{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:20:18Z","timestamp":1787804418353,"version":"build-2784847793"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jconrel.2026.115202","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:35:25Z","timestamp":1784853325000},"page":"115202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Biomimetic nanovesicle mediated GSDME delivery reprograms the tumor immune microenvironment via pyroptosis to enhance radiotherapy"],"prefix":"10.1016","volume":"397","author":[{"given":"Paiyun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoran","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiying","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baixue","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuihong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.115202_bb0005","doi-asserted-by":"crossref","first-page":"e352","DOI":"10.1016\/S1470-2045(24)00075-5","article-title":"Radiotherapy, immunity, and immune checkpoint inhibitors","volume":"25","author":"Lynch","year":"2024","journal-title":"Lancet Oncol."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115202_bb0010","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1140\/epjp\/s13360-026-07641-5","article-title":"Extracellular vesicles and interventional radiotherapy (modern brachytherapy): a translational gap analysis of dose-gradient-driven biological responses","volume":"141","author":"Rosa","year":"2026","journal-title":"Eur. Phys. J. Plus"},{"key":"10.1016\/j.jconrel.2026.115202_bb0015","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41568-024-00714-6","article-title":"Towards targeting the breast cancer immune microenvironment","volume":"24","author":"Harris","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jconrel.2026.115202_bb0020","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41392-023-01462-z","article-title":"Radiation-induced tumor immune microenvironments and potential targets for combination therapy","volume":"8","author":"Guo","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2026.115202_bb0025","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41577-021-00568-1","article-title":"Immunomodulation by radiotherapy in tumour control and normal tissue toxicity","volume":"22","author":"Cytlak","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2026.115202_bb0030","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1186\/s12951-025-03608-3","article-title":"Multifunctional nanoagent for enhanced cancer radioimmunotherapy via pyroptosis and Cgas-sting activation","volume":"23","author":"Xu","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2026.115202_bb0035","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s13046-022-02533-9","article-title":"Otud4-mediated Gsdme deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis","volume":"41","author":"Di","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jconrel.2026.115202_bb0040","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/s41423-022-00905-x","article-title":"Role of pyroptosis in inflammation and cancer","volume":"19","author":"Wei","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jconrel.2026.115202_bb0045","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s12943-025-02506-4","article-title":"Pyroptosis in cancer therapy: a double-edged sword for immune activation and tumor progression","volume":"24","author":"Alishvandi","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jconrel.2026.115202_bb0050","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41580-025-00837-0","article-title":"Mechanistic insights into gasdermin-mediated pyroptosis","volume":"26","author":"Bai","year":"2025","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jconrel.2026.115202_bb0055","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-020-2071-9","article-title":"Gasdermin E suppresses tumour growth by activating anti-tumour immunity","volume":"579","author":"Zhang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2026.115202_bb0060","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13045-024-01545-6","article-title":"Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis","volume":"17","author":"Zhou","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.jconrel.2026.115202_bb0065","article-title":"Pyroptosis-inducing platinum(iv) prodrugs via Gsdme pathway for chemoimmunotherapy and metastasis inhibition in triple-negative breast cancer","volume":"12","author":"Yang","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.115202_bb0070","doi-asserted-by":"crossref","DOI":"10.1002\/EXP.20230171","article-title":"Tumor cell membrane-based vaccines: a potential boost for cancer immunotherapy","volume":"4","author":"Yang","year":"2024","journal-title":"Exploration"},{"key":"10.1016\/j.jconrel.2026.115202_bb0075","doi-asserted-by":"crossref","first-page":"2102330","DOI":"10.1002\/advs.202102330","article-title":"Engineered cell membrane-derived nanoparticles in immune modulation","volume":"8","author":"Yang","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.115202_bb0080","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1021\/acsnano.0c09681","article-title":"Immunogenic hybrid nanovesicles of liposomes and tumor-derived nanovesicles for cancer immunochemotherapy","volume":"15","author":"Hu","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115202_bb0085","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1021\/acsnano.2c09033","article-title":"Tumor-antigen activated dendritic cell membrane-coated biomimetic nanoparticles with orchestrating immune responses promote therapeutic efficacy against glioma","volume":"17","author":"Ma","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115202_bb0090","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s13046-021-02065-8","article-title":"Pyroptosis at the forefront of anticancer immunity","volume":"40","author":"Loveless","year":"2021","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jconrel.2026.115202_bb0095","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cell.2024.11.018","article-title":"Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells","volume":"188","author":"Wright","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.jconrel.2026.115202_bb0100","article-title":"An endoplasmic reticulum stress-specific nanoinducer selectively evokes type-II immunogenic cell death for pyroptotic cancer immunotherapy","volume":"37","author":"Zhang","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115202_bb0105","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/s41419-020-03221-2","article-title":"Detection of immunogenic cell death and its relevance for cancer therapy","volume":"11","author":"Fucikova","year":"2020","journal-title":"Cell Death Dis."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926006061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926006061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:14:55Z","timestamp":1787804095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926006061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":21,"alternative-id":["S0168365926006061"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115202","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomimetic nanovesicle mediated GSDME delivery reprograms the tumor immune microenvironment via pyroptosis to enhance radiotherapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115202","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115202"}}