{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:36:18Z","timestamp":1793450178629,"version":"4.5.0"},"reference-count":201,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372106"],"award-info":[{"award-number":["82372106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515110226"],"award-info":[{"award-number":["2023A1515110226"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005146","name":"Basic Research Programs of Sichuan Province","doi-asserted-by":"publisher","award":["202203021222340"],"award-info":[{"award-number":["202203021222340"]}],"id":[{"id":"10.13039\/501100005146","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005146","name":"Basic Research Programs of Sichuan Province","doi-asserted-by":"publisher","award":["202403021221247"],"award-info":[{"award-number":["202403021221247"]}],"id":[{"id":"10.13039\/501100005146","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jconrel.2026.115255","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T23:41:47Z","timestamp":1786491707000},"page":"115255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Clinical potential and challenges of extracellular vesicles in myocardial infarction therapy"],"prefix":"10.1016","volume":"398","author":[{"given":"Kaiyi","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangfu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangxin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbo","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0005","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0008-6363(01)00434-5","article-title":"The inflammatory response in myocardial infarction","volume":"53","author":"Frangogiannis","year":"2002","journal-title":"Cardiovasc. Res."},{"issue":"10065","key":"10.1016\/j.jconrel.2026.115255_bb0010","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0140-6736(16)30677-8","article-title":"Acute myocardial infarction","volume":"389","author":"Reed","year":"2017","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jconrel.2026.115255_bb0015","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41580-022-00460-3","article-title":"Challenges and directions in studying cell\u2013cell communication by extracellular vesicles","volume":"23","author":"van Niel","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115255_bb0020","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/S0735-1097(98)00088-6","article-title":"Time to therapy and salvage in myocardial infarction","volume":"31","author":"Milavetz","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115255_bb0025","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1056\/NEJMoa0804626","article-title":"Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease","volume":"360","author":"Serruys","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0030","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41392-023-01704-0","article-title":"Clinical applications of stem cell-derived exosomes","volume":"9","author":"Tan","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2026.115255_bb0035","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.yjmcc.2023.12.001","article-title":"Pluripotent stem cell-based cardiac regenerative therapy for heart failure","volume":"187","author":"Soma","year":"2024","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jconrel.2026.115255_bb0040","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.cytogfr.2023.08.005","article-title":"Extracellular vesicles as a novel mediator of interkingdom communication","volume":"73","author":"Huang","year":"2023","journal-title":"Cytokine Growth Factor Rev."},{"issue":"28","key":"10.1016\/j.jconrel.2026.115255_bb0045","doi-asserted-by":"crossref","first-page":"2301010","DOI":"10.1002\/adhm.202301010","article-title":"Clinical translation of extracellular vesicles","volume":"12","author":"Ghodasara","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2026.115255_bb0050","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jconrel.2023.11.057","article-title":"Extracellular vesicles and their engineering strategies, delivery systems, and biomedical applications","volume":"365","author":"Yang","year":"2024","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0055","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.tibtech.2024.08.007","article-title":"Engineering therapeutical extracellular vesicles for clinical translation","volume":"43","author":"Ma","year":"2025","journal-title":"Trends Biotechnol."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115255_bb0060","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1124\/pr.112.005983","article-title":"Classification, functions, and clinical relevance of extracellular vesicles","volume":"64","author":"Van der Pol","year":"2012","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0065","doi-asserted-by":"crossref","first-page":"1647027","DOI":"10.1080\/20013078.2019.1647027","article-title":"Considerations towards a roadmap for collection, handling and storage of blood extracellular vesicles","volume":"8","author":"Clayton","year":"2019","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jconrel.2026.115255_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122976","article-title":"Myocardial delivery of miR30d with peptide-functionalized milk-derived extracellular vesicles for targeted treatment of hypertrophic heart failure","volume":"316","author":"Tong","year":"2025","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.jconrel.2026.115255_bb0075","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18177","article-title":"Avocado-derived extracellular vesicles loaded with ginkgetin and berberine prevent inflammation and macrophage foam cell formation","volume":"28","author":"Sharma","year":"2024","journal-title":"J. Cell. Mol. Med."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115255_bb0080","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41580-023-00576-0","article-title":"Context-specific regulation of extracellular vesicle biogenesis and cargo selection","volume":"24","author":"Dixson","year":"2023","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jconrel.2026.115255_bb0085","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.3390\/cells12172145","article-title":"Extracellular vesicle MicroRNAs in heart failure: pathophysiological mediators and therapeutic targets","volume":"12","author":"Tian","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2026.115255_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.836662","article-title":"Endothelium-released microvesicles transport miR-126 that induces proangiogenic reprogramming in monocytes","volume":"13","author":"Arderiu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2026.115255_bb0095","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115255_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12260","article-title":"Understanding the extracellular vesicle surface for clinical molecular biology","volume":"11","author":"Hallal","year":"2022","journal-title":"J. Extracell. Vesicles"},{"issue":"6","key":"10.1016\/j.jconrel.2026.115255_bb0105","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/s41565-023-01585-y","article-title":"Cellular uptake and in vivo distribution of mesenchymal-stem-cell-derived extracellular vesicles are protein corona dependent","volume":"19","author":"Liam-Or","year":"2024","journal-title":"Nat. Nanotechnol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0110","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12964-023-01089-1","article-title":"Protein corona and exosomes: new challenges and prospects","volume":"21","author":"Heidarzadeh","year":"2023","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.jconrel.2026.115255_bb0115","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12140","article-title":"Formation of a protein corona on the surface of extracellular vesicles in blood plasma","volume":"10","author":"T\u00f3th","year":"2021","journal-title":"J. Extracell. Vesicles"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115255_bb0120","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/cvr\/cvn333","article-title":"Myocardial repair\/remodelling following infarction: roles of local factors","volume":"81","author":"Sun","year":"2009","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115255_bb0125","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1002\/j.2040-4603.2015.tb00664.x","article-title":"Pathophysiology of myocardial infarction","volume":"5","author":"Frangogiannis","year":"2015","journal-title":"Compr. Physiol."},{"issue":"584","key":"10.1016\/j.jconrel.2026.115255_bb0130","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb0202","article-title":"Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates","volume":"13","author":"Li","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115255_bb0135","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/cvr\/cvaa287","article-title":"Angiogenesis after acute myocardial infarction","volume":"117","author":"Wu","year":"2021","journal-title":"Cardiovasc. Res."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115255_bb0140","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1159\/000485949","article-title":"Exosomes from MiR-126-overexpressing adscs are therapeutic in relieving acute myocardial ischaemic injury","volume":"44","author":"Luo","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115255_bb0145","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1089\/scd.2021.0006","article-title":"The vital roles of mesenchymal stem cells and the derived extracellular vesicles in promoting angiogenesis after acute myocardial infarction","volume":"30","author":"Zhang","year":"2021","journal-title":"Stem Cells Dev."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0150","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1186\/s13287-020-01881-7","article-title":"HIF-1\u03b1 overexpression in mesenchymal stem cell-derived exosomes mediates cardioprotection in myocardial infarction by enhanced angiogenesis","volume":"11","author":"Sun","year":"2020","journal-title":"Stem Cell Res Ther"},{"issue":"20","key":"10.1016\/j.jconrel.2026.115255_bb0155","doi-asserted-by":"crossref","first-page":"19613","DOI":"10.1021\/acsnano.3c01534","article-title":"Customized loading of microRNA-126 to small extracellular vesicle-derived vehicles improves cardiac function after myocardial infarction","volume":"17","author":"Bheri","year":"2023","journal-title":"ACS Nano"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115255_bb0160","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/cvr\/cvz139","article-title":"Atorvastatin enhances the therapeutic efficacy of mesenchymal stem cells-derived exosomes in acute myocardial infarction via up-regulating long non-coding RNA H19","volume":"116","author":"Huang","year":"2020","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115255_bb0165","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/s41419-020-2508-y","article-title":"Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis","volume":"11","author":"Wu","year":"2020","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115255_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191616","article-title":"Bone marrow mesenchymal stem cell-derived exosomal miR-21 protects C-kit+ cardiac stem cells from oxidative injury through the PTEN\/PI3K\/Akt axis","volume":"13","author":"Shi","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jconrel.2026.115255_bb0175","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jare.2022.12.014","article-title":"Extracellular vesicle-derived CircWhsc1 promotes cardiomyocyte proliferation and heart repair by activating TRIM59\/STAT3\/Cyclin B2 pathway","volume":"53","author":"Wei","year":"2023","journal-title":"J. Adv. Res."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115255_bb0180","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/cvr\/cvu167","article-title":"Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction","volume":"103","author":"Barile","year":"2014","journal-title":"Cardiovasc. Res."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115255_bb0185","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.3390\/cells10071676","article-title":"Role of neutrophils in cardiac injury and repair following myocardial infarction","volume":"10","author":"Ma","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2026.115255_bb0190","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.2147\/IJN.S436925","article-title":"MSC-derived exosomes mitigate myocardial ischemia\/reperfusion injury by reducing neutrophil infiltration and the formation of neutrophil extracellular traps","volume":"19","author":"Feng","year":"2024","journal-title":"Int. J. Nanomedicine"},{"issue":"10","key":"10.1016\/j.jconrel.2026.115255_bb0195","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1096\/fj.201601244RR","article-title":"Endothelial microparticles prevent lipid-induced endothelial damage via Akt\/eNOS signaling and reduced oxidative stress","volume":"31","author":"Mahmoud","year":"2017","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0200","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41392-022-00925-z","article-title":"Signaling pathways and targeted therapy for myocardial infarction","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115255_bb0205","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12461","article-title":"Adult cardiomyocytes-derived EVs for the treatment of cardiac fibrosis","volume":"13","author":"Prieto-Vila","year":"2024","journal-title":"J. Extracell. Vesicles"},{"issue":"10","key":"10.1016\/j.jconrel.2026.115255_bb0210","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.7150\/thno.72289","article-title":"Acellular cardiac scaffolds enriched with MSC-derived extracellular vesicles limit ventricular remodelling and exert local and systemic immunomodulation in a myocardial infarction porcine model","volume":"12","author":"Mongui\u00f3-Tortajada","year":"2022","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0215","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1038\/s41467-023-37832-y","article-title":"Extracellular vesicles engineering by silicates-activated endothelial progenitor cells for myocardial infarction treatment in male mice","volume":"14","author":"Yu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115255_bb0220","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1152\/physrev.00009.2023","article-title":"Mesenchymal stromal cells for improvement of cardiac function following acute myocardial infarction: a matter of timing","volume":"104","author":"Barr\u00e8re-Lemaire","year":"2024","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jconrel.2026.115255_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117256","article-title":"Protective effects of mesenchymal stem cells-derived extracellular vesicles against ischemia-reperfusion injury of hearts donated after circulatory death: Preliminary study in a pig model","volume":"178","author":"Tolomeo","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115255_bb0230","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1152\/physrev.00009.2023","article-title":"Mesenchymal stromal cells for improvement of cardiac function following acute myocardial infarction: a matter of timing","volume":"104","author":"Barr\u00e8re-Lemaire","year":"2024","journal-title":"Physiol. Rev."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115255_bb0235","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1089\/scd.2018.0242","article-title":"Exosomes derived from human umbilical cord mesenchymal stem cells promote fibroblast-to-myofibroblast differentiation in inflammatory environments and benefit cardioprotective effects","volume":"28","author":"Shi","year":"2019","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.jconrel.2026.115255_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113989","article-title":"Adipose stem cell-derived nanovesicles for cardioprotection: production and identification of therapeutic components","volume":"385","author":"Huang","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115255_bb0245","article-title":"Scalable production of human mesenchymal stromal cell-derived extracellular vesicles under serum-\/xeno-free conditions in a microcarrier-based bioreactor culture system","volume":"8","author":"de Almeida","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115255_bb0250","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1016\/j.ymthe.2018.09.015","article-title":"Exosomes produced from 3D cultures of MSCs by tangential flow filtration show higher yield and improved activity","volume":"26","author":"Haraszti","year":"2018","journal-title":"Mol. Ther."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115255_bb0255","doi-asserted-by":"crossref","DOI":"10.3390\/cells8121536","article-title":"Cardiac progenitor cells from stem cells: learning from genetics and biomaterials","volume":"8","author":"Barreto","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2026.115255_bb0260","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3389\/fphys.2018.01169","article-title":"Exosomes from human cardiac progenitor cells for therapeutic applications: development of a GMP-grade manufacturing method","volume":"9","author":"Andriolo","year":"2018","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0265","article-title":"Modification of cardiac progenitor cell-derived exosomes by miR-322 provides protection against myocardial infarction through Nox2-dependent angiogenesis","volume":"8","author":"Youn","year":"2019","journal-title":"Antioxidants (Basel)."},{"key":"10.1016\/j.jconrel.2026.115255_bb0270","doi-asserted-by":"crossref","first-page":"1005926","DOI":"10.3389\/fcell.2022.1005926","article-title":"MSCs vs. iPSCs: potential in therapeutic applications","volume":"10","author":"Thanaskody","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115255_bb0275","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24054577","article-title":"Small extracellular vesicles derived from induced pluripotent stem cells in the treatment of myocardial injury","volume":"24","author":"Meng","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2026.115255_bb0280","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.3389\/fphys.2018.01794","article-title":"Extracellular vesicles released by human induced-pluripotent stem cell-derived cardiomyocytes promote angiogenesis","volume":"9","author":"Dougherty","year":"2018","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0285","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00395-021-00858-8","article-title":"miR-106a-363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3 pathway in ischemic heart injury","volume":"116","author":"Jung","year":"2021","journal-title":"Basic Res. Cardiol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0290","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.healun.2023.08.011","article-title":"Pleiotropic effects of extracellular vesicles from induced pluripotent stem cell-derived cardiomyocytes on ischemic cardiomyopathy: a preclinical study","volume":"43","author":"Tominaga","year":"2024","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.jconrel.2026.115255_bb0295","doi-asserted-by":"crossref","first-page":"1493290","DOI":"10.3389\/fcvm.2024.1493290","article-title":"Cardiac cells and mesenchymal stem cells derived extracellular vesicles: a potential therapeutic strategy for myocardial infarction","volume":"11","author":"Qin","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"issue":"18","key":"10.1016\/j.jconrel.2026.115255_bb0300","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1093\/eurheartj\/ehae089","article-title":"Injury minimization after myocardial infarction: focus on extracellular vesicles","volume":"45","author":"Barile","year":"2024","journal-title":"Eur. Heart J."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115255_bb0305","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70000","article-title":"Hypoxia and TNF-alpha modulate extracellular vesicle release from human induced pluripotent stem cell-derived cardiomyocytes","volume":"13","author":"Viola","year":"2024","journal-title":"J. Extracell. Vesicles"},{"issue":"40","key":"10.1016\/j.jconrel.2026.115255_bb0310","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1093\/eurheartj\/ehz691","article-title":"Technical challenges for extracellular vesicle research towards clinical translation","volume":"40","author":"Roura","year":"2019","journal-title":"Eur. Heart J."},{"issue":"17","key":"10.1016\/j.jconrel.2026.115255_bb0315","article-title":"Engineering extracellular vesicles as delivery systems in therapeutic applications","volume":"10","author":"Wang","year":"2023","journal-title":"Adv Sci (Weinh)."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115255_bb0320","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1021\/acsnano.0c09873","article-title":"Selection of fluorescent, bioluminescent, and radioactive tracers to accurately reflect extracellular vesicle biodistribution in vivo","volume":"15","author":"L\u00e1zaro-Ib\u00e1\u00f1ez","year":"2021","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0325","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s43556-024-00230-x","article-title":"Targeted delivery of extracellular vesicles: the mechanisms, techniques and therapeutic applications","volume":"5","author":"Zhao","year":"2024","journal-title":"Mol Biomed."},{"key":"10.1016\/j.jconrel.2026.115255_bb0330","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jconrel.2021.01.018","article-title":"Co-delivery of curcumin and miRNA-144-3p using heart-targeted extracellular vesicles enhances the therapeutic efficacy for myocardial infarction","volume":"331","author":"Kang","year":"2021","journal-title":"J. Control. Release"},{"issue":"7","key":"10.1016\/j.jconrel.2026.115255_bb0335","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.7150\/thno.20524","article-title":"Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide","volume":"8","author":"Vandergriff","year":"2018","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0340","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12951-018-0388-4","article-title":"Targeting extracellular vesicles to injured tissue using membrane cloaking and surface display","volume":"16","author":"Antes","year":"2018","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2026.115255_bb0345","doi-asserted-by":"crossref","first-page":"1958941","DOI":"10.1155\/2019\/1958941","article-title":"Exosomes derived from TIMP2-modified human umbilical cord mesenchymal stem cells enhance the repair effect in rat model with myocardial infarction possibly by the Akt\/Sfrp2 pathway","volume":"2019","author":"Ni","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0350","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s40824-023-00410-w","article-title":"Exosomes derived from mir-214-3p overexpressing mesenchymal stem cells promote myocardial repair","volume":"27","author":"Zhu","year":"2023","journal-title":"Biomater Res."},{"key":"10.1016\/j.jconrel.2026.115255_bb0355","article-title":"Dual genes manipulation enhanced chemotherapy potentiates antitumor immunity based on extracellular vesicle system for glioblastoma treatment","volume":"500","author":"Yang","year":"2024","journal-title":"Chem. Eng. J."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115255_bb0360","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.tips.2024.02.006","article-title":"Genetically engineered loaded extracellular vesicles for drug delivery","volume":"45","author":"Erana-Perez","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"issue":"Suppl_1","key":"10.1016\/j.jconrel.2026.115255_bb0365","doi-asserted-by":"crossref","DOI":"10.1161\/circ.150.suppl_1.4147221","article-title":"Surface engineering enhances the therapeutic potential of systemically delivered extracellular vesicles following acute myocardial infarction","volume":"150","author":"Tarvirdizadeh","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.jconrel.2026.115255_bb0370","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jconrel.2024.05.023","article-title":"Small extracellular vesicle-mediated CRISPR-Cas9 RNP delivery for cardiac-specific genome editing","volume":"370","author":"Mun","year":"2024","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115255_bb0375","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"issue":"9","key":"10.1016\/j.jconrel.2026.115255_bb0380","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.7150\/thno.69035","article-title":"Extracellular vesicle-derived miR-144 as a novel mechanism for chronic intermittent hypoxia-induced endothelial dysfunction","volume":"12","author":"Zhang","year":"2022","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0385","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12002","article-title":"Hypoxia and extracellular vesicles: a review on methods, vesicular cargo and functions","volume":"10","author":"Bister","year":"2020","journal-title":"J. Extracell. Vesicles"},{"issue":"22","key":"10.1016\/j.jconrel.2026.115255_bb0390","doi-asserted-by":"crossref","first-page":"6163","DOI":"10.7150\/thno.28021","article-title":"Hypoxia-elicited mesenchymal stem cell-derived exosomes facilitates cardiac repair through miR-125b-mediated prevention of cell death in myocardial infarction","volume":"8","author":"Zhu","year":"2018","journal-title":"Theranostics"},{"issue":"17","key":"10.1016\/j.jconrel.2026.115255_bb0395","doi-asserted-by":"crossref","first-page":"10066","DOI":"10.3390\/ijms231710066","article-title":"Selective loading and variations in the miRNA profile of extracellular vesicles from endothelial-like cells cultivated under normoxia and hypoxia","volume":"23","author":"Robert","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0400","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12916-023-02778-x","article-title":"Atorvastatin-pretreated mesenchymal stem cell-derived extracellular vesicles promote cardiac repair after myocardial infarction via shifting macrophage polarization by targeting microRNA-139-3p\/Stat1 pathway","volume":"21","author":"Ning","year":"2023","journal-title":"BMC Med."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0405","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/s12967-015-0642-6","article-title":"LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosome-shuttled let-7b","volume":"13","author":"Ti","year":"2015","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jconrel.2026.115255_bb0410","doi-asserted-by":"crossref","first-page":"1397722","DOI":"10.3389\/fimmu.2024.1397722","article-title":"Exosome-shuttled miR-150\u20135p from LPS-preconditioned mesenchymal stem cells down-regulate PI3K\/Akt\/mTOR pathway via Irs1 to enhance M2 macrophage polarization and confer protection against sepsis","volume":"15","author":"Zheng","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2026.115255_bb0415","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.3389\/fimmu.2020.01210","article-title":"Increasing the chemical variety of small-molecule-based TLR4 modulators: an overview","volume":"11","author":"Romerio","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jconrel.2026.115255_bb0420","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1291016","article-title":"Effects of preconditioning with TNF\u03b1 and IFN\u03b3 in angiogenic potential of mesenchymal stromal cell-derived extracellular vesicles","volume":"11","author":"Cavallero","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0425","doi-asserted-by":"crossref","first-page":"2356341","DOI":"10.1080\/15476278.2024.2356341","article-title":"Exosomes derived from TNF-\u03b1-treated bone marrow mesenchymal stem cells ameliorate myocardial infarction injury in mice","volume":"20","author":"Wang","year":"2024","journal-title":"Organogenesis"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0430","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13287-019-1224-y","article-title":"Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies","volume":"10","author":"Noronha","year":"2019","journal-title":"Stem Cell Res Ther"},{"issue":"8","key":"10.1016\/j.jconrel.2026.115255_bb0435","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.70002","article-title":"Extracellular vesicles as the next-generation modulators of pharmacokinetics and pharmacodynamics of medications and their potential as adjuvant therapeutics","volume":"14","author":"Liu","year":"2024","journal-title":"Clin. Transl. Med."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0440","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3390\/biom16010058","article-title":"Optimizing extracellular vesicles for cardiac repair post-myocardial infarction: approaches and challenges","volume":"16","author":"Huang","year":"2025","journal-title":"Biomolecules"},{"issue":"11","key":"10.1016\/j.jconrel.2026.115255_bb0445","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1080\/17425247.2025.2555488","article-title":"Clinical insights into extracellular vesicles for targeted myocardial drug delivery","volume":"22","author":"Wang","year":"2025","journal-title":"Expert Opin Drug Deliv."},{"issue":"32","key":"10.1016\/j.jconrel.2026.115255_bb0450","doi-asserted-by":"crossref","first-page":"2303617","DOI":"10.1002\/advs.202303617","article-title":"Beyond extracellular vesicles: hybrid membrane nanovesicles as emerging advanced tools for biomedical applications","volume":"10","author":"Sun","year":"2023","journal-title":"Adv. Sci."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115255_bb0455","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.7150\/thno.52496","article-title":"Engineering extracellular vesicles with platelet membranes fusion enhanced targeted therapeutic angiogenesis in a mouse model of myocardial ischemia reperfusion","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2026.115255_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121529","article-title":"Targeted immunomodulation therapy for cardiac repair by platelet membrane engineering extracellular vesicles via hitching peripheral monocytes","volume":"284","author":"Li","year":"2022","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0465","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1038\/s41467-021-21778-0","article-title":"Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells","volume":"12","author":"Louwe","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115255_bb0470","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.actbio.2023.08.022","article-title":"Targeted heart repair by T\u03b24-loaded cardiac-resident macrophage-derived extracellular vesicles modified with monocyte membranes","volume":"169","author":"Chen","year":"2023","journal-title":"Acta Biomater."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115255_bb0475","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.7150\/thno.52496","article-title":"Engineering extracellular vesicles with platelet membranes fusion enhanced targeted therapeutic angiogenesis in a mouse model of myocardial ischemia reperfusion","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"issue":"8","key":"10.1016\/j.jconrel.2026.115255_bb0480","doi-asserted-by":"crossref","DOI":"10.3390\/cells9081797","article-title":"Feasibility of mechanical extrusion to coat nanoparticles with extracellular vesicle membranes","volume":"9","author":"Van Deun","year":"2020","journal-title":"Cells"},{"issue":"19","key":"10.1016\/j.jconrel.2026.115255_bb0485","doi-asserted-by":"crossref","DOI":"10.1063\/1.4997393","article-title":"Pulling force and surface tension drive membrane fusion","volume":"147","author":"Liu","year":"2017","journal-title":"J. Chem. Phys."},{"issue":"19","key":"10.1016\/j.jconrel.2026.115255_bb0490","article-title":"Extracellular vesicle mimetics: Preparation from top-down approaches and biological functions","volume":"11","author":"Du","year":"2022","journal-title":"Adv. Healthc. Mater."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115255_bb0495","doi-asserted-by":"crossref","DOI":"10.3390\/nano14070639","article-title":"Engineered and mimicked extracellular nanovesicles for therapeutic delivery","volume":"14","author":"Poinsot","year":"2024","journal-title":"Nanomaterials (Basel)"},{"issue":"32","key":"10.1016\/j.jconrel.2026.115255_bb0500","article-title":"Beyond extracellular vesicles: hybrid membrane nanovesicles as emerging advanced tools for biomedical applications","volume":"10","author":"Sun","year":"2023","journal-title":"Adv Sci (Weinh)."},{"issue":"47","key":"10.1016\/j.jconrel.2026.115255_bb0505","doi-asserted-by":"crossref","first-page":"55767","DOI":"10.1021\/acsami.1c08044","article-title":"Extruded mesenchymal stem cell nanovesicles are equally potent to natural extracellular vesicles in cardiac repair","volume":"13","author":"Wang","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"29","key":"10.1016\/j.jconrel.2026.115255_bb0510","doi-asserted-by":"crossref","first-page":"41666","DOI":"10.1021\/acsami.5c06927","article-title":"Microfluidic production of exosome-mimicking lipid nanoparticles for enhanced RNA delivery: role of exosomal proteins","volume":"17","author":"Maeki","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115255_bb0515","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2023.103514","article-title":"Biomimetic cell membrane-coated nanocarriers for targeted siRNA delivery in cancer therapy","volume":"28","author":"Huang","year":"2023","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jconrel.2026.115255_bb0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122505","article-title":"Biomimetic nanodrug targets inflammation and suppresses YAP\/TAZ to ameliorate atherosclerosis","volume":"306","author":"Huang","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115255_bb0525","first-page":"45","article-title":"Stromal-platelet membrane-inspired nanoparticles (SPIN) for targeted heart repair","volume":"53","author":"He","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2026.115255_bb0530","article-title":"Biomimetic nanomaterials in myocardial infarction treatment: Harnessing bionic strategies for advanced therapeutics","volume":"25","author":"Yu","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.jconrel.2026.115255_bb0535","doi-asserted-by":"crossref","first-page":"26316","DOI":"10.3402\/jev.v4.26316","article-title":"Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting","volume":"4","author":"Wiklander","year":"2015","journal-title":"J. Extracell. Vesicles"},{"issue":"10","key":"10.1016\/j.jconrel.2026.115255_bb0540","doi-asserted-by":"crossref","DOI":"10.3390\/cells12101416","article-title":"Current strategies for exosome cargo loading and targeting delivery","volume":"12","author":"Zeng","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2026.115255_bb0545","first-page":"469","article-title":"Augmented cellular uptake and homologous targeting of exosome-based drug loaded IOL for posterior capsular opacification prevention and biosafety improvement","volume":"15","author":"Zhu","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2026.115255_bb0550","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119675","article-title":"Post-production modifications of murine mesenchymal stem cell (mMSC) derived extracellular vesicles (EVs) and impact on their cellular interaction","volume":"231","author":"Le Saux","year":"2020","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0555","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jconrel.2013.08.014","article-title":"Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles","volume":"172","author":"Kooijmans","year":"2013","journal-title":"J. Control. Release"},{"issue":"11","key":"10.1016\/j.jconrel.2026.115255_bb0560","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201801271","article-title":"TPP1 delivery to lysosomes with extracellular vesicles and their enhanced brain distribution in the animal model of batten disease","volume":"8","author":"Haney","year":"2019","journal-title":"Adv. Healthc. Mater."},{"issue":"47","key":"10.1016\/j.jconrel.2026.115255_bb0565","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202403422","article-title":"The evolution of microfluidic-based drug-loading techniques for cells and their derivatives","volume":"20","author":"Tong","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.jconrel.2026.115255_bb0570","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.2147\/IJN.S497428","article-title":"Injured cardiac tissue-targeted delivery of TGF\u03b21 siRNA by FAP aptamer-functionalized extracellular vesicles promotes cardiac repair","volume":"20","author":"Kang","year":"2025","journal-title":"Int. J. Nanomedicine"},{"issue":"17","key":"10.1016\/j.jconrel.2026.115255_bb0575","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1093\/eurheartj\/ehae883","article-title":"Extracellular vesicle-mediated VEGF-A mRNA delivery rescues ischaemic injury with low immunogenicity","volume":"46","author":"You","year":"2025","journal-title":"Eur. Heart J."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115255_bb0580","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12510","article-title":"A critical systematic review of extracellular vesicle clinical trials","volume":"13","author":"Mizenko","year":"2024","journal-title":"J. Extracell. Vesicles"},{"issue":"10","key":"10.1016\/j.jconrel.2026.115255_bb0585","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1161\/CIRCRESAHA.120.315855","article-title":"Gene therapy for the heart lessons learned and future perspectives","volume":"126","author":"Cannat\u00e0","year":"2020","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0590","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41392-023-01309-7","article-title":"CRISPR\/Cas9 therapeutics: progress and prospects","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115255_bb0595","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1021\/acsabm.3c00475","article-title":"Mycophenolic acid-loaded na\u00efve macrophage-derived extracellular vesicles rescue cardiac myoblast after inflammatory injury","volume":"6","author":"Gao","year":"2023","journal-title":"ACS Appl. Bio Mater."},{"issue":"Supplement_2","key":"10.1016\/j.jconrel.2026.115255_bb0600","doi-asserted-by":"crossref","DOI":"10.1093\/ehjci\/ehaa946.3609","article-title":"Curcumin-loaded extracellular vesicles endowed with heart targeting properties facilitate treatment of myocardial infarction","volume":"41","author":"Kang","year":"2020","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115255_bb0605","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/ad6190","article-title":"Enhancing neovascularization post-myocardial infarction through injectable hydrogel functionalized with endothelial-derived EVs","volume":"16","author":"Maiullari","year":"2024","journal-title":"Biofabrication"},{"key":"10.1016\/j.jconrel.2026.115255_bb0610","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121786","article-title":"Decellularized extracellular matrix: new promising and challenging biomaterials for regenerative medicine","volume":"289","author":"Brown","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115255_bb0615","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.biomaterials.2015.08.045","article-title":"Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels","volume":"73","author":"Yue","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115255_bb0620","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.actbio.2018.01.031","article-title":"Independent control of matrix adhesiveness and stiffness within a 3D self-assembling peptide hydrogel","volume":"70","author":"Hogrebe","year":"2018","journal-title":"Acta Biomater."},{"issue":"22","key":"10.1016\/j.jconrel.2026.115255_bb0625","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202200971","article-title":"A pH\/H(2) O(2) \/MMP9 time-response gel system with Sparc(high) tregs derived extracellular vesicles promote recovery after acute myocardial infarction","volume":"11","author":"Cheng","year":"2022","journal-title":"Adv. Healthc. Mater."},{"issue":"43","key":"10.1016\/j.jconrel.2026.115255_bb0630","doi-asserted-by":"crossref","first-page":"58286","DOI":"10.1021\/acsami.4c12285","article-title":"Black-phosphorus-reinforced injectable conductive biodegradable hydrogel for the delivery of ADSC-derived exosomes to repair myocardial infarction","volume":"16","author":"Wang","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0635","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s12951-025-03289-y","article-title":"Stem cells derived exosome laden oxygen generating hydrogel composites with good electrical conductivity for the tissue-repairing process of post-myocardial infarction","volume":"23","author":"Xu","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115255_bb0640","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtcvs.2023.07.014","article-title":"Stem cell-derived exosome patch with coronary artery bypass graft restores cardiac function in chronically ischemic porcine myocardium","volume":"166","author":"Aggarwal","year":"2023","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"13","key":"10.1016\/j.jconrel.2026.115255_bb0645","article-title":"Microneedle patch loaded with exosomes containing MicroRNA-29b prevents cardiac fibrosis after myocardial infarction","volume":"12","author":"Yuan","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.jconrel.2026.115255_bb0650","first-page":"19470","article-title":"Nanoparticle-patch system for localized, effective, and sustained miRNA administration into infarcted myocardium to alleviate myocardial ischemia-reperfusion injury","volume":"18","author":"Chen","year":"2024","journal-title":"ACS Nano."},{"issue":"21","key":"10.1016\/j.jconrel.2026.115255_bb0655","article-title":"Paintable decellularized-ECM hydrogel for preventing cardiac tissue damage","volume":"11","author":"Lee","year":"2024","journal-title":"Adv Sci (Weinh)."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115255_bb0660","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/ac68bc","article-title":"MSC-derived sEV-loaded hyaluronan hydrogel promotes scarless skin healing by immunomodulation in a large skin wound model","volume":"17","author":"Yang","year":"2022","journal-title":"Biomed. Mater."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0665","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41392-025-02312-w","article-title":"Extracellular vesicle-based drug overview: research landscape, quality control and nonclinical evaluation strategies","volume":"10","author":"Xu","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115255_bb0670","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70079","article-title":"Non-specific particle formation during extracellular vesicle labelling with the lipophilic membrane dye PKH26","volume":"14","author":"Haines","year":"2025","journal-title":"J. Extracell. Vesicles"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115255_bb0675","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.molmed.2020.10.006","article-title":"Extracellular vesicles and biomaterial design: new therapies for cardiac repair","volume":"27","author":"Pezzana","year":"2021","journal-title":"Trends Mol. Med."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115255_bb0680","doi-asserted-by":"crossref","first-page":"403","DOI":"10.20517\/evcna.2025.33","article-title":"Extracellular vesicles as vehicles for small non-coding RNA therapeutics: standardization challenges for clinical translation","volume":"6","author":"Luisotti","year":"2025","journal-title":"Extracell Vesicles Circ Nucl Acids."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115255_bb0685","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00604-025-07147-4","article-title":"Limitations and challenges in the characterization of extracellular vesicles from stem cells and serum","volume":"192","author":"Escudero-Cernuda","year":"2025","journal-title":"Mikrochim Acta."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115255_bb0690","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/btm2.10065","article-title":"Impact of cell culture parameters on production and vascularization bioactivity of mesenchymal stem cell-derived extracellular vesicles","volume":"2","author":"Patel","year":"2017","journal-title":"Bioeng. Transl. Med."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115255_bb0695","doi-asserted-by":"crossref","first-page":"1800948","DOI":"10.1002\/advs.201800948","article-title":"3D cellular architecture affects MicroRNA and protein cargo of extracellular vesicles","volume":"6","author":"Rocha","year":"2019","journal-title":"Adv Sci (Weinh)."},{"key":"10.1016\/j.jconrel.2026.115255_bb0700","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2021.108963","article-title":"Bovine extracellular vesicles contaminate human extracellular vesicles produced in cell culture conditioned medium when \u2018exosome-depleted serum\u2019 is utilised","volume":"708","author":"Pham","year":"2021","journal-title":"Arch. Biochem. Biophys."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115255_bb0705","article-title":"Preparation of fibrinogen-depleted human platelet lysate to support heparin-free expansion of umbilical cord-derived mesenchymal stem cells","volume":"12","author":"Kee","year":"2023","journal-title":"Biol.-Basel"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0710","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/s41598-020-57497-7","article-title":"A comparison of methods for the isolation and separation of extracellular vesicles from protein and lipid particles in human serum","volume":"10","author":"Brennan","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0715","doi-asserted-by":"crossref","first-page":"1560809","DOI":"10.1080\/20013078.2018.1560809","article-title":"Comparison of small extracellular vesicles isolated from plasma by ultracentrifugation or size-exclusion chromatography: yield, purity and functional potential","volume":"8","author":"Takov","year":"2019","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jconrel.2026.115255_bb0720","first-page":"10","article-title":"Framework for rapid comparison of extracellular vesicle isolation methods","author":"Ter-Ovanesyan","year":"2021","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0725","doi-asserted-by":"crossref","first-page":"11585","DOI":"10.1038\/s41598-021-91129-y","article-title":"Potential and challenges of specifically isolating extracellular vesicles from heterogeneous populations","volume":"11","author":"Allelein","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2026.115255_bb0730","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114557","article-title":"A 3D culture system improves the yield of MSCs-derived extracellular vesicles and enhances their therapeutic efficacy for heart repair","volume":"161","author":"Sun","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0735","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13287-021-02190-3","article-title":"Hollow-fiber bioreactor production of extracellular vesicles from human bone marrow mesenchymal stromal cells yields nanovesicles that mirrors the immuno-modulatory antigenic signature of the producer cell","volume":"12","author":"Gobin","year":"2021","journal-title":"Stem Cell Res. Ther."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115255_bb0740","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1007\/s12015-022-10351-x","article-title":"A roadmap for the production of a GMP-compatible cell bank of allogeneic bone marrow-derived clonal mesenchymal stromal cells for cell therapy applications","volume":"18","author":"Pakzad","year":"2022","journal-title":"Stem Cell Rev. Rep."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0745","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jcyt.2015.10.001","article-title":"Evaluation of a cell-banking strategy for the production of clinical grade mesenchymal stromal cells from Wharton\u2019s jelly","volume":"18","author":"Oliver-Vila","year":"2016","journal-title":"Cytotherapy"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115255_bb0750","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12162","article-title":"The impact of storage on extracellular vesicles: a systematic study","volume":"11","author":"Gelibter","year":"2022","journal-title":"J. Extracell. Vesicles"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0755","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1186\/s13287-024-04005-7","article-title":"Different storage and freezing protocols for extracellular vesicles: a systematic review","volume":"15","author":"Ahmadian","year":"2024","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0760","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13036-024-00470-z","article-title":"Stabilizing milk-derived extracellular vesicles (mEVs) through lyophilization: a novel trehalose and tryptophan formulation for maintaining structure and Bioactivity during long-term storage","volume":"19","author":"Dogan","year":"2025","journal-title":"J. Biol. Eng."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115255_bb0765","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.1021\/acsbiomaterials.3c00678","article-title":"Comparative studies of different preservation methods and relative freeze-drying formulations for extracellular vesicle pharmaceutical applications","volume":"9","author":"Susa","year":"2023","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.jconrel.2026.115255_bb0770","doi-asserted-by":"crossref","first-page":"30422","DOI":"10.3402\/jev.v5.30422","article-title":"Characterization of procoagulant extracellular vesicles and platelet membrane disintegration in DMSO-cryopreserved platelets","volume":"5","author":"Tegegn","year":"2016","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jconrel.2026.115255_bb0775","first-page":"7","article-title":"Lack of cardiac benefit after intramyocardial or intravenous injection of mesenchymal stem cell-derived extracellular vesicles supports the need for optimized cardiac delivery","author":"Xu","year":"2023","journal-title":"Vessel Plus."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0780","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1186\/s12951-024-03032-z","article-title":"An integrated \u201cEngage & Evasion\u201d approach for mononuclear phagocyte system escape and efficient extracellular vesicle therapy","volume":"22","author":"Liu","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2026.115255_bb0785","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121000","article-title":"Mononuclear phagocyte system blockade using extracellular vesicles modified with CD47 on membrane surface for myocardial infarction reperfusion injury treatment","volume":"275","author":"Wei","year":"2021","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115255_bb0790","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/leu.2014.41","article-title":"MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease","volume":"28","author":"Kordelas","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.jconrel.2026.115255_bb0795","doi-asserted-by":"crossref","first-page":"1625787","DOI":"10.3389\/fmed.2025.1625787","article-title":"Trends in mesenchymal stem cell-derived extracellular vesicles clinical trials 2014-2024: is efficacy optimal in a narrow dose range?","volume":"12","author":"Wang","year":"2025","journal-title":"Front Med (Lausanne)."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115255_bb0800","doi-asserted-by":"crossref","DOI":"10.1002\/jex2.70037","article-title":"Enabling mesenchymal stromal cells and their extracellular vesicles clinical availability-a technological and economical evaluation","volume":"4","author":"Silva","year":"2025","journal-title":"J Extracell Biol."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115255_bb0805","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14050930","article-title":"Nanocarrier-based targeted therapies for myocardial infarction","volume":"14","author":"George","year":"2022","journal-title":"Pharmaceutics"},{"issue":"8","key":"10.1016\/j.jconrel.2026.115255_bb0810","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.7150\/thno.124754","article-title":"Injured cardiac targeting magnetic nanovesicles for mRNA treatment of myocardial infarction","volume":"16","author":"Mun","year":"2026","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2026.115255_bb0815","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122775","article-title":"MSCs biomimetic ultrasonic phase change nanoparticles promotes cardiac functional recovery after acute myocardial infarction","volume":"313","author":"Wang","year":"2025","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.jconrel.2026.115255_bb0820","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70178","article-title":"Magnetically labelled iPSC-derived extracellular vesicles enable MRI\/MPI-guided regenerative therapy for myocardial infarction","volume":"14","author":"Wang","year":"2025","journal-title":"J. Extracell. Vesicles"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115255_bb0825","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/wnan.1311","article-title":"Open challenges in magnetic drug targeting","volume":"7","author":"Shapiro","year":"2015","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115255_bb0830","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1571","article-title":"Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting","volume":"11","author":"Liu","year":"2019","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115255_bb0835","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12445","article-title":"Head-to-head comparison of relevant cell sources of small extracellular vesicles for cardiac repair: superiority of embryonic stem cells","volume":"13","author":"Gonz\u00e1lez-King","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jconrel.2026.115255_bb0840","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.omtn.2023.03.001","article-title":"Extracellular vesicle microRNA and protein cargo profiling in three clinical-grade stem cell products reveals key functional pathways","volume":"32","author":"Vaka","year":"2023","journal-title":"Mol Ther Nucleic Acids."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115255_bb0845","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.tcm.2020.08.003","article-title":"Experimental limitations of extracellular vesicle-based therapies for the treatment of myocardial infarction","volume":"31","author":"Kennedy","year":"2021","journal-title":"Trends Cardiovasc Med."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115255_bb0850","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/scrt474","article-title":"Ethical issues in stem cell research and therapy","volume":"5","author":"King","year":"2014","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0855","doi-asserted-by":"crossref","first-page":"292","DOI":"10.20517\/evcna.2025.129","article-title":"The regulatory landscape for extracellular vesicle therapies: Australian context and future directions","volume":"7","author":"Rudge","year":"2026","journal-title":"Extracell Vesicles Circ Nucl Acids."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115255_bb0860","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70332","article-title":"Regulatory challenges and opportunities for cell-derived extracellular vesicles in pharmaceutical development: a european and global perspective","volume":"15","author":"Limongi","year":"2026","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jconrel.2026.115255_bb0865","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlb.2024.100278","article-title":"Global requirements for manufacturing and validation of clinical grade extracellular vesicles","volume":"6","author":"Thakur","year":"2024","journal-title":"J Liq Biopsy."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0870","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1186\/s13287-019-1522-4","article-title":"LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p\/Sirt1 axis","volume":"10","author":"Mao","year":"2019","journal-title":"Stem Cell Res. Ther."},{"issue":"584","key":"10.1016\/j.jconrel.2026.115255_bb0875","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb0202","article-title":"Small extracellular vesicles containing miR-486-5p promote angiogenesis after myocardial infarction in mice and nonhuman primates","volume":"13","author":"Li","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115255_bb0880","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41419-020-2545-6","article-title":"Exosomal miR-25-3p from mesenchymal stem cells alleviates myocardial infarction by targeting pro-apoptotic proteins and EZH2","volume":"11","author":"Peng","year":"2020","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115255_bb0885","first-page":"4007","article-title":"Exosomes released from mesenchymal stem cells overexpressing microRNA-30e ameliorate heart failure in rats with myocardial infarction","volume":"13","author":"Pu","year":"2021","journal-title":"Am. J. Transl. Res."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115255_bb0890","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1080\/08982104.2023.2293844","article-title":"Astragaloside IV-induced BMSC exosomes promote neovascularization and protect cardiac function in myocardial infarction mice via the miR-411\/HIF-1\u03b1 axis","volume":"34","author":"Yang","year":"2024","journal-title":"J Liposome Res."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115255_bb0895","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.numecd.2021.10.017","article-title":"The BMSC-derived exosomal lncRNA Mir9-3hg suppresses cardiomyocyte ferroptosis in ischemia-reperfusion mice via the Pum2\/PRDX6 axis","volume":"32","author":"Zhang","year":"2022","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115255_bb0900","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s10557-022-07339-7","article-title":"Mesenchymal stem cell-originated exosomal Lnc A2M-AS1 alleviates hypoxia\/reperfusion-induced apoptosis and oxidative stress in cardiomyocytes","volume":"37","author":"Yu","year":"2023","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0905","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41420-022-00909-6","article-title":"Mesenchymal stem cell-derived exosomal microRNA-182-5p alleviates myocardial ischemia\/reperfusion injury by targeting GSDMD in mice","volume":"8","author":"Yue","year":"2022","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0910","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00441-022-03612-1","article-title":"Extracellular vesicles derived from human bone marrow mesenchymal stem cells protect rats against acute myocardial infarction-induced heart failure","volume":"389","author":"Xuan","year":"2022","journal-title":"Cell Tissue Res."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115255_bb0915","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1007\/s10753-021-01460-9","article-title":"Adipose-derived mesenchymal stem cells-derived exosomes carry MicroRNA-671 to alleviate myocardial infarction through inactivating the TGFBR2\/Smad2 axis","volume":"44","author":"Wang","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.jconrel.2026.115255_bb0920","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.yjmcc.2021.08.010","article-title":"Exosomes from adipose-derived stem cells alleviate myocardial infarction via microRNA-31\/FIH1\/HIF-1\u03b1 pathway","volume":"162","author":"Zhu","year":"2022","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115255_bb0925","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.024330","article-title":"Protective effects of MicroRNA-200b-3p encapsulated by mesenchymal stem cells-secreted extracellular vesicles in myocardial infarction via regulating BCL2L11","volume":"11","author":"Wan","year":"2022","journal-title":"J. Am. Heart Assoc."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115255_bb0930","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/15384101.2019.1711305","article-title":"Human umbilical cord mesenchymal stem cells-derived exosomes transfers microRNA-19a to protect cardiomyocytes from acute myocardial infarction by targeting SOX6","volume":"19","author":"Huang","year":"2020","journal-title":"Cell Cycle"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115255_bb0935","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.18632\/aging.202520","article-title":"Transfer of lncRNA UCA1 by hUCMSCs-derived exosomes protects against hypoxia\/reoxygenation injury through impairing miR-143-targeted degradation of Bcl-2","volume":"13","author":"Diao","year":"2021","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0940","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10565-020-09530-8","article-title":"Human umbilical cord blood-derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice","volume":"37","author":"Song","year":"2021","journal-title":"Cell Biol. Toxicol."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115255_bb0945","doi-asserted-by":"crossref","DOI":"10.1016\/j.numecd.2025.104374","article-title":"Overexpression of OTUD5 in IPSCs-derived extracellular vesicles promotes angiogenesis after myocardial infarction by inhibiting endothelial cell ferroptosis","volume":"36","author":"Lu","year":"2026","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"issue":"24","key":"10.1016\/j.jconrel.2026.115255_bb0950","doi-asserted-by":"crossref","first-page":"7403","DOI":"10.7150\/thno.32637","article-title":"Incorporation of small extracellular vesicles in sodium alginate hydrogel as a novel therapeutic strategy for myocardial infarction","volume":"9","author":"Lv","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.jconrel.2026.115255_bb0955","first-page":"324","article-title":"Ameliorating impaired cardiac function in myocardial infarction using exosome-loaded gallic-acid-containing polyurethane scaffolds","volume":"33","author":"Das","year":"2024","journal-title":"Bioact. Mater."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115255_bb0960","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.bbrc.2020.02.009","article-title":"Mesenchymal stem cell-derived extracellular vesicles alone or in conjunction with a SDKP-conjugated self-assembling peptide improve a rat model of myocardial infarction","volume":"524","author":"Firoozi","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115255_bb0965","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12951-024-02410-x","article-title":"Hyaluronic acid stimulation of stem cells for cardiac repair: a cell-free strategy for myocardial infarct","volume":"22","author":"Jeong","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jconrel.2026.115255_bb0970","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121877","article-title":"Biomaterial-embedded extracellular vesicles improve recovery of the dysfunctional myocardium","volume":"291","author":"Pezzana","year":"2022","journal-title":"Biomaterials"},{"issue":"7","key":"10.1016\/j.jconrel.2026.115255_bb0975","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/cvr\/cvy067","article-title":"Sustained release of endothelial progenitor cell-derived extracellular vesicles from shear-thinning hydrogels improves angiogenesis and promotes function after myocardial infarction","volume":"114","author":"Chen","year":"2018","journal-title":"Cardiovasc. Res."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115255_bb0980","article-title":"A novel conductive polypyrrole-chitosan hydrogel containing human endometrial mesenchymal stem cell-derived exosomes facilitated sustained release for cardiac repair","volume":"13","author":"Yan","year":"2024","journal-title":"Adv. Healthc. Mater."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115255_bb0985","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1177\/08853282241251610","article-title":"Release of exosomes from injectable silk fibroin and alginate composite hydrogel for treatment of myocardial infarction","volume":"39","author":"Ni","year":"2024","journal-title":"J. Biomater. Appl."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115255_bb0990","article-title":"Injectable hydrogel with miR-222-engineered extracellular vesicles ameliorates myocardial ischemic reperfusion injury via mechanotransduction","volume":"6","author":"Wang","year":"2025","journal-title":"Cell Rep Med."},{"key":"10.1016\/j.jconrel.2026.115255_bb0995","article-title":"Fabrication of blended nanofibrous cardiac patch transplanted with TGF-\u03b23 and human umbilical cord MSCs-derived exosomes for potential cardiac regeneration after acute myocardial infarction","volume":"54","author":"Ping","year":"2023","journal-title":"Nanomedicine"},{"issue":"26","key":"10.1016\/j.jconrel.2026.115255_bb1000","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202417327","article-title":"Cardiac organoid model inspired micro-robot smart patch to treat myocardial infarction","volume":"37","author":"Wang","year":"2025","journal-title":"Adv. Mater."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115255_bb1005","doi-asserted-by":"crossref","first-page":"11099","DOI":"10.1021\/acsnano.1c00628","article-title":"A minimally invasive exosome spray repairs heart after myocardial infarction","volume":"15","author":"Yao","year":"2021","journal-title":"ACS Nano"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926006590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926006590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:57:57Z","timestamp":1790211477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926006590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":201,"alternative-id":["S0168365926006590"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115255","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical potential and challenges of extracellular vesicles in myocardial infarction therapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115255","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115255"}}