{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T14:53:25Z","timestamp":1793717605419,"version":"4.6.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003645","name":"National Cancer Center","doi-asserted-by":"publisher","award":["2610420"],"award-info":[{"award-number":["2610420"]}],"id":[{"id":"10.13039\/501100003645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008746","name":"National Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008746","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2025-00560571"],"award-info":[{"award-number":["RS-2025-00560571"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jconrel.2026.115212","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:17:09Z","timestamp":1785169029000},"page":"115212","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Cleavage-activatable antibody-photosensitizer conjugate enables tumor-selective photodynamic activation and immunogenic cell death"],"prefix":"10.1016","volume":"398","author":[{"given":"Yeo-Jin","family":"Yoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon Sook","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongdoo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.115212_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.148607","article-title":"Emerging trends and therapeutic applications of monoclonal antibodies","volume":"925","author":"Mekala","year":"2024","journal-title":"Gene"},{"issue":"16","key":"10.1016\/j.jconrel.2026.115212_bb0010","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1056\/NEJMra2312718","article-title":"Neonatal Fc receptor - biology and therapeutics","volume":"392","author":"Bussel","year":"2025","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115212_bb0015","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s11095-023-03649-z","article-title":"Antibody-drug conjugate overview: a state-of-the-art manufacturing process and control strategy","volume":"41","author":"Li","year":"2024","journal-title":"Pharm. Res."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115212_bb0020","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41571-021-00470-8","article-title":"Unlocking the potential of antibody-drug conjugates for cancer therapy","volume":"18","author":"Drago","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115212_bb0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/intimm\/dxaa037","article-title":"Near-infrared photoimmunotherapy of cancer: a new approach that kills cancer cells and enhances anti-cancer host immunity","volume":"33","author":"Kobayashi","year":"2021","journal-title":"Int. Immunol."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115212_bb0030","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1007\/s43630-024-00638-y","article-title":"Recent development of nanomaterials-based PDT to improve immunogenic cell death","volume":"23","author":"Ain","year":"2024","journal-title":"Photochem. Photobiol. Sci."},{"issue":"21","key":"10.1016\/j.jconrel.2026.115212_bb0035","doi-asserted-by":"crossref","first-page":"5117","DOI":"10.3390\/cancers15215117","article-title":"Review of RM-1929 near-infrared photoimmunotherapy clinical efficacy for unresectable and\/or recurrent head and neck squamous cell carcinoma","volume":"15","author":"Miyazaki","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"20","key":"10.1016\/j.jconrel.2026.115212_bb0040","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.1200\/JCO.2003.11.069","article-title":"Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis","volume":"21","author":"Hirsch","year":"2003","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115212_bb0045","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1200\/JCO.2000.18.4.904","article-title":"Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin","volume":"18","author":"Baselga","year":"2000","journal-title":"J. Clin. Oncol."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115212_bb0050","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1021\/acschembio.1c00138","article-title":"Selective neutral pH inhibitor of cathepsin B designed based on cleavage preferences at cytosolic and lysosomal pH conditions","volume":"16","author":"Yoon","year":"2021","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jconrel.2026.115212_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.rechem.2025.102120","article-title":"Design and synthesis of water-solube chlorin derivatives as photosensitizer for photodynamic therapy","volume":"14","author":"Yang","year":"2025","journal-title":"Results Chem."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115212_bb0060","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3390\/biomimetics5040053","article-title":"Learning from nature: bioinspired chlorin-based photosensitizers immobilized on carbon materials for combined photodynamic and photothermal therapy","volume":"5","author":"Dias","year":"2020","journal-title":"Biomimetics (Basel)"},{"issue":"45","key":"10.1016\/j.jconrel.2026.115212_bb0065","doi-asserted-by":"crossref","first-page":"9722","DOI":"10.1021\/bi100907m","article-title":"Distance mapping in proteins using fluorescence spectroscopy: the tryptophan-induced quenching (TrIQ) method","volume":"49","author":"Mansoor","year":"2010","journal-title":"Biochemistry"},{"issue":"1\u20132","key":"10.1016\/j.jconrel.2026.115212_bb0070","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ijpharm.2016.09.071","article-title":"Photosensitizer-conjugated tryptophan-containing peptide ligands as new dual-targeted theranostics for cancers","volume":"513","author":"Kim","year":"2016","journal-title":"Int. J. Pharm."},{"issue":"15","key":"10.1016\/j.jconrel.2026.115212_bb0075","article-title":"Activatable photosensitizers: from fundamental principles to advanced designs","volume":"64","author":"Kwon","year":"2025","journal-title":"Angew. Chem. Int. Ed. Eng."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115212_bb0080","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.3390\/molecules28052348","article-title":"Dissecting the interactions between chlorin e6 and human serum albumin","volume":"28","author":"Marconi","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.jconrel.2026.115212_bb0085","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jconrel.2019.10.010","article-title":"Evaluation of polyvinylpyrrolidone and block copolymer micelle encapsulation of serine chlorin e6 and chlorin e4 on their reactivity towards albumin and transferrin and their cell uptake","volume":"316","author":"Gjuroski","year":"2019","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115212_bb0090","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1039\/D4TB01782J","article-title":"Experimental and computational techniques to investigate the protein resistance of zwitterionic polymers","volume":"13","author":"Lu","year":"2025","journal-title":"J. Mater. Chem. B"},{"issue":"19","key":"10.1016\/j.jconrel.2026.115212_bb0095","doi-asserted-by":"crossref","first-page":"25236","DOI":"10.1021\/acsami.4c01401","article-title":"Machine-learning-aided understanding of protein adsorption on zwitterionic polymer brushes","volume":"16","author":"Okuyama","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115212_bb0100","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115212_bb0105","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.7150\/jca.51537","article-title":"An update in clinical utilization of photodynamic therapy for lung cancer","volume":"12","author":"Wang","year":"2021","journal-title":"J. Cancer"},{"key":"10.1016\/j.jconrel.2026.115212_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2024.102845","article-title":"Neoadjuvant immunotherapy strategies for resectable non-small cell lung cancer (NSCLC): current evidence among special populations and future perspectives","volume":"131","author":"Parisi","year":"2024","journal-title":"Cancer Treat. Rev."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115212_bb0115","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41571-022-00685-3","article-title":"Mitigating acute chemotherapy-associated adverse events in patients with cancer","volume":"19","author":"Kuderer","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2026.115212_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115787","article-title":"Chemotherapy-induced gastrointestinal toxicity: pathogenesis and current management","volume":"216","author":"He","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jconrel.2026.115212_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2022.102427","article-title":"Chemotherapy-induced neutropenia and emerging agents for prevention and treatment: a review","volume":"109","author":"Blayney","year":"2022","journal-title":"Cancer Treat. Rev."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115212_bb0130","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nrc.2017.93","article-title":"Transport of drugs from blood vessels to tumour tissue","volume":"17","author":"Dewhirst","year":"2017","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115212_bb0135","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41416-022-02109-6","article-title":"Cell proliferation, drug distribution and therapeutic effects in relation to the vascular system of solid tumours","volume":"128","author":"Tannock","year":"2023","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115212_bb0140","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1039\/D0BM01148G","article-title":"Quenched cetuximab conjugate for fast fluorescence imaging of EGFR-positive lung cancers","volume":"9","author":"Kim","year":"2021","journal-title":"Biomater. Sci."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115212_bb0145","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1158\/0008-5472.CAN-10-3069","article-title":"Detection of circulating tumor cells in human peripheral blood using surface-enhanced Raman scattering nanoparticles","volume":"71","author":"Wang","year":"2011","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115212_bb0150","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.3892\/ol.2017.6591","article-title":"Non-small cell lung cancer PC-9 cells exhibit increased sensitivity to gemcitabine and vinorelbine upon acquiring resistance to EGFR-tyrosine kinase inhibitors","volume":"14","author":"Hamamoto","year":"2017","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jconrel.2026.115212_bb0155","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1476-4598-7-42","article-title":"Evidence for efficient phosphorylation of EGFR and rapid endocytosis of phosphorylated EGFR via the early\/late endocytic pathway in a gefitinib-sensitive non-small cell lung cancer cell line","volume":"7","author":"Nishimura","year":"2008","journal-title":"Mol. Cancer"},{"issue":"12","key":"10.1016\/j.jconrel.2026.115212_bb0160","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nrc3380","article-title":"Immunogenic cell death and DAMPs in cancer therapy","volume":"12","author":"Krysko","year":"2012","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115212_bb0165","article-title":"Cascade-activatable small-molecule theranostic nanomicelles for photodynamic-immunotherapy of immune-cold lung tumors","volume":"21","author":"Yoon","year":"2026","journal-title":"Asian J. Pharm. Sci."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115212_bb0170","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1002\/1878-0261.12851","article-title":"Targeting immunogenic cell death in cancer","volume":"14","author":"Ahmed","year":"2020","journal-title":"Mol. Oncol."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115212_bb0175","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/php.13267","article-title":"Targeted photodynamic therapy of human head and neck squamous cell carcinoma with anti-epidermal growth factor receptor antibody cetuximab and photosensitizer IR700DX in the mouse skin-fold window chamber model","volume":"96","author":"Peng","year":"2020","journal-title":"Photochem. Photobiol."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115212_bb0180","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.30.12.126002","article-title":"Epidermal growth factor receptor-targeted near-infrared probe cetuximab-IRDye800CW enables stable and tumor-specific fluorescence imaging in colorectal cancer models","volume":"30","author":"Huang","year":"2025","journal-title":"J. Biomed. Opt."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115212_bb0185","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/php.12018","article-title":"Photodynamic tumor eradication with a novel targetable photosensitizer: strong vascular effects and dependence on treatment repetition versus potentiation","volume":"89","author":"Savellano","year":"2013","journal-title":"Photochem. Photobiol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115212_bb0190","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001926","article-title":"Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future","volume":"9","author":"Alzeibak","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jconrel.2026.115212_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109661","article-title":"Chlorin e6-induced photodynamic effect facilitates immunogenic cell death of lung cancer as a result of oxidative endoplasmic reticulum stress and DNA damage","volume":"115","author":"Yu","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115212_bb0200","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3390\/ph15050564","article-title":"Cathepsin B-cleavable polymeric photosensitizer prodrug for selective photodynamic therapy: in vitro studies","volume":"15","author":"Jain","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"issue":"10","key":"10.1016\/j.jconrel.2026.115212_bb0205","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1007\/s00262-011-1047-x","article-title":"Involvement of damage-associated molecular patterns in tumor response to photodynamic therapy: surface expression of calreticulin and high-mobility group box-1 release","volume":"60","author":"Korbelik","year":"2011","journal-title":"Cancer Immunol. Immunother."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926006164?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926006164?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:01:18Z","timestamp":1790211678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926006164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":41,"alternative-id":["S0168365926006164"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115212","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cleavage-activatable antibody-photosensitizer conjugate enables tumor-selective photodynamic activation and immunogenic cell death","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115212","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115212"}}