{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:31:49Z","timestamp":1793442709592,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018532","name":"Major Scientific and Technological Innovation Project of Shandong Province","doi-asserted-by":"publisher","award":["2025ZLGX04"],"award-info":[{"award-number":["2025ZLGX04"]}],"id":[{"id":"10.13039\/501100018532","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jconrel.2026.115349","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:09:56Z","timestamp":1790035796000},"page":"115349","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"PB","title":["Oxygen pump microneedles coupling cuproptosis and disulfidptosis to enhance melanoma immunotherapy"],"prefix":"10.1016","volume":"399","author":[{"given":"Jinli","family":"Pang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianxiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianze","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jconrel.2026.115349_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/cells15030298","article-title":"mRNA vaccines in melanoma immunotherapy\u2014a narrative review","volume":"15","author":"Plewa","year":"2026","journal-title":"Cells"},{"key":"10.1016\/j.jconrel.2026.115349_bb0010","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41572-025-00603-8","article-title":"Cutaneous melanoma","volume":"11","author":"Tasdogan","year":"2025","journal-title":"Nat. Rev. Dis. Primer"},{"key":"10.1016\/j.jconrel.2026.115349_bb0015","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1001\/jama.2025.13074","article-title":"Cutaneous melanoma: a review","volume":"334","author":"Joshi","year":"2025","journal-title":"JAMA"},{"key":"10.1016\/j.jconrel.2026.115349_bb0020","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41577-024-01026-4","article-title":"Cancer cell metabolism and antitumour immunity","volume":"24","author":"De Martino","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jconrel.2026.115349_bb0025","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/s12967-023-04200-9","article-title":"The role of mitochondria in the resistance of melanoma to PD-1 inhibitors","volume":"21","author":"Du","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jconrel.2026.115349_bb0030","article-title":"Advanced therapeutic approach based on LDHs\u2013mimetic oxidoreductase","volume":"13","author":"Song","year":"2026","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.115349_bb0035","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1039\/D0MO00159G","article-title":"Determination of hypoxia signature to predict prognosis and the tumor immune microenvironment in melanoma","volume":"17","author":"Shou","year":"2021","journal-title":"Mol. Omics"},{"key":"10.1016\/j.jconrel.2026.115349_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14061531","article-title":"NRF2 and key transcriptional targets in melanoma redox manipulation","volume":"14","author":"Carpenter","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.jconrel.2026.115349_bb0045","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2120617119","article-title":"Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells","volume":"119","author":"Aurora","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jconrel.2026.115349_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252111651","article-title":"Current insights into the role of UV radiation-induced oxidative stress in melanoma pathogenesis","volume":"25","author":"Gieniusz","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jconrel.2026.115349_bb0055","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12943-021-01316-8","article-title":"The cancer metabolic reprogramming and immune response","volume":"20","author":"Xia","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jconrel.2026.115349_bb0060","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/procel\/pwae003","article-title":"Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond","volume":"15","author":"Mao","year":"2024","journal-title":"Protein Cell"},{"key":"10.1016\/j.jconrel.2026.115349_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122934","article-title":"Bimetallic peroxide-based nanotherapeutics for immunometabolic intervention and induction of immunogenic cell death to augment cancer immunotherapy","volume":"315","author":"Han","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115349_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113775","article-title":"Metal-phenolic networks reverse the immunosuppressive tumor microenvironment via dual metabolism regulation and immunogenic cell death","volume":"383","author":"Nam","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115349_bb0075","doi-asserted-by":"crossref","first-page":"123523","DOI":"10.1016\/j.biomaterials.2025.123523","article-title":"Disrupting intracellular redox homeostasis through copper-driven dual cell death to induce anti-tumor immunotherapy","volume":"324","author":"Wang","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.jconrel.2026.115349_bb0080","article-title":"Disrupting intracellular homeostasis by copper-based nanoinducer with multiple enzyme-mimicking activities to induce disulfidptosis-enhanced pyroptosis for tumor immunotherapy","volume":"36","author":"Jin","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115349_bb0085","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1126\/science.abo3959","article-title":"Copper-induced cell death","volume":"375","author":"Kahlson","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.jconrel.2026.115349_bb0090","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41571-024-00876-0","article-title":"Targeting cuproplasia and cuproptosis in cancer","volume":"21","author":"Tang","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jconrel.2026.115349_bb0095","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41392-022-01229-y","article-title":"Copper homeostasis and cuproptosis in health and disease","volume":"7","author":"Chen","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jconrel.2026.115349_bb0100","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41556-023-01091-2","article-title":"Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis","volume":"25","author":"Liu","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jconrel.2026.115349_bb0105","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41556-023-01100-4","article-title":"Deadly actin collapse by disulfidptosis","volume":"25","author":"Machesky","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jconrel.2026.115349_bb0110","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.ccell.2025.02.015","article-title":"Hypoxia inducible factor-1\u03b1 drives cancer resistance to cuproptosis","volume":"43","author":"Yang","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jconrel.2026.115349_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103757","article-title":"Hypoxia, cuproptosis, and osteoarthritis: unraveling the molecular crosstalk","volume":"85","author":"Jiang","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.jconrel.2026.115349_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2024.102196","article-title":"Sensitizing cuproptosis by endogenous copper-triggered bioorthogonal nanoremodeler","volume":"55","author":"Zhu","year":"2024","journal-title":"Nano Today"},{"key":"10.1016\/j.jconrel.2026.115349_bb0125","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1021\/acsnano.5c19675","article-title":"Self-carrier nanoagonist enabling positive feedback regulation of cuproptosis-immunity for potent antitumor therapy","volume":"20","author":"Jiang","year":"2026","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115349_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12111944","article-title":"Inflammation in myocardial ischemia\/reperfusion injury: underlying mechanisms and therapeutic potential","volume":"12","author":"Francisco","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.jconrel.2026.115349_bb0135","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41581-022-00587-8","article-title":"The effect of HIF on metabolism and immunity","volume":"18","author":"Taylor","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jconrel.2026.115349_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.157408","article-title":"Copper\/iron bimetal phenolic networks boosted apoptosis\/ferroptosis\/cuproptosis combined tumor therapy through dual glutathione depletion","volume":"500","author":"Zhao","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.jconrel.2026.115349_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202308241","article-title":"Self-destructive copper carriers induce pyroptosis and cuproptosis for efficient tumor immunotherapy against dormant and recurrent tumors","volume":"36","author":"Qiao","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.jconrel.2026.115349_bb0150","doi-asserted-by":"crossref","first-page":"30033","DOI":"10.1021\/jacs.4c06338","article-title":"Polyvalent aptamer nanodrug conjugates enable efficient tumor cuproptosis therapy through copper overload and glutathione depletion","volume":"146","author":"Wang","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jconrel.2026.115349_bb0155","first-page":"744","article-title":"Regulating SLC7A11\/GSH\/GPX4 axis by glucose dyshomeostasis to simultaneously promote disulfidptosis, cuproptosis and ferroptosis","volume":"54","author":"Zhang","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2026.115349_bb0160","article-title":"From conceptual design to translational progress: emerging advances in intelligent microneedles for biomedical applications","author":"Yin","year":"2026","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jconrel.2026.115349_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2026.114743","article-title":"Disease-tailored drug delivery microneedle systems: precision engineering for unmet clinical needs","volume":"392","author":"Xiao","year":"2026","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115349_bb0170","article-title":"Multi-stage regulated peptide microneedle for enhancing ferroptosis in melanoma therapy","volume":"36","author":"Wei","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.jconrel.2026.115349_bb0175","first-page":"58","article-title":"A self-monitoring microneedle patch for light-controlled synergistic treatment of melanoma","volume":"27","author":"Wang","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.jconrel.2026.115349_bb0180","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jconrel.2022.06.021","article-title":"Research progress of microneedles in the treatment of melanoma","volume":"348","author":"Li","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115349_bb0185","doi-asserted-by":"crossref","first-page":"100208","DOI":"10.1016\/j.mtbio.2022.100208","article-title":"Towards principled design of cancer nanomedicine to accelerate clinical translation","volume":"13","author":"Souri","year":"2022","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.jconrel.2026.115349_bb0190","doi-asserted-by":"crossref","DOI":"10.4028\/b-4W7Te2","article-title":"Applications of surface modification technologies in nanomedicine for deep tumor penetration","volume":"8","author":"Li","year":"2020","journal-title":"Adv. Sci."},{"key":"10.1016\/j.jconrel.2026.115349_bb0195","doi-asserted-by":"crossref","first-page":"8947","DOI":"10.1038\/s41467-024-53280-8","article-title":"Microorganism microneedle micro-engine depth drug delivery","volume":"15","author":"Zheng","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115349_bb0200","doi-asserted-by":"crossref","first-page":"88","DOI":"10.54517\/wt.v3i1.1639","article-title":"Application prospects for wearable body surface microfluidic system in sports","volume":"3","author":"Bian","year":"2021","journal-title":"Wearable Technol."},{"key":"10.1016\/j.jconrel.2026.115349_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.133428","article-title":"Hyaluronic acid-based multifunctional nanoplatform for glucose deprivation-enhanced chemodynamic\/photothermal synergistic cancer therapy","volume":"275","author":"Liu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jconrel.2026.115349_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2025.111877","article-title":"Bioinspired polyphenols nanoparticles-assembled microneedles integrating antioxidant defense with immune-melanogenic reprogramming for precision vitiligo phototherapy","volume":"37","author":"Hu","year":"2026","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.jconrel.2026.115349_bb0215","doi-asserted-by":"crossref","first-page":"13197","DOI":"10.1039\/D0TA04939E","article-title":"Electrochemical deposition and thermoelectric characterisation of a semiconducting 2-D metal\u2013organic framework thin film","volume":"8","author":"de L. Gonzalez-Juarez","year":"2020","journal-title":"J. Mater. Chem. A"},{"key":"10.1016\/j.jconrel.2026.115349_bb0220","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1038\/s41467-021-24571-1","article-title":"Large-area synthesis of nanoscopic catalyst-decorated conductive MOF film using microfluidic-based solution shearing","volume":"12","author":"Kim","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jconrel.2026.115349_bb0225","first-page":"1218","article-title":"Redox-active metal\u2013organic framework nanocrystals for the simultaneous adsorption, detection, and detoxification of heavy metal cations","volume":"18","author":"Damacet","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2026.115349_bb0230","doi-asserted-by":"crossref","first-page":"12404","DOI":"10.1021\/acsami.2c00089","article-title":"Tunable carrier type of a semiconducting 2D metal\u2013organic framework Cu3(HHTP)2","volume":"14","author":"de Lourdes Gonzalez-Juarez","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jconrel.2026.115349_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2026.101387","article-title":"Programmed cell death network in cancer drug resistance: a framework for therapeutic intervention","volume":"86","author":"Guo","year":"2026","journal-title":"Drug Resist. Updat."}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926007534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926007534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T09:49:33Z","timestamp":1793440173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926007534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":47,"alternative-id":["S0168365926007534"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115349","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxygen pump microneedles coupling cuproptosis and disulfidptosis to enhance melanoma immunotherapy","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115349","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115349"}}