated with atherosclerotic plaque stability and lower risk for cardiovascular events","volume":"119","author":"Edsfeldt","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jconrel.2026.115062_bb0255","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s41419-023-06154-8","article-title":"Autophagy: regulator of cell death","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jconrel.2026.115062_bb0260","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/s41401-025-01687-4","article-title":"LAMTOR5 promotes hepatoma growth in mice by disrupting LC3-p62-mediated autophagy and preventing p62 proteasome degradation","volume":"47","author":"Xu","year":"2026","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jconrel.2026.115062_bb0265","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41467-020-20185-1","article-title":"p62\/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response","volume":"12","author":"Kageyama","year":"2021","journal-title":"Nat. Commun."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926004657?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926004657?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T15:51:39Z","timestamp":1793893899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926004657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":53,"alternative-id":["S0168365926004657"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115062","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineering ROS-responsive size-transformable nanoassemblies to reprogram plaque microenvironment and activate autophagy for atherosclerosis therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115062"}}