{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:30:51Z","timestamp":1792549851578,"version":"4.5.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,7,21]],"date-time":"2027-07-21T00:00:00Z","timestamp":1816128000000},"content-version":"am","delay-in-days":323,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jconrel.2026.115187","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:02:39Z","timestamp":1784246559000},"page":"115187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["In vivo systemic toxicity of silica nanoparticles: Effects of sex, dose, and nanoparticle physicochemical properties"],"prefix":"10.1016","volume":"397","author":[{"given":"Sushanto Kumar","family":"Saha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md","family":"Adnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Arunachalam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrettin","family":"Tonbul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Jedrzkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitish","family":"Khurana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Ghandehari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jconrel.2026.115187_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17121602","article-title":"Advances in mesoporous silica and hybrid nanoparticles for drug delivery: synthesis, functionalization, and biomedical applications","volume":"17","author":"Almatroudi","year":"2025","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115187_bb0010","doi-asserted-by":"crossref","first-page":"124","DOI":"10.4103\/2230-973X.160844","article-title":"Mesoporous silica nanoparticles in target drug delivery system: a review","volume":"5","author":"Bharti","year":"2015","journal-title":"Int. J. Pharm. Investig."},{"key":"10.1016\/j.jconrel.2026.115187_bb0015","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jcis.2018.02.053","article-title":"Multifunctional nanomedicine with silica: role of silica in nanoparticles for theranostic, imaging, and drug monitoring","volume":"521","author":"Chen","year":"2018","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jconrel.2026.115187_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113053","article-title":"Silica nanoparticles: biomedical applications and toxicity","volume":"151","author":"Huang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jconrel.2026.115187_bb0025","doi-asserted-by":"crossref","DOI":"10.1177\/2041731413503357","article-title":"Silica-based mesoporous nanoparticles for controlled drug delivery","volume":"4","author":"Kwon","year":"2013","journal-title":"J. Tissue Eng."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115187_bb0030","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s12668-025-02386-4","article-title":"Development and fabrication of mesoporous silica nanoparticle loaded in situ nasal gel of scutellarin for Alzheimer\u2019s disease","volume":"16","author":"Mankar","year":"2026","journal-title":"BioNanoScience"},{"key":"10.1016\/j.jconrel.2026.115187_bb0035","doi-asserted-by":"crossref","DOI":"10.1007\/s12668-025-02046-7","article-title":"Development and fabrication of zwitterionic functionalised mesoporous silica nanoparticles of lappaol F for breast cancer","volume":"15","author":"Mankar","year":"2025","journal-title":"BioNanoScience"},{"key":"10.1016\/j.jconrel.2026.115187_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.nxnano.2026.100402","article-title":"Development and optimization of tivozanib loaded amine functionalized mesoporous silica nanoparticles for enhanced drug delivery","volume":"9","author":"Siddheshwar","year":"2026","journal-title":"Next Nanotechnol."},{"key":"10.1016\/j.jconrel.2026.115187_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120344","article-title":"Effect of colloidal silicon dioxide and moisture on powder flow properties: predicting in-process performance using image-based analysis","volume":"597","author":"Blanco","year":"2021","journal-title":"Int. J. Pharm."},{"issue":"20","key":"10.1016\/j.jconrel.2026.115187_bb0050","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1002\/anie.200604738","article-title":"Hybrid silica nanoparticles for multimodal imaging","volume":"46","author":"Rieter","year":"2007","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.jconrel.2026.115187_bb0055","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fmolb.2020.00193","article-title":"Nanoparticle-based drug delivery in cancer therapy and its role in overcoming drug resistance","volume":"7","author":"Yao","year":"2020","journal-title":"Front. Mol. Biosci."},{"issue":"260","key":"10.1016\/j.jconrel.2026.115187_bb0060","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009524","article-title":"Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe","volume":"6","author":"Phillips","year":"2014","journal-title":"Sci. Transl. Med."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115187_bb0065","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/s41578-021-00385-x","article-title":"Clinical translation of silica nanoparticles","volume":"6","author":"Janjua","year":"2021","journal-title":"Nat. Rev. Mater."},{"issue":"37","key":"10.1016\/j.jconrel.2026.115187_bb0070","doi-asserted-by":"crossref","first-page":"18590","DOI":"10.1073\/pnas.1906929116","article-title":"Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study","volume":"116","author":"Rastinehad","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.jconrel.2026.115187_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14122703","article-title":"Key parameters for the rational design, synthesis, and functionalization of biocompatible mesoporous silica nanoparticles","volume":"14","author":"Florensa","year":"2022","journal-title":"Pharmaceutics"},{"issue":"6","key":"10.1016\/j.jconrel.2026.115187_bb0080","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1080\/17435390.2024.2401448","article-title":"Immunological properties of silica nanoparticles: a structure-activity relationship study","volume":"18","author":"Grunberger","year":"2024","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.jconrel.2026.115187_bb0085","article-title":"Mesoporous silica nanoparticle-based nanomedicine: preparation, functional modification, and theranostic applications","volume":"34","author":"Liu","year":"2025","journal-title":"Mater. Today Bio"},{"issue":"32","key":"10.1016\/j.jconrel.2026.115187_bb0090","doi-asserted-by":"crossref","first-page":"13202","DOI":"10.1039\/D3NR01332D","article-title":"Nanoparticles with transformable physicochemical properties for overcoming biological barriers","volume":"15","author":"Lu","year":"2023","journal-title":"Nanoscale"},{"issue":"23","key":"10.1016\/j.jconrel.2026.115187_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/nano15231766","article-title":"Nanotoxicity of porous silica nanoparticles: physicochemical properties and mechanistic cellular endpoints","volume":"15","author":"Patel","year":"2025","journal-title":"Nanomaterials"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115187_bb0100","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1021\/acsbiomedchemau.2c00040","article-title":"Sex-specific silica nanoparticle protein corona compositions exposed to male and female BALB\/c mice plasmas","volume":"3","author":"Ashkarran","year":"2023","journal-title":"ACS Bio Med. Chem. Au"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115187_bb0105","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1007\/s10565-022-09776-4","article-title":"Silica nanoparticles induce ovarian granulosa cell apoptosis via activation of the PERK-ATF4-CHOP-ERO1alpha pathway-mediated IP3R1-dependent calcium mobilization","volume":"39","author":"Chen","year":"2023","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.jconrel.2026.115187_bb0110","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.biomaterials.2015.02.070","article-title":"Macrophage silica nanoparticle response is phenotypically dependent","volume":"53","author":"Herd","year":"2015","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.jconrel.2026.115187_bb0115","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1007\/s11051-011-0524-7","article-title":"Differential toxicity of amorphous silica nanoparticles toward phagocytic and epithelial cells","volume":"13","author":"Malugin","year":"2011","journal-title":"J. Nanopart. Res."},{"key":"10.1016\/j.jconrel.2026.115187_bb0120","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jconrel.2020.05.027","article-title":"One-year chronic toxicity evaluation of single dose intravenously administered silica nanoparticles in mice and their Ex vivo human hemocompatibility","volume":"324","author":"Mohammadpour","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115187_bb0125","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jconrel.2019.04.041","article-title":"Subchronic toxicity of silica nanoparticles as a function of size and porosity","volume":"304","author":"Mohammadpour","year":"2019","journal-title":"J. Control. Release"},{"issue":"12","key":"10.1016\/j.jconrel.2026.115187_bb0130","doi-asserted-by":"crossref","first-page":"584","DOI":"10.5414\/CP204837","article-title":"Prediction of silica nanoparticle biodistribution using a calibrated physiologically based model: unbound fraction and elimination rate constants for the kidneys and phagocytosis identified as major determinants","volume":"63","author":"Parrot","year":"2025","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115187_bb0135","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1080\/17435390.2024.2418088","article-title":"Role of physicochemical properties in silica nanoparticle-mediated immunostimulation","volume":"18","author":"Grunberger","year":"2024","journal-title":"Nanotoxicology"},{"issue":"12","key":"10.1016\/j.jconrel.2026.115187_bb0140","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/s41563-020-0755-z","article-title":"The dose threshold for nanoparticle tumour delivery","volume":"19","author":"Ouyang","year":"2020","journal-title":"Nat. Mater."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115187_bb0145","doi-asserted-by":"crossref","first-page":"7442","DOI":"10.1021\/nn404501g","article-title":"Facing the truth about nanotechnology in drug delivery","volume":"7","author":"Park","year":"2013","journal-title":"ACS Nano"},{"issue":"Pt B","key":"10.1016\/j.jconrel.2026.115187_bb0150","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jconrel.2015.08.056","article-title":"Pre-clinical immunotoxicity studies of nanotechnology-formulated drugs: challenges, considerations and strategy","volume":"220","author":"Dobrovolskaia","year":"2015","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115187_bb0155","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1021\/nn2043803","article-title":"Influence of geometry, porosity, and surface characteristics of silica nanoparticles on acute toxicity: their vasculature effect and tolerance threshold","volume":"6","author":"Yu","year":"2012","journal-title":"ACS Nano"},{"issue":"7","key":"10.1016\/j.jconrel.2026.115187_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/polym15071596","article-title":"Nanoparticles as drug delivery systems: a review of the implication of nanoparticles\u2019 physicochemical properties on responses in biological systems","volume":"15","author":"Yusuf","year":"2023","journal-title":"Polymers (Basel)"},{"issue":"null","key":"10.1016\/j.jconrel.2026.115187_bb0165","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.2147\/IJN.S126823","article-title":"In vivo toxicologic study of larger silica nanoparticles in mice","volume":"12","author":"Chan","year":"2017","journal-title":"Int. J. Nanomedicine"},{"issue":"23","key":"10.1016\/j.jconrel.2026.115187_bb0170","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1002\/adma.201205292","article-title":"In vivo bio-safety evaluations and diagnostic\/therapeutic applications of chemically designed mesoporous silica nanoparticles","volume":"25","author":"Chen","year":"2013","journal-title":"Adv. Mater."},{"issue":"24","key":"10.1016\/j.jconrel.2026.115187_bb0175","doi-asserted-by":"crossref","first-page":"9597","DOI":"10.1021\/ac801882g","article-title":"In vivo study of biodistribution and urinary excretion of surface-modified silica nanoparticles","volume":"80","author":"He","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jconrel.2026.115187_bb0180","doi-asserted-by":"crossref","unstructured":"Kim, J.H., et al., Immunotoxicity of silicon dioxide nanoparticles with different sizes and electrostatic charge. Int. J. Nanomedicine, 2014. 9 Suppl 2(Suppl 2): p. 183\u201393.","DOI":"10.2147\/IJN.S57934"},{"issue":"6","key":"10.1016\/j.jconrel.2026.115187_bb0185","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.biomaterials.2010.10.035","article-title":"Single and repeated dose toxicity of mesoporous hollow silica nanoparticles in intravenously exposed mice","volume":"32","author":"Liu","year":"2011","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115187_bb0190","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/smll.200800926","article-title":"Mesoporous silica nanoparticles for reducing hemolytic activity towards mammalian red blood cells","volume":"5","author":"Slowing","year":"2009","journal-title":"Small"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115187_bb0195","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1021\/acs.molpharmaceut.5c01782","article-title":"Macrophage responses to silica nanoparticles: role of physicochemical properties and surface modification","volume":"23","author":"Tonbul","year":"2026","journal-title":"Mol. Pharm."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115187_bb0200","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.etap.2010.05.004","article-title":"Repeated-dose toxicity and inflammatory responses in mice by oral administration of silver nanoparticles","volume":"30","author":"Park","year":"2010","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115187_bb0205","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijpharm.2007.11.005","article-title":"Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes","volume":"354","author":"Ishida","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115187_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113640","article-title":"Effects of silica nanoparticles with varied physicochemical properties on the survival and functionality of saturated macrophages","volume":"381","author":"Saha","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115187_bb0215","author":"Charles River Laboratories International, I"},{"issue":"12","key":"10.1016\/j.jconrel.2026.115187_bb0220","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1097\/00000478-199512000-00007","article-title":"Chronic hepatitis. An update on terminology and reporting","volume":"19","author":"Batts","year":"1995","journal-title":"Am. J. Surg. Pathol."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115187_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14122605","article-title":"Biological features of nanoparticles: protein corona formation and interaction with the immune system","volume":"14","author":"Panico","year":"2022","journal-title":"Pharmaceutics"},{"issue":"12","key":"10.1016\/j.jconrel.2026.115187_bb0230","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/nnano.2012.207","article-title":"Biomolecular coronas provide the biological identity of nanosized materials","volume":"7","author":"Monopoli","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2026.115187_bb0235","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fchem.2014.00108","article-title":"Biomolecular corona on nanoparticles: a survey of recent literature and its implications in targeted drug delivery","volume":"2","author":"Pearson","year":"2014","journal-title":"Front. Chem."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115187_bb0240","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nnano.2013.181","article-title":"Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology","volume":"8","author":"Tenzer","year":"2013","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jconrel.2026.115187_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijft.2026.101593","article-title":"Multiphysics CFD\u2013FSI\u2013DPM analysis of nanoparticle transport and near-wall retention in carotid artery bifurcations","volume":"32","author":"Kyi","year":"2026","journal-title":"Int. J. Thermofluids"},{"issue":"5","key":"10.1016\/j.jconrel.2026.115187_bb0250","doi-asserted-by":"crossref","DOI":"10.1002\/cnm.3568","article-title":"The effect of pharmaceutical nanoparticles and atherosclerosis in aorta artery on the instable blood velocity based on numerical method","volume":"38","author":"Motaghedifar","year":"2022","journal-title":"Int. J. Numer. Methods Biomed. Eng."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115187_bb0255","doi-asserted-by":"crossref","DOI":"10.3390\/ph15111352","article-title":"Magnetic nanoparticles for drug delivery through tapered stenosed artery with blood based non-Newtonian fluid","volume":"15","author":"Bhatti","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115187_bb0260","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3390\/s90100645","article-title":"Reduction of non-specific protein adsorption using poly(ethylene) glycol (PEG) modified polyacrylate hydrogels in immunoassays for staphylococcal enterotoxin B detection","volume":"9","author":"Charles","year":"2009","journal-title":"Sensors"},{"issue":"55","key":"10.1016\/j.jconrel.2026.115187_bb0265","doi-asserted-by":"crossref","first-page":"29134","DOI":"10.1039\/C4RA03277B","article-title":"Effect of surface properties in protein corona development on mesoporous silica nanoparticles","volume":"4","author":"Clemments","year":"2014","journal-title":"RSC Adv."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115187_bb0270","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.biomaterials.2009.10.046","article-title":"The effect of PEGylation of mesoporous silica nanoparticles on nonspecific binding of serum proteins and cellular responses","volume":"31","author":"He","year":"2010","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115187_bb0275","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1038\/s41467-021-23230-9","article-title":"Sex as an important factor in nanomedicine","volume":"12","author":"Hajipour","year":"2021","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115187_bb0280","doi-asserted-by":"crossref","DOI":"10.1002\/anbr.202200089","article-title":"Sex-based differences in the biodistribution of nanoparticles and their effect on hormonal, immune, and metabolic function","volume":"2","author":"Poley","year":"2022","journal-title":"Adv. NanoBiomed. Res."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115187_bb0285","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115187_bb0290","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1021\/acsnano.7b06212","article-title":"Effect of cell sex on uptake of nanoparticles: the overlooked factor at the nanobio interface","volume":"12","author":"Serpooshan","year":"2018","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115187_bb0295","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1039\/C7EN00071E","article-title":"Female versus male biological identities of nanoparticles determine the interaction with immune cells in fish","volume":"4","author":"Hayashi","year":"2017","journal-title":"Environ. Sci. Nano"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115187_bb0300","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.xphs.2023.11.001","article-title":"Treatment-induced and pre-existing anti-peg antibodies: prevalence, clinical implications, and future perspectives","volume":"113","author":"Gaballa","year":"2024","journal-title":"J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115187_bb0305","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jconrel.2007.05.015","article-title":"PEGylated liposomes elicit an anti-PEG IgM response in a T cell-independent manner","volume":"122","author":"Ishida","year":"2007","journal-title":"J. Control. Release"},{"issue":"24","key":"10.1016\/j.jconrel.2026.115187_bb0310","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.1158\/1078-0432.CCR-10-0978","article-title":"Phase I and pharmacokinetic studies of CYT-6091, a novel PEGylated colloidal gold-rhTNF nanomedicine","volume":"16","author":"Libutti","year":"2010","journal-title":"Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115187_bb0315","article-title":"PEGylation in pharmaceutical development: current status and emerging trends in macromolecular and immunotherapeutic drugs","volume":"16","author":"Santhanakrishnan","year":"2024","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115187_bb0320","doi-asserted-by":"crossref","DOI":"10.1080\/10717544.2025.2494775","article-title":"PEGylation technology: addressing concerns, moving forward","volume":"32","author":"Simberg","year":"2025","journal-title":"Drug Deliv."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115187_bb0325","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/wnan.1339","article-title":"Anti-PEG immunity: emergence, characteristics, and unaddressed questions","volume":"7","author":"Yang","year":"2015","journal-title":"WIREs Nanomed. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115187_bb0330","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10937404.2022.2153456","article-title":"Nanomaterial-induced toxicity in pathophysiological models representative of individuals with pre-existing medical conditions","volume":"26","author":"Sreedharan","year":"2023","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115187_bb0335","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1021\/acs.est.6b05200","article-title":"Susceptibility of overweight mice to liver injury as a result of the ZnO nanoparticle-enhanced liver deposition of Pb2+","volume":"51","author":"Jia","year":"2017","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115187_bib361","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1021\/nn304439f","article-title":"Nanoparticle geometry and surface orientation influence mode of cellular uptake","volume":"7","author":"Herd","year":"2013","journal-title":"ACS Nano."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115187_bib362","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1021\/nl403949h","article-title":"Shape and orientation matter for the cellular uptake of nonspherical particles","volume":"14","author":"Dasgupta","year":"2014","journal-title":"Nano Lett."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115187_bib363","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1038\/s41598-017-03834-2","article-title":"A comparison between sphere and rod nanoparticles regarding their in vivo biological behavior and pharmacokinetics","volume":"7","author":"Zhao","year":"2017","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115187_bb0340","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J. Basic Clin. Pharm."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115187_bb0345","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics9020012","article-title":"Liposomal formulations in clinical use: an updated review","volume":"9","author":"Bulbake","year":"2017","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115187_bb0350","article-title":"Comparisons of the biodistribution and toxicological examinations after repeated intravenous administration of silver and gold nanoparticles in mice","volume":"7","author":"Yang","year":"2017","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115187_bb0355","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11102848","article-title":"Investigating acute hepatitis after SARS-CoV-2 vaccination or infection: a genetic case series","volume":"11","author":"Bernasconi","year":"2023","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115187_bb0360","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.gande.2024.01.003","article-title":"Impact of COVID-19 vaccines on liver function: a state of the art and challenges for healthcare providers","volume":"2","author":"Elumalai","year":"2024","journal-title":"Gastroenterol. Endosc."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926005900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926005900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:20:24Z","timestamp":1787804424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926005900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":75,"alternative-id":["S0168365926005900"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115187","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo systemic toxicity of silica nanoparticles: Effects of sex, dose, and nanoparticle physicochemical properties","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115187","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115187"}}