{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:01:54Z","timestamp":1790215314975,"version":"4.1.0"},"reference-count":297,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007156","name":"Innovation and Technology Commission - Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003452","name":"Innovation and Technology Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jconrel.2026.115277","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T22:40:32Z","timestamp":1787438432000},"page":"115277","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Pharmaceutical cocrystals beyond enteral drug delivery: from concept to translation"],"prefix":"10.1016","volume":"398","author":[{"given":"Si Nga","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shing Fung","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.115277_bb0005","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1039\/CT8936301314","article-title":"XCVI.\u2014Halogen derivatives of quinone. Part III. Derivatives of quinhydrone","volume":"63","author":"Ling","year":"1893","journal-title":"J. Chem. Soc. Trans."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb0010","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1021\/ar00172a005","article-title":"Encoding and decoding hydrogen-bond patterns of organic compounds","volume":"23","author":"Etter","year":"1990","journal-title":"Acc. Chem. Res."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115277_bb0015","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1021\/j100165a007","article-title":"Hydrogen bonds as design elements in organic chemistry","volume":"95","author":"Etter","year":"1991","journal-title":"J. Phys. Chem."},{"issue":"72","key":"10.1016\/j.jconrel.2026.115277_bb0020","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1039\/b505883j","article-title":"Building co-crystals with molecular sense and supramolecular sensibility","volume":"7","author":"Aaker\u00f6y","year":"2005","journal-title":"CrystEngComm"},{"issue":"21","key":"10.1016\/j.jconrel.2026.115277_bb0025","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1002\/anie.199523111","article-title":"Supramolecular synthons in crystal engineering\u2014a new organic synthesis","volume":"34","author":"Desiraju","year":"1995","journal-title":"Angew. Chem. Int. Ed. Engl."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb0030","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1021\/cr960091b","article-title":"Crystal engineering and organometallic architecture","volume":"98","author":"Braga","year":"1998","journal-title":"Chem. Rev."},{"issue":"29","key":"10.1016\/j.jconrel.2026.115277_bb0035","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1039\/b504668h","article-title":"Making crystals from crystals: a green route to crystal engineering and polymorphism","volume":"41","author":"Braga","year":"2005","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jconrel.2026.115277_bb0040","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1039\/b402150a","article-title":"Crystal engineering of the composition of pharmaceutical phases. Do pharmaceutical co-crystals represent a new path to improved medicines?","volume":"17","author":"Almarsson","year":"2004","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jconrel.2026.115277_bb0045","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1039\/b207369m","article-title":"Mechanochemistry and co-crystal formation: effect of solvent on reaction kinetics","volume":"20","author":"Shan","year":"2002","journal-title":"Chem. Commun."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115277_bb0050","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1039\/b400978a","article-title":"Solvent-drop grinding: green polymorph control of cocrystallisation","volume":"40","author":"Trask","year":"2004","journal-title":"Chem. Commun."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115277_bb0055","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1021\/cg800764n","article-title":"Recent advances in understanding the mechanism of cocrystal formation via grinding","volume":"9","author":"Friscic","year":"2009","journal-title":"Crystal Growth Des."},{"issue":"13","key":"10.1016\/j.jconrel.2026.115277_bb0060","doi-asserted-by":"crossref","first-page":"11514","DOI":"10.1021\/acs.chemrev.1c00987","article-title":"Crystal engineering of pharmaceutical cocrystals in the discovery and development of improved drugs","volume":"122","author":"Bolla","year":"2022","journal-title":"Chem. Rev."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115277_bb0065","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1021\/mp0601345","article-title":"The salt\u2212 cocrystal continuum: the influence of crystal structure on ionization state","volume":"4","author":"Childs","year":"2007","journal-title":"Mol. Pharm."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115277_bb0070","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s12039-010-0055-2","article-title":"Crystal engineering: A brief overview","volume":"122","author":"Desiraju","year":"2010","journal-title":"J. Chem. Sci."},{"issue":"82","key":"10.1016\/j.jconrel.2026.115277_bb0075","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1039\/b313552g","article-title":"Crystal and co-crystal","volume":"5","author":"Desiraju","year":"2003","journal-title":"CrystEngComm"},{"issue":"91","key":"10.1016\/j.jconrel.2026.115277_bb0080","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1039\/b315687g","article-title":"Crystal and co-crystal: a second opinion","volume":"5","author":"Dunitz","year":"2003","journal-title":"CrystEngComm"},{"issue":"13","key":"10.1016\/j.jconrel.2026.115277_bb0085","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1039\/C8CE01076E","article-title":"Robust bulk preparation and characterization of sulfamethazine and saccharine salt and cocrystal polymorphs","volume":"21","author":"Perumalla","year":"2019","journal-title":"CrystEngComm"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb0090","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1021\/acs.cgd.9b01299","article-title":"Selective synthesis of a salt and a cocrystal of the ethionamide\u2013salicylic acid system","volume":"20","author":"Bernasconi","year":"2019","journal-title":"Cryst. Growth Des."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115277_bb0095","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1039\/C8CE02066C","article-title":"Living in the salt-cocrystal continuum: indecisive organic complexes with thermochromic behaviour","volume":"21","author":"Jones","year":"2019","journal-title":"CrystEngComm"},{"issue":"16","key":"10.1016\/j.jconrel.2026.115277_bb0100","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1039\/C7CE02204B","article-title":"A salt or a co-crystal\u2013when crystallization protocol matters","volume":"20","author":"Losev","year":"2018","journal-title":"CrystEngComm"},{"issue":"20","key":"10.1016\/j.jconrel.2026.115277_bb0105","doi-asserted-by":"crossref","first-page":"6362","DOI":"10.1039\/c2ce26055g","article-title":"Acid\u2013base crystalline complexes and the p K a rule","volume":"14","author":"Cruz-Cabeza","year":"2012","journal-title":"CrystEngComm"},{"issue":"5","key":"10.1016\/j.jconrel.2026.115277_bb0110","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1021\/cg3002948","article-title":"Polymorphs, salts, and cocrystals: what\u2019s in a name?","volume":"12","author":"Aitipamula","year":"2012","journal-title":"Cryst. Growth Des."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115277_bb0115","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.1021\/acs.cgd.8b00933","article-title":"Creating cocrystals: a review of pharmaceutical cocrystal preparation routes and applications","volume":"18","author":"Karimi-Jafari","year":"2018","journal-title":"Cryst. Growth Des."},{"issue":"54","key":"10.1016\/j.jconrel.2026.115277_bb0120","doi-asserted-by":"crossref","first-page":"8342","DOI":"10.1039\/C6CC02943D","article-title":"Pharmaceutical cocrystals: walking the talk","volume":"52","author":"Bolla","year":"2016","journal-title":"Chem. Commun."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115277_bb0125","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.tips.2018.10.006","article-title":"Pharmaceutical cocrystal drug products: an outlook on product development","volume":"39","author":"Shaikh","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115277_bb0130","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1021\/cg900129f","article-title":"Pharmaceutical cocrystals and their physicochemical properties","volume":"9","author":"Schultheiss","year":"2009","journal-title":"Crystal Growth Des."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb0135","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1517\/17425240902828304","article-title":"Pharmaceutical co-crystals\u2013an opportunity for drug product enhancement","volume":"6","author":"Miroshnyk","year":"2009","journal-title":"Expert Opin. Drug Deliv."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115277_bb0140","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1021\/cg801039j","article-title":"Solubility advantage of pharmaceutical cocrystals","volume":"9","author":"Good","year":"2009","journal-title":"Crystal Growth Des."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb0145","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1021\/cg0503346","article-title":"Phase solubility diagrams of cocrystals are explained by solubility product and solution complexation","volume":"6","author":"Nehm","year":"2006","journal-title":"Cryst. Growth Des."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115277_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pcrysgrow.2016.07.001","article-title":"Spring and parachute: how cocrystals enhance solubility","volume":"62","author":"Bavishi","year":"2016","journal-title":"Prog. Cryst. Growth Charact. Mater."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115277_bb0155","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3109\/03639045.2014.971027","article-title":"Solubility and dissolution enhancement strategies: current understanding and recent trends","volume":"41","author":"Jain","year":"2015","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115277_bb0160","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1517\/17425247.2011.606808","article-title":"Oral formulation strategies to improve solubility of poorly water-soluble drugs","volume":"8","author":"Singh","year":"2011","journal-title":"Expert Opin. Drug Deliv."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115277_bb0165","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1007\/s11095-012-0709-5","article-title":"Simultaneously improving the mechanical properties, dissolution performance, and hygroscopicity of ibuprofen and flurbiprofen by cocrystallization with nicotinamide","volume":"29","author":"Chow","year":"2012","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb0170","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1021\/acs.cgd.7b01371","article-title":"Simultaneous improvement of epalrestat photostability and solubility via cocrystallization: a case study","volume":"18","author":"Putra","year":"2018","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.jconrel.2026.115277_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119089","article-title":"Simultaneous taste-masking and oral bioavailability enhancement of Ligustrazine by forming sweet salts","volume":"577","author":"Zhao","year":"2020","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb0180","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1021\/cg5018642","article-title":"Correlation among crystal structure, mechanical behavior, and tabletability in the co-crystals of vanillin isomers","volume":"15","author":"Krishna","year":"2015","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.jconrel.2026.115277_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.123939","article-title":"Cocrystallization improves the tabletability of ligustrazine despite a reduction in plasticity","volume":"654","author":"Vreeman","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115277_bb0190","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1021\/cg700843s","article-title":"Improving mechanical properties of caffeine and methyl gallate crystals by cocrystallization","volume":"8","author":"Sun","year":"2008","journal-title":"Crystal Growth Des."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115277_bb0195","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.1021\/acs.cgd.1c00512","article-title":"An elusive drug\u2013drug cocrystal prepared using a heteroseeding strategy","volume":"21","author":"Liu","year":"2021","journal-title":"Cryst. Growth Des."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115277_bb0200","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1021\/acs.cgd.8b01873","article-title":"Cocrystal engineering of itraconazole with suberic acid via rotary evaporation and spray drying","volume":"19","author":"Weng","year":"2019","journal-title":"Cryst. Growth Des."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115277_bb0205","doi-asserted-by":"crossref","first-page":"5534","DOI":"10.1021\/acs.cgd.8b00849","article-title":"Cocrystallization of curcumin with benzenediols and benzenetriols via rapid solvent removal","volume":"18","author":"Wong","year":"2018","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.jconrel.2026.115277_bb0210","series-title":"Regulatory Classification of Pharmaceutical Co-Crystals Guidance for Industry","author":"U.S. Food and Drug Administration","year":"2018"},{"key":"10.1016\/j.jconrel.2026.115277_bb0215","series-title":"Reflection Paper on the Use of Cocrystals of Active Substances in Medicinal Products","author":"European Medicines Agency","year":"2015"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115277_bb0220","doi-asserted-by":"crossref","first-page":"355","DOI":"10.15171\/apb.2018.042","article-title":"A review about regulatory status and recent patents of pharmaceutical co-crystals","volume":"8","author":"Kumar","year":"2018","journal-title":"Adv. Pharmaceut. Bull."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115277_bb0225","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1021\/acs.molpharmaceut.4c00289","article-title":"Optimizing drug development: harnessing the sustainability of pharmaceutical cocrystals","volume":"21","author":"Aitipamula","year":"2024","journal-title":"Mol. Pharm."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115277_bb0230","doi-asserted-by":"crossref","DOI":"10.1002\/agt2.70372","article-title":"Advances and challenges in machine learning-based image analysis for monitoring and predicting organic crystal formation","volume":"7","author":"Ma","year":"2026","journal-title":"Aggregate"},{"key":"10.1016\/j.jconrel.2026.115277_bb0235","series-title":"MCC-GCN: Leveraging Graph Convolutional Networks for Multicomponent Crystal Classification in Cocrystal, Salt and Solvate","author":"Deng","year":"2026"},{"key":"10.1016\/j.jconrel.2026.115277_bb0240","article-title":"Sustainability in drug discovery","volume":"12","author":"Wynendaele","year":"2021","journal-title":"Med. Drug Discov."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb0245","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00216-010-4300-9","article-title":"Pharmaceutical residues in environmental waters and wastewater: current state of knowledge and future research","volume":"399","author":"Fatta-Kassinos","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jpp\/rgad097","article-title":"Pharmaceutical co-crystals: a green way to enhance drug stability and solubility for improved therapeutic efficacy","volume":"76","author":"Chettri","year":"2024","journal-title":"J. Pharm. Pharmacol."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115277_bb0255","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3390\/pharmaceutics13060790","article-title":"Mechanochemistry: a green approach in the preparation of pharmaceutical cocrystals","volume":"13","author":"Solares-Briones","year":"2021","journal-title":"Pharmaceutics"},{"issue":"8","key":"10.1016\/j.jconrel.2026.115277_bb0260","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1021\/acs.molpharmaceut.5b00250","article-title":"Mechanistic and kinetic insight into spontaneous cocrystallization of isoniazid and benzoic acid","volume":"12","author":"Sarcevica","year":"2015","journal-title":"Mol. Pharm."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb0265","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/jphp.12123","article-title":"Process monitoring and visualization solutions for hot-melt extrusion: a review","volume":"66","author":"Saerens","year":"2014","journal-title":"J. Pharm. Pharmacol."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115277_bb0270","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1021\/acs.molpharmaceut.6b00134","article-title":"Mechanochemical synthesis of pharmaceutical cocrystal suspensions via hot melt extrusion: feasibility studies and physicochemical characterization","volume":"13","author":"Li","year":"2016","journal-title":"Mol. Pharm."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb0275","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s12247-020-09512-7","article-title":"Hot melt extrusion: an emerging green technique for the synthesis of high-quality pharmaceutical cocrystals","volume":"17","author":"Panzade","year":"2022","journal-title":"J. Pharm. Innov."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115277_bb0280","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1021\/acs.molpharmaceut.7b00979","article-title":"Mechanochemical synthesis of pharmaceutical cocrystal suspensions via hot melt extrusion: enhancing cocrystal yield","volume":"15","author":"Li","year":"2017","journal-title":"Mol. Pharm."},{"issue":"10.33263","key":"10.1016\/j.jconrel.2026.115277_bb0285","article-title":"Deep eutectic solvents as an alternate to other harmful solvents","volume":"12","author":"Sekharan","year":"2022","journal-title":"Biointerface Res. Appl. Chem."},{"issue":"13","key":"10.1016\/j.jconrel.2026.115277_bb0290","doi-asserted-by":"crossref","first-page":"5593","DOI":"10.1021\/acs.cgd.4c00374","article-title":"Slurry in deep eutectic solvents: a green and efficient cocrystal synthesis approach via solvate formation","volume":"24","author":"Zhen","year":"2024","journal-title":"Cryst. Growth Des."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115277_bb0295","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.1021\/acs.cgd.3c00155","article-title":"Cocrystal or salt crystallization for active pharmaceutical ingredients by using deep eutectic solvents","volume":"23","author":"Ito","year":"2023","journal-title":"Cryst. Growth Des."},{"issue":"18","key":"10.1016\/j.jconrel.2026.115277_bb0300","doi-asserted-by":"crossref","first-page":"7686","DOI":"10.1021\/acs.cgd.4c00988","article-title":"An efficient and organic solvent-free slurry method for cocrystal synthesis: using betaine deep eutectic solvents as dual-functional solvents and reactants","volume":"24","author":"Dai","year":"2024","journal-title":"Cryst. Growth Des."},{"issue":"44","key":"10.1016\/j.jconrel.2026.115277_bb0305","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202300819","article-title":"Tinkering with mechanochemical tools for scale up","volume":"62","author":"Reynes","year":"2023","journal-title":"Angew. Chem. Int. Ed."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb0310","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1208\/s12249-015-0360-7","article-title":"Hot-melt extrusion: from theory to application in pharmaceutical formulation","volume":"17","author":"Patil","year":"2016","journal-title":"AAPS PharmSciTech"},{"issue":"21","key":"10.1016\/j.jconrel.2026.115277_bb0315","doi-asserted-by":"crossref","first-page":"11060","DOI":"10.1021\/cr300162p","article-title":"Deep eutectic solvents (DESs) and their applications","volume":"114","author":"Smith","year":"2014","journal-title":"Chem. Rev."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115277_bb0320","doi-asserted-by":"crossref","first-page":"7420","DOI":"10.1021\/acs.cgd.8b01898","article-title":"Pharmaceutical cocrystals: molecules, crystals, formulations, medicines","volume":"19","author":"Yousef","year":"2019","journal-title":"Cryst. Growth Des."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115277_bb0325","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.3390\/pharmaceutics15092174","article-title":"Recent advances in co-former screening and formation prediction of multicomponent solid forms of low molecular weight drugs","volume":"15","author":"Deng","year":"2023","journal-title":"Pharmaceutics"},{"issue":"21","key":"10.1016\/j.jconrel.2026.115277_bb0330","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202502410","article-title":"Unlocking the potential of machine learning in co-crystal prediction by a novel approach integrating molecular thermodynamics","volume":"64","author":"Song","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.jconrel.2026.115277_bb0335","first-page":"1","article-title":"Co-crystallization: a green chemistry approach for sustainable material design and industrial applications","author":"Bhaskar","year":"2025","journal-title":"Green. Fut. Nanotechnol. Environ. Educ."},{"key":"10.1016\/j.jconrel.2026.115277_bb0340","author":"DeepCeutix"},{"issue":"48","key":"10.1016\/j.jconrel.2026.115277_bb0345","doi-asserted-by":"crossref","first-page":"21711","DOI":"10.1002\/anie.202009467","article-title":"Co-crystal prediction by artificial neural networks","volume":"59","author":"Devogelaer","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"issue":"44","key":"10.1016\/j.jconrel.2026.115277_bb0350","doi-asserted-by":"crossref","first-page":"6875","DOI":"10.1039\/C9CE01110B","article-title":"Cocrystal design by network-based link prediction","volume":"21","author":"Devogelaer","year":"2019","journal-title":"CrystEngComm"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb0355","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1007\/s13347-021-00477-0","article-title":"Transparency and the black box problem: why we do not trust AI","volume":"34","author":"Von Eschenbach","year":"2021","journal-title":"Philos. Technol."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb0360","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1021\/jacs.3c13030","article-title":"Thermodynamic stability is a poor indicator of cocrystallization in models of organic molecules","volume":"146","author":"Pimonova","year":"2024","journal-title":"J. Am. Chem. Soc."},{"issue":"24","key":"10.1016\/j.jconrel.2026.115277_bb0365","doi-asserted-by":"crossref","first-page":"15543","DOI":"10.1021\/acsomega.1c01330","article-title":"Progress in research on artificial intelligence applied to polymorphism and cocrystal prediction","volume":"6","author":"Heng","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.jconrel.2026.115277_bb0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.139868","article-title":"A comprehensive review on theoretical screening methods for pharmaceutical cocrystals","volume":"1321","author":"Roshni","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.jconrel.2026.115277_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125202","article-title":"Navigating translational research in nanomedicine: a strategic guide to formulation and manufacturing","volume":"671","author":"Zhang","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb0380","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.addr.2018.06.009","article-title":"Practical guidelines for the characterization and quality control of pure drug nanoparticles and nano-cocrystals in the pharmaceutical industry","volume":"131","author":"Peltonen","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115277_bb0385","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1208\/s12249-025-03228-y","article-title":"Advances in pharmaceutical cocrystals and nano-cocrystals: strategies for enhancing solubility and translating to clinical use","volume":"26","author":"Rao","year":"2025","journal-title":"AAPS PharmSciTech"},{"issue":"25","key":"10.1016\/j.jconrel.2026.115277_bb0390","doi-asserted-by":"crossref","first-page":"8213","DOI":"10.1002\/chem.201203810","article-title":"Ultrasound-assisted construction of halogen-bonded nanosized cocrystals that exhibit thermosensitive luminescence","volume":"19","author":"Yan","year":"2013","journal-title":"Chem Eur J"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb0395","doi-asserted-by":"crossref","first-page":"6575","DOI":"10.1038\/srep06575","article-title":"Continuous engineering of nano-cocrystals for medical and energetic applications","volume":"4","author":"Spitzer","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jconrel.2026.115277_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123300","article-title":"The first nano-cocrystal formulation of marine drug cytarabine with uracil based on cocrystal nanonization strategy for long-acting injection exhibiting enhanced antitumor activity","volume":"644","author":"Yu","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124993","article-title":"Preparation and characterization of andrographolide nano-cocrystals using hummer acoustic resonance technology","volume":"668","author":"Qu","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb0410","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.ejps.2017.09.020","article-title":"Phenazopyridine-phthalimide nano-cocrystal: release rate and oral bioavailability enhancement","volume":"109","author":"Huang","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb0415","first-page":"154","article-title":"A nano-cocrystal strategy to improve the dissolution rate and oral bioavailability of baicalein","volume":"14","author":"Pi","year":"2019","journal-title":"Asian J. Pharmaceut. Sci."},{"issue":"13","key":"10.1016\/j.jconrel.2026.115277_bb0420","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1039\/C9CE01930H","article-title":"Preparation and optimization of nano-sized cocrystals using a quality by design approach","volume":"22","author":"Thakor","year":"2020","journal-title":"CrystEngComm"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb0425","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s12247-026-10379-3","article-title":"Nano-cocrystal delivery system of curcumin: physicochemical characterization, antioxidant activity, cytotoxicity against MCF-7 cells and topical gel formulation","volume":"21","author":"Saleem","year":"2026","journal-title":"J. Pharm. Innov."},{"key":"10.1016\/j.jconrel.2026.115277_bb0430","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.addr.2014.10.022","article-title":"Inhaled formulations and pulmonary drug delivery systems for respiratory infections","volume":"85","author":"Zhou","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jconrel.2026.115277_bb0435","series-title":"Respiratory Delivery of Biologics, Nucleic Acids, and Vaccines","first-page":"123","article-title":"Intranasal and Inhaled Vaccines","author":"Chow","year":"2024"},{"key":"10.1016\/j.jconrel.2026.115277_bb0440","first-page":"1","article-title":"Robust peptide\/RNA complexes prepared with microfluidic mixing for pulmonary delivery by nebulisation","author":"Ma","year":"2025","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.jconrel.2026.115277_bb0445","doi-asserted-by":"crossref","first-page":"114539","DOI":"10.1016\/j.jconrel.2025.114539","article-title":"Understanding excipient interactions unlocks untapped potential of RNA-lipid nanoparticles in dry powder formulations for local pulmonary delivery","volume":"390","author":"Martini","year":"2025","journal-title":"J. Control. Release"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb0450","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1080\/17425247.2023.2185220","article-title":"Shaping the future from the small scale: dry powder inhalation of CRISPR-Cas9 lipid nanoparticles for the treatment of lung diseases","volume":"20","author":"Carneiro","year":"2023","journal-title":"Expert Opin. Drug Deliv."},{"issue":"22","key":"10.1016\/j.jconrel.2026.115277_bb0455","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1080\/17435889.2025.2550231","article-title":"Recent advances in the nanoplatform-mediated delivery of gene editing technologies to the lungs","volume":"20","author":"Marschhofer","year":"2025","journal-title":"Nanomedicine"},{"key":"10.1016\/j.jconrel.2026.115277_bb0460","doi-asserted-by":"crossref","first-page":"126419","DOI":"10.1016\/j.ijpharm.2025.126419","article-title":"Eradication of Pseudomonas aeruginosa using fixed-dose combination of probiotics and bacteriophages: development of an inhalable powder","volume":"687","author":"Byun","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb0465","series-title":"Respiratory Delivery of Biologics, Nucleic Acids, and Vaccines","first-page":"149","article-title":"Respiratory delivery of probiotics to improve lung health","author":"Byun","year":"2024"},{"key":"10.1016\/j.jconrel.2026.115277_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123272","article-title":"Enhanced powder dispersion of dual-excipient spray-dried powder formulations of a monoclonal antibody and its fragment for local treatment of severe asthma","volume":"644","author":"Pan","year":"2023","journal-title":"Int. J. Pharm."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115277_bb0475","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1517\/17425247.2015.977783","article-title":"Dry powder inhalers in COPD, lung inflammation and pulmonary infections","volume":"12","author":"Muralidharan","year":"2015","journal-title":"Expert Opin. Drug Deliv."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115277_bb0480","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02267-19","article-title":"A novel inhaled dry-powder formulation of ribavirin allows for efficient lung delivery in healthy participants and those with chronic obstructive pulmonary disease in a phase 1 study","volume":"64","author":"Dumont","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jconrel.2026.115277_bb0485","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jconrel.2023.04.029","article-title":"Neutralisation of SARS-CoV-2 by monoclonal antibody through dual targeting powder formulation","volume":"358","author":"Seow","year":"2023","journal-title":"J. Control. Release"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb0490","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tips.2022.11.006","article-title":"Inhalable neutralizing antibodies\u2013promising approach to combating respiratory viral infections","volume":"44","author":"Chow","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jconrel.2026.115277_bb0495","series-title":"Co-Spray Drying of Cannabidiol and Vancomycin Combination Powder Formulations for the Treatment of Methicillin-Resistant Staphylococcus aureus Respiratory Infections","author":"Kwong","year":"2026"},{"key":"10.1016\/j.jconrel.2026.115277_bb0500","first-page":"1","article-title":"Spray-dried micellar dry powder inhalation of curcumin for lung-targeted delivery in non-small cell lung cancer therapy","author":"Ghodke","year":"2025","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.jconrel.2026.115277_bb0505","doi-asserted-by":"crossref","first-page":"107753","DOI":"10.1016\/j.jddst.2025.107753","article-title":"Inhalable curcumin\u2013sodium cholesteryl sulfate (Cur\u2013SCS) nanoparticles: a dry powder formulation for targeted lung cancer therapy","volume":"115","author":"Sornsute","year":"2025","journal-title":"J. Drug Delivery Sci. Technol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb0510","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.amjms.2023.03.002","article-title":"Pulmonary hypertension inhaled therapies: an updated review","volume":"366","author":"El-Kersh","year":"2023","journal-title":"Am J Med Sci"},{"issue":"40","key":"10.1016\/j.jconrel.2026.115277_bb0515","doi-asserted-by":"crossref","first-page":"7005","DOI":"10.1039\/D1CE00825K","article-title":"Cocrystal engineering of pharmaceutical solids: therapeutic potential and challenges","volume":"23","author":"Wong","year":"2021","journal-title":"CrystEngComm"},{"key":"10.1016\/j.jconrel.2026.115277_bb0520","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1208\/s12249-012-9883-3","article-title":"Theophylline cocrystals prepared by spray drying: physicochemical properties and aerosolization performance","volume":"14","author":"Alhalaweh","year":"2013","journal-title":"AAPS PharmSciTech"},{"issue":"9","key":"10.1016\/j.jconrel.2026.115277_bb0525","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S1461-5347(98)00099-6","article-title":"Dry powder formulations for pulmonary delivery","volume":"1","author":"Malcolmson","year":"1998","journal-title":"Pharmaceut. Sci. Technol. Today"},{"key":"10.1016\/j.jconrel.2026.115277_bb0530","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.addr.2014.04.005","article-title":"Dry powders for oral inhalation free of lactose carrier particles","volume":"75","author":"Healy","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb0535","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0378-5173(00)00347-1","article-title":"The influence of carrier morphology on drug delivery by dry powder inhalers","volume":"200","author":"Zeng","year":"2000","journal-title":"Int. J. Pharm."},{"issue":"1-2","key":"10.1016\/j.jconrel.2026.115277_bb0540","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0378-5173(99)00400-7","article-title":"The influence of lactose carrier on the content homogeneity and dispersibility of beclomethasone dipropionate from dry powder aerosols","volume":"197","author":"Zeng","year":"2000","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb0545","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(99)00164-7","article-title":"The use of different grades of lactose as a carrier for aerosolised salbutamol sulphate","volume":"191","author":"Larhrib","year":"1999","journal-title":"Int. J. Pharm."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115277_bb0550","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1007\/s11095-022-03363-2","article-title":"Advancements in particle engineering for inhalation delivery of small molecules and biotherapeutics","volume":"39","author":"Chang","year":"2022","journal-title":"Pharm. Res."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb0555","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1208\/s12249-024-02741-w","article-title":"Excipients for novel inhaled dosage forms: an overview","volume":"25","author":"Yousry","year":"2024","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jconrel.2026.115277_bb0560","doi-asserted-by":"crossref","first-page":"107946","DOI":"10.1016\/j.jddst.2025.107946","article-title":"Xinafoic acid as a novel excipient to enhance dispersion and stability of spray dried highly hygroscopic inhalable beta-hydroxybutyrate powders","volume":"116","author":"Tai","year":"2025","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.jconrel.2026.115277_bb0565","author":"U.S. Food and Drug Administration"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb0570","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3390\/pharmaceutics14020300","article-title":"Rational development of a carrier-free dry powder inhalation formulation for respiratory viral infections via quality by design: a drug-drug cocrystal of favipiravir and theophylline","volume":"14","author":"Wong","year":"2022","journal-title":"Pharmaceutics"},{"issue":"9","key":"10.1016\/j.jconrel.2026.115277_bb0575","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1021\/mp500303a","article-title":"Computational predictions of glass-forming ability and crystallization tendency of drug molecules","volume":"11","author":"Alhalaweh","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb0580","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/s12249-020-01803-z","article-title":"Autophagy-inducing inhalable co-crystal formulation of niclosamide-nicotinamide for lung cancer therapy","volume":"21","author":"Ray","year":"2020","journal-title":"AAPS PharmSciTech"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb0585","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/03639045.2020.1716367","article-title":"Application of spray freeze drying to theophylline-oxalic acid cocrystal engineering for inhaled dry powder technology","volume":"46","author":"Tanaka","year":"2020","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115277_bb0590","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3390\/pharmaceutics12121209","article-title":"Effects of the glass-forming ability and annealing conditions on cocrystallization behaviors via rapid solvent removal: a case study of voriconazole","volume":"12","author":"Wong","year":"2020","journal-title":"Pharmaceutics"},{"issue":"9","key":"10.1016\/j.jconrel.2026.115277_bb0595","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1021\/acs.cgd.5c00163","article-title":"Modulating milling-induced amorphization propensity of drug crystals by cocrystallization","volume":"25","author":"Chattoraj","year":"2025","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.jconrel.2026.115277_bb0600","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122983","article-title":"Synthesis of the first remdesivir cocrystal: design, characterization, and therapeutic potential for pulmonary delivery","volume":"640","author":"Wong","year":"2023","journal-title":"Int. J. Pharm."},{"issue":"16","key":"10.1016\/j.jconrel.2026.115277_bb0605","doi-asserted-by":"crossref","first-page":"6535","DOI":"10.1039\/D5NJ00425J","article-title":"Designing lenalidomide cocrystals with an extended-release profile for improved pulmonary drug delivery","volume":"49","author":"Screen","year":"2025","journal-title":"New J. Chem."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115277_bb0610","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1039\/D4CE00021H","article-title":"Discovery of New Cocrystals beyond Serendipity: Lessons Learned from Successes and Failures","volume":"26","author":"Wong","year":"2024","journal-title":"CrystEngComm"},{"key":"10.1016\/j.jconrel.2026.115277_bb0615","unstructured":"Chow, S.F., K.H. Low, and S.N. Wong, Novel cocrystals of dexamethasone. 2023, Google Patents."},{"key":"10.1016\/j.jconrel.2026.115277_bb0620","doi-asserted-by":"crossref","first-page":"126454","DOI":"10.1016\/j.ijpharm.2025.126454","article-title":"Electrosprayed co-crystals of levofloxacin for inhalation: a strategy for excipient-free dry powder antibiotics","volume":"688","author":"Sun","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb0625","doi-asserted-by":"crossref","first-page":"125748","DOI":"10.1016\/j.ijpharm.2025.125748","article-title":"Ciprofloxacin-loaded electrosprayed lactose particles","volume":"680","author":"Liu","year":"2025","journal-title":"Int. J. Pharm."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115277_bb0630","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/(SICI)1096-9888(199707)32:7<677::AID-JMS536>3.0.CO;2-G","article-title":"Electrospray: principles and practice","volume":"32","author":"Gaskell","year":"1997","journal-title":"J. Mass Spectrom."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115277_bb0635","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s11095-023-03534-9","article-title":"Advances in pulmonary drug delivery systems and inhalation formulations","volume":"40","author":"Lam","year":"2023","journal-title":"Pharm. Res."},{"key":"10.1016\/j.jconrel.2026.115277_bb0640","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejpb.2017.02.013","article-title":"Enhanced pulmonary absorption of poorly soluble itraconazole by micronized cocrystal dry powder formulations","volume":"115","author":"Karashima","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb0645","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s13346-020-00891-5","article-title":"Intranasal drug delivery: opportunities and toxicologic challenges during drug development","volume":"12","author":"Keller","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115277_bb0650","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1124\/jpet.119.258152","article-title":"Nose-to-brain delivery","volume":"370","author":"Wang","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115277_bb0655","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3390\/pharmaceutics6030378","article-title":"Intranasal DNA vaccine for protection against respiratory infectious diseases: the delivery perspectives","volume":"6","author":"Xu","year":"2014","journal-title":"Pharmaceutics"},{"issue":"11","key":"10.1016\/j.jconrel.2026.115277_bb0660","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1592\/phco.22.16.1458.33692","article-title":"Intranasal corticosteroids for allergic rhinitis","volume":"22","author":"Trangsrud","year":"2002","journal-title":"Pharmacother. J. Human Pharmacol. Drug Ther."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115277_bb0665","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1080\/17425247.2023.2263363","article-title":"Nasal delivery as a strategy for the prevention and treatment of COVID-19","volume":"20","author":"Sonvico","year":"2023","journal-title":"Expert Opin. Drug Deliv."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb0670","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/1932296814557518","article-title":"Intranasal glucagon: a promising approach for treatment of severe hypoglycemia","volume":"9","author":"Pontiroli","year":"2014","journal-title":"J. Diabetes Sci. Technol."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb0675","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00431-019-03519-0","article-title":"Intranasal treatment of vitamin B12 deficiency in children","volume":"179","author":"Estourgie-van Burk","year":"2020","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.jconrel.2026.115277_bb0680","article-title":"Intranasal fentanyl for the management of acute pain in children","volume":"10","author":"Murphy","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb0685","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.nurt.2009.01.002","article-title":"Intranasal delivery of antiepileptic medications for treatment of seizures","volume":"6","author":"Wermeling","year":"2009","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jconrel.2026.115277_bb0690","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.121658","article-title":"Particulate levodopa nose-to-brain delivery targets dopamine to the brain with no plasma exposure","volume":"618","author":"Dimiou","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115277_bb0695","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.3390\/pharmaceutics15061660","article-title":"Chitosan-based thermogelling system for nose-to-brain donepezil delivery: optimising formulation properties and nasal deposition profile","volume":"15","author":"Perku\u0161i\u0107","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jconrel.2026.115277_bb0700","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jconrel.2016.02.032","article-title":"Development of siRNA-loaded chitosan nanoparticles targeting Galectin-1 for the treatment of glioblastoma multiforme via intranasal administration","volume":"227","author":"Van Woensel","year":"2016","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb0705","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/s41598-017-01279-1","article-title":"Sensitization of glioblastoma tumor micro-environment to chemo-and immunotherapy by Galectin-1 intranasal knock-down strategy","volume":"7","author":"Van Woensel","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115277_bb0710","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.3390\/cancers5031020","article-title":"Formulations for intranasal delivery of pharmacological agents to combat brain disease: a new opportunity to tackle GBM?","volume":"5","author":"Van Woensel","year":"2013","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115277_bb0715","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3390\/pharmaceutics13030385","article-title":"Nasal powder formulations: in-vitro characterisation of the impact of powders on nasal residence time and sensory effects","volume":"13","author":"Trenkel","year":"2021","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115277_bb0720","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4155\/tde-2019-0086","article-title":"Nasal formulations for drug administration and characterization of nasal preparations in drug delivery","volume":"11","author":"Scherlie\u00df","year":"2020","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.jconrel.2026.115277_bb0725","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejpb.2022.05.002","article-title":"Spray dried powders for nasal delivery: Process and formulation considerations","volume":"176","author":"Henriques","year":"2022","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb0730","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/17425247.2020.1714589","article-title":"A consensus research agenda for optimising nasal drug delivery","volume":"17","author":"Forbes","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jconrel.2026.115277_bb0735","doi-asserted-by":"crossref","first-page":"123896","DOI":"10.1016\/j.ijpharm.2024.123896","article-title":"Development of favipiravir dry powders for intranasal delivery: an integrated cocrystal and particle engineering approach via spray freeze drying","volume":"653","author":"Wong","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb0740","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122630","article-title":"Optimising nasal powder drug delivery\u2013characterisation of the effect of excipients on drug absorption","volume":"633","author":"Trenkel","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb0745","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ijpharm.2019.02.026","article-title":"How to characterize a nasal product. The state of the art of in vitro and ex vivo specific methods","volume":"561","author":"Salade","year":"2019","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb0750","doi-asserted-by":"crossref","first-page":"104156","DOI":"10.1016\/j.xphs.2026.104156","article-title":"Overcoming translational barriers in nose-to-brain drug delivery for clinical applications","volume":"11","author":"Zhang","year":"2026","journal-title":"J. Pharm. Sci."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115277_bb0755","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1007\/s11095-022-03388-7","article-title":"In vitro regional deposition of nasal sprays in an idealized nasal inlet: comparison with in vivo gamma scintigraphy","volume":"39","author":"Chen","year":"2022","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb0760","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/jamp.2024.0029","article-title":"Characterization of spray-dried powders using a coated alberta idealized nasal inlet","volume":"38","author":"Duong","year":"2025","journal-title":"J. Aerosol Med. Pulmonary Drug Deliv."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb0765","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jaerosci.2010.11.002","article-title":"Effects of surface smoothness on inertial particle deposition in human nasal models","volume":"42","author":"Schroeter","year":"2011","journal-title":"J. Aerosol Sci."},{"key":"10.1016\/j.jconrel.2026.115277_bb0770","first-page":"1","article-title":"Rational development of fingolimod nano-embedded microparticles as nose-to-brain neuroprotective therapy for ischemic stroke","author":"Zhang","year":"2024","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.jconrel.2026.115277_bb0775","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.compbiomed.2016.08.002","article-title":"Effects of nasal drug delivery device and its orientation on sprayed particle deposition in a realistic human nasal cavity","volume":"77","author":"Tong","year":"2016","journal-title":"Comput. Biol. Med."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb0780","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0738-081X(95)00078-T","article-title":"Evaluation of biomechanical properties of human skin","volume":"13","author":"Edwards","year":"1995","journal-title":"Clin. Dermatol."},{"issue":"18","key":"10.1016\/j.jconrel.2026.115277_bb0785","first-page":"2065","article-title":"Skin barrier and transdermal drug delivery","volume":"3","author":"Prausnitz","year":"2012","journal-title":"Dermatology"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb0790","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijpharm.2012.06.005","article-title":"The structure and function of the stratum corneum","volume":"435","author":"Menon","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb0795","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.121082","article-title":"A molecular mechanism investigation of the transdermal\/topical absorption classification system on the basis of drug skin permeation and skin retention","volume":"608","author":"Tian","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb0800","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jconrel.2014.05.022","article-title":"Transdermal drug delivery: 30+ years of war and still fighting!","volume":"190","author":"Wiedersberg","year":"2014","journal-title":"J. Control. Release"},{"issue":"1-3","key":"10.1016\/j.jconrel.2026.115277_bb0805","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"23","author":"Lipinski","year":"1997","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb0810","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(99)00095-2","article-title":"Passive enhancement strategies in topical and transdermal drug delivery","volume":"184","author":"Hadgraft","year":"1999","journal-title":"Int. J. Pharm."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115277_bb0815","article-title":"Active enhancement methods for intra-and transdermal drug delivery: a review","volume":"82","author":"Zorec","year":"2013","journal-title":"Zdravniski Vestnik"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb0820","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s13346-021-00909-6","article-title":"Enhancement strategies for transdermal drug delivery systems: Current trends and applications","volume":"12","author":"Ramadon","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb0825","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0168-3659(98)00187-4","article-title":"Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations","volume":"59","author":"Suhonen","year":"1999","journal-title":"J. Control. Release"},{"issue":"11","key":"10.1016\/j.jconrel.2026.115277_bb0830","doi-asserted-by":"crossref","first-page":"2102685","DOI":"10.1002\/adhm.202102685","article-title":"Ionic Liquid-Mediated Transdermal Delivery of Thrombosis-Detecting Nanosensors","volume":"11","author":"Bekdemir","year":"2022","journal-title":"Adv. Healthc. Mater."},{"issue":"27","key":"10.1016\/j.jconrel.2026.115277_bb0835","doi-asserted-by":"crossref","first-page":"1901103","DOI":"10.1002\/adma.201901103","article-title":"Design principles of ionic liquids for transdermal drug delivery","volume":"31","author":"Tanner","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115277_bb0840","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124615","article-title":"Influence of co-solvents on properties of terpene-based eutectic mixtures: implications for skin delivery","volume":"664","author":"Czyrski","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115277_bb0845","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2174\/157016306780136772","article-title":"Prodrug strategy for enhancing drug delivery via skin","volume":"3","author":"Fang","year":"2006","journal-title":"Curr. Drug Discov. Technol."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115277_bb0850","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1211\/0022357001774804","article-title":"Ion-pair formation as a strategy to enhance topical delivery of salicylic acid","volume":"52","author":"Megwa","year":"2000","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.jconrel.2026.115277_bb0855","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ijpharm.2018.11.073","article-title":"Nanoformulation of curcumin-loaded eudragit-nutriosomes to counteract malaria infection by a dual strategy: Improving antioxidant intestinal activity and systemic efficacy","volume":"556","author":"Manconi","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb0860","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.colsurfb.2015.02.046","article-title":"Formulation optimization and in vitro skin penetration of spironolactone loaded solid lipid nanoparticles","volume":"128","author":"Kelidari","year":"2015","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.jconrel.2026.115277_bb0865","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.ejpb.2017.04.012","article-title":"Preparation and characterization of dutasteride-loaded nanostructured lipid carriers coated with stearic acid-chitosan oligomer for topical delivery","volume":"117","author":"Noor","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb0870","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2015.10.049","article-title":"Nanoparticles and nanofibers for topical drug delivery","volume":"240","author":"Goyal","year":"2016","journal-title":"J. Control. Release"},{"issue":"18","key":"10.1016\/j.jconrel.2026.115277_bb0875","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1039\/D4TB00110A","article-title":"Novel SmartReservoirs for hydrogel-forming microneedles to improve the transdermal delivery of rifampicin","volume":"12","author":"Abraham","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jconrel.2026.115277_bb0880","doi-asserted-by":"crossref","first-page":"1454903","DOI":"10.3389\/fbioe.2025.1454903","article-title":"Innovative hydrogels in cutaneous wound healing: current status and future perspectives","volume":"13","author":"Sawadkar","year":"2025","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb0885","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/17425247.2018.1444025","article-title":"Nanocrystal: a novel approach to overcome skin barriers for improved topical drug delivery","volume":"15","author":"Patel","year":"2018","journal-title":"Expert Opin. Drug Deliv."},{"issue":"32","key":"10.1016\/j.jconrel.2026.115277_bb0890","doi-asserted-by":"crossref","first-page":"38745","DOI":"10.1021\/acsami.1c11179","article-title":"Albendazole nanocrystal-based dissolving microneedles with improved pharmacokinetic performance for enhanced treatment of cystic echinococcosis","volume":"13","author":"Permana","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2026.115277_bb0895","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.colsurfb.2016.03.026","article-title":"Diclofenac acid nanocrystals as an effective strategy to reduce in vivo skin inflammation by improving dermal drug bioavailability","volume":"143","author":"Pireddu","year":"2016","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.jconrel.2026.115277_bb0900","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ejpb.2020.06.025","article-title":"Dissolving microneedle-mediated dermal delivery of itraconazole nanocrystals for improved treatment of cutaneous candidiasis","volume":"154","author":"Permana","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb0905","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejpb.2016.03.026","article-title":"Microneedle-mediated delivery of donepezil: potential for improved treatment options in Alzheimer\u2019s disease","volume":"103","author":"Kearney","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb0910","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119584","article-title":"Iontophoretic skin delivery systems: Success and failures","volume":"586","author":"Bakshi","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb0915","series-title":"Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement","first-page":"3","article-title":"Sonophoresis: ultrasound-mediated transdermal drug delivery","author":"Mitragotri","year":"2017"},{"issue":"5","key":"10.1016\/j.jconrel.2026.115277_bb0920","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.addr.2003.10.027","article-title":"Skin electroporation for transdermal and topical delivery","volume":"56","author":"Denet","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb0925","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jconrel.2011.05.003","article-title":"Microsecond thermal ablation of skin for transdermal drug delivery","volume":"154","author":"Lee","year":"2011","journal-title":"J. Control. Release"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb0930","doi-asserted-by":"crossref","first-page":"305","DOI":"10.15171\/bi.2018.33","article-title":"Recent advances in improving oral drug bioavailability by cocrystals","volume":"8","author":"Emami","year":"2018","journal-title":"BioImpacts: BI"},{"issue":"8","key":"10.1016\/j.jconrel.2026.115277_bb0935","doi-asserted-by":"crossref","first-page":"4430","DOI":"10.1021\/acs.cgd.6b00552","article-title":"Improving the membrane permeability of 5-fluorouracil via cocrystallization","volume":"16","author":"Dai","year":"2016","journal-title":"Cryst. Growth Des."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115277_bb0940","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1021\/acs.molpharmaceut.5b00020","article-title":"Cocrystals of hydrochlorothiazide: solubility and diffusion\/permeability enhancements through drug\u2013coformer interactions","volume":"12","author":"Sanphui","year":"2015","journal-title":"Mol. Pharm."},{"issue":"33","key":"10.1016\/j.jconrel.2026.115277_bb0945","doi-asserted-by":"crossref","first-page":"6457","DOI":"10.1039\/c3ce41017j","article-title":"Simultaneously enhancing the solubility and permeability of acyclovir by crystal engineering approach","volume":"15","author":"Yan","year":"2013","journal-title":"CrystEngComm"},{"issue":"9","key":"10.1016\/j.jconrel.2026.115277_bb0950","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.1021\/acs.cgd.9b00313","article-title":"Isoniazid-resveratrol cocrystal: a novel alternative for topical treatment of cutaneous tuberculosis","volume":"19","author":"Rosa","year":"2019","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.jconrel.2026.115277_bb0955","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/s12249-019-1360-9","article-title":"Cocrystal of 5-fluorouracil: characterization and evaluation of biopharmaceutical parameters","volume":"20","author":"Gautam","year":"2019","journal-title":"AAPS PharmSciTech"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb0960","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1039\/D5MD00001G","article-title":"Betaine\u2013salicylic acid cocrystal for enhanced skincare and acne treatment","volume":"16","author":"Wang","year":"2025","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.jconrel.2026.115277_bb0965","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejpb.2020.01.021","article-title":"Cocrystal formulations: a case study of topical formulations consisting of ferulic acid cocrystals","volume":"149","author":"Aitipamula","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115277_bb0970","doi-asserted-by":"crossref","first-page":"5090","DOI":"10.1021\/acs.molpharmaceut.3c00398","article-title":"Accelerated wound healing with a diminutive scar through cocrystal engineered curcumin","volume":"20","author":"Samie","year":"2023","journal-title":"Mol. Pharm."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115277_bb0975","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1021\/cg200704s","article-title":"Fast dissolving curcumin cocrystals","volume":"11","author":"Sanphui","year":"2011","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.jconrel.2026.115277_bb0980","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ejps.2018.07.038","article-title":"Cocrystallization as a novel approach to enhance the transdermal administration of meloxicam","volume":"123","author":"Machado","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.jconrel.2026.115277_bb0985","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124959","article-title":"Towards the discovery of unrevealed flufenamic acid cocrystals via structural resemblance for enhanced topical drug delivery","volume":"668","author":"Li","year":"2025","journal-title":"Int. J. Pharm."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115277_bb0990","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2217\/nnm-2016-0405","article-title":"Aceclofenac cocrystal nanoliposomes for rheumatoid arthritis with better dermatokinetic attributes: a preclinical study","volume":"12","author":"Sharma","year":"2017","journal-title":"Nanomedicine"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb0995","first-page":"1","article-title":"Novel quercetin-ascorbic acid nano cocrystals: a carrier-free strategy for enhancement of solubility, topical anti-oxidant activity and cytotoxicity","volume":"27","author":"Abbas","year":"2026","journal-title":"AAPS PharmSciTech"},{"issue":"39","key":"10.1016\/j.jconrel.2026.115277_bb1000","doi-asserted-by":"crossref","first-page":"54553","DOI":"10.1021\/acsami.5c13207","article-title":"Strategic modulation of isoniazid solubility through cocrystal formation for long-acting microneedle therapy of tuberculosis","volume":"17","author":"Fandi\u00f1o","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2026.115277_bb1005","first-page":"1","article-title":"Dissolving microneedles incorporating kopexil multicomponent crystals for improved transdermal delivery","author":"Deng","year":"2026","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.jconrel.2026.115277_bb1010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.120152","article-title":"Enhancing intradermal delivery of tofacitinib citrate: comparison between powder-loaded hollow microneedle arrays and dissolving microneedle arrays","volume":"593","author":"Carcamo-Martinez","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb1015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124691","article-title":"Enhanced long-acting simvastatin delivery via effervescent powder-carrying hollow microneedles and nanocrystal-loaded microneedles","volume":"665","author":"Qin","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb1020","unstructured":"Barbier, R., et al., Cocrystals of naloxone and naltrexone. 2021, Google Patents."},{"key":"10.1016\/j.jconrel.2026.115277_bb1025","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2147\/CCID.S84765","article-title":"Salicylic acid as a peeling agent: a comprehensive review","author":"Arif","year":"2015","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb1030","first-page":"259","article-title":"The beneficial biological properties of salicylic acid","volume":"32","author":"Randjelovi\u0107","year":"2015","journal-title":"Acta facultatis medicae Naissensis"},{"key":"10.1016\/j.jconrel.2026.115277_bb1035","series-title":"Salicylic Acid: Summary Report","author":"Yoon","year":"2021"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb1040","first-page":"285","article-title":"A review of the range of effects of niacinamide in human skin","volume":"5","author":"Matts","year":"2002","journal-title":"IFSCC Mag."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb1045","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/jocd.12119","article-title":"A review of nicotinamide: treatment of skin diseases and potential side effects","volume":"13","author":"Rolfe","year":"2014","journal-title":"J. Cosmet. Dermatol."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115277_bb1050","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.clindermatol.2009.05.010","article-title":"Cosmeceuticals vitamins","volume":"27","author":"Manela-Azulay","year":"2009","journal-title":"Clin. Dermatol."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb1055","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1208\/s12249-023-02516-9","article-title":"Ocular drug delivery: a comprehensive review","volume":"24","author":"Ahmed","year":"2023","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.jconrel.2026.115277_bb1060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119577","article-title":"The prominence of the dosage form design to treat ocular diseases","volume":"586","author":"Campos","year":"2020","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb1065","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4103\/0975-8453.75042","article-title":"Ophthalmic drug delivery system: challenges and approaches","volume":"1","author":"Patel","year":"2010","journal-title":"Syst. Rev. Pharm."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115277_bb1070","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1021\/acs.biomac.5c00292","article-title":"Thermoresponsive hydrogels with tunable viscoelasticity for extended ocular drug delivery","volume":"26","author":"Pilipenko","year":"2025","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jconrel.2026.115277_bb1075","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jconrel.2019.05.034","article-title":"Hydrogel-based ocular drug delivery systems: emerging fabrication strategies, applications, and bench-to-bedside manufacturing considerations","volume":"306","author":"Cooper","year":"2019","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115277_bb1080","doi-asserted-by":"crossref","first-page":"291","DOI":"10.4103\/0110-5558.72419","article-title":"Ocular inserts\u2014advancement in therapy of eye diseases","volume":"1","author":"Kumari","year":"2010","journal-title":"J. Adv. Pharmaceut. Technol. Res."},{"key":"10.1016\/j.jconrel.2026.115277_bb1085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122453","article-title":"Biodistribution of progesterone in the eye after topical ocular administration via drops or inserts","volume":"630","author":"Alambiaga-Caravaca","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb1090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122028","article-title":"Improved ocular delivery of quercetin and resveratrol: a comparative study between binary and ternary cyclodextrin complexes","volume":"624","author":"Krsti\u0107","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb1095","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ijpharm.2017.04.010","article-title":"Cyclodextrins and topical drug delivery to the anterior and posterior segments of the eye","volume":"531","author":"Loftsson","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb1100","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jconrel.2024.05.013","article-title":"Hollow microneedles for ocular drug delivery","volume":"371","author":"Gade","year":"2024","journal-title":"J. Control. Release"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb1105","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/17425247.2016.1218460","article-title":"Minimally invasive microneedles for ocular drug delivery","volume":"14","author":"Thakur Singh","year":"2017","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jconrel.2026.115277_bb1110","doi-asserted-by":"crossref","first-page":"114027","DOI":"10.1016\/j.jconrel.2025.114027","article-title":"Efficacy versus immunogenicity of LNP-mediated delivery of mRNA and self-amplifying RNA upon intravitreal injection in the mouse eye","volume":"385","author":"Li","year":"2025","journal-title":"J. Control. Release"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb1115","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/bph.12330","article-title":"Small-interfering RNA s (siRNA s) as a promising tool for ocular therapy","volume":"170","author":"Guzman-Aranguez","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115277_bb1120","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/02713683.2019.1565890","article-title":"Morphology and composition of the inner limiting membrane: species-specific variations and relevance toward drug delivery research","volume":"44","author":"Peynshaert","year":"2019","journal-title":"Curr. Eye Res."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb1125","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1021\/acs.molpharmaceut.9b00707","article-title":"Ocular biodistribution of spironolactone after a single intravitreal injection of a biodegradable sustained-release polymer in rats","volume":"17","author":"Dahmana","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb1130","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108151","article-title":"Hyaluronic acid coating of gold nanoparticles for intraocular drug delivery: evaluation of the surface properties and effect on their distribution","volume":"198","author":"Apaolaza","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.jconrel.2026.115277_bb1135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124141","article-title":"A sterilizable platform based on crosslinked xanthan gum for controlled-release of polymeric micelles: ocular application for the delivery of neuroprotective compounds to the posterior eye segment","volume":"657","author":"Signorini","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb1140","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/17425247.2019.1597848","article-title":"Topical application of polymeric nanomicelles in ophthalmology: a review on research efforts for the noninvasive delivery of ocular therapeutics","volume":"16","author":"Grimaudo","year":"2019","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.jconrel.2026.115277_bb1145","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125435","article-title":"Optimizing riboflavin delivery with co-crystal and in situ hydrogel formulations for management of keratoconus: a comprehensive investigation with in vitro, ex vivo and in vivo studies","volume":"674","author":"Aytekin","year":"2025","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb1150","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1021\/acs.molpharmaceut.5c01332","article-title":"Engineering cocrystal-loaded nanofibers for ocular therapy: a hybrid electrospinning\u2013electrospraying strategy","volume":"23","author":"Darwesh","year":"2026","journal-title":"Mol. Pharm."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115277_bb1155","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s12247-025-10218-x","article-title":"Mesalamine and ascorbic acid drug\u2013drug cocrystal-loaded suppositories: a coadministrative approach for localized treatment of ulcerative colitis","volume":"20","author":"Desai","year":"2025","journal-title":"J. Pharm. Innov."},{"key":"10.1016\/j.jconrel.2026.115277_bb1160","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.3389\/fphar.2019.01196","article-title":"Physiological and pharmaceutical considerations for rectal drug formulations","volume":"10","author":"Hua","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115277_bb1165","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1080\/10837450.2018.1484766","article-title":"Advances in rectal drug delivery systems","volume":"23","author":"Purohit","year":"2018","journal-title":"Pharm. Dev. Technol."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115277_bb1170","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1517\/13543776.11.6.981","article-title":"Fast-dissolving intraoral drug delivery systems","volume":"11","author":"Liang","year":"2001","journal-title":"Expert Opin. Therapeut. Patents"},{"issue":"11","key":"10.1016\/j.jconrel.2026.115277_bb1175","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1016\/j.xphs.2017.07.009","article-title":"Drug delivery innovations to address global health challenges for pediatric and geriatric populations (through improvements in patient compliance)","volume":"106","author":"Boateng","year":"2017","journal-title":"J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb1180","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0165-3806(02)00463-7","article-title":"A quantitative study of fungiform papillae and taste pore density in adults and children","volume":"138","author":"Segovia","year":"2002","journal-title":"Dev. Brain Res."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115277_bb1185","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103107","article-title":"Age-related differences in bitter taste and efficacy of bitter blockers","volume":"9","author":"Mennella","year":"2014","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.jconrel.2026.115277_bb1190","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1177\/014556139907800707","article-title":"Xerostomia: a prevalent condition in the elderly","volume":"78","author":"Astor","year":"1999","journal-title":"Ear Nose Throat J."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb1195","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cger.2013.10.009","article-title":"Dysphagia in the elderly","volume":"30","author":"Khan","year":"2014","journal-title":"Clin. Geriatr. Med."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115277_bb1200","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1021\/acs.jafc.6b04835","article-title":"Vertebrate bitter taste receptors: keys for survival in changing environments","volume":"66","author":"Behrens","year":"2016","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb1205","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/87559128509540773","article-title":"Bitter compounds: occurrence and structure-activity relationships","volume":"1","author":"Belitz","year":"1985","journal-title":"Food Rev. Int."},{"key":"10.1016\/j.jconrel.2026.115277_bb1210","doi-asserted-by":"crossref","first-page":"1449536","DOI":"10.3389\/fchem.2024.1449536","article-title":"One of the major challenges of masking the bitter taste in medications: an overview of quantitative methods for bitterness","volume":"12","author":"Wang","year":"2024","journal-title":"Front. Chem."},{"key":"10.1016\/j.jconrel.2026.115277_bb1215","doi-asserted-by":"crossref","first-page":"126345","DOI":"10.1016\/j.ijpharm.2025.126345","article-title":"Evaluation of bitterness in mother tinctures by an electronic tongue: impact of cyclodextrin complexation","volume":"686","author":"Kallel","year":"2025","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb1220","first-page":"183","article-title":"A donepezil\/cyclodextrin complexation orodispersible film: effect of cyclodextrin on taste-masking based on dynamic process and in vivo drug absorption","volume":"14","author":"Liu","year":"2019","journal-title":"Asian J. Pharmaceut. Sci."},{"issue":"1-2","key":"10.1016\/j.jconrel.2026.115277_bb1225","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijpharm.2013.07.072","article-title":"In vitro and in vivo correlation of disintegration and bitter taste masking using orally disintegrating tablet containing ion exchange resin-drug complex","volume":"455","author":"Kim","year":"2013","journal-title":"Int. J. Pharm."},{"issue":"1-2","key":"10.1016\/j.jconrel.2026.115277_bb1230","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijpharm.2012.11.047","article-title":"Bitterness prediction of H1-antihistamines and prediction of masking effects of artificial sweeteners using an electronic tongue","volume":"441","author":"Ito","year":"2013","journal-title":"Int. J. Pharm."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115277_bb1235","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3109\/03639045.2012.758636","article-title":"Evaluation of taste-masking effects of pharmaceutical sweeteners with an electronic tongue system","volume":"40","author":"Choi","year":"2014","journal-title":"Drug Dev. Ind. Pharm."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115277_bb1240","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1080\/10408398.2024.2326012","article-title":"A review on natural sweeteners, sweet taste modulators and bitter masking compounds: structure-activity strategies for the discovery of novel taste molecules","volume":"65","author":"An","year":"2025","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb1245","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1039\/D4PM00191E","article-title":"Strategies for beating the bitter taste of pharmaceutical formulations towards better therapeutic outcomes","volume":"2","author":"Sanjay","year":"2025","journal-title":"RSC Pharm."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115277_bb1250","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1007\/s00894-013-1780-5","article-title":"Prodrugs for masking bitter taste of antibacterial drugs\u2014a computational approach","volume":"19","author":"Karaman","year":"2013","journal-title":"J. Mol. Model."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115277_bb1255","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1023\/A:1015958417047","article-title":"Improved buccal delivery of opioid analgesics and antagonists with bitterless prodrugs","volume":"5","author":"Hussain","year":"1988","journal-title":"Pharm. Res."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115277_bb1260","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1021\/acs.molpharmaceut.7b00423","article-title":"Expedited development of diphenhydramine orally disintegrating tablet through integrated crystal and particle engineering","volume":"14","author":"Wang","year":"2017","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb1265","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ijpharm.2017.08.100","article-title":"Expedited development of a high dose orally disintegrating metformin tablet enabled by sweet salt formation with acesulfame","volume":"532","author":"Wang","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb1270","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1021\/acs.cgd.5b01484","article-title":"Sweet berberine","volume":"16","author":"Wang","year":"2016","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.jconrel.2026.115277_bb1275","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jconrel.2017.06.002","article-title":"Mechanical microencapsulation: The best technique in taste masking for the manufacturing scale-Effect of polymer encapsulation on drug targeting","volume":"260","author":"Al-Kasmi","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115277_bb1280","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126259","article-title":"Taste masking and stability improvement of Korean red ginseng (Panax ginseng) by nanoencapsulation using chitosan and gelatin","volume":"250","author":"Han","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb1285","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1517\/17425247.2013.747508","article-title":"Cocrystallization for successful drug delivery","volume":"10","author":"Sun","year":"2013","journal-title":"Expert Opin. Drug Deliv."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115277_bb1290","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1080\/10837450.2016.1242625","article-title":"Xylitol as a potential co-crystal co-former for enhancing dissolution rate of felodipine: preparation and evaluation of sublingual tablets","volume":"23","author":"Arafa","year":"2018","journal-title":"Pharm. Dev. Technol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb1295","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s43094-020-00033-1","article-title":"Formulation and evaluation of buccal films of piroxicam co-crystals","volume":"6","author":"Ammanage","year":"2020","journal-title":"Future J. Pharmaceut. Sci."},{"issue":"1-2","key":"10.1016\/j.jconrel.2026.115277_bb1300","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ijpharm.2005.11.046","article-title":"Taste masking analysis in pharmaceutical formulation development using an electronic tongue","volume":"310","author":"Zheng","year":"2006","journal-title":"Int. J. Pharm."},{"issue":"1-2","key":"10.1016\/j.jconrel.2026.115277_bb1305","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ijpharm.2010.11.028","article-title":"Taste sensing systems (electronic tongues) for pharmaceutical applications","volume":"417","author":"Woertz","year":"2011","journal-title":"Int. J. Pharm."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115277_bb1310","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1211\/0022357022106","article-title":"Evaluation of the bitterness of antibiotics using a taste sensor","volume":"55","author":"Uchida","year":"2003","journal-title":"J. Pharm. Pharmacol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb1315","doi-asserted-by":"crossref","first-page":"12074","DOI":"10.1038\/s41598-017-12359-7","article-title":"Bitter or not? BitterPredict, a tool for predicting taste from chemical structure","volume":"7","author":"Dagan-Wiener","year":"2017","journal-title":"Sci. Rep."},{"issue":"15","key":"10.1016\/j.jconrel.2026.115277_bb1320","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.3390\/s24154799","article-title":"Taste sensor assessment of bitterness in medicines: overview and recent topics","volume":"24","author":"Uchida","year":"2024","journal-title":"Sensors"},{"issue":"2","key":"10.1016\/j.jconrel.2026.115277_bb1325","doi-asserted-by":"crossref","first-page":"S238","DOI":"10.1111\/1750-3841.12342","article-title":"Comparison of the hedonic general labeled magnitude scale with the hedonic 9-point scale","volume":"79","author":"Kalva","year":"2014","journal-title":"J. Food Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb1330","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s12668-025-02261-2","article-title":"Formulation and optimization of zopiclone co-crystal based fast-dissolving oral films for insomnia management","volume":"16","author":"Godge","year":"2026","journal-title":"BioNanoScience"},{"issue":"8","key":"10.1016\/j.jconrel.2026.115277_bb1335","article-title":"Formulation and evaluation of bioadhesive buccal Films of Domperidone co-crystals by using Tamarind kernel powder as mucoadhesive polymer","volume":"14","author":"Rongali","year":"2024","journal-title":"J. Drug Deliv. Therapeut."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb1340","article-title":"L-proline as co-crystal forming amino acid for enhanced dissolution rate of lamotrigine: development of oral dispersible tablet","volume":"34","author":"Abdelrahman","year":"2023","journal-title":"Indonesian J. Pharm. Majalah Farmasi Indonesia"},{"key":"10.1016\/j.jconrel.2026.115277_bb1345","series-title":"Formulation and Evaluation of Orally Disintegrating Film (ODF) Containing Piperine-succinic Acid Cocrystal","author":"Hasanah","year":"2023"},{"key":"10.1016\/j.jconrel.2026.115277_bb1350","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1039\/C6GC03413F","article-title":"Organic synthesis by Twin Screw Extrusion (TSE): continuous, scalable and solvent-free","volume":"6","author":"Crawford","year":"2017","journal-title":"Green Chem."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115277_bb1355","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1002\/jps.23025","article-title":"Solution-mediated phase transformation: significance during dissolution and implications for bioavailability","volume":"101","author":"Greco","year":"2012","journal-title":"J. Pharm. Sci."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115277_bb1360","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1021\/acs.molpharmaceut.0c00587","article-title":"Effects of coformer and polymer on particle surface solution-mediated phase transformation of cocrystals in aqueous media","volume":"17","author":"Omori","year":"2020","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.jconrel.2026.115277_bb1365","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2020.101566","article-title":"Solution-mediated phase transformation at particle surface during cocrystal dissolution","volume":"56","author":"Omori","year":"2020","journal-title":"J. Drug Delivery Sci. Technol."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115277_bb1370","doi-asserted-by":"crossref","first-page":"6719","DOI":"10.1021\/acs.cgd.6b01434","article-title":"Harvesting potential dissolution advantages of soluble cocrystals by depressing precipitation using the common coformer effect","volume":"16","author":"Yamashita","year":"2016","journal-title":"Cryst. Growth Des."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb1375","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ijpharm.2017.12.020","article-title":"Production of cocrystals in an excipient matrix by spray drying","volume":"536","author":"Walsh","year":"2018","journal-title":"Int. J. Pharm."},{"issue":"1-2","key":"10.1016\/j.jconrel.2026.115277_bb1380","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijpharm.2016.04.010","article-title":"Green production of cocrystals using a new solvent-free approach by spray congealing","volume":"506","author":"Duarte","year":"2016","journal-title":"Int. J. Pharm."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115277_bb1385","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.1021\/cg401179s","article-title":"Cocrystallization by freeze-drying: preparation of novel multicomponent crystal forms","volume":"13","author":"Eddleston","year":"2013","journal-title":"Cryst. Growth Des."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115277_bb1390","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1021\/acs.cgd.9b01619","article-title":"Extended release of highly water soluble isoniazid attained through cocrystallization with curcumin","volume":"20","author":"Xuan","year":"2020","journal-title":"Cryst. Growth Des."},{"key":"10.1016\/j.jconrel.2026.115277_bb1395","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122283","article-title":"Feasibility of high melting point hydrochlorothiazide processing via cocrystal formation by hot melt extrusion paired fused filament fabrication as a 3D-printed cocrystal tablet","volume":"628","author":"Nyavanandi","year":"2022","journal-title":"Int. J. Pharm."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115277_bb1400","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1039\/C2CE26519B","article-title":"Rapid preparation of pharmaceutical co-crystals with thermal ink-jet printing","volume":"15","author":"Buanz","year":"2013","journal-title":"CrystEngComm"},{"key":"10.1016\/j.jconrel.2026.115277_bb1405","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119953","article-title":"Development of piroxicam mini-tablets enabled by spherical cocrystallization","volume":"590","author":"Chen","year":"2020","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115277_bb1410","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1021\/acs.cgd.9b00219","article-title":"Spherical cocrystallization\u2014an enabling technology for the development of high dose direct compression tablets of poorly soluble drugs","volume":"19","author":"Chen","year":"2019","journal-title":"Cryst. Growth Des."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115277_bb1415","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ejps.2010.08.012","article-title":"Ultrasound assisted cocrystallization from solution (USSC) containing a non-congruently soluble cocrystal component pair: Caffeine\/maleic acid","volume":"41","author":"Aher","year":"2010","journal-title":"Eur. J. Pharm. Sci."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115277_bb1420","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1039\/C9CE01886G","article-title":"Microwave assisted slurry conversion crystallization for manufacturing of new co-crystals of sulfamethazine and sulfamerazine","volume":"22","author":"Ahuja","year":"2020","journal-title":"CrystEngComm"},{"issue":"6","key":"10.1016\/j.jconrel.2026.115277_bb1425","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1021\/acs.cgd.6b00289","article-title":"A new method for producing pharmaceutical co-crystals: laser irradiation of powder blends","volume":"16","author":"Titapiwatanakun","year":"2016","journal-title":"Cryst. Growth Des."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115277_bb1430","doi-asserted-by":"crossref","first-page":"5982","DOI":"10.1021\/acs.cgd.2c00624","article-title":"New cocrystallization method: non-photochemical laser-induced nucleation of a cocrystal of caffeine\u2013gallic acid in water","volume":"22","author":"Mellah","year":"2022","journal-title":"Cryst. Growth Des."},{"issue":"1-2","key":"10.1016\/j.jconrel.2026.115277_bb1435","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ijpharm.2017.02.027","article-title":"High-throughput screening and scale-up of cocrystals using resonant acoustic mixing","volume":"521","author":"Nagapudi","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115277_bb1440","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1038\/s41467-026-69483-0","article-title":"Non-macrocyclic molecular design enables cavity-adaptive cocrystals with high elasticity and low-threshold lasing","volume":"17","author":"Feng","year":"2026","journal-title":"Nat. Commun."},{"issue":"16","key":"10.1016\/j.jconrel.2026.115277_bb1445","doi-asserted-by":"crossref","first-page":"6830","DOI":"10.1021\/acs.cgd.5c00779","article-title":"Stereochemical control of cocrystal and hybrid salt\u2013cocrystal formation in the baclofen\u2013mandelic acid system","volume":"25","author":"Songsermsawad","year":"2025","journal-title":"Cryst. Growth Des."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115277_bb1450","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1039\/C9QM00760A","article-title":"Stimuli-responsive behaviors of organic charge transfer cocrystals: recent advances and perspectives","volume":"4","author":"Sun","year":"2020","journal-title":"Mater. Chem. Front."},{"key":"10.1016\/j.jconrel.2026.115277_bb1455","doi-asserted-by":"crossref","DOI":"10.1016\/j.powtec.2024.120126","article-title":"Cocrystal formulation design of 4-aminosalicylic acid and isoniazid via spray-drying based on a ternary phase diagram toward simultaneous pulmonary delivery","volume":"445","author":"Mo","year":"2024","journal-title":"Powder Technol."},{"key":"10.1016\/j.jconrel.2026.115277_bb1460","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1208\/s12249-018-1101-5","article-title":"Development and characterization of dapsone cocrystal prepared by scalable production methods","volume":"19","author":"do Amaral","year":"2018","journal-title":"AAPS PharmSciTech"},{"issue":"33","key":"10.1016\/j.jconrel.2026.115277_bb1465","doi-asserted-by":"crossref","first-page":"5875","DOI":"10.1039\/D2CE00758D","article-title":"Expanding the solid-state landscape of dexamethasone: a specific sandwich structure in facilitating the formation of kinetically stable cocrystals from mechanochemistry","volume":"24","author":"Wong","year":"2022","journal-title":"CrystEngComm"},{"key":"10.1016\/j.jconrel.2026.115277_bb1470","series-title":"Food Additives-From Chemistry to Safety","article-title":"Chemistry of food sweeteners","author":"Garba","year":"2024"},{"key":"10.1016\/j.jconrel.2026.115277_bb1475","series-title":"Sweeteners: Nutritional Aspects, Applications, and Production Technology","author":"Varzakas","year":"2012"},{"issue":"6","key":"10.1016\/j.jconrel.2026.115277_bb1480","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1021\/acs.cgd.5b00207","article-title":"Sweet theophylline cocrystal with two tautomers of acesulfame","volume":"15","author":"Wang","year":"2015","journal-title":"Cryst. Growth Des."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115277_bb1485","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s11095-007-9394-1","article-title":"Indomethacin\u2013saccharin cocrystal: design, synthesis and preliminary pharmaceutical characterization","volume":"25","author":"Basavoju","year":"2008","journal-title":"Pharm. Res."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926006814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926006814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:08:10Z","timestamp":1790212090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926006814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":297,"alternative-id":["S0168365926006814"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115277","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmaceutical cocrystals beyond enteral drug delivery: from concept to translation","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115277","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115277"}}