{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:18:00Z","timestamp":1787807880046,"version":"build-2784847793"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione Italiana per la Ricerca sul Cancro Airc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013465","name":"AFM-Telethon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013465","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019920","name":"SATT Network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007366","name":"Italian Multiple Sclerosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jconrel.2026.115128","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:26:13Z","timestamp":1782861973000},"page":"115128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Muscle contribution in lipid nanoparticle mediated mRNA vaccine delivery and efficacy"],"prefix":"10.1016","volume":"397","author":[{"given":"Mathieu","family":"Repellin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Ugel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"De Sanctis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Coudert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Anselmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Andretto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Scionti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris","family":"Dimastromatteo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Sidi-Boumedine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Carras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Dugas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Brunel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Malatesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kryza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Schaeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Jacquier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Lollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.115128_bb0005","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/s41565-019-0591-y","article-title":"The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs","volume":"14","author":"Akinc","year":"2019","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2026.115128_bb0010","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa2035389","article-title":"Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine","volume":"384","author":"Baden","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2026.115128_bb0015","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/s41586-020-2814-7","article-title":"COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses","volume":"586","author":"Sahin","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2026.115128_bb0020","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41392-024-02002-z","article-title":"Progress and prospects of mRNA-based drugs in pre-clinical and clinical applications","volume":"9","author":"Shi","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2026.115128_bb0025","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41541-023-00656-4","article-title":"An optimized messenger RNA vaccine candidate protects non-human primates from Zika virus infection","volume":"8","author":"Bollman","year":"2023","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.jconrel.2026.115128_bb0030","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1056\/NEJMoa2307079","article-title":"Efficacy and safety of an mRNA-based RSV PreF vaccine in older adults","volume":"389","author":"Wilson","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2026.115128_bb0035","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/978-3-319-69194-7_8","article-title":"Plasticity of the muscle stem cell microenvironment","volume":"1041","author":"Dinulovic","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jconrel.2026.115128_bb0040","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s43587-024-00613-3","article-title":"Human skeletal muscle aging atlas","volume":"4","author":"Kedlian","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.jconrel.2026.115128_bb0045","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.ymthe.2024.01.020","article-title":"Lymph node macrophages drive innate immune responses to enhance the anti-tumor efficacy of mRNA vaccines","volume":"32","author":"Kubara","year":"2024","journal-title":"Mol. Ther. J. Am. Soc. Gene Ther."},{"key":"10.1016\/j.jconrel.2026.115128_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202202528","article-title":"Delivering mRNA to secondary lymphoid tissues by phosphatidylserine-loaded lipid nanoparticles","volume":"12","author":"Gomi","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2026.115128_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2023.102083","article-title":"mRNA vaccine trafficking and resulting protein expression after intramuscular administration","volume":"35","author":"Hassett","year":"2024","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.jconrel.2026.115128_bb0060","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2309472120","article-title":"Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects","volume":"120","author":"Chen","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jconrel.2026.115128_bb0065","first-page":"1","article-title":"mRNA vaccine immunity is enhanced by hepatocyte detargeting and not dependent on dendritic cell expression","author":"Marks","year":"2026","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jconrel.2026.115128_bb0070","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/gt.2010.124","article-title":"Skeletal muscle cells: from local inflammatory response to active immunity","volume":"18","author":"Marino","year":"2011","journal-title":"Gene Ther."},{"key":"10.1016\/j.jconrel.2026.115128_bb0075","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.autrev.2017.12.005","article-title":"Skeletal muscle cells actively shape (auto)immune responses","volume":"17","author":"Afzali","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jconrel.2026.115128_bb0080","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20211504","article-title":"IL-17A-producing \u03b3\u03b4T cells promote muscle regeneration in a microbiota-dependent manner","volume":"219","author":"Mann","year":"2022","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jconrel.2026.115128_bb0085","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jconrel.2022.11.042","article-title":"Hybrid core-shell particles for mRNA systemic delivery","volume":"353","author":"Andretto","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115128_bb0090","series-title":"Nanoparticules pour la liberation d\u2019acides nucleiques","author":"Lollo","year":"2023"},{"key":"10.1016\/j.jconrel.2026.115128_bb0095","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-50093-7","article-title":"Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation","volume":"15","author":"Su","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115128_bb0100","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.xphs.2022.12.026","article-title":"Effect of cholesterol content of lipid composition in mRNA-LNPs on the protein expression in the injected site and liver after local administration in mice","volume":"112","author":"Kawaguchi","year":"2023","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2026.115128_bb0105","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/j.celrep.2018.07.056","article-title":"Chemical landscape for tissue clearing based on hydrophilic reagents","volume":"24","author":"Tainaka","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jconrel.2026.115128_bb0110","doi-asserted-by":"crossref","DOI":"10.1172\/JCI67382","article-title":"Tumor endothelial marker 1-specific DNA vaccination targets tumor vasculature","volume":"124","author":"Facciponte","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2026.115128_bb0115","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1182\/blood-2009-07-233270","article-title":"Autoimmune B-cell lymphopenia after successful adoptive therapy with telomerase-specific T lymphocytes","volume":"115","author":"Ugel","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jconrel.2026.115128_bb0120","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/jcp.20724","article-title":"CD44 regulates myoblast migration and differentiation","volume":"209","author":"Mylona","year":"2006","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.jconrel.2026.115128_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/cells9092034","article-title":"Hybrid biopolymer and lipid nanoparticles with improved transfection efficacy for mRNA","volume":"9","author":"Siewert","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2026.115128_bb0130","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1021\/acsnano.8b01516","article-title":"On the formation and morphology of lipid nanoparticles containing Ionizable cationic lipids and siRNA","volume":"12","author":"Kulkarni","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115128_bb0135","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1038\/s41467-021-23722-8","article-title":"Tight docking of membranes before fusion represents a metastable state with unique properties","volume":"12","author":"Witkowska","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115128_bb0140","doi-asserted-by":"crossref","first-page":"5179","DOI":"10.1039\/D3SM00387F","article-title":"Planar confined water organisation in lipid bilayer stacks of phosphatidylcholine and phosphatidylethanolamine","volume":"19","author":"Vancuylenberg","year":"2023","journal-title":"Soft Matter"},{"key":"10.1016\/j.jconrel.2026.115128_bb0145","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.xphs.2020.12.006","article-title":"Addressing the cold reality of mRNA vaccine stability","volume":"110","author":"Crommelin","year":"2021","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2026.115128_bb0150","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jconrel.2009.10.024","article-title":"An overview of liposome lyophilization and its future potential","volume":"142","author":"Chen","year":"2010","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"10.1016\/j.jconrel.2026.115128_bb0155","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jconrel.2023.03.039","article-title":"Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures","volume":"357","author":"Meulewaeter","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115128_bb0160","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/s42003-021-02441-2","article-title":"Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration","volume":"4","author":"Carrasco","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jconrel.2026.115128_bb0165","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nm.3105","article-title":"Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion","volume":"19","author":"Hailemichael","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.jconrel.2026.115128_bb0170","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.jaip.2018.12.003","article-title":"Immediate hypersensitivity to polyethylene glycols and polysorbates: more common than we have recognized","volume":"7","author":"Stone","year":"2019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jconrel.2026.115128_bb0175","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1056\/NEJMra2035343","article-title":"Maintaining safety with SARS-CoV-2 vaccines","volume":"384","author":"Castells","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2026.115128_bb0180","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.722411","article-title":"Tuning the Immunostimulation properties of cationic lipid Nanocarriers for nucleic acid delivery","volume":"12","author":"Dey","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2026.115128_bb0185","article-title":"A combinatorial library of lipid nanoparticles for cell type-specific mRNA delivery","volume":"10","author":"Naidu","year":"2023","journal-title":"Adv. Sci. Weinh. Baden-Wurtt. Ger."},{"key":"10.1016\/j.jconrel.2026.115128_bb0190","doi-asserted-by":"crossref","first-page":"18758","DOI":"10.1021\/acsnano.3c02251","article-title":"An Ionizable lipid material with a vitamin E scaffold as an mRNA vaccine platform for efficient cytotoxic T cell responses","volume":"17","author":"Oyama","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115128_bb0195","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.xphs.2022.11.001","article-title":"The storage and in-use stability of mRNA vaccines and therapeutics: not a cold case","volume":"112","author":"Oude Blenke","year":"2023","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2026.115128_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1294929","article-title":"Straight to the point: targeted mRNA-delivery to immune cells for improved vaccine design","volume":"14","author":"Clemente","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2026.115128_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.omtn.2019.01.013","article-title":"Optimization of lipid nanoparticles for intramuscular administration of mRNA vaccines","volume":"15","author":"Hassett","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.jconrel.2026.115128_bb0210","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.ymthe.2025.01.008","article-title":"Visualizing lipid nanoparticle trafficking for mRNA vaccine delivery in non-human primates","volume":"33","author":"Buckley","year":"2025","journal-title":"Mol. Ther. J. Am. Soc. Gene Ther."},{"key":"10.1016\/j.jconrel.2026.115128_bb0215","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1021\/acs.molpharmaceut.2c01024","article-title":"Delivery and expression of mRNA in the secondary lymphoid organs drive immune responses to lipid nanoparticle-mRNA vaccines after intramuscular injection","volume":"20","author":"Takanashi","year":"2023","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2026.115128_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/nu10111564","article-title":"Glutamine: metabolism and immune function, supplementation and clinical translation","volume":"10","author":"Cruzat","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.jconrel.2026.115128_bb0225","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1096\/fj.01-0876rev","article-title":"Muscle-derived interleukin-6: mechanisms for activation and possible biological roles","volume":"16","author":"Febbraio","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.jconrel.2026.115128_bb0230","doi-asserted-by":"crossref","first-page":"eaba3458","DOI":"10.1126\/sciadv.aba3458","article-title":"Skeletal muscle antagonizes antiviral CD8+ T cell exhaustion","volume":"6","author":"Wu","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2026.115128_bb0235","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.omtm.2020.03.008","article-title":"Skeletal muscle is an antigen reservoir in integrase-defective lentiviral vector-induced long-term immunity","volume":"17","author":"Lin","year":"2020","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.jconrel.2026.115128_bb0240","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41573-021-00283-5","article-title":"mRNA vaccines for infectious diseases: principles, delivery and clinical translation","volume":"20","author":"Chaudhary","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2026.115128_bb0245","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.smim.2017.09.007","article-title":"Modulating the immune system through nanotechnology","volume":"34","author":"Dacoba","year":"2017","journal-title":"Semin. Immunol."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926005316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926005316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:24:10Z","timestamp":1787804650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926005316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":49,"alternative-id":["S0168365926005316"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115128","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Muscle contribution in lipid nanoparticle mediated mRNA vaccine delivery and efficacy","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115128","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115128"}}