{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:33:50Z","timestamp":1793338430493,"version":"4.5.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32302844"],"award-info":[{"award-number":["32302844"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M750114"],"award-info":[{"award-number":["2024M750114"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Controlled Release"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jconrel.2026.115353","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:51:38Z","timestamp":1789501898000},"page":"115353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"PA","title":["A nano-adjuvant platform potentiates immunity for potent mucosal and systemic defense against influenza"],"prefix":"10.1016","volume":"399","author":[{"given":"Hanghang","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zekun","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongzhou","family":"lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anchun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifeng","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"820","key":"10.1016\/j.jconrel.2026.115353_bb0005","doi-asserted-by":"crossref","first-page":"eady2282","DOI":"10.1126\/scitranslmed.ady2282","article-title":"An intramuscular prime and mucosal boost vaccine regimen protects against lethal clade 2.3.4.4b H5N1 challenge in cynomolgus macaques","volume":"17","author":"Lasrado","year":"2025","journal-title":"Sci. Transl. Med."},{"issue":"757","key":"10.1016\/j.jconrel.2026.115353_bb0010","doi-asserted-by":"crossref","first-page":"eadm7471","DOI":"10.1126\/scitranslmed.adm7471","article-title":"Improving vaccine equity by increasing vaccine thermostability","volume":"16","author":"Hare","year":"2024","journal-title":"Sci. Transl. Med."},{"issue":"39","key":"10.1016\/j.jconrel.2026.115353_bb0015","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adx7487","article-title":"Development of SARS-CoV-2 as a viral vector: a novel intranasal bivalent vaccine for SARS-CoV-2 and RSV","volume":"11","author":"Xu","year":"2025","journal-title":"Sci. Adv."},{"issue":"22","key":"10.1016\/j.jconrel.2026.115353_bb0020","doi-asserted-by":"crossref","first-page":"eadn7786","DOI":"10.1126\/sciadv.adn7786","article-title":"Vaccine targeting to mucosal lymphoid tissues promotes humoral immunity in the gastrointestinal tract","volume":"10","author":"Kocabiyik","year":"2024","journal-title":"Sci. Adv."},{"issue":"94","key":"10.1016\/j.jconrel.2026.115353_bb0025","doi-asserted-by":"crossref","first-page":"eadi8039","DOI":"10.1126\/sciimmunol.adi8039","article-title":"AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans","volume":"9","author":"Grigoryan","year":"2024","journal-title":"Sci. Immunol."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115353_bb0030","doi-asserted-by":"crossref","first-page":"eadt0341","DOI":"10.1126\/sciadv.adt0341","article-title":"A polyvalent vaccine for selectively killing tumor-associated bacteria to prevent cancer metastasis","volume":"11","author":"Kang","year":"2025","journal-title":"Sci. Adv."},{"issue":"104","key":"10.1016\/j.jconrel.2026.115353_bb0035","doi-asserted-by":"crossref","first-page":"eado5937","DOI":"10.1126\/sciimmunol.ado5937","article-title":"Linking vaccine adjuvant mechanisms of action to function","volume":"10","author":"Ben-Akiva","year":"2025","journal-title":"Sci. Immunol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115353_bb0040","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41467-025-64829-6","article-title":"Intranasal replicon vaccine establishes mucosal immunity and protects against H5N1 and H7N9 influenza","volume":"17","author":"Ykema","year":"2026","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115353_bb0045","doi-asserted-by":"crossref","first-page":"2045853","DOI":"10.1080\/21645515.2022.2045853","article-title":"COVID-19 intranasal vaccines: current progress, advantages, prospects, and challenges","volume":"18","author":"Dhama","year":"2022","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.jconrel.2026.115353_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114054","article-title":"An intranasally- and intramuscularly-deliverable nanostructured lipid carrier-replicon RNA vaccine drives protective systemic and mucosal immunity","volume":"385","author":"McClary","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.jconrel.2026.115353_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2024.102156","article-title":"A metalloprotein nanoparticle scaffold co-delivers antigens and adjuvants with metal-enhanced STING activation for vaccination preventing viral infections","volume":"55","author":"Li","year":"2024","journal-title":"Nano Today"},{"issue":"11","key":"10.1016\/j.jconrel.2026.115353_bb0060","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/nmat3775","article-title":"Engineering synthetic vaccines using cues from natural immunity","volume":"12","author":"Irvine","year":"2013","journal-title":"Nat. Mater."},{"issue":"41","key":"10.1016\/j.jconrel.2026.115353_bb0065","doi-asserted-by":"crossref","first-page":"eadn9961","DOI":"10.1126\/sciadv.adn9961","article-title":"Lipopolyplex-formulated mRNA cancer vaccine elicits strong neoantigen-specific T cell responses and antitumor activity","volume":"10","author":"Fan","year":"2024","journal-title":"Sci. Adv."},{"issue":"47","key":"10.1016\/j.jconrel.2026.115353_bb0070","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adp3680","article-title":"mRNA compartmentalization via multimodule DNA nanostructure assembly augments the immunogenicity and efficacy of cancer mRNA vaccine","volume":"10","author":"Guo","year":"2024","journal-title":"Sci. Adv."},{"issue":"29","key":"10.1016\/j.jconrel.2026.115353_bb0075","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202504458","article-title":"Chiral aluminum oxyhydroxide supraparticles as adjuvants","volume":"37","author":"Li","year":"2025","journal-title":"Adv. Mater."},{"issue":"43","key":"10.1016\/j.jconrel.2026.115353_bb0080","doi-asserted-by":"crossref","first-page":"eadx1576","DOI":"10.1126\/sciadv.adx1576","article-title":"The evolution of nanomedicine: the rise of next-generation nanomaterials in cancer nanomedicine","volume":"11","author":"Forgham","year":"2025","journal-title":"Sci. Adv."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115353_bb0085","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41565-020-0732-3","article-title":"Immune-mediated approaches against COVID-19","volume":"15","author":"Florindo","year":"2020","journal-title":"Nat. Nanotechnol."},{"issue":"3","key":"10.1016\/j.jconrel.2026.115353_bb0090","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1172\/JCI81083","article-title":"Beyond antigens and adjuvants: formulating future vaccines","volume":"126","author":"Moyer","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jconrel.2026.115353_bb0095","doi-asserted-by":"crossref","first-page":"5289","DOI":"10.2147\/IJN.S140363","article-title":"Nanostructured delivery systems with improved leishmanicidal activity: a critical review","volume":"12","author":"Bruni","year":"2017","journal-title":"Int. J. Nanomedicine"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115353_bb0100","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s12010-014-1084-y","article-title":"Chitosan-assisted immunotherapy for intervention of experimental leishmaniasis via amphotericin B-loaded solid lipid nanoparticles","volume":"174","author":"Jain","year":"2014","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.jconrel.2026.115353_bb0105","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.actbio.2015.03.001","article-title":"Stealth filaments: polymer chain length and conformation affect the in vivo fate of PEGylated potato virus","volume":"19","author":"Lee","year":"2015","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jconrel.2026.115353_bb0110","doi-asserted-by":"crossref","first-page":"13520","DOI":"10.1038\/ncomms13520","article-title":"Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months","volume":"7","author":"Pelliccia","year":"2016","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.jconrel.2026.115353_bb0115","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1021\/acs.nanolett.3c03806","article-title":"Virus-like particles armored by an endoskeleton","volume":"24","author":"Wu","year":"2024","journal-title":"Nano Lett."},{"issue":"806","key":"10.1016\/j.jconrel.2026.115353_bb0120","doi-asserted-by":"crossref","first-page":"eadu7646","DOI":"10.1126\/scitranslmed.adu7646","article-title":"Adenovirus and mRNA vaccines as well as mucosal boosting improve protective efficacy against influenza virus challenge in macaques","volume":"17","author":"Jacob-Dolan","year":"2025","journal-title":"Sci. Transl. Med."},{"issue":"6755","key":"10.1016\/j.jconrel.2026.115353_bb0125","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1126\/science.adx8639","article-title":"The consequences of letting avian influenza run rampant in US poultry","volume":"389","author":"Sorrell","year":"2025","journal-title":"Science"},{"issue":"15","key":"10.1016\/j.jconrel.2026.115353_bb0130","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2424889122","article-title":"A monoclonal anti-hemagglutinin stem antibody modified with zanamivir protects against both influenza A and B viruses","volume":"122","author":"Liu","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115353_bb0135","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/jmwh.13203","article-title":"Influenza and influenza vaccine: a review","volume":"66","author":"Nypaver","year":"2021","journal-title":"J. Midwifery Womens Health"},{"issue":"19","key":"10.1016\/j.jconrel.2026.115353_bb0140","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2024998118","article-title":"Intranasal vaccination with influenza HA\/GO-PEI nanoparticles provides immune protection against homo- and heterologous strains","volume":"118","author":"Dong","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"39","key":"10.1016\/j.jconrel.2026.115353_bb0145","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2422171122","article-title":"Intranasal hemagglutinin protein boosters induce protective mucosal immunity against influenza A viruses in mice","volume":"122","author":"Moriyama","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.jconrel.2026.115353_bb0150","doi-asserted-by":"crossref","first-page":"12370","DOI":"10.1021\/acsnano.0c06109","article-title":"Engineering antiviral vaccines","volume":"14","author":"Zhou","year":"2020","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.jconrel.2026.115353_bb0155","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41591-020-0753-3","article-title":"Engineered immunogen binding to alum adjuvant enhances humoral immunity","volume":"26","author":"Moyer","year":"2020","journal-title":"Nat. Med."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115353_bb0160","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ni.1631","article-title":"Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization","volume":"9","author":"Hornung","year":"2008","journal-title":"Nat. Immunol."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115353_bb0165","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1021\/acscentsci.9b00476","article-title":"BigSMILES: a structurally-based line notation for describing macromolecules","volume":"5","author":"Lin","year":"2019","journal-title":"ACS Cent. Sci."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115353_bb0170","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1021\/acsnano.3c10339","article-title":"Surface cross-linking by macromolecular tethers enhances virus-like particles\u2019 resilience to mucosal stress factors","volume":"18","author":"Ali","year":"2024","journal-title":"ACS Nano"},{"issue":"5","key":"10.1016\/j.jconrel.2026.115353_bb0175","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1021\/acsnano.2c10352","article-title":"Biomineralized MnO(2) nanoplatforms mediated delivery of immune checkpoint inhibitors with STING pathway activation to potentiate cancer radio-immunotherapy","volume":"17","author":"Deng","year":"2023","journal-title":"ACS Nano"},{"issue":"12","key":"10.1016\/j.jconrel.2026.115353_bb0180","doi-asserted-by":"crossref","first-page":"20400","DOI":"10.1021\/acsnano.2c06646","article-title":"Tumor microenvironment-activable manganese-boosted catalytic immunotherapy combined with PD-1 checkpoint blockade","volume":"16","author":"Zhao","year":"2022","journal-title":"ACS Nano"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115353_bb0185","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nri3818","article-title":"The ins and outs of MHC class II-mediated antigen processing and presentation","volume":"15","author":"Roche","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"34","key":"10.1016\/j.jconrel.2026.115353_bb0190","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202406683","article-title":"Gold nanodots-anchored cobalt ferrite nanoflowers as versatile tumor microenvironment modulators for reinforced redox dyshomeostasis","volume":"11","author":"Zeng","year":"2024","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115353_bb0195","doi-asserted-by":"crossref","first-page":"5888","DOI":"10.1038\/s41467-023-41592-0","article-title":"pH-gated nanoparticles selectively regulate lysosomal function of tumour-associated macrophages for cancer immunotherapy","volume":"14","author":"Tang","year":"2023","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.jconrel.2026.115353_bb0200","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1021\/acsbiomaterials.0c01291","article-title":"Intranasal subunit vaccination strategies employing nanomaterials and biomaterials","volume":"7","author":"Cossette","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"7","key":"10.1016\/j.jconrel.2026.115353_bb0205","doi-asserted-by":"crossref","first-page":"7005","DOI":"10.1021\/acsnano.4c14735","article-title":"Multilayer adjuvanted influenza protein nanoparticles improve intranasal delivery and antigen-specific immunity","volume":"19","author":"Park","year":"2025","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115353_bb0210","doi-asserted-by":"crossref","first-page":"6468","DOI":"10.1038\/s41467-023-42189-3","article-title":"Lipid nanoparticles with PEG-variant surface modifications mediate genome editing in the mouse retina","volume":"14","author":"Gautam","year":"2023","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.jconrel.2026.115353_bb0215","doi-asserted-by":"crossref","first-page":"9217","DOI":"10.1021\/acsnano.5b03876","article-title":"Impact of surface polyethylene glycol (PEG) density on biodegradable nanoparticle transport in mucus ex vivo and distribution in vivo","volume":"9","author":"Xu","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.jconrel.2026.115353_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119903","article-title":"Enabling sublingual peptide immunization with molecular self-assemblies","volume":"241","author":"Kelly","year":"2020","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115353_bb0225","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.immuni.2014.10.004","article-title":"T follicular helper cell differentiation, function, and roles in disease","volume":"41","author":"Crotty","year":"2014","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.jconrel.2026.115353_bb0230","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1586\/erv.13.35","article-title":"Immunological assessment of influenza vaccines and immune correlates of protection","volume":"12","author":"Reber","year":"2013","journal-title":"Expert Rev. Vaccines"},{"issue":"13","key":"10.1016\/j.jconrel.2026.115353_bb0235","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202415887","article-title":"Generating self-adjuvated nanofiber vaccines by coating bacterial flagella with antigens","volume":"37","author":"Fu","year":"2025","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115353_bb0240","first-page":"143","article-title":"Modulation of the human immune response by the non-toxic and non-pyrogenic adjuvant aluminium hydroxide: effect on antigen uptake and antigen presentation","volume":"61","author":"Mannhalter","year":"1985","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.jconrel.2026.115353_bb0245","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1080\/08830185.2024.2404095","article-title":"Re-inventing traditional aluminum-based adjuvants: insight into a century of advancements","volume":"44","author":"Gogoi","year":"2025","journal-title":"Int. Rev. Immunol."},{"issue":"19","key":"10.1016\/j.jconrel.2026.115353_bb0250","doi-asserted-by":"crossref","first-page":"2205409","DOI":"10.1002\/adma.202205409","article-title":"Manganese-based tumor immunotherapy","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv. Mater."},{"issue":"4","key":"10.1016\/j.jconrel.2026.115353_bb0255","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2217\/nnm.11.19","article-title":"Nanoparticle PEGylation for imaging and therapy","volume":"6","author":"Jokerst","year":"2011","journal-title":"Nanomed"},{"issue":"43","key":"10.1016\/j.jconrel.2026.115353_bb0260","doi-asserted-by":"crossref","first-page":"e6639","DOI":"10.1073\/pnas.1606050113","article-title":"Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination","volume":"113","author":"Tam","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115353_bb0265","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.3762\/bjnano.16.133","article-title":"PEGylated lipids in lipid nanoparticle delivery dynamics and therapeutic innovation","volume":"16","author":"Gao","year":"2025","journal-title":"Beilstein J. Nanotechnol."},{"issue":"6","key":"10.1016\/j.jconrel.2026.115353_bb0270","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1007\/s13346-020-00816-2","article-title":"Nose-to-brain drug delivery mediated by polymeric nanoparticles: influence of PEG surface coating","volume":"10","author":"de Oliveira Junior","year":"2020","journal-title":"Drug Deliv. Transl. Res."},{"issue":"11","key":"10.1016\/j.jconrel.2026.115353_bb0275","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/pharmaceutics16111423","article-title":"Modified PEG-lipids enhance the nasal mucosal immune capacity of lipid nanoparticle mRNA vaccines","volume":"16","author":"Li","year":"2024","journal-title":"Pharmaceutics"},{"issue":"11","key":"10.1016\/j.jconrel.2026.115353_bb0280","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.2217\/nnm-2016-0047","article-title":"Nanoparticles coated with high molecular weight PEG penetrate mucus and provide uniform vaginal and colorectal distribution in vivo","volume":"11","author":"Maisel","year":"2016","journal-title":"Nanomed"},{"key":"10.1016\/j.jconrel.2026.115353_bb0285","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3389\/fimmu.2012.00406","article-title":"Mechanism of immunopotentiation and safety of aluminum adjuvants","volume":"3","author":"HogenEsch","year":"2013","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.jconrel.2026.115353_bb0290","doi-asserted-by":"crossref","first-page":"10834","DOI":"10.1021\/nn404211j","article-title":"Engineering an effective immune adjuvant by designed control of shape and crystallinity of aluminum oxyhydroxide nanoparticles","volume":"7","author":"Sun","year":"2013","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115353_bb0295","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.0105-2896.2005.00301.x","article-title":"Cross-presentation: underlying mechanisms and role in immune surveillance","volume":"207","author":"Rock","year":"2005","journal-title":"Immunol. Rev."},{"issue":"8","key":"10.1016\/j.jconrel.2026.115353_bb0300","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nri3254","article-title":"Cross-presentation by dendritic cells","volume":"12","author":"Joffre","year":"2012","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.jconrel.2026.115353_bb0305","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s40064-015-0972-0","article-title":"The mechanisms of action of vaccines containing aluminum adjuvants: an in vitro vs in vivo paradigm","volume":"4","author":"Ghimire","year":"2015","journal-title":"Springerplus"},{"issue":"23","key":"10.1016\/j.jconrel.2026.115353_bb0310","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1016\/j.vaccine.2007.03.045","article-title":"Activation of dendritic cells and induction of CD4+ T cell differentiation by aluminum-containing adjuvants","volume":"25","author":"Sokolovska","year":"2007","journal-title":"Vaccines"},{"issue":"4","key":"10.1016\/j.jconrel.2026.115353_bb0315","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.immuni.2018.03.017","article-title":"Manganese increases the sensitivity of the cGAS-STING pathway for double-stranded DNA and is required for the host defense against DNA viruses","volume":"48","author":"Wang","year":"2018","journal-title":"Immunity"},{"issue":"7198","key":"10.1016\/j.jconrel.2026.115353_bb0320","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/nature06939","article-title":"Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants","volume":"453","author":"Eisenbarth","year":"2008","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.jconrel.2026.115353_bb0325","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41541-018-0089-x","article-title":"Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want","volume":"3","author":"HogenEsch","year":"2018","journal-title":"NPJ Vaccines"}],"container-title":["Journal of Controlled Release"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926007571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168365926007571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:22:26Z","timestamp":1793337746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168365926007571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":65,"alternative-id":["S0168365926007571"],"URL":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115353","relation":{},"ISSN":["0168-3659"],"issn-type":[{"value":"0168-3659","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A nano-adjuvant platform potentiates immunity for potent mucosal and systemic defense against influenza","name":"articletitle","label":"Article Title"},{"value":"Journal of Controlled Release","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jconrel.2026.115353","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115353"}}