{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:33:55Z","timestamp":1793338435363,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007277","name":"Icahn School of Medicine at Mount Sinai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007277","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011668","name":"Empire State Development","doi-asserted-by":"publisher","award":["135897"],"award-info":[{"award-number":["135897"]}],"id":[{"id":"10.13039\/100011668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jconrel.2026.115321","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:12:10Z","timestamp":1788221530000},"page":"115321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PA","title":["Nitric oxide-assisted lipid nanoparticles amplify mRNA vaccine responses"],"prefix":"10.1016","volume":"399","author":[{"given":"Zhengwei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinglingge","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xucheng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonger","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alister","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline R.","family":"Ferrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya Ying","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhou","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jconrel.2026.115321_bb0005","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrd.2017.243","article-title":"mRNA vaccines \u2014 a new era in vaccinology","volume":"17","author":"Pardi","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115321_bb0010","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/s41573-025-01237-x","article-title":"RNA chemistry and therapeutics","volume":"24","author":"Wang","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115321_bb0015","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/s41587-022-01294-2","article-title":"The clinical progress of mRNA vaccines and immunotherapies","volume":"40","author":"Barbier","year":"2022","journal-title":"Nat. Biotechnol."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115321_bb0020","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41573-021-00283-5","article-title":"mRNA vaccines for infectious diseases: principles, delivery and clinical translation","volume":"20","author":"Chaudhary","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115321_bb0025","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/s41573-024-00977-6","article-title":"The 60-year evolution of lipid nanoparticles for nucleic acid delivery","volume":"23","author":"Cullis","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115321_bb0030","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/s41570-025-00770-y","article-title":"Chemical strategies for brain delivery of genomic therapy","volume":"9","author":"Li","year":"2025","journal-title":"Nat. Rev. Chem."},{"issue":"33","key":"10.1016\/j.jconrel.2026.115321_bb0035","doi-asserted-by":"crossref","first-page":"eadw0730","DOI":"10.1126\/sciadv.adw0730","article-title":"Lipid nanoparticles for mRNA delivery in brain via systemic administration","volume":"11","author":"Cao","year":"2025","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115321_bb0040","doi-asserted-by":"crossref","first-page":"6645","DOI":"10.1038\/s41467-023-42280-9","article-title":"Nanomechanical action opens endo-lysosomal compartments","volume":"14","author":"Zhao","year":"2023","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115321_bb0045","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nbt.2612","article-title":"Image-based analysis of lipid nanoparticle\u2013mediated siRNA delivery, intracellular trafficking and endosomal escape","volume":"31","author":"Gilleron","year":"2013","journal-title":"Nat. Biotechnol."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115321_bb0050","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1039\/D0BM01947J","article-title":"Illuminating endosomal escape of polymorphic lipid nanoparticles that boost mRNA delivery","volume":"9","author":"Herrera","year":"2021","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.jconrel.2026.115321_bb0055","doi-asserted-by":"crossref","DOI":"10.1038\/s41587-026-03022-6","article-title":"In vivo endosomal escape assay identifies mechanisms for efficient hepatic LNP delivery","author":"Jozi\u0107","year":"2026","journal-title":"Nat. Biotechnol."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115321_bb0060","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1039\/c2cs15271a","article-title":"Nitric oxide release: part III. Measurement and reporting","volume":"41","author":"Coneski","year":"2012","journal-title":"Chem. Soc. Rev."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115321_bb0065","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1039\/D5BM01825K","article-title":"Engineering delivery platforms for controlled nitric oxide release","volume":"14","author":"Choi","year":"2026","journal-title":"Biomater. Sci."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115321_bb0070","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/s41565-019-0570-3","article-title":"Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies","volume":"14","author":"Sung","year":"2019","journal-title":"Nat. Nanotechnol."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115321_bb0075","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1056\/NEJM200002173420704","article-title":"Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical inhaled nitric oxide research group","volume":"342","author":"Clark","year":"2000","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115321_bb0080","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1021\/acs.molpharmaceut.2c00973","article-title":"Fluorescent self-reporting lipid nanoparticles for nitric oxide\/gene co-delivery and combination therapy","volume":"20","author":"Yang","year":"2023","journal-title":"Mol. Pharm."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115321_bb0085","doi-asserted-by":"crossref","first-page":"2400329","DOI":"10.1002\/adtp.202400329","article-title":"Cocktail polyplexes with synchronous flightless I siRNA and nitric oxide release for potential chronic wound healing","volume":"7","author":"Kharaziha","year":"2024","journal-title":"Adv. Ther."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115321_bb0090","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1038\/s41467-025-57045-9","article-title":"Bioactive nanomotor enabling efficient intestinal barrier penetration for colorectal cancer therapy","volume":"16","author":"Wang","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115321_bb0095","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mattod.2023.11.011","article-title":"Nitric oxide-assisted mucus-walking zwitterionic nanocomplexes for synergistic treatment of severe respiratory infectious disease","volume":"72","author":"Park","year":"2024","journal-title":"Mater. Today"},{"issue":"8","key":"10.1016\/j.jconrel.2026.115321_bb0100","doi-asserted-by":"crossref","first-page":"2413518","DOI":"10.1002\/advs.202413518","article-title":"Nitric oxide-releasing nanoscale metal-organic layer overcomes hypoxia and reactive oxygen species diffusion barriers to enhance cancer radiotherapy","volume":"12","author":"Xiong","year":"2025","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115321_bb0105","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1038\/s41467-025-57149-2","article-title":"LNP-RNA-mediated antigen presentation leverages SARS-CoV-2-specific immunity for cancer treatment","volume":"16","author":"Xue","year":"2025","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115321_bb0110","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41563-020-00886-0","article-title":"Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR\u2013Cas gene editing","volume":"20","author":"Liu","year":"2021","journal-title":"Nat. Mater."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115321_bb0115","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/s41467-024-55137-6","article-title":"Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering","volume":"16","author":"Padilla","year":"2025","journal-title":"Nat. Commun."},{"issue":"19","key":"10.1016\/j.jconrel.2026.115321_bb0120","doi-asserted-by":"crossref","first-page":"16007","DOI":"10.1021\/jacs.4c16326","article-title":"Furan-derived lipid nanoparticles for transporting mRNA to the central nervous system","volume":"147","author":"Liu","year":"2025","journal-title":"J. Am. Chem. Soc."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836592600725X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016836592600725X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:26:32Z","timestamp":1793337992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016836592600725X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":24,"alternative-id":["S016836592600725X"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115321","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitric oxide-assisted lipid nanoparticles amplify mRNA vaccine responses","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115321","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115321"}}