{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:01:01Z","timestamp":1790215261862,"version":"4.1.0"},"reference-count":143,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jconrel.2026.115241","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T23:34:33Z","timestamp":1786059273000},"page":"115241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Engineering integrated drug\u2013device systems for autonomous administration, programmable release, and therapeutic control"],"prefix":"10.1016","volume":"398","author":[{"given":"Ningye","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoao","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dapeng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.115241_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101853","article-title":"Emerging trends in drug-device combination for advanced disease diagnosis and therapy","volume":"50","author":"Liu","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2026.115241_bb0010","first-page":"5","article-title":"Lifestyle medicine: why do we need it?, medical","volume":"28","author":"Pijl","year":"2018","journal-title":"Sci. Educ."},{"issue":"19","key":"10.1016\/j.jconrel.2026.115241_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26195905","article-title":"Controlled drug delivery systems: current status and future directions","volume":"26","author":"Adepu","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jconrel.2026.115241_bb0020","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.jconrel.2022.12.029","article-title":"Colonic drug delivery: formulating the next generation of colon-targeted therapeutics","volume":"353","author":"McCoubrey","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115241_bb0025","doi-asserted-by":"crossref","first-page":"792","DOI":"10.2471\/BLT.17.205732","article-title":"Recognizing noncommunicable diseases as a global health security threat","volume":"96","author":"Saha","year":"2018","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.jconrel.2026.115241_bb0030","doi-asserted-by":"crossref","first-page":"586","DOI":"10.2471\/BLT.17.206763","article-title":"Global susceptibility and response to noncommunicable diseases","volume":"96","author":"Hatefi","year":"2018","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.jconrel.2026.115241_bb0035","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1016\/j.apsb.2022.02.002","article-title":"Why 90% of clinical drug development fails and how to improve it?","volume":"12","author":"Sun","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2026.115241_bb0040","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/17425247.2022.2051476","article-title":"Progress and limitations of oral peptide delivery as a potentially transformative therapy","volume":"19","author":"Tran","year":"2022","journal-title":"Expert Opin. Drug Deliv."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115241_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/asi6040062","article-title":"Advances and challenges in IoT-based smart drug delivery systems: a comprehensive review","volume":"6","author":"Raikar","year":"2023","journal-title":"Appl. Syst. Innov."},{"key":"10.1016\/j.jconrel.2026.115241_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113997","article-title":"Toward closed-loop drug delivery: integrating wearable technologies with transdermal drug delivery systems","volume":"179","author":"Manikkath","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.115241_bb0055","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1208\/s12248-015-9814-9","article-title":"Drug delivery approaches in addressing clinical pharmacology-related issues: opportunities and challenges","volume":"17","author":"Wen","year":"2015","journal-title":"AAPS J."},{"key":"10.1016\/j.jconrel.2026.115241_bb0060","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S0140-6736(25)01280-2","article-title":"Metrics for diplomats: is mortality from non-communicable diseases increasing or decreasing?","volume":"406","author":"Bovet","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2026.115241_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121435","article-title":"Wearable and implantable devices for drug delivery: applications and challenges","volume":"283","author":"Kar","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115241_bb0070","doi-asserted-by":"crossref","first-page":"4116","DOI":"10.1007\/s44174-025-00479-y","article-title":"Wearable devices for subcutaneous delivery of large-volume biologics: design, use, and regulatory perspective","volume":"4","author":"Sunstrom","year":"2026","journal-title":"Biomed. Mater. Devices"},{"key":"10.1016\/j.jconrel.2026.115241_bb0075","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nrd.2017.66","article-title":"Combination products: modernizing the regulatory paradigm","volume":"16","author":"Hunter","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2026.115241_bb0080","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1056\/NEJMhle1113918","article-title":"Regulation of medical devices in the United States and European Union","volume":"366","author":"Kramer","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2026.115241_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113857","article-title":"Integration of personalized drug delivery systems into digital health","volume":"176","author":"Raijada","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.115241_bb0090","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41573-023-00670-0","article-title":"Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems","volume":"22","author":"Baryakova","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2026.115241_bb0095","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.bja.2025.01.021","article-title":"A near miss from unintended free flow administration of propofol caused by infusion pump malfunction","volume":"134","author":"Michaelsen","year":"2025","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.jconrel.2026.115241_bb0100","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.medj.2024.03.020","article-title":"Closed-loop automated drug infusion regulator: a clinically translatable, closed-loop drug delivery system for personalized drug dosing","volume":"5","author":"DeRidder","year":"2024","journal-title":"Med"},{"key":"10.1016\/j.jconrel.2026.115241_bb0105","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jcis.2023.01.024","article-title":"Microfluidic jet impact: spreading, splashing, soft substrate deformation and injection","volume":"636","author":"van der Ven","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.jconrel.2026.115241_bb0110","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41578-018-0070-3","article-title":"Ingestible electronics for diagnostics and therapy","volume":"4","author":"Steiger","year":"2019","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.jconrel.2026.115241_bb0115","doi-asserted-by":"crossref","first-page":"e291","DOI":"10.1016\/S2589-7500(23)00248-0","article-title":"Remote digital health technologies for improving the care of people with respiratory disorders","volume":"6","author":"Dunn","year":"2024","journal-title":"Lancet Digit. Health"},{"key":"10.1016\/j.jconrel.2026.115241_bb0120","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrd1304","article-title":"Current status and future potential of transdermal drug delivery","volume":"3","author":"Prausnitz","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2026.115241_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1690","article-title":"Recent advances in combination of microneedles and nanomedicines for lymphatic targeted drug delivery","volume":"13","author":"Permana","year":"2021","journal-title":"WIREs Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2026.115241_bb0130","doi-asserted-by":"crossref","first-page":"2302410","DOI":"10.1002\/adma.202302410","article-title":"Exploiting unique features of microneedles to modulate immunity","volume":"35","author":"Edwards","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115241_bb0135","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jconrel.2017.11.048","article-title":"Microneedles as the technique of drug delivery enhancement in diverse organs and tissues","volume":"270","author":"Rzhevskiy","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115241_bb0140","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1126\/science.aau2277","article-title":"An ingestible self-orienting system for oral delivery of macromolecules","volume":"363","author":"Abramson","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2026.115241_bb0145","doi-asserted-by":"crossref","first-page":"365ra157","DOI":"10.1126\/scitranslmed.aag2374","article-title":"Oral, ultra\u2013long-lasting drug delivery: application toward malaria elimination goals","volume":"8","author":"Bellinger","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2026.115241_bb0150","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/s41586-025-09304-4","article-title":"Mechanical underwater adhesive devices for soft substrates","volume":"643","author":"Kang","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2026.115241_bb0155","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1001\/archsurg.2009.78","article-title":"New world of patient safety: 23rd Annual Samuel Jason Mixter lecture","volume":"144","author":"Leape","year":"2009","journal-title":"Arch. Surg."},{"key":"10.1016\/j.jconrel.2026.115241_bb0160","doi-asserted-by":"crossref","DOI":"10.1136\/qshc.2005.016030","article-title":"Mistake proofing: changing designs to reduce error","volume":"15","author":"Grout","year":"2006","journal-title":"Quality Safety Health Care"},{"key":"10.1016\/j.jconrel.2026.115241_bb0165","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1056\/NEJMsa020847","article-title":"Improving safety with information technology","volume":"348","author":"Bates","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2026.115241_bb0170","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev-bioeng-110122-010848","article-title":"Recent developments in aerosol pulmonary drug delivery: new technologies, new cargos, and new targets","volume":"26","author":"Woodward","year":"2024","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2026.115241_bb0175","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S0140-6736(10)60926-9","article-title":"Aerosol drug delivery: developments in device design and clinical use","volume":"377","author":"Dolovich","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2026.115241_bb0180","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.eururo.2025.02.010","article-title":"A systematic review of novel intravesical approaches for the treatment of patients with non\u2013muscle-invasive bladder cancer","volume":"88","author":"Ghodoussipour","year":"2025","journal-title":"Eur. Urol."},{"key":"10.1016\/j.jconrel.2026.115241_bb0185","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.chest.2016.03.041","article-title":"Systematic review of errors in inhaler use: has patient technique improved over time?","volume":"150","author":"Sanchis","year":"2016","journal-title":"Chest"},{"key":"10.1016\/j.jconrel.2026.115241_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113926","article-title":"Devices for drug delivery in the gastrointestinal tract: a review of systems physically interacting with the mucosa for enhanced delivery","volume":"177","author":"Byrne","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.115241_bb0195","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/s41586-024-08202-5","article-title":"Cephalopod-inspired jetting devices for gastrointestinal drug delivery","volume":"636","author":"Arrick","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.jconrel.2026.115241_bb0200","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nrd2076","article-title":"Current status and future prospects of needle-free liquid jet injectors","volume":"5","author":"Mitragotri","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2026.115241_bb0205","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jconrel.2004.04.006","article-title":"Needle-free jet injections: dependence of jet penetration and dispersion in the skin on jet power","volume":"97","author":"Schramm-Baxter","year":"2004","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115241_bb0210","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1039\/D0LC00646G","article-title":"Needle-free delivery of fluids from compact laser-based jet injector","volume":"20","author":"Krizek","year":"2020","journal-title":"Lab Chip"},{"key":"10.1016\/j.jconrel.2026.115241_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.114109","article-title":"Jet injectors: perspectives for small volume delivery with lasers","volume":"182","author":"Schoppink","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.115241_bb0220","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.addr.2003.10.026","article-title":"Iontophoretic drug delivery","volume":"56","author":"Kalia","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.115241_bb0225","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.addr.2003.10.027","article-title":"Skin electroporation for transdermal and topical delivery","volume":"56","author":"Denet","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.115241_bb0230","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.ymthe.2024.03.022","article-title":"Carrier-free mRNA vaccine induces robust immunity against SARS-CoV-2 in mice and non-human primates without systemic reactogenicity","volume":"32","author":"Abbasi","year":"2024","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jconrel.2026.115241_bb0235","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/S0140-6736(14)60524-9","article-title":"Needle-free jet injection for administration of influenza vaccine: a randomised non-inferiority trial","volume":"384","author":"McAllister","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jconrel.2026.115241_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2020.100368","article-title":"Insulin delivery with a needle-free insulin injector versus a conventional insulin pen in Chinese patients with type 2 diabetes mellitus: a 16-week, multicenter, randomized clinical trial (the FREE study)","volume":"23","author":"Ji","year":"2020","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.jconrel.2026.115241_bb0245","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1111\/j.1526-4610.2009.01530.x","article-title":"Needle-free subcutaneous sumatriptan (Sumavel DosePro): bioequivalence and ease of use","volume":"49","author":"Brandes","year":"2009","journal-title":"Headache"},{"key":"10.1016\/j.jconrel.2026.115241_bb0250","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/S0278-2391(98)90601-2","article-title":"Subcutaneous administration of midazolam: a comparison of the Bioject jet injector with the conventional syringe and needle","volume":"56","author":"Bennett","year":"1998","journal-title":"J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.jconrel.2026.115241_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2017.e00395","article-title":"Feasibility of conducting intradermal vaccination campaign with inactivated poliovirus vaccine using Tropis intradermal needle free injection system, Karachi, Pakistan","volume":"3","author":"Yousafzai","year":"2017","journal-title":"Heliyon"},{"key":"10.1016\/j.jconrel.2026.115241_bb0260","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1089\/dia.2013.0250","article-title":"A pilot study to examine the tolerability and device preference in type 1 diabetes of insulin aspart administered by InsuJet compared with subcutaneous injection","volume":"16","author":"Reutens","year":"2014","journal-title":"Diabetes Technol. Ther."},{"key":"10.1016\/j.jconrel.2026.115241_bb0265","doi-asserted-by":"crossref","first-page":"5067","DOI":"10.1038\/s41598-020-61924-0","article-title":"Repetitive regime of highly focused liquid microjets for needle-free injection","volume":"10","author":"Krizek","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2026.115241_bb0270","doi-asserted-by":"crossref","first-page":"14544","DOI":"10.1038\/s41598-021-94018-6","article-title":"Dynamic mechanical interaction between injection liquid and human tissue simulant induced by needle-free injection of a highly focused microjet","volume":"11","author":"Miyazaki","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2026.115241_bb0275","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/s41541-022-00469-x","article-title":"A DNA vaccine targeting VEE virus delivered by needle-free jet-injection protects macaques against aerosol challenge","volume":"7","author":"Suschak","year":"2022","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.jconrel.2026.115241_bb0280","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev-bioeng-071813-104622","article-title":"Electroporation-based technologies for medicine: principles, applications, and challenges","volume":"16","author":"Yarmush","year":"2014","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2026.115241_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtn.2023.102070","article-title":"Intradermal DNA vaccine delivery using vacuum-controlled, needle-free electroporation","volume":"34","author":"Generotti","year":"2023","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.jconrel.2026.115241_bb0290","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jconrel.2017.02.011","article-title":"Microneedle, bio-microneedle and bio-inspired microneedle: a review","volume":"251","author":"Ma","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115241_bb0295","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1021\/acs.biomac.1c01325","article-title":"Facile photolithographic fabrication of Zwitterionic polymer microneedles with protein aggregation inhibition for transdermal drug delivery","volume":"23","author":"Pitakjakpipop","year":"2022","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2026.115241_bb0300","article-title":"Extensible and swellable hydrogel-forming microneedles for deep point-of-care sampling and drug deployment","volume":"34","author":"Liu","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jconrel.2026.115241_bb0305","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.biomaterials.2015.04.007","article-title":"Clinical study and stability assessment of a novel transcutaneous influenza vaccination using a dissolving microneedle patch","volume":"57","author":"Hirobe","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115241_bb0310","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4161\/hv.8.1.18419","article-title":"Current evidence on intradermal influenza vaccines administered by Soluvia\u2122 licensed micro injection system","volume":"8","author":"Icardi","year":"2012","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.jconrel.2026.115241_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113794","article-title":"Dissolving microneedles in transdermal drug delivery: a critical analysis of limitations and translation challenges","volume":"383","author":"Moawad","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115241_bb0320","doi-asserted-by":"crossref","DOI":"10.3390\/polym14081608","article-title":"Microneedles in action: microneedling and microneedles-assisted transdermal delivery","volume":"14","author":"Lim","year":"2022","journal-title":"Polymers"},{"key":"10.1016\/j.jconrel.2026.115241_bb0325","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0140-6736(17)30575-5","article-title":"The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial","volume":"390","author":"Rouphael","year":"2017","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.jconrel.2026.115241_bb0330","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1038\/s41467-021-21989-5","article-title":"A mussel-inspired film for adhesion to wet buccal tissue and efficient buccal drug delivery","volume":"12","author":"Hu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115241_bb0335","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202313728","article-title":"Conformal fixation strategies and bioadhesives for soft bioelectronics","volume":"34","author":"Park","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2026.115241_bb0340","article-title":"Blue-ringed octopus-inspired microneedle patch for robust tissue surface adhesion and active injection drug delivery","volume":"9","author":"Zhu","year":"2026","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2026.115241_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.celbio.2025.100100","article-title":"Bioinspired ultra-adhesive microneedle patch for long-lasting deep drug delivery","volume":"1","author":"Liu","year":"2025","journal-title":"Cell Biomater."},{"key":"10.1016\/j.jconrel.2026.115241_bb0350","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/s41551-021-00810-0","article-title":"Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity","volume":"6","author":"Freedman","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2026.115241_bb0355","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.rmed.2019.09.008","article-title":"Real-life inhaler adherence and technique: time to get smarter!","volume":"158","author":"Chrystyn","year":"2019","journal-title":"Respir. Med."},{"key":"10.1016\/j.jconrel.2026.115241_bb0360","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s40261-019-00835-z","article-title":"The Respimat\u00ae soft mist inhaler: implications of drug delivery characteristics for patients","volume":"39","author":"Iwanaga","year":"2019","journal-title":"Clin. Drug Investig."},{"key":"10.1016\/j.jconrel.2026.115241_bb0365","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/alr.22141","article-title":"EXHANCE-12: 1-year study of the exhalation delivery system with fluticasone (EDS-FLU) in chronic rhinosinusitis","volume":"8","author":"Palmer","year":"2018","journal-title":"Int. Forum Allergy Rhinol."},{"key":"10.1016\/j.jconrel.2026.115241_bb0370","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jaci.2018.06.010","article-title":"NAVIGATE II: randomized, double-blind trial of the exhalation delivery system with fluticasone for nasal polyposis","volume":"143","author":"Leopold","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jconrel.2026.115241_bb0375","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.pt.2016.12.008","article-title":"Oral, slow-release ivermectin: biting back at malaria vectors","volume":"33","author":"Chaccour","year":"2017","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.jconrel.2026.115241_bb0380","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1056\/NEJMra050100","article-title":"Adherence to medication","volume":"353","author":"Osterberg","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2026.115241_bb0385","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/adhm.201300139","article-title":"Implantable silk composite microneedles for programmable vaccine release kinetics and enhanced immunogenicity in transcutaneous immunization","volume":"3","author":"DeMuth","year":"2014","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2026.115241_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.115003","article-title":"Polymeric in situ forming depots for long-acting drug delivery systems","volume":"200","author":"Pandya","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.115241_bb0395","doi-asserted-by":"crossref","first-page":"e1054","DOI":"10.1016\/S2214-109X(19)30265-7","article-title":"Efficacy of the 1-year (13-cycle) segesterone acetate and ethinylestradiol contraceptive vaginal system: results of two multicentre, open-label, single-arm, phase 3 trials","volume":"7","author":"Archer","year":"2019","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.jconrel.2026.115241_bb0400","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1056\/NEJMoa1506110","article-title":"Use of a vaginal ring containing dapivirine for HIV-1 prevention in women","volume":"375","author":"Baeten","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2026.115241_bb0405","article-title":"TAR-200 for Bacillus Calmette-Gu\u00e9rin\u2013unresponsive high-risk non\u2013muscle-invasive bladder cancer: results from the phase IIb SunRISe-1 study","volume":"0","author":"Daneshmand","year":"2025","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2026.115241_bb0410","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/JU.0000000000002186","article-title":"Primary chemoablation of low-grade intermediate-risk nonmuscle-invasive bladder cancer using UGN-102, a mitomycin-containing reverse thermal gel (optima II): a phase 2b, open-label, single-arm trial","volume":"207","author":"Chevli","year":"2022","journal-title":"J. Urol."},{"key":"10.1016\/j.jconrel.2026.115241_bb0415","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1056\/NEJMoa1204724","article-title":"Levonorgestrel intrauterine system versus medical therapy for menorrhagia","volume":"368","author":"Gupta","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2026.115241_bb0420","doi-asserted-by":"crossref","first-page":"eadp3611","DOI":"10.1126\/scitranslmed.adp3611","article-title":"A wearable osmotic microneedle patch provides high-capacity sustained drug delivery in animal models","volume":"16","author":"Zhao","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2026.115241_bb0425","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.addr.2012.02.003","article-title":"Osmotic micropumps for drug delivery","volume":"64","author":"Herrlich","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.115241_bb0430","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.actbio.2020.08.023","article-title":"Active pharmaceutical ingredient poly(ionic liquid)-based microneedles for the treatment of skin acne infection","volume":"115","author":"Zhang","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2026.115241_bb0435","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1164\/rccm.201807-1318OC","article-title":"Amikacin liposome inhalation suspension for treatment-refractory lung disease caused by Mycobacterium avium complex (CONVERT). A prospective, open-label, randomized study","volume":"198","author":"Griffith","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jconrel.2026.115241_bb0440","doi-asserted-by":"crossref","first-page":"9471","DOI":"10.1038\/s41467-024-53914-x","article-title":"Charge-assisted stabilization of lipid nanoparticles enables inhaled mRNA delivery for mucosal vaccination","volume":"15","author":"Liu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115241_bb0445","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41563-022-01404-0","article-title":"Species-agnostic polymeric formulations for inhalable messenger RNA delivery to the lung","volume":"22","author":"Rotolo","year":"2023","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jconrel.2026.115241_bb0450","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1038\/s41467-024-45628-x","article-title":"Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115241_bb0455","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-58278-4","article-title":"Catechol-based chemistry for hypoglycemia-responsive delivery of zinc-glucagon via hydrogel-based microneedle patch technology","volume":"16","author":"GhavamiNejad","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115241_bb0460","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jconrel.2019.11.001","article-title":"Inflammation-triggered local drug release ameliorates colitis by inhibiting dendritic cell migration and Th1\/Th17 differentiation","volume":"316","author":"Regmi","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115241_bb0465","doi-asserted-by":"crossref","first-page":"8260","DOI":"10.1073\/pnas.1505405112","article-title":"Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery","volume":"112","author":"Yu","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jconrel.2026.115241_bb0470","article-title":"Glucose-responsive microneedle patch for closed-loop dual-hormone delivery in mice and pigs","volume":"8","author":"Yang","year":"2026","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2026.115241_bb0475","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/s41467-023-35990-7","article-title":"An integrated Mg battery-powered iontophoresis patch for efficient and controllable transdermal drug delivery","volume":"14","author":"Zhou","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115241_bb0480","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1038\/s41467-024-46046-9","article-title":"Magnetically driven capsules with multimodal response and multifunctionality for biomedical applications","volume":"15","author":"Sun","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115241_bb0485","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1310\/hpj5101-71","article-title":"Fentanyl Iontophoretic transdermal system","volume":"51","author":"Cada","year":"2016","journal-title":"Hosp. Pharm."},{"key":"10.1016\/j.jconrel.2026.115241_bb0490","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2217\/pmt.13.71","article-title":"Sumatriptan iontophoretic transdermal system for the acute treatment of migraine","volume":"4","author":"Vikelis","year":"2014","journal-title":"Pain Manag."},{"key":"10.1016\/j.jconrel.2026.115241_bb0495","article-title":"A wearable transdermal device for on-demand drug delivery","volume":"8","author":"Wang","year":"2025","journal-title":"Matter"},{"key":"10.1016\/j.jconrel.2026.115241_bb0500","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/s41467-023-44532-0","article-title":"Digital automation of transdermal drug delivery with high spatiotemporal resolution","volume":"15","author":"Wang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115241_bb0505","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa5937","article-title":"Ultrasound-mediated gastrointestinal drug delivery","volume":"7","author":"Schoellhammer","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jconrel.2026.115241_bb0510","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1056\/NEJMoa0808145","article-title":"Radiofrequency ablation in Barrett\u2019s esophagus with dysplasia","volume":"360","author":"Shaheen","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2026.115241_bb0515","doi-asserted-by":"crossref","first-page":"22135","DOI":"10.18632\/oncotarget.14029","article-title":"A multicenter phase II study of salvage photodynamic therapy using talaporfin sodium (ME2906) and a diode laser (PNL6405EPG) for local failure after chemoradiotherapy or radiotherapy for esophageal cancer","volume":"8","author":"Yano","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jconrel.2026.115241_bb0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.125156","article-title":"Multi-drug sequential release systems: construction and application for synergistic tumor treatment","volume":"670","author":"Yang","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115241_bb0525","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122260","article-title":"Next generation 3D-printed intravaginal ring for prevention of HIV and unintended pregnancy","volume":"301","author":"Young","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115241_bb0530","first-page":"13892","article-title":"Novel double-layer dissolving microneedles for transmucosal sequential delivery of multiple drugs in the treatment of oral mucosa diseases","volume":"15","author":"Meng","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2026.115241_bb0535","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.jconrel.2024.10.059","article-title":"Next-generation 3D printed multipurpose prevention intravaginal ring for prevention of HIV, HSV-2, and unintended pregnancy","volume":"376","author":"Dahl","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115241_bb0540","first-page":"903","article-title":"An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection","volume":"22","author":"Mei","year":"2023","journal-title":"Nat. Mater."},{"key":"10.1016\/j.jconrel.2026.115241_bb0545","doi-asserted-by":"crossref","first-page":"14084","DOI":"10.1021\/acs.chemrev.3c00380","article-title":"Bioadhesive technology platforms","volume":"123","author":"Wu","year":"2023","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jconrel.2026.115241_bb0550","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev-bioeng-062117-121156","article-title":"Engineering the mucus barrier","volume":"20","author":"Carlson","year":"2018","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2026.115241_bb0555","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.eclinm.2019.08.013","article-title":"Smart medication adherence monitoring in clinical drug trials: a prerequisite for personalised medicine?","volume":"15","author":"Zijp","year":"2019","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.jconrel.2026.115241_bb0560","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1056\/NEJMp1716206","article-title":"Swallowing a spy - the potential uses of digital adherence monitoring","volume":"378","author":"Rosenbaum","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2026.115241_bb0565","doi-asserted-by":"crossref","DOI":"10.2196\/30786","article-title":"A novel digital pill system for medication adherence measurement and reporting: usability validation study","volume":"8","author":"Baumgartner","year":"2021","journal-title":"JMIR Hum. Factors"},{"key":"10.1016\/j.jconrel.2026.115241_bb0570","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S2213-2600(22)00534-3","article-title":"Use of digital measurement of medication adherence and lung function to guide the management of uncontrolled asthma (INCA Sun): a multicentre, single-blinded, randomised clinical trial","volume":"11","author":"Hale","year":"2023","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.jconrel.2026.115241_bb0575","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1016\/j.jaip.2022.08.023","article-title":"Effectiveness of a digital inhaler system for patients with asthma: a 12-week, open-label, randomized study (CONNECT1)","volume":"10","author":"Hoyte","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jconrel.2026.115241_bb0580","doi-asserted-by":"crossref","first-page":"2201600","DOI":"10.1002\/admt.202201600","article-title":"Wireless and flexible optoelectronic system for in situ monitoring of vaginal pH using a bioresorbable fluorescence sensor","volume":"8","author":"Paghi","year":"2023","journal-title":"Adv. Mater. Technol."},{"key":"10.1016\/j.jconrel.2026.115241_bb0585","doi-asserted-by":"crossref","first-page":"S978","DOI":"10.14309\/01.ajg.0001034848.57615.ac","article-title":"S1370 single ascending dose results from a phase 1 clinical trial of BT-600, a combination product of the NaviCap targeted oral delivery platform and tofacitinib","volume":"119","author":"Feagan","year":"2024","journal-title":"Off. J. Am. College Gastroenterol."},{"key":"10.1016\/j.jconrel.2026.115241_bb0590","doi-asserted-by":"crossref","DOI":"10.1177\/14799731251366969","article-title":"The evolving landscape of digital inhaler platforms and adherence support in chronic airways disease","volume":"22","author":"Aung","year":"2025","journal-title":"Chron. Respir. Dis."},{"key":"10.1016\/j.jconrel.2026.115241_bb0595","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1289\/EHP266","article-title":"Feasibility of deploying inhaler sensors to identify the impacts of environmental triggers and built environment factors on asthma short-acting bronchodilator use","volume":"125","author":"Su","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.jconrel.2026.115241_bb0600","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jaip.2023.11.037","article-title":"Effectiveness of a maintenance and reliever Digihaler system in asthma: 24-week randomized study (CONNECT2)","volume":"12","author":"Mosnaim","year":"2024","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jconrel.2026.115241_bb0605","doi-asserted-by":"crossref","DOI":"10.1177\/2045894018798921","article-title":"Switching inhaled iloprost formulations in patients with pulmonary arterial hypertension: the VENTASWITCH trial","volume":"8","author":"Richter","year":"2018","journal-title":"Pulm. Circ."},{"key":"10.1016\/j.jconrel.2026.115241_bb0610","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/s41551-022-00916-z","article-title":"A wearable electrochemical biosensor for the monitoring of metabolites and nutrients","volume":"6","author":"Wang","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2026.115241_bb0615","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-35074-y","article-title":"A self-powered ingestible wireless biosensing system for real-time in situ monitoring of gastrointestinal tract metabolites","volume":"13","author":"De la Paz","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115241_bb0620","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1038\/s41564-025-02057-w","article-title":"Ingestible optoelectronic capsules enable bidirectional communication with engineered microbes for controllable therapeutic interventions","volume":"10","author":"Zhang","year":"2025","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.jconrel.2026.115241_bb0625","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0174729","article-title":"An intravaginal ring for real-time evaluation of adherence to therapy","volume":"12","author":"Moss","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2026.115241_bb0630","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adf7388","article-title":"A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds","volume":"9","author":"Shirzaei Sani","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2026.115241_bb0635","doi-asserted-by":"crossref","DOI":"10.2196\/26189","article-title":"The impact of digital patient portals on health outcomes, system efficiency, and patient attitudes: updated systematic literature review","volume":"23","author":"Carini","year":"2021","journal-title":"J. Med. Internet Res."},{"key":"10.1016\/j.jconrel.2026.115241_bb0640","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jaip.2015.11.022","article-title":"Effectiveness of population health management using the propeller health asthma platform: a randomized clinical trial","volume":"4","author":"Merchant","year":"2016","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jconrel.2026.115241_bb0645","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41378-025-01089-w","article-title":"Integrated individually addressable microneedle arrays for robust glucose monitoring and on-demand insulin releasing","volume":"11","author":"Wei","year":"2025","journal-title":"Microsyst. Nanoeng."},{"key":"10.1016\/j.jconrel.2026.115241_bb0650","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1056\/NEJMsb1609216","article-title":"Real-world evidence \u2014 what is it and what can it tell us?","volume":"375","author":"Sherman","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2026.115241_bb0655","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00125-022-05744-z","article-title":"Automated insulin delivery: benefits, challenges, and recommendations. A consensus report of the Joint Diabetes Technology Working Group of the European Association for the Study of Diabetes and the American Diabetes Association","volume":"66","author":"Sherr","year":"2023","journal-title":"Diabetologia"},{"key":"10.1016\/j.jconrel.2026.115241_bb0660","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1038\/s41551-025-01389-6","article-title":"A biochemical sensor with continuous extended stability in vivo","volume":"9","author":"Chen","year":"2025","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2026.115241_bb0665","doi-asserted-by":"crossref","first-page":"e335","DOI":"10.1016\/S2589-7500(19)30131-1","article-title":"Microneedle biosensors for real-time, minimally invasive drug monitoring of phenoxymethylpenicillin: a first-in-human evaluation in healthy volunteers","volume":"1","author":"Rawson","year":"2019","journal-title":"Lancet Digit. Health"},{"key":"10.1016\/j.jconrel.2026.115241_bb0670","doi-asserted-by":"crossref","DOI":"10.4028\/b-fVvR5S","article-title":"Skin preparation\u2013free, stretchable microneedle adhesive patches for reliable electrophysiological sensing and exoskeleton robot control","volume":"10","author":"Kim","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jconrel.2026.115241_bb0675","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202213560","article-title":"Smart skin-adhesive patches: from design to biomedical applications","volume":"33","author":"Wong","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2026.115241_bb0680","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nrd3974","article-title":"Challenges and approaches for the development of safer immunomodulatory biologics","volume":"12","author":"Sathish","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jconrel.2026.115241_bb0685","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/s41551-021-00698-w","article-title":"The evolution of commercial drug delivery technologies","volume":"5","author":"Vargason","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2026.115241_bb0690","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1056\/NEJMp2308736","article-title":"Coverage for emerging technologies \u2014 bridging regulatory approval and patient access","volume":"389","author":"Kadakia","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2026.115241_bb0695","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1056\/NEJMp1311439","article-title":"Expediting Drug Development 2014; The FDA\u2019s New 201c;Breakthrough Therapy 201d; Designation","volume":"369","author":"Sherman","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jconrel.2026.115241_bb0700","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s13346-021-00938-1","article-title":"A robotic pill for oral delivery of biotherapeutics: safety, tolerability, and performance in healthy subjects","volume":"12","author":"Dhalla","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.jconrel.2026.115241_bb0705","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1378\/chest.08-1421","article-title":"Efficacy and safety of inhaled aztreonam lysine for airway pseudomonas in cystic fibrosis","volume":"135","author":"Retsch-Bogart","year":"2009","journal-title":"Chest"},{"key":"10.1016\/j.jconrel.2026.115241_bb0710","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1124\/pharmrev.120.000108","article-title":"Inhaled medicines: past, present, and future","volume":"74","author":"Anderson","year":"2022","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jconrel.2026.115241_bb0715","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1016\/j.jaip.2021.02.028","article-title":"Digital health technology in asthma: a comprehensive scoping review","volume":"9","author":"Mosnaim","year":"2021","journal-title":"J Allergy Clin Immunol Pract"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926006450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926006450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:06:09Z","timestamp":1790211969000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926006450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":143,"alternative-id":["S0168365926006450"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115241","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineering integrated drug\u2013device systems for autonomous administration, programmable release, and therapeutic control","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115241","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115241"}}