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Biol."},{"key":"10.1016\/j.jconrel.2026.115204_bb0680","doi-asserted-by":"crossref","DOI":"10.1016\/j.virol.2024.110285","article-title":"Strengths and limitations of SARS-CoV-2 virus-like particle systems","volume":"601","author":"Sultana","year":"2025","journal-title":"Virology"},{"key":"10.1016\/j.jconrel.2026.115204_bb0685","doi-asserted-by":"crossref","first-page":"14651","DOI":"10.1038\/s41598-022-18681-z","article-title":"Optimized production and fluorescent labeling of SARS-CoV-2 virus-like particles","volume":"12","author":"Gourdelier","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2026.115204_bb0690","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.jcis.2022.12.090","article-title":"Mechanical tuning of virus-like particles","volume":"634","author":"Radiom","year":"2023","journal-title":"J. Colloid Interface Sci."},{"issue":"42","key":"10.1016\/j.jconrel.2026.115204_bb0695","doi-asserted-by":"crossref","first-page":"15110","DOI":"10.1073\/pnas.0504407102","article-title":"Single-particle tracking of murine polyoma virus-like particles on live cells and artificial membranes","volume":"102","author":"Ewers","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115204_bb0700","doi-asserted-by":"crossref","first-page":"9145","DOI":"10.1038\/s41467-025-64200-9","article-title":"Muscle-specific gene editing therapy via mammalian fusogen-directed virus-like particles","volume":"16","author":"Zhou","year":"2025","journal-title":"Nat. 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