{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:01:55Z","timestamp":1790215315127,"version":"4.1.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570768"],"award-info":[{"award-number":["82570768"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070659"],"award-info":[{"award-number":["82070659"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82122010"],"award-info":[{"award-number":["82122010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460135"],"award-info":[{"award-number":["82460135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2024QC351"],"award-info":[{"award-number":["ZR2024QC351"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA0918504"],"award-info":[{"award-number":["2024YFA0918504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jconrel.2026.115253","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T07:01:45Z","timestamp":1786518105000},"page":"115253","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Intranasal nanoparticle targeting neutrophil ORAI1 mitigates pancreatitis- and sepsis-associated acute lung injury"],"prefix":"10.1016","volume":"398","author":[{"given":"Zihan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingye","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bintao","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine C.L.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10252","key":"10.1016\/j.jconrel.2026.115253_bb0005","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0140-6736(20)31310-6","article-title":"Acute pancreatitis","volume":"396","author":"Boxhoorn","year":"2020","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jconrel.2026.115253_bb0010","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1053\/j.gastro.2024.12.029","article-title":"Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: update 2024","volume":"168","author":"Peery","year":"2025","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.jconrel.2026.115253_bb0015","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1097\/CM9.0000000000002164","article-title":"Burden of pancreatitis and associated risk factors in China, 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"135","author":"Han","year":"2022","journal-title":"Chin. Med. J."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115253_bb0020","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/jama.2020.20317","article-title":"Acute pancreatitis: a review","volume":"325","author":"Mederos","year":"2021","journal-title":"JAMA"},{"issue":"17","key":"10.1016\/j.jconrel.2026.115253_bb0025","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.3748\/wjg.v16.i17.2094","article-title":"Acute lung injury and ARDS in acute pancreatitis: mechanisms and potential intervention","volume":"16","author":"Zhou","year":"2010","journal-title":"World J. Gastroenterol."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115253_bb0030","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41575-019-0158-2","article-title":"New insights into acute pancreatitis","volume":"16","author":"Lee","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115253_bb0035","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"issue":"18","key":"10.1016\/j.jconrel.2026.115253_bb0040","doi-asserted-by":"crossref","first-page":"11778","DOI":"10.1021\/acsnano.4c00218","article-title":"Inflammation and acinar cell dual-targeting nanomedicines for synergistic treatment of acute pancreatitis via Ca(2+) homeostasis regulation and pancreas autodigestion inhibition","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"issue":"29","key":"10.1016\/j.jconrel.2026.115253_bb0045","doi-asserted-by":"crossref","first-page":"19283","DOI":"10.1021\/acsnano.4c05369","article-title":"Biomimetic trypsin-responsive structure-bridged mesoporous organosilica nanomedicine for precise treatment of acute pancreatitis","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"issue":"8","key":"10.1016\/j.jconrel.2026.115253_bb0050","doi-asserted-by":"crossref","first-page":"7562","DOI":"10.1021\/acsnano.2c12722","article-title":"Extracellular vesicle ITGAM and ITGB2 mediate severe acute pancreatitis-related acute lung injury","volume":"17","author":"Hu","year":"2023","journal-title":"ACS Nano"},{"issue":"32","key":"10.1016\/j.jconrel.2026.115253_bb0055","doi-asserted-by":"crossref","first-page":"21009","DOI":"10.1021\/acsnano.4c01900","article-title":"Intracellularly synthesized artificial exosome treats acute lung injury","volume":"18","author":"Liang","year":"2024","journal-title":"ACS Nano"},{"issue":"12","key":"10.1016\/j.jconrel.2026.115253_bb0060","doi-asserted-by":"crossref","first-page":"11626","DOI":"10.1021\/acsnano.3c02075","article-title":"An inhalable hybrid biomimetic nanoplatform for sequential drug release and remodeling lung immune homeostasis in acute lung injury treatment","volume":"17","author":"Liu","year":"2023","journal-title":"ACS Nano"},{"issue":"9","key":"10.1016\/j.jconrel.2026.115253_bb0065","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.3390\/biomedicines10092179","article-title":"Lipid nanoparticles as delivery vehicles for inhaled therapeutics","volume":"10","author":"Leong","year":"2022","journal-title":"Biomedicines"},{"issue":"10","key":"10.1016\/j.jconrel.2026.115253_bb0070","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1038\/s41587-023-01679-x","article-title":"Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing","volume":"41","author":"Li","year":"2023","journal-title":"Nat. Biotechnol."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115253_bb0075","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2314747121","article-title":"Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery","volume":"121","author":"Zhao","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"10","key":"10.1016\/j.jconrel.2026.115253_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines12101148","article-title":"Recent advances in lipid nanoparticles and their safety concerns for mRNA delivery","volume":"12","author":"Wang","year":"2024","journal-title":"Vaccines"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115253_bb0085","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/S0016-5085(99)70192-7","article-title":"The role of intercellular adhesion molecule 1 and neutrophils in acute pancreatitis and pancreatitis-associated lung injury","volume":"116","author":"Frossard","year":"1999","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115253_bb0090","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1053\/gast.2002.30348","article-title":"Matrix metalloproteinase-9 promotes neutrophil migration and alveolar capillary leakage in pancreatitis-associated lung injury in the rat","volume":"122","author":"Keck","year":"2002","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115253_bb0095","doi-asserted-by":"crossref","first-page":"1800786","DOI":"10.1183\/13993003.00786-2018","article-title":"Neutrophils disturb pulmonary microcirculation in sepsis-induced acute lung injury","volume":"53","author":"Park","year":"2019","journal-title":"Eur. Respir. J."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115253_bb0100","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41420-023-01614-8","article-title":"Neutrophil extracellular traps contribute to immunothrombosis formation via the STING pathway in sepsis-associated lung injury","volume":"9","author":"Zhu","year":"2023","journal-title":"Cell Death Discov."},{"issue":"10358","key":"10.1016\/j.jconrel.2026.115253_bb0105","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0140-6736(22)01485-4","article-title":"Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes","volume":"400","author":"Bos","year":"2022","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115253_bb0110","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1182\/blood-2009-05-224659","article-title":"Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow","volume":"115","author":"Schaff","year":"2010","journal-title":"Blood"},{"issue":"39","key":"10.1016\/j.jconrel.2026.115253_bb0115","doi-asserted-by":"crossref","first-page":"24403","DOI":"10.1073\/pnas.2008032117","article-title":"ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense","volume":"117","author":"Grimes","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115253_bb0120","article-title":"Neutrophil-specific ORAI1 calcium channel inhibition reduces pancreatitis-associated acute lung injury","volume":"5","author":"Niu","year":"2024","journal-title":"Function (Oxf)"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115253_bb0125","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nprot.2009.243","article-title":"Experimental acute biliary pancreatitis induced by retrograde infusion of bile acids into the mouse pancreatic duct","volume":"5","author":"Perides","year":"2010","journal-title":"Nat. Protoc."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115253_bb0130","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1053\/j.gastro.2015.04.015","article-title":"Inhibitors of ORAI1 prevent cytosolic calcium-associated injury of human pancreatic acinar cells and acute pancreatitis in 3 mouse models","volume":"149","author":"Wen","year":"2015","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115253_bb0135","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3109\/1547691X.2013.792886","article-title":"Protection of mice against lipopolysaccharide-induced endotoxic shock by pinocembrin is correlated with regulation of cytokine secretion","volume":"11","author":"Soromou","year":"2014","journal-title":"J. Immunotoxicol."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115253_bb0140","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1136\/gut.2006.105833","article-title":"Suppression of transforming growth factor beta signalling aborts caerulein induced pancreatitis and eliminates restricted stimulation at high caerulein concentrations","volume":"56","author":"Wildi","year":"2007","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115253_bb0145","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00441-019-03023-9","article-title":"Mouse model to study pulmonary intravascular macrophage recruitment and lung inflammation in acute necrotizing pancreatitis","volume":"378","author":"Vrolyk","year":"2019","journal-title":"Cell Tissue Res."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115253_bb0150","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115253_bb0155","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41596-022-00755-x","article-title":"Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery","volume":"18","author":"Wang","year":"2023","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jconrel.2026.115253_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.01165","article-title":"Intranasal delivery of targeted nanoparticles loaded with miR-132 to brain for the treatment of neurodegenerative diseases","volume":"11","author":"Su","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115253_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100029","article-title":"Analysis of myeloid cells in mouse tissues with flow cytometry","volume":"1","author":"Liu","year":"2020","journal-title":"STAR Protoc"},{"issue":"17","key":"10.1016\/j.jconrel.2026.115253_bb0170","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"Fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115253_bb0175","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115253_bb0180","doi-asserted-by":"crossref","first-page":"R22","DOI":"10.1186\/gb-2011-12-3-r22","article-title":"Improving RNA-Seq expression estimates by correcting for fragment bias","volume":"12","author":"Roberts","year":"2011","journal-title":"Genome Biol."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115253_bb0185","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"issue":"Database issue","key":"10.1016\/j.jconrel.2026.115253_bb0190","first-page":"D480","article-title":"KEGG for linking genomes to life and the environment","volume":"36","author":"Kanehisa","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.jconrel.2026.115253_bb0195","doi-asserted-by":"crossref","first-page":"D330","DOI":"10.1093\/nar\/gky1055","article-title":"The gene ontology resource: 20 years and still GOing strong","volume":"47","author":"The Gene Ontology, C","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"43","key":"10.1016\/j.jconrel.2026.115253_bb0200","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115253_bb0205","doi-asserted-by":"crossref","first-page":"5430","DOI":"10.1021\/acs.analchem.8b00661","article-title":"Nanoliter-scale oil-air-droplet chip-based single cell proteomic analysis","volume":"90","author":"Li","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jconrel.2026.115253_bb0210","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-1-62703-845-4_3","article-title":"Neutrophil isolation from nonhuman species","volume":"1124","author":"Siemsen","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jconrel.2026.115253_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2022.108994","article-title":"Optimization of the Transwell(R) assay for the analysis of neutrophil chemotaxis using flow cytometry to refine the clinical investigation of immunodeficient patients","volume":"238","author":"Lauwers","year":"2022","journal-title":"Clin. Immunol."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115253_bb0220","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3892\/etm.2021.9784","article-title":"Differentiation of HL-60 cells in serum-free hematopoietic cell media enhances the production of neutrophil extracellular traps","volume":"21","author":"Guo","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jconrel.2026.115253_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103072","article-title":"Macrophage Tim-3 maintains intestinal homeostasis in DSS-induced colitis by suppressing neutrophil necroptosis","volume":"70","author":"Wang","year":"2024","journal-title":"Redox Biol."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115253_bb0230","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1177\/0963689718815824","article-title":"Inflammatory smooth muscle cells induce endothelial cell alterations to influence cerebral aneurysm progression via regulation of integrin and VEGF expression","volume":"28","author":"Liu","year":"2019","journal-title":"Cell Transplant."},{"key":"10.1016\/j.jconrel.2026.115253_bb0235","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00184","article-title":"Extracellular acidification inhibits the ROS-dependent formation of neutrophil extracellular traps","volume":"8","author":"Behnen","year":"2017","journal-title":"Front. Immunol."},{"issue":"23","key":"10.1016\/j.jconrel.2026.115253_bb0240","first-page":"2526","article-title":"Acute respiratory distress syndrome: the Berlin Definition","volume":"307","author":"Force","year":"2012","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.jconrel.2026.115253_bb0245","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1113\/JP277856","article-title":"The Orai Ca(2+) channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis","volume":"597","author":"Waldron","year":"2019","journal-title":"J. Physiol."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115253_bb0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082944","article-title":"Antibody-mediated targeting of the Orai1 calcium channel inhibits T cell function","volume":"8","author":"Cox","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115253_bb0255","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3109\/1547691X.2014.915897","article-title":"Inhibition of CRAC with a human anti-ORAI1 monoclonal antibody inhibits T-cell-derived cytokine production but fails to inhibit a T-cell-dependent antibody response in the cynomolgus monkey","volume":"12","author":"Gaida","year":"2015","journal-title":"J. Immunotoxicol."},{"issue":"40","key":"10.1016\/j.jconrel.2026.115253_bb0260","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abn6552","article-title":"Distinct roles of ORAI1 in T cell-mediated allergic airway inflammation and immunity to influenza A virus infection","volume":"8","author":"Wang","year":"2022","journal-title":"Sci. Adv."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115253_bb0265","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/MPA.0000000000001793","article-title":"Auxora for the treatment of patients with acute pancreatitis and accompanying systemic inflammatory response syndrome: clinical development of a calcium release-activated calcium channel inhibitor","volume":"50","author":"Bruen","year":"2021","journal-title":"Pancreas"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115253_bb0270","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13054-022-03964-8","article-title":"Auxora vs. placebo for the treatment of patients with severe COVID-19 pneumonia: a randomized-controlled clinical trial","volume":"26","author":"Bruen","year":"2022","journal-title":"Crit. Care"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115253_bb0275","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1038\/s41467-019-10329-3","article-title":"Selective recruitment of different Ca(2+)-dependent transcription factors by STIM1-Orai1 channel clusters","volume":"10","author":"Lin","year":"2019","journal-title":"Nat. Commun."},{"issue":"28","key":"10.1016\/j.jconrel.2026.115253_bb0280","doi-asserted-by":"crossref","first-page":"16638","DOI":"10.1073\/pnas.1915386117","article-title":"STIM2 targets Orai1\/STIM1 to the AKAP79 signaling complex and confers coupling of Ca(2+) entry with NFAT1 activation","volume":"117","author":"Son","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5412","key":"10.1016\/j.jconrel.2026.115253_bb0285","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1126\/science.284.5412.339","article-title":"Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD","volume":"284","author":"Wang","year":"1999","journal-title":"Science"},{"issue":"41","key":"10.1016\/j.jconrel.2026.115253_bb0290","doi-asserted-by":"crossref","first-page":"15803","DOI":"10.1073\/pnas.0808249105","article-title":"Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria","volume":"105","author":"Cereghetti","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"45","key":"10.1016\/j.jconrel.2026.115253_bb0295","doi-asserted-by":"crossref","first-page":"37698","DOI":"10.1074\/jbc.M502247200","article-title":"Inhibition of the calcineurin-NFAT interaction by small organic molecules reflects binding at an allosteric site","volume":"280","author":"Kang","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115253_bb0300","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.immuni.2017.09.003","article-title":"Store-operated Ca(2+) entry controls clonal expansion of T cells through metabolic reprogramming","volume":"47","author":"Vaeth","year":"2017","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115253_bb0305","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s10059-013-0073-2","article-title":"Orai1-NFAT signalling pathway triggered by T cell receptor stimulation","volume":"35","author":"Srikanth","year":"2013","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.jconrel.2026.115253_bb0310","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1161\/CIRCRESAHA.111.246777","article-title":"Orai1-mediated I (CRAC) is essential for neointima formation after vascular injury","volume":"109","author":"Zhang","year":"2011","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115253_bb0315","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1161\/CIRCRESAHA.116.309548","article-title":"ORAI1 activates proliferation of lymphatic endothelial cells in response to laminar flow through Kruppel-like factors 2 and 4","volume":"120","author":"Choi","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.jconrel.2026.115253_bb0320","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.649476","article-title":"Calcium channel protein ORAI1 mediates TGF-beta induced epithelial-to-mesenchymal transition in colorectal cancer cells","volume":"11","author":"Kang","year":"2021","journal-title":"Front. Oncol."},{"issue":"28","key":"10.1016\/j.jconrel.2026.115253_bb0325","doi-asserted-by":"crossref","first-page":"43239","DOI":"10.18632\/oncotarget.9755","article-title":"Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral\/oropharyngeal squamous cell carcinoma","volume":"7","author":"Lee","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jconrel.2026.115253_bb0330","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cytogfr.2021.07.001","article-title":"ALCAM\/CD166: a pleiotropic mediator of cell adhesion, stemness and cancer progression","volume":"61","author":"Ferragut","year":"2021","journal-title":"Cytokine Growth Factor Rev."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115253_bb0335","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1016\/j.febslet.2006.04.013","article-title":"Activated leukocyte cell adhesion molecule is a component of the endothelial junction involved in transendothelial monocyte migration","volume":"580","author":"Masedunskas","year":"2006","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115253_bb0340","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.mvr.2007.10.006","article-title":"Heterogeneity of barrier function in the lung reflects diversity in endothelial cell junctions","volume":"75","author":"Ofori-Acquah","year":"2008","journal-title":"Microvasc. Res."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115253_bb0345","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1177\/0271678X16678639","article-title":"ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood-brain barrier","volume":"37","author":"Lyck","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"518","key":"10.1016\/j.jconrel.2026.115253_bb0350","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaw0475","article-title":"Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers","volume":"11","author":"Michel","year":"2019","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115253_bb0355","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1007\/s10753-022-01765-3","article-title":"ALCAM deficiency alleviates LPS-induced acute lung injury by inhibiting inflammatory response","volume":"46","author":"Li","year":"2023","journal-title":"Inflammation"},{"issue":"8","key":"10.1016\/j.jconrel.2026.115253_bb0360","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1164\/rccm.201703-0532OC","article-title":"Activated leukocyte cell adhesion molecule stimulates the T-cell response in allergic asthma","volume":"197","author":"Kim","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926006577?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926006577?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:08:21Z","timestamp":1790212101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926006577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":72,"alternative-id":["S0168365926006577"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115253","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intranasal nanoparticle targeting neutrophil ORAI1 mitigates pancreatitis- and sepsis-associated acute lung injury","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115253","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115253"}}