{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:00:38Z","timestamp":1790215238806,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003086","name":"Basque Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Espa\u00f1a Ministerio de Ciencia Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jconrel.2026.115196","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:45:34Z","timestamp":1785393934000},"page":"115196","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Stable, long-acting mesenchymal stromal cell secretome delivery via injectable starPEG\u2013heparin hydrogels for sustained immunomodulation"],"prefix":"10.1016","volume":"398","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7063-7053","authenticated-orcid":false,"given":"Maria","family":"Rossello-Gelabert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1132-808X","authenticated-orcid":false,"given":"Lucas","family":"Schirmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1359-1095","authenticated-orcid":false,"given":"Uwe","family":"Freudenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7064-4563","authenticated-orcid":false,"given":"Edorta","family":"Santos-Vizcaino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0189-3448","authenticated-orcid":false,"given":"Carsten","family":"Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3947-409X","authenticated-orcid":false,"given":"Rosa Maria","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.115196_bb0005","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41392-025-02313-9","article-title":"Mesenchymal stem cells in treating human diseases: molecular mechanisms and clinical studies","volume":"10","author":"Han","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2026.115196_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176719","article-title":"Mesenchymal stem cells biological and biotechnological advances: implications for clinical applications","volume":"977","author":"Pharoun","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jconrel.2026.115196_bb0015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cytogfr.2022.07.002","article-title":"Clinical progress in MSC-based therapies for the management of severe COVID-19","volume":"68","author":"Rossello-Gelabert","year":"2022","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.jconrel.2026.115196_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.960909","article-title":"Comparison of EV-free fraction, EVs, and total secretome of amniotic mesenchymal stromal cells for their immunomodulatory potential: a translational perspective","volume":"13","author":"Papait","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2026.115196_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120633","article-title":"Dissecting the effects of preconditioning with inflammatory cytokines and hypoxia on the angiogenic potential of mesenchymal stromal cell (MSC)-derived soluble proteins and extracellular vesicles (EVs)","volume":"269","author":"Gorgun","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115196_bb0030","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41392-022-00932-0","article-title":"The secretion profile of mesenchymal stem cells and potential applications in treating human diseases","volume":"7","author":"Han","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2026.115196_bb0035","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41536-024-00382-y","article-title":"Proteomic profiling of iPSC- and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing","volume":"10","author":"Hodgson-Garms","year":"2025","journal-title":"npj Regener. Med."},{"key":"10.1016\/j.jconrel.2026.115196_bb0040","doi-asserted-by":"crossref","first-page":"9379","DOI":"10.3390\/ijms24119379","article-title":"Potency assays for mesenchymal stromal cell secretome-based products for tissue regeneration","volume":"24","author":"Sagaradze","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2026.115196_bb0045","doi-asserted-by":"crossref","first-page":"2616807","DOI":"10.1155\/2021\/2616807","article-title":"Comparing the therapeutic potential of stem cells and their secretory products in regenerative medicine","volume":"2021","author":"Foo","year":"2021","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.jconrel.2026.115196_bb0050","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s13287-025-04315-4","article-title":"Fine-tuning licensing strategies to boost MSC-based immunomodulatory secretome","volume":"16","author":"Rossello-Gelabert","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jconrel.2026.115196_bb0055","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202001689","article-title":"Effects of mesenchymal stem cell-derived paracrine signals and their delivery strategies","volume":"10","author":"Chang","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2026.115196_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202370081","article-title":"Suppressing mesenchymal stromal cell ferroptosis via targeting a metabolism-epigenetics axis corrects their poor retention and insufficient healing benefits in the injured liver milieu","volume":"10","author":"Hu","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.115196_bb0065","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41392-024-01936-8","article-title":"Pharmacokinetic characteristics of mesenchymal stem cells in translational challenges","volume":"9","author":"Shan","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2026.115196_bb0070","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/stmcls\/sxad087","article-title":"Procoagulant properties of mesenchymal stem cells and extracellular vesicles: a novel aspect of thrombosis pathogenesis","volume":"42","author":"Yang","year":"2024","journal-title":"Stem Cells"},{"key":"10.1016\/j.jconrel.2026.115196_bb0075","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41420-022-01107-0","article-title":"Mesenchymal\/stromal stem cells: necessary factors in tumour progression","volume":"8","author":"Li","year":"2022","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.jconrel.2026.115196_bb0080","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/med.22002","article-title":"Translating mesenchymal stem cell and their exosome research into GMP-compliant advanced therapy products: promises, problems and prospects","volume":"44","author":"Ma","year":"2024","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jconrel.2026.115196_bb0085","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.jcyt.2024.04.074","article-title":"GMP-compliant extracellular vesicles derived from umbilical cord mesenchymal stromal cells: manufacturing and pre-clinical evaluation in ARDS treatment","volume":"26","author":"Costa-Ferro","year":"2024","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jconrel.2026.115196_bb0090","doi-asserted-by":"crossref","first-page":"1421854","DOI":"10.3389\/fimmu.2024.1421854","article-title":"Advances and clinical challenges of mesenchymal stem cell therapy","volume":"15","author":"Mei","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2026.115196_bb0095","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.stem.2018.05.004","article-title":"Mesenchymal stromal cells: clinical challenges and therapeutic opportunities","volume":"22","author":"Galipeau","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jconrel.2026.115196_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.969178","article-title":"Mesenchymal stromal cells: preclinical and clinical challenges","volume":"10","author":"Oliva","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jconrel.2026.115196_bb0105","doi-asserted-by":"crossref","first-page":"eaba6884","DOI":"10.1126\/sciadv.aba6884","article-title":"Shattering barriers toward clinically meaningful MSC therapies","volume":"6","author":"Levy","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2026.115196_bb0110","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3390\/cells7110190","article-title":"Pilot production of mesenchymal stem\/stromal freeze-dried secretome for cell-free regenerative nanomedicine: a validated GMP-compliant process","volume":"7","author":"Bari","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2026.115196_bb0115","article-title":"Freeze-dried mesenchymal stem cells: from bench to bedside","volume":"8","author":"Paresishvili","year":"2024","journal-title":"Adv. Biol. (Weinh.)"},{"key":"10.1016\/j.jconrel.2026.115196_bb0120","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.3390\/pharmaceutics13081129","article-title":"Freeze-dried mesenchymal stem cell-secretome pharmaceuticalization: optimization of formulation and manufacturing process robustness","volume":"13","author":"Mocchi","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2026.115196_bb0125","doi-asserted-by":"crossref","first-page":"849","DOI":"10.3390\/pharmaceutics14040849","article-title":"Development of a lyophilized off-the-shelf mesenchymal stem cell-derived acellular therapeutic","volume":"14","author":"Driscoll","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2026.115196_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2018.10.032","article-title":"Preservation of exosomes at room temperature using lyophilization","volume":"553","author":"Charoenviriyakul","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115196_bb0135","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.biologicals.2014.07.005","article-title":"Stabilization of a recombinant human epidermal growth factor parenteral formulation through freeze-drying","volume":"42","author":"Santana","year":"2014","journal-title":"Biologicals"},{"key":"10.1016\/j.jconrel.2026.115196_bb0140","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.1021\/acsomega.3c08280","article-title":"Extracellular vesicles and hydrogels: an innovative approach to tissue regeneration","volume":"9","author":"Hashemi","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.jconrel.2026.115196_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202001948","article-title":"Engineering the MSC secretome: a hydrogel-focused approach","volume":"10","author":"Wechsler","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2026.115196_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119557","article-title":"Glycosaminoglycan-based hydrogels with programmable host reactions","volume":"228","author":"Schirmer","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115196_bb0155","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-1-0716-2655-9_8","article-title":"Three-dimensional biohybrid starPEG\u2013heparin hydrogel cultures for modeling human neuronal development and Alzheimer\u2019s disease pathology","volume":"2561","author":"Siddiqui","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jconrel.2026.115196_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.112268","article-title":"Bioresponsive starPEG\u2013heparin hydrogel coatings on vascular stents for enhanced hemocompatibility","volume":"128","author":"Johnbosco","year":"2021","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115196_bb0165","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1515\/hsz-2021-0175","article-title":"Tuning the network charge of biohybrid hydrogel matrices to modulate the release of SDF-1","volume":"402","author":"K\u00fchn","year":"2021","journal-title":"Biol. Chem."},{"issue":"17","key":"10.1016\/j.jconrel.2026.115196_bb0170","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202202803","article-title":"Sustained release of human adipose tissue stem cell secretome from star-shaped poly(ethylene glycol) glycosaminoglycan hydrogels promotes motor improvements after complete transection in a spinal cord injury rat model","volume":"12","author":"Silva","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2026.115196_bb0175","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.actbio.2022.04.023","article-title":"Granular PEG hydrogels mediate osteoporotic MSC clustering via N-cadherin influencing the pro-resorptive bias of their secretory profile","volume":"145","author":"Rao","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2026.115196_bb0180","article-title":"Unravelling the molecular network structure of biohybrid hydrogels","volume":"34","author":"Sievers-Liebschner","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.jconrel.2026.115196_bb0185","article-title":"Cell secretomes used as sole building blocks enable the fabrication of stable hydrogels for biomedical applications","volume":"12","author":"Santos-Coquillat","year":"2025","journal-title":"Matter"},{"key":"10.1016\/j.jconrel.2026.115196_bb0190","first-page":"87","article-title":"Biomedical applications of engineered heparin-based materials","volume":"31","author":"Nazarzadeh Zare","year":"2023","journal-title":"Bioact. Mater."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115196_bb0195","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1021\/acsbiomaterials.5c00597","article-title":"Hydrogel-based strategies for managing rheumatoid arthritis: from sustained drug release to cell-based therapies","volume":"11","author":"Back","year":"2025","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"14","key":"10.1016\/j.jconrel.2026.115196_bb0200","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202202202","article-title":"Exploring the potential of PEG-heparin hydrogels to support long-term ex vivo culture of patient-derived breast explant tissues","volume":"12","author":"Koch","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2026.115196_bb0205","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1186\/s13287-025-04775-8","article-title":"Immortalized human hair follicle-derived mesenchymal-like stromal cells for the long-term production of scalable immunomodulatory and regenerative secretome","volume":"16","author":"Rossello-Gelabert","year":"2025","journal-title":"Stem Cell Res. Ther."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115196_bb0210","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jcyt.2023.04.001","article-title":"Extracellular vesicles released by hair follicle and adipose mesenchymal stromal cells induce comparable neuroprotective and anti-inflammatory effects in primary neuronal and microglial cultures","volume":"25","author":"Hernando","year":"2023","journal-title":"Cytotherapy"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115196_bb0215","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s13287-022-02824-0","article-title":"Extracellular vesicles from hair follicle-derived mesenchymal stromal cells: isolation, characterization and therapeutic potential for chronic wound healing","volume":"13","author":"Las Heras","year":"2022","journal-title":"Stem Cell Res. Ther."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115196_bb0220","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3390\/biomedicines10020253","article-title":"Human hair follicle-derived mesenchymal stromal cells from the lower dermal sheath as a competitive alternative for immunomodulation","volume":"10","author":"Hernaez-Estrada","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.jconrel.2026.115196_bb0225","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1021\/bc500217z","article-title":"Chemoselective peptide functionalization of starPEG\u2013GAG hydrogels","volume":"25","author":"Tsurkan","year":"2014","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.jconrel.2026.115196_bb0230","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1126\/science.1171643","article-title":"Growth factors, matrices, and forces combine and control stem cells","volume":"324","author":"Discher","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2026.115196_bb0235","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1093\/glycob\/9.7.705","article-title":"Structural features in heparin that interact with VEGF165 and modulate its biological activity","volume":"9","author":"Ono","year":"1999","journal-title":"Glycobiology"},{"key":"10.1016\/j.jconrel.2026.115196_bb0240","doi-asserted-by":"crossref","first-page":"7985","DOI":"10.1016\/j.biomaterials.2010.07.021","article-title":"FGF-2 and VEGF functionalization of starPEG\u2013heparin hydrogels to modulate biomolecular and physical cues of angiogenesis","volume":"31","author":"Zieris","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115196_bb0245","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0378-5173(89)90306-2","article-title":"A simple equation for the description of solute release. III. Coupling of diffusion and relaxation","volume":"57","author":"Peppas","year":"1989","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115196_bb0250","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/gels3010006","article-title":"Hydrogels for biomedical applications: their characteristics and the mechanisms behind them","volume":"3","author":"Chai","year":"2017","journal-title":"Gels"},{"key":"10.1016\/j.jconrel.2026.115196_bb0255","series-title":"Polymer Physics","author":"Rubinstein","year":"2003"},{"key":"10.1016\/j.jconrel.2026.115196_bb0260","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/s41377-022-00980-9","article-title":"Light-induced tumor theranostics based on chemical-exfoliated borophene","volume":"11","author":"Xie","year":"2022","journal-title":"Light Sci. Appl."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115196_bb0265","doi-asserted-by":"crossref","first-page":"20230128","DOI":"10.1002\/EXP.20230128","article-title":"Detection of biological loads in sewage using the automated robot-driven photoelectrochemical biosensing platform","volume":"4","author":"Zhang","year":"2024","journal-title":"Exploration"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926005997?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926005997?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:03:59Z","timestamp":1790211839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926005997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":53,"alternative-id":["S0168365926005997"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115196","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stable, long-acting mesenchymal stromal cell secretome delivery via injectable starPEG\u2013heparin hydrogels for sustained immunomodulation","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115196","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115196"}}