{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:10:12Z","timestamp":1790212212145,"version":"4.1.0"},"reference-count":154,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023978","name":"Comiss\u00e3o de Coordena\u00e7\u00e3o e Desenvolvimento Regional do Norte","doi-asserted-by":"publisher","award":["Norte2020\/CCDR-N"],"award-info":[{"award-number":["Norte2020\/CCDR-N"]}],"id":[{"id":"10.13039\/501100023978","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","award":["Norte-01-0145-FEDER-022190"],"award-info":[{"award-number":["Norte-01-0145-FEDER-022190"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon Europe","doi-asserted-by":"publisher","award":["101168752"],"award-info":[{"award-number":["101168752"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jconrel.2026.115246","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T23:30:21Z","timestamp":1786404621000},"page":"115246","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hydrogels as controlled delivery systems for cardiac repair and regeneration"],"prefix":"10.1016","volume":"398","author":[{"given":"Annalisa","family":"Perioli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui L.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana R.","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo A.","family":"Pires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"25","key":"10.1016\/j.jconrel.2026.115246_bb0005","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990-2019: update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"issue":"38","key":"10.1016\/j.jconrel.2026.115246_bb0010","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC guidelines for the management of acute coronary syndromes: developed by the task force on the management of acute coronary syndromes of the European Society of Cardiology (ESC)","volume":"44","author":"Byrne","year":"2023","journal-title":"Eur. Heart J."},{"issue":"20","key":"10.1016\/j.jconrel.2026.115246_bb0015","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000617","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"138","author":"Thygesen","year":"2018","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115246_bb0020","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1002\/j.2040-4603.2015.tb00664.x","article-title":"Pathophysiology of myocardial infarction","volume":"5","author":"Frangogiannis","year":"2015","journal-title":"Compr. Physiol."},{"issue":"30","key":"10.1016\/j.jconrel.2026.115246_bb0025","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1093\/eurheartj\/ehx343","article-title":"Cardiomyocyte renewal in the human heart: insights from the fall-out","volume":"38","author":"L\u00e1z\u00e1r","year":"2017","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115246_bb0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","article-title":"The biological basis for cardiac repair after myocardial infarction from inflammation to fibrosis","volume":"119","author":"Prabhu","year":"2016","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115246_bb0035","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nmat2441","article-title":"Complexity in biomaterials for tissue engineering","volume":"8","author":"Place","year":"2009","journal-title":"Nat. Mater."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115246_bb0040","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1161\/CIRCRESAHA.116.304872","article-title":"Similar effect of autologous and allogeneic cell therapy for ischemic heart disease","volume":"116","author":"Jansen","year":"2015","journal-title":"Circ. Res."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115246_bb0045","article-title":"Stem cell therapy for chronic ischaemic heart disease and congestive heart failure","volume":"2016","author":"Fisher","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115246_bb0050","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-025-04678-8","article-title":"Stem cell therapy for myocardial infarction and atherosclerosis: mechanisms, challenges, and future directions","volume":"16","author":"Wan","year":"2025","journal-title":"Stem Cell Res. Ther."},{"issue":"27","key":"10.1016\/j.jconrel.2026.115246_bb0055","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1002\/adma.201505349","article-title":"Biomaterial-enhanced cell and drug delivery: lessons learned in the cardiac field and future perspectives","volume":"28","author":"O\u2019Neill","year":"2016","journal-title":"Adv. Mater."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115246_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201500122","article-title":"Injectable hydrogels for cardiac tissue repair after myocardial infarction","volume":"2","author":"Hasan","year":"2015","journal-title":"Adv. Sci."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115246_bb0065","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41551-019-0442-z","article-title":"Use of a supramolecular polymeric hydrogel as an effective post-operative pericardial adhesion barrier","volume":"3","author":"Stapleton","year":"2019","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.jconrel.2026.115246_bb0070","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.copbio.2016.02.008","article-title":"Recent advances in hyaluronic acid hydrogels for biomedical applications","volume":"40","author":"Highley","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.jconrel.2026.115246_bb0075","series-title":"Hydrogels for Biomedical Applications","first-page":"18","volume":"64","author":"Hoffman","year":"2012"},{"key":"10.1016\/j.jconrel.2026.115246_bb0080","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.eurpolymj.2015.05.014","article-title":"An overview of injectable polymeric hydrogels for tissue engineering","volume":"72","author":"Sivashanmugam","year":"2015","journal-title":"Eur. Polym. J."},{"issue":"32\u201333","key":"10.1016\/j.jconrel.2026.115246_bb0085","first-page":"3307","article-title":"Hydrogels in regenerative medicine","volume":"21","author":"Slaughter","year":"2009"},{"issue":"8","key":"10.1016\/j.jconrel.2026.115246_bb0090","article-title":"Mechanochemical adhesion and plasticity in multifiber hydrogel networks","volume":"32","author":"Davidson","year":"2020"},{"issue":"21","key":"10.1016\/j.jconrel.2026.115246_bb0095","first-page":"6532","article-title":"Spatiotemporal hydrogel biomaterials for regenerative medicine","volume":"46","author":"Brown","year":"2017"},{"issue":"10","key":"10.1016\/j.jconrel.2026.115246_bb0100","first-page":"115","article-title":"Overview of natural hydrogels for regenerative medicine applications","volume":"30","author":"Catoira","year":"2019"},{"issue":"10","key":"10.1016\/j.jconrel.2026.115246_bb0105","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41570-022-00420-7","article-title":"Chemical strategies to engineer hydrogels for cell culture","volume":"6","author":"Lou","year":"2022","journal-title":"Nature Reviews Chemistry"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115246_bb0110","first-page":"505","article-title":"Hydrogel composite materials for tissue engineering scaffolds","volume":"65","author":"Shapiro","year":"2013"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115246_bb0115","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3390\/gels4020051","article-title":"Application of composite hydrogels to control physical properties in tissue engineering and regenerative medicine","volume":"4","author":"Sheffield","year":"2018","journal-title":"Gels"},{"issue":"5","key":"10.1016\/j.jconrel.2026.115246_bb0120","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1161\/CIRCRESAHA.114.302533","article-title":"Myocardial extracellular matrix","volume":"114","author":"Rienks","year":"2014","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115246_bb0125","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1039\/C8BM01348A","article-title":"Native cardiac environment and its impact on engineering cardiac tissue","volume":"7","author":"Schwach","year":"2019","journal-title":"Biomater. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115246_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e41157","article-title":"The role of the extracellular matrix in cardiac regeneration","volume":"11","author":"Wang","year":"2025","journal-title":"Heliyon"},{"issue":"19","key":"10.1016\/j.jconrel.2026.115246_bb0135","doi-asserted-by":"crossref","first-page":"4792","DOI":"10.1016\/j.biomaterials.2012.03.039","article-title":"Sustained delivery of SDF-1\u03b1 from heparin-based hydrogels to attract circulating pro-angiogenic cells","volume":"33","author":"Prokoph","year":"2012","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115246_bb0140","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jconrel.2012.04.049","article-title":"A novel, biased-like SDF-1 derivative acts synergistically with starPEG-based heparin hydrogels and improves eEPC migration in vitro","volume":"162","author":"Baumann","year":"2012","journal-title":"Journal of Controlled Release, Article"},{"issue":"6","key":"10.1016\/j.jconrel.2026.115246_bb0145","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nmat3922","article-title":"Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition","volume":"13","author":"Purcell","year":"2014","journal-title":"Nat. Mater."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115246_bb0150","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.201800167","article-title":"Composite biomaterials as long-lasting scaffolds for 3D bioprinting of highly aligned muscle tissue","volume":"18","author":"Garc\u00eda-Lizarribar","year":"2018","journal-title":"Macromol. Biosci."},{"issue":"23","key":"10.1016\/j.jconrel.2026.115246_bb0155","doi-asserted-by":"crossref","first-page":"20589","DOI":"10.1021\/acsami.8b22343","article-title":"Mechanically biomimetic gelatin\u2013gellan gum hydrogels for 3D culture of beating human cardiomyocytes","volume":"11","author":"Koivisto","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115246_bb0160","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.biomaterials.2012.10.008","article-title":"Fully defined in situ cross-linkable alginate and hyaluronic acid hydrogels for myocardial tissue engineering","volume":"34","author":"Dahlmann","year":"2013","journal-title":"Biomaterials"},{"issue":"36","key":"10.1016\/j.jconrel.2026.115246_bb0165","doi-asserted-by":"crossref","first-page":"32254","DOI":"10.1021\/acsnano.5c07064","article-title":"Hierarchical structures of protein-fiber-infused aminoglycan hydrogels to promote myocardial repair","volume":"19","author":"Qin","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115246_bb0170","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ijbiomac.2018.11.256","article-title":"Injectable chitosan\/\u03ba-carrageenan hydrogel designed with au nanoparticles: a conductive scaffold for tissue engineering demands","volume":"126","author":"Pourjavadi","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115246_bb0175","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/j.biomaterials.2010.11.008","article-title":"Integration of multiple cell-matrix interactions into alginate scaffolds for promoting cardiac tissue regeneration","volume":"32","author":"Sapir","year":"2011","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115246_bb0180","first-page":"664","article-title":"Designing peptide based nanomaterials","volume":"37","author":"Ulijn","year":"2008"},{"issue":"28","key":"10.1016\/j.jconrel.2026.115246_bb0185","doi-asserted-by":"crossref","first-page":"5867","DOI":"10.1039\/C7OB01092C","article-title":"Self-assembly of bioactive peptides, peptide conjugates, and peptide mimetic materials","volume":"15","author":"Edwards-Gayle","year":"2017","journal-title":"Organic Biomolecular Chemistry"},{"key":"10.1016\/j.jconrel.2026.115246_bb0190","article-title":"Recent advances in polymer hydrogel nanoarchitectures and applications","volume":"4","author":"Idumah","year":"2021"},{"issue":"5","key":"10.1016\/j.jconrel.2026.115246_bb0195","first-page":"1403","article-title":"Effect of enzyme concentration of the morphology and properties of enzymatically triggered peptide hydrogels","volume":"14","author":"Guilbaud","year":"2013"},{"issue":"32","key":"10.1016\/j.jconrel.2026.115246_bb0200","first-page":"9619","article-title":"pH as a trigger of peptide \u03b2-sheet self-assembly and reversible switching between nematic and isotropic phases","volume":"125","author":"Aggeli","year":"2003"},{"issue":"34","key":"10.1016\/j.jconrel.2026.115246_bb0205","first-page":"10471","article-title":"Self-assembling peptide\/thermoresponsive polymer composite hydrogels: effect of peptide\u2013polymer interactions on hydrogel properties","volume":"30","author":"Maslovskis","year":"2014"},{"issue":"31","key":"10.1016\/j.jconrel.2026.115246_bb0210","first-page":"7457","article-title":"Effect of ionic strength on the self-assembly, morphology and gelation of pH responsive \u03b2-sheet tape-forming peptides","volume":"63","author":"Carrick","year":"2007"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115246_bb0215","first-page":"1224","article-title":"Self-healing conductive hydrogels: preparation, properties and applications","volume":"12","author":"Deng","year":"2020"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115246_bb0220","first-page":"126","article-title":"The extracellular matrix in development and morphogenesis: a dynamic view","volume":"341","author":"Rozario","year":"2010"},{"issue":"23","key":"10.1016\/j.jconrel.2026.115246_bb0225","first-page":"12418","article-title":"Emergent mechanical properties of self-assembled polymeric capsules","volume":"97","author":"Castellano","year":"2000"},{"issue":"84","key":"10.1016\/j.jconrel.2026.115246_bb0230","doi-asserted-by":"crossref","first-page":"9800","DOI":"10.1039\/c3cc46297h","article-title":"Sol\u2013gel conversion based on photoswitching between noncovalently and covalently linked netlike supramolecular polymers","volume":"49","author":"Zhang","year":"2013","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jconrel.2026.115246_bb0235","first-page":"43","article-title":"Biomaterials via peptide assembly: design, characterization, and application in tissue engineering","volume":"140","author":"Gray","year":"2022"},{"key":"10.1016\/j.jconrel.2026.115246_bb0240","article-title":"Patterned glycopeptide-based supramolecular hydrogel promotes the alignment and contractility of iPSC-derived cardiomyocytes","volume":"167","author":"Castro","year":"2025"},{"issue":"13","key":"10.1016\/j.jconrel.2026.115246_bb0245","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.3390\/polym15132824","article-title":"Three-dimensionally printed hydrogel cardiac patch for infarct regeneration based on natural polysaccharides","volume":"15","author":"Loureiro","year":"2023","journal-title":"Polymers"},{"issue":"7","key":"10.1016\/j.jconrel.2026.115246_bb0250","first-page":"2000","article-title":"From waste of marine culture to natural patch in cardiac tissue engineering","volume":"6","author":"He","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2026.115246_bb0255","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.11022","article-title":"Preparation and characterization of gelatin-polysaccharide composite hydrogels for tissue engineering","volume":"9","author":"Ye","year":"2021","journal-title":"PeerJ"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115246_bb0260","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.biomaterials.2012.10.008","article-title":"Fully defined in situ cross-linkable alginate and hyaluronic acid hydrogels for myocardial tissue engineering","volume":"34","author":"Dahlmann","year":"2013","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115246_bb0265","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/term.3238","article-title":"3D bioprinting of an electroactive and self-healing polysaccharide hydrogels","volume":"16","author":"Wang","year":"2022","journal-title":"J. Tissue Eng. Regen. Med."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115246_bb0270","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1007\/s40843-025-3619-1","article-title":"A dual-dynamically crosslinked hydrogel for cardiac repair with microenvironment regulation and angiogenic functions","volume":"68","author":"Zhang","year":"2025","journal-title":"Sci. China-Mater."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115246_bb0275","first-page":"163","article-title":"A self-healing, all-organic, conducting, composite peptide hydrogel as pressure sensor and electrogenic cell soft substrate","volume":"13","author":"Chakraborty","year":"2018"},{"issue":"26","key":"10.1016\/j.jconrel.2026.115246_bb0280","article-title":"Nanoengineered peptide-based antimicrobial conductive supramolecular biomaterial for cardiac tissue engineering","volume":"33","author":"Chakraborty","year":"2021"},{"issue":"5","key":"10.1016\/j.jconrel.2026.115246_bb0285","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s12265-011-9287-x","article-title":"The biocompatibility manifesto: biocompatibility for the twenty-first century","volume":"4","author":"Ratner","year":"2011","journal-title":"J. Cardiovasc. Transl. Res."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115246_bb0290","doi-asserted-by":"crossref","DOI":"10.1002\/adbi.202300197","article-title":"Essential role of anisotropy in bioengineered cardiac tissue models","volume":"8","author":"Jain","year":"2024","journal-title":"Advanced Biology"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115246_bb0295","article-title":"From de novo peptides to native proteins: advancements in biomaterial scaffolds for acute ischemic stroke repair","volume":"13","author":"Tang","year":"2018"},{"issue":"6","key":"10.1016\/j.jconrel.2026.115246_bb0300","first-page":"5604","article-title":"Supramolecular adhesive hydrogels for tissue engineering applications","volume":"122","author":"Zhao","year":"2022"},{"key":"10.1016\/j.jconrel.2026.115246_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.131175","article-title":"An injectable polyacrylamide\/chitosan-based hydrogel with highly adhesive, stretchable and electroconductive properties loaded with irbesartan for treatment of myocardial ischemia-reperfusion injury","volume":"266","author":"Zhu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115246_bb0310","article-title":"Supramolecular conductive hydrogels for tissue engineering applications","volume":"26","author":"Bhavsar","year":"2025"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115246_bb0315","doi-asserted-by":"crossref","DOI":"10.1063\/1.5116579","article-title":"The rationale and emergence of electroconductive biomaterial scaffolds in cardiac tissue engineering","volume":"3","author":"Solazzo","year":"2019","journal-title":"APL Bioengineering"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115246_bb0320","first-page":"2578","article-title":"Injectable decellularized extracellular matrix hydrogel containing stromal cell-derived factor 1 promotes transplanted cardiomyocyte engraftment and functional regeneration after myocardial infarction","volume":"15","author":"Wu","year":"2023"},{"key":"10.1016\/j.jconrel.2026.115246_bb0325","first-page":"52450","article-title":"An injectable and drug-loaded supramolecular hydrogel for local catheter injection into the pig heart","volume":"100","author":"Pape","year":"2015"},{"key":"10.1016\/j.jconrel.2026.115246_bb0330","article-title":"A bioactive hydrogel patch accelerates revascularization in ischemic lesions for tissue repair","volume":"13","author":"Liu","year":"2025"},{"issue":"5","key":"10.1016\/j.jconrel.2026.115246_bb0335","article-title":"Injection-free delivery of MSC-derived extracellular vesicles for myocardial infarction therapeutics","volume":"11","author":"Tang","year":"2022"},{"issue":"8","key":"10.1016\/j.jconrel.2026.115246_bb0340","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1021\/acsbiomaterials.2c00454","article-title":"Role of biomaterials in cardiac repair and regeneration: therapeutic intervention for myocardial infarction","volume":"8","author":"Tariq","year":"2022","journal-title":"ACS Biomaterials Science & Engineering"},{"issue":"25","key":"10.1016\/j.jconrel.2026.115246_bb0345","first-page":"48668","article-title":"Recent advances in shear-thinning and self-healing hydrogels for biomedical applications","volume":"137","author":"Uman","year":"2020"},{"issue":"13","key":"10.1016\/j.jconrel.2026.115246_bb0350","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.3390\/polym16131878","article-title":"Injectable hydrogels in cardiovascular tissue engineering","volume":"16","author":"Patel","year":"2024","journal-title":"Polymers"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115246_bb0355","first-page":"184","article-title":"Intramyocardial stem cell injection: go(ne) with the flow","volume":"38","author":"van den Akker","year":"2016","journal-title":"European Heart Journal"},{"key":"10.1016\/j.jconrel.2026.115246_bb0360","first-page":"482","article-title":"Peptide-based supramolecular hydrogels for local drug delivery","volume":"174","author":"Zhang","year":"2021"},{"issue":"14","key":"10.1016\/j.jconrel.2026.115246_bb0365","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202303685","article-title":"Dough-kneading-inspired design of an adhesive cardiac patch to attenuate cardiac fibrosis and improve cardiac function via regulating Glycometabolism","volume":"13","author":"Sun","year":"2024","journal-title":"Adv. Healthc. Mater."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115246_bb0370","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202302940","article-title":"A sequential dual functional supramolecular hydrogel with promoted drug release to scavenge ROS and stabilize HIF-1\u03b1 for myocardial infarction treatment","volume":"13","author":"Wang","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2026.115246_bb0375","first-page":"20","article-title":"Wet adhesive hydrogel cardiac patch loaded with anti-oxidative, autophagy-regulating molecule capsules and MSCs for restoring infarcted myocardium","volume":"21","author":"Wu","year":"2023","journal-title":"Bioact. Mater."},{"issue":"42","key":"10.1016\/j.jconrel.2026.115246_bb0380","first-page":"38429","article-title":"Injectable citrate-based hydrogel as an angiogenic biomaterial improves cardiac repair after myocardial infarction","volume":"11","author":"Yuan","year":"2019"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115246_bb0385","article-title":"Sulfated and phosphorylated agarose as biomaterials for a biomimetic paradigm for FGF-2 release","volume":"10","author":"Forget","year":"2025","journal-title":"Biomimetics-Basel"},{"issue":"22","key":"10.1016\/j.jconrel.2026.115246_bb0390","doi-asserted-by":"crossref","first-page":"32066","DOI":"10.1021\/acsami.5c06438","article-title":"Bioactive peptide-based electroactive hydrogels for myocardial infarction treatment via electrical and microenvironmental regulation","volume":"17","author":"Luo","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115246_bb0395","first-page":"2880","article-title":"Rebuilding postinfarcted cardiac functions by injecting TIIA@ PDA nanoparticle-cross-linked ROS-sensitive hydrogels","volume":"11","author":"Wang","year":"2018"},{"key":"10.1016\/j.jconrel.2026.115246_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121877","article-title":"Biomaterial-embedded extracellular vesicles improve recovery of the dysfunctional myocardium","volume":"291","author":"Pezzana","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115246_bb0405","article-title":"Biomaterial-embedded extracellular vesicles improve recovery of the dysfunctional myocardium","volume":"291","author":"Pezzana","year":"2022"},{"issue":"Pt 2","key":"10.1016\/j.jconrel.2026.115246_bb0410","article-title":"An injectable exosome-loaded hyaluronic acid-polylysine hydrogel for cardiac repair via modulating oxidative stress and the inflammatory microenvironment","volume":"275","author":"Ren","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"Pt 2","key":"10.1016\/j.jconrel.2026.115246_bb0415","article-title":"Mitochondria-loaded alginate-based hydrogel accelerated angiogenesis in a rat model of acute myocardial infarction","volume":"260","author":"Hassanpour","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"27","key":"10.1016\/j.jconrel.2026.115246_bb0420","first-page":"17138","article-title":"Self-healing conductive injectable hydrogels with antibacterial activity as cell delivery carrier for cardiac cell therapy","volume":"8","author":"Dong","year":"2016"},{"issue":"12","key":"10.1016\/j.jconrel.2026.115246_bb0425","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1002\/jbm.a.37774","article-title":"Fabrication of chitin-fibrin hydrogels to construct the 3D artificial extracellular matrix scaffold for vascular regeneration and cardiac tissue engineering","volume":"112","author":"Yang","year":"2024","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"6","key":"10.1016\/j.jconrel.2026.115246_bb0430","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1021\/acsnano.7b00221","article-title":"Injectable Fullerenol\/alginate hydrogel for suppression of oxidative stress damage in Brown adipose-derived stem cells and cardiac repair","volume":"11","author":"Hao","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115246_bb0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2021.101306","article-title":"Chinese herb-crosslinked hydrogel bearing rBMSCs-laden polyzwitterion microgels: self-adaptive manipulation of micromilieu and stemness maintenance for restoring infarcted myocardium","volume":"41","author":"Liu","year":"2021","journal-title":"Nano Today"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115246_bb0440","first-page":"237","article-title":"Supramolecular hydrogels for long-term bioengineered stem cell therapy","volume":"4","author":"Yeom","year":"2015"},{"key":"10.1016\/j.jconrel.2026.115246_bb0445","article-title":"An injectable and conductive TEMPOL\/polypyrrole integrated peptide co-assembly hydrogel promotes functional maturation of cardiomyocytes for myocardial infarction repair","volume":"236","author":"Zhan","year":"2022"},{"issue":"7","key":"10.1016\/j.jconrel.2026.115246_bb0450","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1021\/acsbiomaterials.0c00340","article-title":"Reactive oxygen species scavenging and biodegradable peptide hydrogel as 3D culture scaffold for cardiomyocytes","volume":"6","author":"Shen","year":"2020","journal-title":"ACS Biomater Sci. Eng."},{"issue":"29","key":"10.1016\/j.jconrel.2026.115246_bb0455","first-page":"24459","article-title":"Folic acid derived hydrogel enhances the survival and promotes therapeutic efficacy of iPS cells for acute myocardial infarction","volume":"10","author":"Li","year":"2018"},{"issue":"25","key":"10.1016\/j.jconrel.2026.115246_bb0460","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300696","article-title":"Supramolecular assemblies of glycopeptides enhance gap junction maturation of human induced pluripotent stem cell-derived cardiomyocytes via inducing spheroids formation to optimize cardiac repair","volume":"12","author":"Li","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2026.115246_bb0465","article-title":"Enzymatic self-assembly nanofibers anchoring mesenchymal stem cells induce cell spheroids and amplify paracrine function for myocardial infarction therapy","volume":"436","author":"Fan","year":"2022"},{"key":"10.1016\/j.jconrel.2026.115246_bb0470","series-title":"Single-Cell Encapsulation of Mesenchymal Stromal Cells Via ECM-Mimetic Supramolecular Hydrogels Enhances Therapeutic Efficacy","author":"Wei","year":"2025"},{"key":"10.1016\/j.jconrel.2026.115246_bb0475","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.jconrel.2022.12.027","article-title":"Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications","volume":"353","author":"Mondal","year":"2023","journal-title":"J. Control. Release"},{"issue":"12","key":"10.1016\/j.jconrel.2026.115246_bb0480","doi-asserted-by":"crossref","first-page":"8002","DOI":"10.1097\/JS9.0000000000002109","article-title":"Revolutionizing medicine: recent developments and future prospects in stem-cell therapy","volume":"110","author":"Hussen","year":"2024","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.jconrel.2026.115246_bb0485","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.2147\/IJN.S417422","article-title":"Current knowledge and future perspectives of exosomes as nanocarriers in diagnosis and treatment of diseases","volume":"18","author":"Zou","year":"2023","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2026.115246_bb0490","doi-asserted-by":"crossref","DOI":"10.1093\/stcltm\/szac044","article-title":"Mesenchymal stromal cell mitochondrial transfer as a cell rescue strategy in regenerative medicine: a review of evidence in preclinical models","author":"Tan","year":"2022","journal-title":"Stem Cells Transl. Med."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115246_bb0495","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/stem.632","article-title":"Human mesenchymal stem cells reprogram adult cardiomyocytes toward a progenitor-like state through partial cell fusion and mitochondria transfer","volume":"29","author":"Acquistapace","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.jconrel.2026.115246_bb0500","first-page":"72","article-title":"Extracellular vesicles as drug delivery systems: lessons from the liposome field","volume":"195","author":"van der Meel","year":"2014"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115246_bb0505","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: exosomes, microvesicles, and friends","volume":"200","author":"Raposo","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jconrel.2026.115246_bb0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112784","article-title":"Exosomes from different cells: characteristics, modifications, and therapeutic applications","volume":"207","author":"Li","year":"2020","journal-title":"Eur. J. Med. Chem."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115246_bb0515","first-page":"351","article-title":"Rheological and syringeability properties of highly concentrated human polyclonal immunoglobulin solutions","volume":"76","author":"Burckbuchler","year":"2010"},{"issue":"20","key":"10.1016\/j.jconrel.2026.115246_bb0520","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201900847","article-title":"Injectable supramolecular ureidopyrimidinone hydrogels provide sustained release of extracellular vesicle therapeutics","volume":"8","author":"Mol","year":"2019","journal-title":"Adv. Healthc. Mater."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115246_bb0525","first-page":"70","article-title":"A fast pH-switchable and self-healing supramolecular hydrogel carrier for guided, local catheter injection in the infarcted myocardium","volume":"3","author":"Bastings","year":"2014"},{"key":"10.1016\/j.jconrel.2026.115246_bb0530","doi-asserted-by":"crossref","first-page":"5495","DOI":"10.2147\/IJN.S420301","article-title":"Intranasal delivery of endothelial cell-derived extracellular vesicles with supramolecular gel attenuates myocardial ischemia-reperfusion injury","volume":"18","author":"Wang","year":"2023","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jconrel.2026.115246_bb0535","first-page":"95","article-title":"Stem cell-inspired secretome-rich injectable hydrogel to repair injured cardiac tissue","volume":"69","author":"Waters","year":"2018"},{"issue":"14","key":"10.1016\/j.jconrel.2026.115246_bb0540","doi-asserted-by":"crossref","first-page":"7371","DOI":"10.1039\/C5NR07806G","article-title":"Stem cell secretome-rich nanoclay hydrogel: a dual action therapy for cardiovascular regeneration","volume":"8","author":"Waters","year":"2016","journal-title":"Nanoscale"},{"issue":"6","key":"10.1016\/j.jconrel.2026.115246_bb0545","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1166\/jbn.2020.2945","article-title":"Fluorescent magnetic iron oxide nanoparticle encapsulated protein hydrogel against doxorubicin-associated cardiotoxicity and for enhanced cardiomyocyte survival","volume":"16","author":"Dong","year":"2020","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.jconrel.2026.115246_bb0550","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.procbio.2021.01.021","article-title":"Precise engineering of iron oxide nanoparticle-encapsulated protein hydrogel: implications for cardiac toxicity and ultrasound contrast agents","volume":"102","author":"Zhang","year":"2021","journal-title":"Process Biochem."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115246_bb0555","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-87939-z","article-title":"Intrapericardial injection of hydrogels with ASC and their secretome to treat dilated cardiomyopathies","volume":"15","author":"Liguori","year":"2025","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115246_bb0560","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/abcff9","article-title":"Bioactive decellularized cardiac extracellular matrix-based hydrogel as a sustained-release platform for human adipose tissue-derived stromal cell-secreted factors","volume":"16","author":"Liguori","year":"2021","journal-title":"Biomed. Mater."},{"key":"10.1016\/j.jconrel.2026.115246_bb0565","series-title":"Targeted Delivery of Engineered Adipose-Derived Stem Cell Secretome to Promote Cardiac Repair after Myocardial Infarction","first-page":"113765","author":"Guan","year":"2025"},{"key":"10.1016\/j.jconrel.2026.115246_bb0570","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.145877","article-title":"Combining HUMSC secretome and a conductive hydrogel enhances angiogenesis and electrical transmission at myocardial infarct sites to support cardiac repair","volume":"474","author":"He","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jconrel.2026.115246_bb0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.136400","article-title":"Bio-functionalized hydrogel patches of chitosan for the functional recovery of infarcted myocardial tissue","volume":"281","author":"Domeng\u00e9","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jconrel.2026.115246_bb0580","article-title":"V1-Cal hydrogelation enhances its effects on ventricular remodeling reduction and cardiac function improvement post myocardial infarction","volume":"433","author":"Wang","year":"2022"},{"issue":"24","key":"10.1016\/j.jconrel.2026.115246_bb0585","article-title":"Bioenergetic metabolism modulatory peptide hydrogel for cardiac protection and repair after myocardial infarction","volume":"34","author":"Zhang","year":"2024"},{"key":"10.1016\/j.jconrel.2026.115246_bb0590","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114552","article-title":"Supramolecular antioxidant conductive injectable hydrogel encapsulating L-arginine for synergistic modulation of myocardial infarction","volume":"390","author":"Yu","year":"2026","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115246_bb0595","first-page":"111","article-title":"Dual delivery of an NF-\u03baB inhibitor and IL-10 through supramolecular hydrogels polarizes macrophages and promotes cardiac repair after myocardial infarction","volume":"164","author":"Wang","year":"2023"},{"key":"10.1016\/j.jconrel.2026.115246_bb0600","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jconrel.2025.01.039","article-title":"ROS-differentiated release of Apelin-13 from hydrogel comprehensively treats myocardial ischemia-reperfusion injury","volume":"379","author":"Zhen","year":"2025","journal-title":"J. Control. Release"},{"issue":"25","key":"10.1016\/j.jconrel.2026.115246_bb0605","first-page":"4161","article-title":"The inhibition of postinfarct ventricle remodeling without polycythaemia following local sustained intramyocardial delivery of erythropoietin within a supramolecular hydrogel","volume":"30","author":"Wang","year":"2009"},{"issue":"37","key":"10.1016\/j.jconrel.2026.115246_bb0610","first-page":"17327","article-title":"Photo-crosslinkable elastomeric protein-derived supramolecular peptide hydrogel with controlled therapeutic CO-release","volume":"11","author":"Kim","year":"2019"},{"issue":"34","key":"10.1016\/j.jconrel.2026.115246_bb0615","article-title":"A mixed component supramolecular hydrogel to improve mice cardiac function and alleviate ventricular remodeling after acute myocardial infarction","volume":"27","author":"Chen","year":"2017"},{"issue":"8","key":"10.1016\/j.jconrel.2026.115246_bb0620","first-page":"1458","article-title":"Bifunctional supramolecular hydrogel alleviates myocardial ischemia\/reperfusion injury by inhibiting autophagy and apoptosis","volume":"14","author":"Deng","year":"2018"},{"key":"10.1016\/j.jconrel.2026.115246_bb0625","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.actbio.2022.06.039","article-title":"An injectable co-assembled hydrogel blocks reactive oxygen species and inflammation cycle resisting myocardial ischemia-reperfusion injury","volume":"149","author":"Liao","year":"2022","journal-title":"Acta Biomater."},{"issue":"5824","key":"10.1016\/j.jconrel.2026.115246_bb0630","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1126\/science.1139089","article-title":"Control of stress-dependent cardiac growth and gene expression by a MicroRNA","volume":"316","author":"Van Rooij","year":"2007","journal-title":"Science"},{"issue":"35","key":"10.1016\/j.jconrel.2026.115246_bb0635","doi-asserted-by":"crossref","first-page":"13027","DOI":"10.1073\/pnas.0805038105","article-title":"Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis","volume":"105","author":"Van Rooij","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115246_bb0640","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nrd3864","article-title":"MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles","volume":"11","author":"Van Rooij","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115246_bb0645","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41569-019-0216-z","article-title":"MicroRNA-directed cardiac repair after myocardial infarction in pigs","volume":"16","author":"Lim","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"issue":"580","key":"10.1016\/j.jconrel.2026.115246_bb0650","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd0914","article-title":"Cell type\u2013specific microRNA therapies for myocardial infarction","volume":"13","author":"Liu","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115246_bb0655","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nrcardio.2009.56","article-title":"MicroRNAs and cardiac pathology","volume":"6","author":"Latronico","year":"2009","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115246_bb0660","doi-asserted-by":"crossref","DOI":"10.1002\/adtp.202300241","article-title":"Hydrogel-based delivery of antimiR-195 improves cardiac efficacy after ischemic injury","volume":"7","author":"Eding","year":"2024","journal-title":"Adv. Therap."},{"key":"10.1016\/j.jconrel.2026.115246_bb0665","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122732","article-title":"Enhancing miR-19a\/b induced cardiomyocyte proliferation in infarcted hearts by alleviating oxidant stress and controlling miR-19 release","volume":"312","author":"Wang","year":"2025","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115246_bb0670","article-title":"Injectable supramolecular hydrogel\/microgel composites for therapeutic delivery","volume":"19","author":"Chen","year":"2019"},{"key":"10.1016\/j.jconrel.2026.115246_bb0675","article-title":"ROS scavenging activity of polydopamine nanoparticle-loaded supramolecular gelatin-based hydrogel promoted cardiomyocyte proliferation","volume":"259","author":"Zarkesh","year":"2024"},{"issue":"6679 Suppl","key":"10.1016\/j.jconrel.2026.115246_bb0680","first-page":"5","article-title":"Drug delivery and targeting","volume":"392","author":"Langer","year":"1998","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115246_bb0685","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2165\/00002018-199410030-00005","article-title":"Novel oral drug formulations","volume":"10","author":"Florence","year":"1994","journal-title":"Drug Saf."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115246_bb0690","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1208\/s12249-024-02786-x","article-title":"A comprehensive review of hydrogel-based drug delivery systems: classification, properties, recent trends, and applications","volume":"25","author":"Hameed","year":"2024","journal-title":"AAPS PharmSciTech"},{"issue":"12","key":"10.1016\/j.jconrel.2026.115246_bb0695","doi-asserted-by":"crossref","first-page":"16071","DOI":"10.1038\/natrevmats.2016.71","article-title":"Designing hydrogels for controlled drug delivery","volume":"1","author":"Li","year":"2016","journal-title":"Nat. Rev. Mater."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115246_bb0700","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.ymthe.2022.11.017","article-title":"Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting","volume":"31","author":"Anttila","year":"2023","journal-title":"Mol. Ther."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115246_bb0705","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/ejhf.449","article-title":"One-year follow-up results from AUGMENT-HF: a multicentre randomized controlled clinical trial of the efficacy of left ventricular augmentation with Algisyl in the treatment of heart failure","volume":"18","author":"Mann","year":"2016","journal-title":"Eur. J. Heart Fail."},{"issue":"8054","key":"10.1016\/j.jconrel.2026.115246_bb0715","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41586-024-08463-0","article-title":"Engineered heart muscle allografts for heart repair in primates and humans","volume":"639","author":"Jebran","year":"2025","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.jconrel.2026.115246_bb0720","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/CIRCINTERVENTIONS.114.001478","article-title":"Intracoronary delivery of injectable bioabsorbable scaffold (IK-5001) to treat left ventricular remodeling after ST-elevation myocardial infarction","volume":"7","author":"Frey","year":"2014","journal-title":"Circ. Cardiovasc. Interv."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115246_bb0725","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3727\/096368907783338217","article-title":"Myocardial assistance by grafting a new bioartificial upgraded myocardium (MAGNUM clinical trial): one year follow-up","volume":"16","author":"Chachques","year":"2007","journal-title":"Cell Transplant."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115246_bb0730","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jacc.2017.11.047","article-title":"Transplantation of human embryonic stem cell\u2013derived cardiovascular progenitors for severe ischemic left ventricular dysfunction","volume":"71","author":"Menasch\u00e9","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115246_bb0735","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.16236","article-title":"Effect of intramyocardial grafting collagen scaffold with mesenchymal stromal cells in patients with chronic ischemic heart disease","volume":"3","author":"He","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.jconrel.2026.115246_bb0740","author":"Yamamoto"},{"key":"10.1016\/j.jconrel.2026.115246_bb0745","author":"Rioult"},{"key":"10.1016\/j.jconrel.2026.115246_bb0750","author":"E. M. Agency"},{"key":"10.1016\/j.jconrel.2026.115246_bb0755","author":"U. S. F. a. D. Administration"},{"issue":"21","key":"10.1016\/j.jconrel.2026.115246_bb0760","doi-asserted-by":"crossref","first-page":"15748","DOI":"10.3390\/ijms242115748","article-title":"From static to dynamic: smart materials pioneering additive manufacturing in regenerative medicine","volume":"24","author":"Kantaros","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2026.115246_bb0765","doi-asserted-by":"crossref","DOI":"10.1038\/s41551-026-01681-z","article-title":"4D-printed adaptive hydrogel tissue expanders for ear and breast reconstruction","author":"Wang","year":"2026","journal-title":"Nature Biomed. Eng."},{"key":"10.1016\/j.jconrel.2026.115246_bb0770","article-title":"4D printed cardiac occlusion device with efficient anticoagulation, proendothelialization, and precise localization","author":"Yang","year":"2025","journal-title":"Adv. Funct. Mater."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115246_bb0775","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3390\/gels9110845","article-title":"Exploring the potential of artificial intelligence for hydrogel development \u2014 a short review","volume":"9","author":"Negut","year":"2023","journal-title":"Gels"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926006504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926006504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:56:11Z","timestamp":1790211371000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926006504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":154,"alternative-id":["S0168365926006504"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115246","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogels as controlled delivery systems for cardiac repair and regeneration","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115246","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115246"}}