{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:24:37Z","timestamp":1791815077955,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32341007"],"award-info":[{"award-number":["32341007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12275135"],"award-info":[{"award-number":["12275135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91857000"],"award-info":[{"award-number":["91857000"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92268120"],"award-info":[{"award-number":["92268120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82404494"],"award-info":[{"award-number":["82404494"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92357306"],"award-info":[{"award-number":["92357306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jconrel.2026.115256","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T23:41:25Z","timestamp":1786491685000},"page":"115256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Targeted KRAS suppression in colorectal cancer via in vivo self-assembled siRNAs encapsulated in endogenous small extracellular vesicles"],"prefix":"10.1016","volume":"398","author":[{"given":"Ying","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxia","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jconrel.2026.115256_bb0005","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/s41573-020-0089-1","article-title":"RAS-targeted therapies: is the undruggable drugged? (vol 19, pg 533, 2020)","volume":"19","author":"Moore","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"issue":"14","key":"10.1016\/j.jconrel.2026.115256_bb0010","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1158\/0008-5472.CAN-19-3682","article-title":"The frequency of ras mutations in cancer","volume":"80","author":"Prior","year":"2020","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115256_bb0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc969","article-title":"Targeting ras signalling pathways in cancer therapy","volume":"3","author":"Downward","year":"2003","journal-title":"Nat. Rev. Cancer"},{"issue":"11","key":"10.1016\/j.jconrel.2026.115256_bb0020","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nrd4389","article-title":"Drugging the undruggable RAS: mission possible?","volume":"13","author":"Cox","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"issue":"7477","key":"10.1016\/j.jconrel.2026.115256_bb0025","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nature12796","article-title":"K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions","volume":"503","author":"Ostrem","year":"2013","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.jconrel.2026.115256_bb0030","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1056\/NEJMoa1917239","article-title":"KRASG12C inhibition with sotorasib in advanced solid tumors","volume":"383","author":"Hong David","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"7407","key":"10.1016\/j.jconrel.2026.115256_bb0035","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","author":"Muzny","year":"2012","journal-title":"Nature"},{"issue":"7592","key":"10.1016\/j.jconrel.2026.115256_bb0040","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature16965","article-title":"Genomic analyses identify molecular subtypes of pancreatic cancer","volume":"531","author":"Bailey","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115256_bb0045","article-title":"Crosstalk between KRAS and miRNA in cancer","volume":"8","author":"Shen","year":"2026","journal-title":"ExRNA"},{"issue":"7968","key":"10.1016\/j.jconrel.2026.115256_bb0050","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41586-023-06123-3","article-title":"Pan-KRAS inhibitor disables oncogenic signalling and tumour growth","volume":"619","author":"Kim","year":"2023","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115256_bb0055","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1021\/acs.jmedchem.1c01688","article-title":"Identification of MRTX1133, a noncovalent, potent, and selective KRASG12D inhibitor","volume":"65","author":"Wang","year":"2022","journal-title":"J. Med. Chem."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115256_bb0060","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1038\/s41591-022-02007-7","article-title":"Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor","volume":"28","author":"Hallin","year":"2022","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115256_bb0065","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41571-022-00671-9","article-title":"The current state of the art and future trends in RAS-targeted cancer therapies","volume":"19","author":"Punekar","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2026.115256_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174178","article-title":"siRNA: mechanism of action, challenges, and therapeutic approaches","volume":"905","author":"Alshaer","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jconrel.2026.115256_bb0075","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.actbio.2023.07.008","article-title":"Targeted nanodelivery of siRNA against KRAS G12D inhibits pancreatic cancer","volume":"168","author":"Huang","year":"2023","journal-title":"Acta Biomater."},{"issue":"7659","key":"10.1016\/j.jconrel.2026.115256_bb0080","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature22341","article-title":"Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer","volume":"546","author":"Kamerkar","year":"2017","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115256_bb0085","article-title":"ExRNA as theranostic agents in cancer: current progress and future perspectives","volume":"7","author":"Nik Abd Rahman","year":"2025","journal-title":"ExRNA"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115256_bb0090","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41392-020-0207-x","article-title":"Therapeutic siRNA: state of the art","volume":"5","author":"Hu","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115256_bb0095","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41573-019-0017-4","article-title":"The current state and future directions of RNAi-based therapeutics","volume":"18","author":"Setten","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115256_bb0100","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tcb.2011.12.001","article-title":"Secreted microRNAs: a new form of intercellular communication","volume":"22","author":"Chen","year":"2012","journal-title":"Trends Cell Biol."},{"issue":"6478","key":"10.1016\/j.jconrel.2026.115256_bb0105","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115256_bb0110","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115256_bb0115","article-title":"Examining the evidence for exRNAs as communication molecules and emerging cancer biomarkers: a new therapeutic strategy","volume":"5","author":"Yang","year":"2023","journal-title":"ExRNA"},{"issue":"14","key":"10.1016\/j.jconrel.2026.115256_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12182","article-title":"Updating MISEV: evolving the minimal requirements for studies of extracellular vesicles","volume":"10","author":"Witwer","year":"2021","journal-title":"J. Extracell. Vesicles"},{"issue":"6","key":"10.1016\/j.jconrel.2026.115256_bb0125","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41422-021-00491-z","article-title":"In vivo self-assembled small RNAs as a new generation of RNAi therapeutics","volume":"31","author":"Fu","year":"2021","journal-title":"Cell Res."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115256_bb0130","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1093\/brain\/awab354","article-title":"Therapeutic reversal of Huntington\u2019s disease by in vivo self-assembled siRNAs","volume":"144","author":"Zhang","year":"2021","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115256_bb0135","article-title":"In vivo self-assembled siRNA as a modality for combination therapy of ulcerative colitis","volume":"13","author":"Zhou","year":"2022","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115256_bb0140","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/brain\/awaf291","article-title":"In vivo self-assembled SOD1-siRNAs mitigate muscle atrophy and denervation in amyotrophic lateral sclerosis","volume":"149","author":"Guo","year":"2026","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115256_bb0145","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/brain\/awae304","article-title":"Treatment of neurological pathology and inflammation in Machado\u2013Joseph disease through in vivo self-assembled siRNA","volume":"148","author":"Li","year":"2025","journal-title":"Brain"},{"key":"10.1016\/j.jconrel.2026.115256_bb0150","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jconrel.2023.04.026","article-title":"In vivo self-assembled small RNA targets H19 lncRNA for the treatment of colorectal cancer","volume":"358","author":"Sun","year":"2023","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115256_bb0155","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jconrel.2010.09.015","article-title":"A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery","volume":"148","author":"Li","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115256_bb0160","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jconrel.2016.08.033","article-title":"Characterization of TCP-1 probes for molecular imaging of colon cancer","volume":"239","author":"Liu","year":"2016","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115256_bb0165","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2023.5554","article-title":"A potential tumor marker: chaperonin containing TCP-1 controls the development of malignant tumors (review)","volume":"63","author":"Zheng","year":"2023","journal-title":"Int. J. Oncol."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115256_bb0170","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/sj.gt.3302210","article-title":"Hydroporation as the mechanism of hydrodynamic delivery","volume":"11","author":"Zhang","year":"2004","journal-title":"Gene Ther."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115256_bb0175","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/sj.gt.3300947","article-title":"Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA","volume":"6","author":"Liu","year":"1999","journal-title":"Gene Ther."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115256_bb0180","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1089\/10430349950017734","article-title":"High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA","volume":"10","author":"Zhang","year":"1999","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.jconrel.2026.115256_bb0185","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-026-01827-1","article-title":"From tumor targeting to tumor accessibility: surface-engineered bacteria as precision living therapeutics for translational medicine","author":"Qiao","year":"2026","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115256_bb0190","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41392-023-01703-1","article-title":"Camouflaging attenuated Salmonella by cryo-shocked macrophages for tumor-targeted therapy","volume":"9","author":"Wu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115256_bb0195","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41573-019-0027-2","article-title":"The current state and future directions of RNAi-based therapeutics (vol 18, pg 421, 2019)","volume":"19","author":"Setten","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115256_bb0200","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nmeth854","article-title":"3\u2032 UTR seed matches, but not overall identity, are associated with RNAi off-targets","volume":"3","author":"Birmingham","year":"2006","journal-title":"Nat. Methods"},{"issue":"7781","key":"10.1016\/j.jconrel.2026.115256_bb0205","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41586-019-1694-1","article-title":"The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity","volume":"575","author":"Canon","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115256_bb0210","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1158\/2159-8290.CD-19-1167","article-title":"The KRASG12C inhibitor MRTX849 provides insight toward therapeutic susceptibility of KRAS-mutant cancers in mouse models and patients","volume":"10","author":"Hallin","year":"2020","journal-title":"Cancer Discov."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926006607?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926006607?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:04:15Z","timestamp":1790211855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926006607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":42,"alternative-id":["S0168365926006607"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115256","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted KRAS suppression in colorectal cancer via in vivo self-assembled siRNAs encapsulated in endogenous small extracellular vesicles","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115256","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115256"}}