{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:21:12Z","timestamp":1793334072788,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jconrel.2026.115111","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:33:35Z","timestamp":1781800415000},"page":"115111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A TIGIT nanotrapping-guided STING-activatable immunometabolic strategy overcomes innate immune silence and T cell exhaustion in breast cancer"],"prefix":"10.1016","volume":"397","author":[{"given":"Shuai","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyan","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohui","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Jie","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiwen","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.115111_bb0005","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.trecan.2024.02.008","article-title":"The anti-cancer immune response in breast cancer: current and emerging biomarkers and treatments","volume":"10","author":"Rayson","year":"2024","journal-title":"Trends Cancer"},{"key":"10.1016\/j.jconrel.2026.115111_bb0010","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/S0140-6736(24)02135-4","article-title":"Cadonilimab plus platinum-based chemotherapy with or without bevacizumab as first-line treatment for persistent, recurrent, or metastatic cervical cancer (COMPASSION-16): a randomised, double-blind, placebo-controlled phase 3 trial in China","volume":"404","author":"Wu","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2026.115111_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.breast.2024.103694","article-title":"Stakeholders' experiences and perceptions of male breast cancer: a qualitative evidence synthesis","volume":"74","author":"Ye","year":"2024","journal-title":"Breast"},{"key":"10.1016\/j.jconrel.2026.115111_bb0020","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1016\/j.immuni.2022.10.002","article-title":"Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer","volume":"55","author":"Nixon","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.jconrel.2026.115111_bb0025","first-page":"753","article-title":"Breast cancer: multiple subtypes within a tumor?, trends","volume":"3","author":"Yeo","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.jconrel.2026.115111_bb0030","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41565-022-01098-0","article-title":"A nanovaccine for antigen self-presentation and immunosuppression reversal as a personalized cancer immunotherapy strategy","volume":"17","author":"Liu","year":"2022","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2026.115111_bb0035","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrc3239","article-title":"The blockade of immune checkpoints in cancer immunotherapy","volume":"12","author":"Pardoll","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2026.115111_bb0040","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41586-022-05443-0","article-title":"Ferroptosis of tumour neutrophils causes immune suppression in cancer","volume":"612","author":"Kim","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2026.115111_bb0045","first-page":"808","article-title":"Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors","volume":"3","author":"Zhang","year":"2022","journal-title":"Nat. Can."},{"key":"10.1016\/j.jconrel.2026.115111_bb0050","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1126\/science.abb4255","article-title":"Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic","volume":"369","author":"Chin","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2026.115111_bb0055","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/s41565-022-01225-x","article-title":"Zinc cyclic di-AMP nanoparticles target and suppress tumours via endothelial STING activation and tumour-associated macrophage reinvigoration","volume":"17","author":"Yang","year":"2022","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2026.115111_bb0060","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/s41565-021-00962-9","article-title":"Amplifying STING activation by cyclic dinucleotide\u2013manganese particles for local and systemic cancer metalloimmunotherapy","volume":"16","author":"Sun","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2026.115111_bb0065","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06373-1","article-title":"cGAS-STING drives ageing-related inflammation and neurodegeneration","volume":"620","author":"Gulen","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2026.115111_bb0070","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1158\/1078-0432.CCR-22-3322","article-title":"MEK inhibition sensitizes pancreatic cancer to STING agonism by tumor cell-intrinsic amplification of Type I IFN signaling","volume":"29","author":"Ghukasyan","year":"2023","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jconrel.2026.115111_bb0075","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.cmet.2019.08.003","article-title":"Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis","volume":"30","author":"Chung","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.jconrel.2026.115111_bb0080","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.chembiol.2023.05.005","article-title":"Cancer cell-autonomous cGAS-STING response confers drug resistance","volume":"30","author":"Lv","year":"2023","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.jconrel.2026.115111_bb0085","article-title":"In situ STING-activating nanovaccination with TIGIT blockade for enhanced immunotherapy of anti-PD-1-resistant tumors","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115111_bb0090","article-title":"Acid-ionizable iron nanoadjuvant augments STING activation for personalized vaccination immunotherapy of cancer","volume":"35","author":"Chen","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115111_bb0095","doi-asserted-by":"crossref","first-page":"7285","DOI":"10.1016\/j.cell.2024.09.048","article-title":"IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion","volume":"187","author":"Herhaus","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2026.115111_bb0100","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/35006664","article-title":"The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate","volume":"404","author":"Yasutomo","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2026.115111_bb0105","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-025-10004-2","article-title":"Individualized mRNA vaccines evoke durable T cell immunity in adjuvant TNBC","author":"Sahin","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2026.115111_bb0110","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.cell.2023.01.040","article-title":"Deciphering breast cancer: from biology to the clinic","volume":"186","author":"Nolan","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2026.115111_bb0115","doi-asserted-by":"crossref","DOI":"10.4028\/b-XDTcg5","article-title":"Inhibition of endoplasmic reticulum stress cooperates with SLC7A11 to promote disulfidptosis and suppress tumor growth upon glucose limitation","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.115111_bb0120","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41589-018-0031-6","article-title":"FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation","volume":"14","author":"Gaschler","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jconrel.2026.115111_bb0125","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jconrel.2026.115111_bb0130","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41418-022-01051-7","article-title":"SOCS2-enhanced ubiquitination of SLC7A11 promotes ferroptosis and radiosensitization in hepatocellular carcinoma","volume":"30","author":"Chen","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jconrel.2026.115111_bb0135","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.trecan.2025.06.006","article-title":"Transcriptional regulation of cuproptosis resistance in cancer therapy","volume":"11","author":"Tang","year":"2025","journal-title":"Trends Cancer"},{"key":"10.1016\/j.jconrel.2026.115111_bb0140","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2026.115111_bb0145","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.ccell.2025.02.015","article-title":"Hypoxia inducible factor-1α drives cancer resistance to cuproptosis","volume":"43","author":"Yang","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jconrel.2026.115111_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122300","article-title":"A STING pathway-activatable contrast agent for MRI-guided tumor immunoferroptosis synergistic therapy","volume":"302","author":"Guo","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115111_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122905","article-title":"Biologically logic-gated Trojan-horse strategy for personalized triple-negative breast cancer precise therapy by selective ferroptosis and STING pathway provoking","volume":"315","author":"Guo","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115111_bb0160","first-page":"193","article-title":"A self-accelerating \u2018copper bomb\u2019 strategy activated innate and adaptive immune response against triple-negative breast cancer","volume":"49","author":"Xu","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2026.115111_bb0165","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1873","article-title":"Improved cancer immunotherapy strategies by nanomedicine","volume":"15","author":"Guo","year":"2023","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2026.115111_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2025.102749","article-title":"A nuclei bombing nano-system improves STING-activated cancer immunotherapy","volume":"63","author":"Guo","year":"2025","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2026.115111_bb0175","article-title":"One-step symbiosis of bimetallic peroxides nanoparticles to induce ferroptosis\/cuproptosis and activate cGAS-STING pathway for enhanced tumor immunotherapy","volume":"37","author":"Liu","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115111_bb0180","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41422-023-00788-1","article-title":"Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression","volume":"33","author":"Qiu","year":"2023","journal-title":"Cell Res."},{"key":"10.1016\/j.jconrel.2026.115111_bb0185","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41392-025-02216-9","article-title":"STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation","volume":"10","author":"Wang","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2026.115111_bb0190","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12943-020-01190-w","article-title":"m(6)A-dependent glycolysis enhances colorectal cancer progression","volume":"19","author":"Shen","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jconrel.2026.115111_bb0195","article-title":"MRI-guided tumor therapy based on synergy of ferroptosis, immunosuppression reversal and disulfidptosis","volume":"20","author":"Guo","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2026.115111_bb0200","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202308241","article-title":"Self-destructive copper carriers induce pyroptosis and cuproptosis for efficient tumor immunotherapy against dormant and recurrent tumors","volume":"36","author":"Qiao","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115111_bb0205","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202404971","article-title":"Glutathione-scavenging celastrol-cu nanoparticles induce self-amplified cuproptosis for augmented cancer immunotherapy","volume":"36","author":"Lu","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115111_bb0210","first-page":"1834","article-title":"TIGIT and PD-L1 co-blockade promotes clonal expansion of multipotent, non-exhausted antitumor T cells by facilitating co-stimulation","volume":"5","author":"Nutsch","year":"2024","journal-title":"Nat. Can."},{"key":"10.1016\/j.jconrel.2026.115111_bb0215","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/ni.1674","article-title":"The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells","volume":"10","author":"Yu","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jconrel.2026.115111_bb0220","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1172\/JCI80445","article-title":"TIGIT and PD-1 impair tumor antigen-specific CD8+ T cells in melanoma patients","volume":"125","author":"Chauvin","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2026.115111_bb0225","article-title":"Stimuli-responsive CuFeTe2 nanosheets for amplified Cuproptosis\/Ferroptosis in triple-negative breast cancer therapy","volume":"13","author":"Liu","year":"2026","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.115111_bb0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40164-024-00592-6","article-title":"Safety and efficacy of CD33-targeted CAR-NK cell therapy for relapsed\/refractory AML: preclinical evaluation and phase I trial","volume":"14","author":"Huang","year":"2025","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.jconrel.2026.115111_bb0235","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41565-022-01261-7","article-title":"Targeting the activity of T cells by membrane surface redox regulation for cancer theranostics","volume":"18","author":"Shi","year":"2023","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2026.115111_bb0240","article-title":"Two-dimensional ultra-thin nanosheets with extraordinarily high drug loading and long blood circulation for cancer therapy","volume":"18","author":"Zhang","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2026.115111_bb0245","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1021\/acs.nanolett.3c00434","article-title":"An intelligent cell-derived nanorobot bridges synergistic crosstalk between sonodynamic therapy and cuproptosis to promote cancer treatment","volume":"23","author":"Chen","year":"2023","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2026.115111_bb0250","doi-asserted-by":"crossref","first-page":"8107","DOI":"10.1021\/acs.nanolett.4c01864","article-title":"The convergence of sonodynamic therapy and cuproptosis in the dual-responsive biomimetic cytoNano for precision mitochondrial intervention in cancer treatment","volume":"24","author":"Li","year":"2024","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2026.115111_bb0255","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1021\/acscentsci.4c02188","article-title":"Discovery of natural resorcylic acid lactones as novel potent copper ionophores covalently targeting PRDX1 to induce cuproptosis for triple-negative breast cancer therapy","volume":"11","author":"Feng","year":"2025","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.jconrel.2026.115111_bb0260","article-title":"Biodegradable ferric phosphate nanocarriers with tumor-specific activation and glutathione depletion for tumor self-enhanced ferroptosis and chemotherapy","volume":"34","author":"Li","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2026.115111_bb0265","doi-asserted-by":"crossref","first-page":"9904","DOI":"10.1021\/acsnano.0c02765","article-title":"Co-delivery of peptide neoantigens and stimulator of interferon genes agonists enhances response to cancer vaccines","volume":"14","author":"Shae","year":"2020","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115111_bb0270","doi-asserted-by":"crossref","first-page":"8179","DOI":"10.1021\/acs.nanolett.4c02192","article-title":"A \u201cferroptosis-amplifier\u201d hydrogel for eliminating refractory cancer stem cells post-lumpectomy","volume":"24","author":"Zhu","year":"2024","journal-title":"Nano Lett."},{"key":"10.1016\/j.jconrel.2026.115111_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101663","article-title":"Cycloacceleration of ferroptosis and calcicoptosis for magnetic resonance imaging-guided colorectal cancer therapy","volume":"47","author":"Guo","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2026.115111_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120542","article-title":"In situ activation of STING pathway with polymeric SN38 for cancer chemoimmunotherapy","volume":"268","author":"Zhao","year":"2021","journal-title":"Biomaterials"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926005146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926005146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:19:39Z","timestamp":1787804379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926005146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":56,"alternative-id":["S0168365926005146"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115111","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A TIGIT nanotrapping-guided STING-activatable immunometabolic strategy overcomes innate immune silence and T cell exhaustion in breast cancer","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115111","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115111"}}